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Sample Preparation and Post-separation Analysis Searching in 'SWISS-2DPAGE' for entry matching: P53_HUMAN SWISS-2DPAGE:  P53_HUMAN P53_HUMAN General information about the entry View entry in simple text format Entry name P53_HUMAN Primary accession number P04637 integrated into SWISS-2DPAGE on  September 1, 1997 (release 6) 2D Annotations were last modified on May 15, 2003 (version 2) General Annotations were last modified on  May 19, 2011 (version 14) Name and origin of the protein Description RecName: Full=Cellular tumor antigen p53; AltName: Full=Antigen NY-CO-13; AltName: Full=Phosphoprotein p53; AltName: Full=Tumor suppressor p53;. Gene name Name=TP53 Synonyms=P53 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   MAPPING ON GEL MEDLINE=97295311; PubMed=9150953; [NCBI, Expasy, EBI, Israel, Japan] Sanchez J.-C., Wirth P., Jaccoud S., Appel R.D., Sarto C., Wilkins M.R., Hochstrasser D.F. ''''''Simultaneous analysis of cyclin and oncogene expression using multiple monoclonal antibody immunoblots'';'';'' Electrophoresis 18(1):638-641(1997) [2]   MAPPING ON GEL Demalte-Annessi I., Sanchez J.-C., Hoogland C., Rouge V., Binz P.-A., Appel R.D., Hochstrasser D.F. Submitted (JAN-1999) to SWISS-2DPAGE 2D PAGE maps for identified proteins How to interpret a protein DLD1_HUMAN {Colorectal adenocarcinoma cell line (DL-1)} Homo sapiens (Human) Tissue: Colon adenocarcinoma   map experimental info   protein estimated location   DLD1_HUMAN MAP LOCATIONS: SPOT 2D-001DWU: pI=6.65; Mw=51091 SPOT 2D-001DX7: pI=6.54; Mw=51091 SPOT 2D-001DXN: pI=6.23; Mw=51091 SPOT 2D-001DXY: pI=6.78; Mw=50698 SPOT 2D-001DYA: pI=6.90; Mw=50309 MAPPING (identification): IMMUNOBLOTTING [2]. HEPG2_HUMAN {HepG2} Homo sapiens (Human) Tissue: Hepatoblastoma   map experimental info   protein estimated location   HEPG2_HUMAN MAP LOCATIONS: SPOT 2D-0012ID: pI=6.31; Mw=53782 SPOT 2D-0012IE: pI=6.34; Mw=53483 SPOT 2D-0012IF: pI=6.61; Mw=53333 SPOT 2D-0012IG: pI=6.73; Mw=53184 SPOT 2D-0012IH: pI=6.84; Mw=53036 SPOT 2D-0012II: pI=6.49; Mw=51143 SPOT 2D-0012IJ: pI=6.72; Mw=51143 SPOT 2D-0012IK: pI=6.35; Mw=50715 SPOT 2D-0012IL: pI=6.86; Mw=50715 SPOT 2D-0012IM: pI=6.92; Mw=50433 MAPPING (identification): IMMUNOBLOTTING [1]. LIVER_HUMAN {Liver} Homo sapiens (Human) Tissue: Liver   map experimental info   protein estimated location   LIVER_HUMAN MAP LOCATIONS: SPOT 2D-0010A3: pI=6.49; Mw=57009 SPOT 2D-0010A4: pI=6.57; Mw=57009 SPOT 2D-0010A5: pI=6.18; Mw=56538 SPOT 2D-0010A6: pI=6.34; Mw=56382 SPOT 2D-0010A7: pI=6.24; Mw=56382 SPOT 2D-0010A8: pI=6.68; Mw=52619 SPOT 2D-0010A9: pI=6.80; Mw=52619 SPOT 2D-0010AA: pI=6.43; Mw=51327 SPOT 2D-0010AB: pI=6.55; Mw=51469 SPOT 2D-0010AC: pI=6.31; Mw=51327 MAPPING (identification): IMMUNOBLOTTING [1]. Copyright This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss). Cross-references UniProtKB/Swiss-Prot P04637; P53_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 2011_10 Entry name P53_HUMAN Primary accession number P04637 Secondary accession number(s) Q15086 Q15087 Q15088 Q16535 Q16807 Q16808 Q16809 Q16810 Q16811 Q16848 Q2XN98 Q3LRW1 Q3LRW2 Q3LRW3 