Attention: World-2DPAGE is no longer maintained.

SWISS-2DPAGE  Search by  [accession number]  [description, ID or gene]  [author names]  [spot ID / serial number]  [identification methods]  [pI / Mw range]  [combined fields]  Maps  [experimental info]  [protein list]  [graphical interface]      Select Remote Interfaces [All Interfaces] World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Sample Preparation and Post-separation Analysis Searching in 'SWISS-2DPAGE' for entry matching: P35232 SWISS-2DPAGE:  P35232 P35232 General information about the entry View entry in simple text format Entry name PHB_HUMAN Primary accession number P35232 integrated into SWISS-2DPAGE on  January 15, 1999 (release 9) 2D Annotations were last modified on March 31, 2004 (version 2) General Annotations were last modified on  May 19, 2011 (version 9) Name and origin of the protein Description RecName: Full=Prohibitin;. Gene name Name=PHB Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   MAPPING ON GEL Demalte-Annessi I., Sanchez J.-C., Hoogland C., Rouge V., Binz P.-A., Appel R.D., Hochstrasser D.F. Submitted (JAN-1999) to SWISS-2DPAGE [2]   MAPPING ON GEL Vuadens F., Crettaz D., Telenti A., Quadroni M., Duchosal M.A., Schneider P., Tissot J.-D. ''''''New insights into HIV lymphocyte infection'';'';'' (IN) Sanchez J.-C., Corthals G.L., Hochstrasser D.F. (eds.)Biomedical Application of Proteomics, pp.245-262, Wiley-VCH, Weinheim (2004) 2D PAGE maps for identified proteins How to interpret a protein DLD1_HUMAN {Colorectal adenocarcinoma cell line (DL-1)} Homo sapiens (Human) Tissue: Colon adenocarcinoma   map experimental info   protein estimated location   DLD1_HUMAN MAP LOCATIONS: SPOT 2D-001EOL: pI=5.36; Mw=27132   [identification data] MAPPING (identification): Peptide mass fingerprinting [1]. LYMPHOCYTE_HUMAN {Lymphocytes} Homo sapiens (Human) Tissue: Lymphocyte   map experimental info   protein estimated location   LYMPHOCYTE_HUMAN MAP LOCATIONS: SPOT 2D-001YCL: pI=5.40; Mw=26439   [identification data] MAPPING (identification): Peptide mass fingerprinting [2]. Copyright This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss). Cross-references DOSAC-COBS 2D-PAGE P35232; P35232. DOSAC-COBS-2DPAGE P35232; PHB_HUMAN. OGP-WWW P35232. PMMA-2DPAGE P35232; PHB_HUMAN. REPRODUCTION-2DPAGE IPI00017334; IPI00017334. REPRODUCTION-2DPAGE P35232; P35232. Siena-2DPAGE P35232; PHB_HUMAN. UCD-2DPAGE P35232; PHB_HUMAN. UniProtKB/Swiss-Prot P35232; PHB_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 2011_10 Entry name PHB_HUMAN Primary accession number P35232 Secondary accession number(s) Q4VBQ0 Sequence was last modified on  February 1, 1994 (version 1) Annotations were last modified on  October 19, 2011 (version 115) Name and origin of the protein Description RecName: Full=Prohibitin; Gene name Name=PHB Encoded on Name=PHB Keywords 3D-structure; Acetylation; Coiled coil; Complete proteome; Direct protein sequencing; DNA synthesis; Membrane; Mitochondrion; Mitochondrion inner membrane; Phosphoprotein; Polymorphism; Proto-oncogene; Reference proteome. Copyright Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL S85655; AAB21614.1; -; mRNA EMBL L14272; AAO18340.1; -; Genomic_DNA EMBL BT007411; AAP36079.1; -; mRNA EMBL BC013401; AAH13401.1; -; mRNA EMBL BC095460; AAH95460.1; -; mRNA IPI IPI00017334; -; . PIR I52690; I52690; . RefSeq NP_002625.1; NM_002634.2; . UniGene Hs.514303; -; . PDB 1LU7; Model; -; A=1-272 PDBsum 1LU7; -; . ProteinModelPortal P35232; -; . DIP DIP-24248N; -; . IntAct P35232; 39; . MINT MINT-1158239; -; . STRING P35232; -; . PhosphoSite P35232; -; . SWISS-2DPAGE P35232; -; . DOSAC-COBS-2DPAGE P35232; -; . OGP P35232; -; . PMMA-2DPAGE P35232; -; . REPRODUCTION-2DPAGE IPI00017334; -; . REPRODUCTION-2DPAGE P35232; -; . UCD-2DPAGE P35232; -; . PeptideAtlas P35232; -; . PRIDE P35232; -; . Ensembl ENST00000300408; ENSP00000300408; ENSG00000167085; . GeneID 5245; -; . KEGG hsa:5245; -; . UCSC uc002iox.1; human; . CTD 5245; -; . GeneCards GC17M042846; -; . H-InvDB HIX0013960; -; . HGNC HGNC:8912; PHB; . HPA HPA003280; -; . MIM 176705; gene; . neXtProt NX_P35232; -; . eggNOG prNOG19550; -; . HOGENOM HBG680510; -; . HOVERGEN HBG004457; -; . InParanoid P35232; -; . OMA IALEDVS; -; . OrthoDB EOG4X3H23; -; . PhylomeDB P35232; -; . NextBio 20266; -; . ArrayExpress P35232; -; . Bgee P35232; -; . CleanEx HS_PHB; -; . Genevestigator P35232; -; . GermOnline ENSG00000167085; Homo sapiens; . GO GO:0005887; C:integral to plasma membrane; IDA:HGNC; . GO GO:0005743; C:mitochondrial inner membrane; TAS:UniProtKB; . GO GO:0005654; C:nucleoplasm; IDA:UniProtKB; . GO GO:0042826; F:histone deacetylase binding; IPI:BHF-UCL; . GO GO:0044212; F:transcription regulatory region DNA binding; IDA:BHF-UCL; . GO GO:0071354; P:cellular response to interleukin-6; IDA:BHF-UCL; . GO GO:0006260; P:DNA replication; IEA:UniProtKB-KW; . GO GO:0016575; P:histone deacetylation; IDA:UniProtKB; . GO GO:0060766; P:negative regulation of androgen receptor signaling pathway; IDA:BHF-UCL; . GO GO:0030308; P:negative regulation of cell growth; IMP:BHF-UCL; . GO GO:0008285; P:negative regulation of cell proliferation; IMP:BHF-UCL; . GO GO:2000323; P:negative regulation of glucocorticoid receptor signaling pathway; IDA:BHF-UCL; . GO GO:0010944; P:negative regulation of transcription by competitive promoter binding; IDA:BHF-UCL; . GO GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL; . GO GO:0045893; P:positive regulation of transcription; DNA-dependent; IDA:UniProtKB GO GO:0050847; P:progesterone receptor signaling pathway; IDA:BHF-UCL; . GO GO:0042981; P:regulation of apoptosis; TAS:UniProtKB; . InterPro IPR001107; Band_7; . InterPro IPR000163; Prohibitin; . PANTHER PTHR23222; Prohibitin; 1; . Pfam PF01145; Band_7; 1; . PRINTS PR00679; PROHIBITIN; . SMART SM00244; PHB; 1; . SWISS-2DPAGE (search AC)