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Sample Preparation and Post-separation Analysis Searching in 'SWISS-2DPAGE' for entry matching: P28072 SWISS-2DPAGE:  P28072 P28072 General information about the entry View entry in simple text format Entry name PSB6_HUMAN Primary accession number P28072 integrated into SWISS-2DPAGE on  August 1, 1993 (release 0) 2D Annotations were last modified on May 15, 2003 (version 1) General Annotations were last modified on  May 19, 2011 (version 13) Name and origin of the protein Description RecName: Full=Proteasome subunit beta type-6; EC=3.4.25.1; AltName: Full=Macropain delta chain; AltName: Full=Multicatalytic endopeptidase complex delta chain; AltName: Full=Proteasome delta chain; AltName: Full=Proteasome subunit Y; Flags: Precursor;. Gene name Name=PSMB6 Synonyms=LMPY, Y Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   MAPPING ON GEL MEDLINE=96007935; PubMed=7498158; [NCBI, Expasy, EBI, Israel, Japan] Gravel P., Sanchez J.-C., Walzer C., Golaz O., Hochstrasser D.F., Balant L.P., Hughes G.J., Garcia-Sevilla J., Guimon J. ''''''Human blood platelet protein map established by two-dimensional polyacrylamide gel electrophoresis'';'';'' Electrophoresis 16(1):1152-1159(1995) [2]   MAPPING ON GEL MEDLINE=94147970; PubMed=8313871; [NCBI, Expasy, EBI, Israel, Japan] Golaz O., Hughes G.J., Frutiger S., Paquet N., Bairoch A., Pasquali C., Sanchez J.-C., Tissot J.-D., Appel R.D., Walzer C., Balant L.P., Hochstrasser D.F. ''''''Plasma and red blood cell protein maps: update 1993'';'';'' Electrophoresis 14(1):1223-1231(1993) [3]   MAPPING ON GEL MEDLINE=96007934; PubMed=7498157; [NCBI, Expasy, EBI, Israel, Japan] Sanchez J.-C., Appel R.D., Golaz O.G., Pasquali C., Ravier F., Bairoch A., Hochstrasser D.F. ''''''Inside SWISS-2DPAGE database'';'';'' Electrophoresis 16(1):1131-1151(1995) 2D PAGE maps for identified proteins How to interpret a protein PLATELET_HUMAN {Platelet} Homo sapiens (Human) Tissue: Platelet   map experimental info   protein estimated location   PLATELET_HUMAN MAP LOCATIONS: SPOT 2D-000GEZ: pI=4.88; Mw=23182 MAPPING (identification): MATCHING WITH THE RBC MASTER GEL [1]. RBC_HUMAN {Red blood cells} Homo sapiens (Human) Tissue: Erythrocyte   map experimental info   protein estimated location   RBC_HUMAN MAP LOCATIONS: SPOT 2D-0006KR: pI=4.90; Mw=22700 MAPPING (identification): MICROSEQUENCING [2]. U937_HUMAN {Macrophage Like Cell Line} Homo sapiens (Human) Tissue: Histiocytic lymphoma   map experimental info   protein estimated location   U937_HUMAN MAP LOCATIONS: SPOT 2D-000D4Z: pI=4.90; Mw=22748 MAPPING (identification): MATCHING WITH THE LIVER MASTER GEL [3]. Copyright This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss). Cross-references OGP-WWW P28072. PHCI-2DPAGE P28072; PSB6_HUMAN. Siena-2DPAGE P28072; PSB6_HUMAN. UniProtKB/Swiss-Prot P28072; PSB6_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 2011_10 Entry name PSB6_HUMAN Primary accession number P28072 Secondary accession number(s) Q96J55 Sequence was last modified on  May 10, 2002 (version 4) Annotations were last modified on  October 19, 2011 (version 129) Name and origin of the protein Description RecName: Full=Proteasome subunit beta type-6; EC=3.4.25.1; AltName: Full=Macropain delta chain; AltName: Full=Multicatalytic endopeptidase complex delta chain; AltName: Full=Proteasome delta chain; AltName: Full=Proteasome subunit Y; Flags: Precursor; Gene name Name=PSMB6 Synonyms=LMPY, Y Encoded on