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Sample Preparation and Post-separation Analysis

Searching in 'SWISS-2DPAGE' for entry matching: P28066



General information about the entry
View entry in simple text format
Entry namePSA5_HUMAN
Primary accession numberP28066
integrated into SWISS-2DPAGE on March 31, 2004 (release 17)
2D Annotations were last modified onMarch 31, 2004 (version 1)
General Annotations were last modified on May 19, 2011 (version 6)
Name and origin of the protein
DescriptionRecName: Full=Proteasome subunit alpha type-5; EC=; AltName: Full=Macropain zeta chain; AltName: Full=Multicatalytic endopeptidase complex zeta chain; AltName: Full=Proteasome zeta chain;.
Gene nameName=PSMA5
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Vuadens F., Crettaz D., Telenti A., Quadroni M., Duchosal M.A., Schneider P., Tissot J.-D.
''''''New insights into HIV lymphocyte infection'';'';''
(IN) Sanchez J.-C., Corthals G.L., Hochstrasser D.F. (eds.)Biomedical Application of Proteomics, pp.245-262, Wiley-VCH, Weinheim (2004)
  • SUBUNIT: The proteasome is composed of at least 15 non identical subunits which form a highly ordered ring-shaped structure
2D PAGE maps for identified proteins
How to interpret a protein

Homo sapiens (Human)
Tissue: Lymphocyte
  map experimental info
  protein estimated location

pI=4.55; Mw=26669  [identification data]

MAPPING (identification):
ESI tandem mass spectrometry [1].

This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See or send email from
DOSAC-COBS 2D-PAGEP28066; P28066.
Siena-2DPAGEP28066; PSA5_HUMAN.
UniProtKB/Swiss-ProtP28066; PSA5_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.

External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry namePSA5_HUMAN
Primary accession numberP28066
Secondary accession number(s) B2R8F6 Q3T1C1 Q6IBF7
Sequence was last modified on October 31, 2003 (version 3)
Annotations were last modified on October 19, 2011 (version 131)
Name and origin of the protein
DescriptionRecName: Full=Proteasome subunit alpha type-5; EC=; AltName: Full=Macropain zeta chain; AltName: Full=Multicatalytic endopeptidase complex zeta chain; AltName: Full=Proteasome zeta chain;
Gene nameName=PSMA5
Encoded onName=PSMA5
KeywordsAcetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Hydrolase; Nucleus; Phosphoprotein; Protease; Proteasome; Reference proteome; Threonine protease.
Copyrighted by the UniProt Consortium, see Distributed under the Creative Commons Attribution-NoDerivs License
EMBLX61970; CAA43962.1; -; mRNA
EMBLCR456847; CAG33128.1; -; mRNA
EMBLAK313351; BAG36153.1; -; mRNA
EMBLAL356735; CAH70887.1; -; Genomic_DNA
EMBLAL390252; CAH70887.1; JOINED; Genomic_DNA
EMBLAL390252; CAI13171.1; -; Genomic_DNA
EMBLAL356735; CAI13171.1; JOINED; Genomic_DNA
EMBLCH471122; EAW56381.1; -; Genomic_DNA
EMBLBC102018; AAI02019.1; -; mRNA
EMBLBC102019; AAI02020.1; -; mRNA
EMBLBC102020; AAI02021.1; -; mRNA
EMBLBC103751; AAI03752.1; -; mRNA
IPIIPI00291922; -; .
PIRS17521; S17521; .
RefSeqNP_002781.2; NM_002790.3; .
UniGeneHs.485246; -; .
ProteinModelPortalP28066; -; .
SMRP28066; 8-241; .
IntActP28066; 8; .
MINTMINT-1178571; -; .
STRINGP28066; -; .
MEROPST01.975; -; .
PhosphoSiteP28066; -; .
SWISS-2DPAGEP28066; -; .
Aarhus/Ghent-2DPAGE9136; IEF; .
PeptideAtlasP28066; -; .
PRIDEP28066; -; .
EnsemblENST00000271308; ENSP00000271308; ENSG00000143106; .
GeneID5686; -; .
KEGGhsa:5686; -; .
UCSCuc001dxn.1; human; .
CTD5686; -; .
GeneCardsGC01M107837; -; .
H-InvDBHIX0000848; -; .
HPAHPA028392; -; .
HPAHPA028398; -; .
HPAHPA028441; -; .
MIM176844; gene; .
neXtProtNX_P28066; -; .
PharmGKBPA33879; -; .
eggNOGprNOG13538; -; .
HOGENOMHBG499923; -; .
HOVERGENHBG003005; -; .
InParanoidP28066; -; .
OrthoDBEOG4R503K; -; .
PhylomeDBP28066; -; .
ReactomeREACT_11045; Signaling by Wnt; .
ReactomeREACT_13; Metabolism of amino acids and derivatives; .
ReactomeREACT_13505; Proteasome mediated degradation of PAK-2p34; .
ReactomeREACT_152; Cell Cycle; Mitotic; .
ReactomeREACT_1538; Cell Cycle Checkpoints; .
ReactomeREACT_21257; Metabolism of RNA; .
ReactomeREACT_383; DNA Replication; .
ReactomeREACT_578; Apoptosis; .
ReactomeREACT_6185; HIV Infection; .
ReactomeREACT_6850; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; .
ReactomeREACT_6900; Immune System; .
NextBio22086; -; .
ArrayExpressP28066; -; .
BgeeP28066; -; .
CleanExHS_PSMA5; -; .
GenevestigatorP28066; -; .
GermOnlineENSG00000143106; Homo sapiens; .
GOGO:0005829; C:cytosol; TAS:Reactome; .
GOGO:0005654; C:nucleoplasm; TAS:Reactome; .
GOGO:0019773; C:proteasome core complex; alpha-subunit complex; IEA:InterPro
GOGO:0005515; F:protein binding; IPI:UniProtKB; .
GOGO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW; .
GOGO:0031145; P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; TAS:Reactome; .
GOGO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome; .
GOGO:0006915; P:apoptosis; TAS:Reactome; .
GOGO:0006977; P:DNA damage response; signal transduction by p53 class mediator resulting in cell cycle arrest; TAS:Reactome
GOGO:0000082; P:G1/S transition of mitotic cell cycle; TAS:Reactome; .
GOGO:0000216; P:M/G1 transition of mitotic cell cycle; TAS:Reactome; .
GOGO:0016071; P:mRNA metabolic process; TAS:Reactome; .
GOGO:0051436; P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome; .
GOGO:0051437; P:positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome; .
GOGO:0000209; P:protein polyubiquitination; TAS:Reactome; .
GOGO:0042981; P:regulation of apoptosis; TAS:Reactome; .
GOGO:0006521; P:regulation of cellular amino acid metabolic process; TAS:Reactome; .
GOGO:0000084; P:S phase of mitotic cell cycle; TAS:Reactome; .
GOGO:0016032; P:viral reproduction; TAS:Reactome; .
InterProIPR000426; Proteasome_asu_CS; .
InterProIPR023332; Proteasome_suA-type; .
InterProIPR001353; Proteasome_sua/b; .
PfamPF00227; Proteasome; 1; .
PfamPF10584; Proteasome_A_N; 1; .
SMARTSM00948; Proteasome_A_N; 1; .


SWISS-2DPAGE (search AC)

Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the Expasy web server