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Sample Preparation and Post-separation Analysis

Searching in 'SWISS-2DPAGE' for entry matching: P52292



General information about the entry
View entry in simple text format
Entry nameIMA2_HUMAN
Primary accession numberP52292
integrated into SWISS-2DPAGE on May 15, 2003 (release 16)
2D Annotations were last modified onMay 15, 2003 (version 1)
General Annotations were last modified on May 19, 2011 (version 6)
Name and origin of the protein
DescriptionRecName: Full=Importin subunit alpha-2; AltName: Full=Karyopherin subunit alpha-2; AltName: Full=RAG cohort protein 1; AltName: Full=SRP1-alpha;.
Gene nameName=KPNA2
Synonyms=RCH1, SRP1
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
PubMed=12429849; [NCBI, Expasy, EBI, Israel, Japan]
Scherl A., Coute Y., Deon C., Calle A., Kindbeiter K., Sanchez J.-C., Greco A., Hochstrasser D.F., Diaz J.-J.
''''''Functional proteomic analysis of human nucleolus'';'';''
Mol. Biol. Cell. 13(1):4100-4109(2002)
2D PAGE maps for identified proteins
How to interpret a protein

NUCLEOLI_HELA_1D_HUMAN {SDS-PAGE of nucleolar proteins from Human HeLa cells}
Homo sapiens (Human)
Tissue: Cervix carcinoma
  map experimental info
  protein estimated location

Mw=56716  [identification data]
Mw=55139  [identification data]

MAPPING (identification):
Tandem mass spectrometry [1].

This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See or send email from
UniProtKB/Swiss-ProtP52292; IMA2_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.

External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameIMA2_HUMAN
Primary accession numberP52292
Secondary accession number(s) B9EJD6 Q9BRU5
Sequence was last modified on October 1, 1996 (version 1)
Annotations were last modified on October 19, 2011 (version 140)
Name and origin of the protein
DescriptionRecName: Full=Importin subunit alpha-2; AltName: Full=Karyopherin subunit alpha-2; AltName: Full=RAG cohort protein 1; AltName: Full=SRP1-alpha;
Gene nameName=KPNA2
Synonyms=RCH1, SRP1
Encoded onName=KPNA2; Synonyms=RCH1, SRP1
Keywords3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Host-virus interaction; Nucleus; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Repeat; Transport.
Copyrighted by the UniProt Consortium, see Distributed under the Creative Commons Attribution-NoDerivs License
EMBLU28386; AAA69957.1; -; mRNA
EMBLAJ303086; CAC83080.1; -; Genomic_DNA
EMBLCH471099; EAW89041.1; -; Genomic_DNA
EMBLBC005978; AAH05978.1; -; mRNA
EMBLBC146905; AAI46906.1; -; mRNA
EMBLU09559; AAA65700.1; -; mRNA
IPIIPI00002214; -; .
PIRA56516; A56516; .
RefSeqNP_002257.1; NM_002266.2; .
UniGeneHs.594238; -; .
PDB1EFX; X-ray; 3.00 A; C=204-212
PDB1QGK; X-ray; 2.50 A; B=11-54
PDB1QGR; X-ray; 2.30 A; B=28-54
PDB3FEX; X-ray; 3.55 A; C=70-529
PDB3FEY; X-ray; 2.20 A; C=70-529
PDBsum1EFX; -; .
PDBsum1QGK; -; .
PDBsum1QGR; -; .
PDBsum3FEX; -; .
PDBsum3FEY; -; .
ProteinModelPortalP52292; -; .
SMRP52292; 11-499; .
DIPDIP-6205N; -; .
IntActP52292; 15; .
MINTMINT-94121; -; .
STRINGP52292; -; .
PhosphoSiteP52292; -; .
SWISS-2DPAGEP52292; -; .
PeptideAtlasP52292; -; .
PRIDEP52292; -; .
EnsemblENST00000330459; ENSP00000332455; ENSG00000182481; .
GeneID3838; -; .
KEGGhsa:3838; -; .
UCSCuc002jgk.1; human; .
CTD3838; -; .
GeneCardsGC17P061416; -; .
H-InvDBHIX0021306; -; .
HPACAB015460; -; .
MIM600685; gene; .
neXtProtNX_P52292; -; .
PharmGKBPA30186; -; .
eggNOGprNOG08271; -; .
HOGENOMHBG590318; -; .
HOVERGENHBG001846; -; .
InParanoidP52292; -; .
OrthoDBEOG4JWVDH; -; .
PhylomeDBP52292; -; .
Pathway_Interaction_DBsmad2_3pathway; Regulation of cytoplasmic and nuclear SMAD2/3 signaling; .
Pathway_Interaction_DBnfat_3pathway; Role of Calcineurin-dependent NFAT signaling in lymphocytes; .
NextBio15087; -; .
ArrayExpressP52292; -; .
BgeeP52292; -; .
CleanExHS_KPNA2; -; .
GenevestigatorP52292; -; .
GermOnlineENSG00000182481; Homo sapiens; .
GOGO:0005737; C:cytoplasm; TAS:ProtInc; .
GOGO:0005643; C:nuclear pore; IEA:InterPro; .
GOGO:0005654; C:nucleoplasm; TAS:ProtInc; .
GOGO:0042826; F:histone deacetylase binding; IPI:BHF-UCL; .
GOGO:0008139; F:nuclear localization sequence binding; IDA:UniProtKB; .
GOGO:0008565; F:protein transporter activity; IEA:InterPro; .
GOGO:0006259; P:DNA metabolic process; TAS:ProtInc; .
GOGO:0000085; P:G2 phase of mitotic cell cycle; TAS:ProtInc; .
GOGO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW; .
GOGO:0000072; P:M phase specific microtubule process; TAS:ProtInc; .
GOGO:0006607; P:NLS-bearing substrate import into nucleus; IDA:UniProtKB; .
GOGO:0000018; P:regulation of DNA recombination; TAS:ProtInc; .
InterProIPR011989; ARM-like; .
InterProIPR016024; ARM-type_fold; .
InterProIPR000225; Armadillo; .
InterProIPR002652; Importin-a-like_IBB-bd_dom; .
Gene3DG3DSA:; ARM-like; 1; .
PfamPF00514; Arm; 8; .
PfamPF01749; IBB; 1; .
SMARTSM00185; ARM; 8; .
SUPFAMSSF48371; ARM-type_fold; 1; .
PROSITEPS51214; IBB; 1; .


SWISS-2DPAGE (search AC)

Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the Expasy web server