Name=PSMB6; Synonyms=LMPY, Y Keywords Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Host-virus interaction; Hydrolase; Nucleus; Polymorphism; Protease; Proteasome; Reference proteome; Threonine protease; Zymogen. Copyright Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL D29012; BAA06098.1; -; mRNA EMBL BC000835; AAH00835.1; -; mRNA EMBL X61971; CAA43963.1; -; mRNA IPI IPI00000811; -; . PIR B54589; B54589; . PIR S17522; S17522; . RefSeq NP_002789.1; NM_002798.1; . UniGene Hs.77060; -; . ProteinModelPortal P28072; -; . SMR P28072; 35-236; . IntAct P28072; 6; . MINT MINT-5004163; -; . STRING P28072; -; . PhosphoSite P28072; -; . SWISS-2DPAGE P28072; -; . OGP P28072; -; . PHCI-2DPAGE P28072; -; . PeptideAtlas P28072; -; . PRIDE P28072; -; . Ensembl ENST00000270586; ENSP00000270586; ENSG00000142507; . GeneID 5694; -; . KEGG hsa:5694; -; . UCSC uc002fzb.1; human; . CTD 5694; -; . GeneCards GC17P004587; -; . H-InvDB HIX0202476; -; . HGNC HGNC:9543; PSMB6; . HPA HPA023312; -; . MIM 600307; gene; . neXtProt NX_P28072; -; . PharmGKB PA33888; -; . eggNOG prNOG16286; -; . HOGENOM HBG314521; -; . HOVERGEN HBG000123; -; . InParanoid P28072; -; . OMA GTSIMAV; -; . OrthoDB EOG40CHHX; -; . PhylomeDB P28072; -; . Reactome REACT_11045; Signaling by Wnt; . Reactome REACT_13; Metabolism of amino acids and derivatives; . Reactome REACT_13505; Proteasome mediated degradation of PAK-2p34; . Reactome REACT_152; Cell Cycle; Mitotic; . Reactome REACT_1538; Cell Cycle Checkpoints; . Reactome REACT_21257; Metabolism of RNA; . Reactome REACT_383; DNA Replication; . Reactome REACT_578; Apoptosis; . Reactome REACT_6185; HIV Infection; . Reactome REACT_6850; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; . Reactome REACT_6900; Immune System; . NextBio 22118; -; . ArrayExpress P28072; -; . Bgee P28072; -; . CleanEx HS_PSMB6; -; . Genevestigator P28072; -; . GermOnline ENSG00000142507; Homo sapiens; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0005654; C:nucleoplasm; TAS:Reactome; . GO GO:0005839; C:proteasome core complex; NAS:UniProtKB; . GO GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW; . GO GO:0031145; P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; TAS:Reactome; . GO GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome; . GO GO:0006915; P:apoptosis; TAS:Reactome; . GO GO:0006977; P:DNA damage response; signal transduction by p53 class mediator resulting in cell cycle arrest; TAS:Reactome GO GO:0000082; P:G1/S transition of mitotic cell cycle; TAS:Reactome; . GO GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW; . GO GO:0000216; P:M/G1 transition of mitotic cell cycle; TAS:Reactome; . GO GO:0016071; P:mRNA metabolic process; TAS:Reactome; . GO GO:0051436; P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome; . GO GO:0051437; P:positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome; . GO GO:0000209; P:protein polyubiquitination; TAS:Reactome; . GO GO:0042981; P:regulation of apoptosis; TAS:Reactome; . GO GO:0006521; P:regulation of cellular amino acid metabolic process; TAS:Reactome; . GO GO:0000084; P:S phase of mitotic cell cycle; TAS:Reactome; . GO GO:0016032; P:viral reproduction; TAS:Reactome; . InterPro IPR000243; Pept_T1A_subB; . InterPro IPR016050; Proteasome_bsu_CS; . InterPro IPR001353; Proteasome_sua/b; . InterPro IPR023333; Proteasome_suB-type; . Pfam PF00227; Proteasome; 1; . PRINTS PR00141; PROTEASOME; . PROSITE PS00854; PROTEASOME_B_1; 1; . PROSITE PS51476; PROTEASOME_B_2; 1; . SWISS-2DPAGE (search AC)