Q3LRW4 Q3LRW5 Q86UG1 Q8J016 Q99659 Q9BTM4 Q9HAQ8 Q9NP68 Q9NPJ2 Q9NZD0 Q9UBI2 Q9UQ61 Sequence was last modified on  November 24, 2009 (version 4) Annotations were last modified on  October 19, 2011 (version 190) Name and origin of the protein Description RecName: Full=Cellular tumor antigen p53; AltName: Full=Antigen NY-CO-13; AltName: Full=Phosphoprotein p53; AltName: Full=Tumor suppressor p53; Gene name Name=TP53 Synonyms=P53 Encoded on Name=TP53; Synonyms=P53 Keywords 3D-structure; Acetylation; Activator; Alternative promoter usage; Alternative splicing; Apoptosis; Cell cycle; Complete proteome; Cytoplasm; Disease mutation; DNA-binding; Endoplasmic reticulum; Glycoprotein; Host-virus interaction; Isopeptide bond; Li-Fraumeni syndrome; Metal-binding; Methylation; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transcription; Transcription regulation; Tumor suppressor; Ubl conjugation; Zinc. Copyright Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL X02469; CAA26306.1; -; mRNA EMBL M13121; AAA59987.1; -; Genomic_DNA EMBL M13112; AAA59987.1; JOINED; Genomic_DNA EMBL M13113; AAA59987.1; JOINED; Genomic_DNA EMBL M13114; AAA59987.1; JOINED; Genomic_DNA EMBL M13115; AAA59987.1; JOINED; Genomic_DNA EMBL M13116; AAA59987.1; JOINED; Genomic_DNA EMBL M13117; AAA59987.1; JOINED; Genomic_DNA EMBL M13118; AAA59987.1; JOINED; Genomic_DNA EMBL M13119; AAA59987.1; JOINED; Genomic_DNA EMBL M13120; AAA59987.1; JOINED; Genomic_DNA EMBL K03199; AAA59989.1; -; mRNA EMBL M14694; AAA61211.1; -; mRNA EMBL M14695; AAA61212.1; -; mRNA EMBL M22898; AAA59988.1; -; Genomic_DNA EMBL M22882; AAA59988.1; JOINED; Genomic_DNA EMBL M22883; AAA59988.1; JOINED; Genomic_DNA EMBL M22884; AAA59988.1; JOINED; Genomic_DNA EMBL M22887; AAA59988.1; JOINED; Genomic_DNA EMBL M22888; AAA59988.1; JOINED; Genomic_DNA EMBL M22894; AAA59988.1; JOINED; Genomic_DNA EMBL M22895; AAA59988.1; JOINED; Genomic_DNA EMBL M22896; AAA59988.1; JOINED; Genomic_DNA EMBL M22897; AAA59988.1; JOINED; Genomic_DNA EMBL X01405; CAA25652.1; -; mRNA EMBL X60011; CAA42626.1; -; mRNA EMBL X60012; CAA42627.1; ALT_TERM; mRNA EMBL X60013; CAA42628.1; -; mRNA EMBL X60014; CAA42629.1; -; mRNA EMBL X60015; CAA42630.1; -; mRNA EMBL X60016; CAA42631.1; -; mRNA EMBL X60017; CAA42632.1; -; mRNA EMBL X60018; CAA42633.1; -; mRNA EMBL X60019; CAA42634.1; -; mRNA EMBL X60020; CAA42635.1; -; mRNA EMBL AF307851; AAG28785.1; -; mRNA EMBL DQ186648; ABA29753.1; -; mRNA EMBL DQ186649; ABA29754.1; -; mRNA EMBL DQ186650; ABA29755.1; -; mRNA EMBL DQ186651; ABA29756.1; -; mRNA EMBL DQ186652; ABA29757.1; -; mRNA EMBL DQ191317; ABB80262.1; -; mRNA EMBL DQ286964; ABB80266.1; -; mRNA EMBL X54156; CAA38095.1; -; Genomic_DNA EMBL U94788; AAC12971.1; -; Genomic_DNA EMBL AY838896; AAV80424.1; -; Genomic_DNA EMBL AF135121; AAD28535.1; -; Genomic_DNA EMBL AF135120; AAD28535.1; JOINED; Genomic_DNA EMBL AF136271; AAD28628.1; -; Genomic_DNA EMBL AF136270; AAD28628.1; JOINED; Genomic_DNA EMBL AB082923; BAC16799.1; -; mRNA EMBL AK312568; BAG35463.1; -; mRNA EMBL AC007421; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL AC087388; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL CH471108; EAW90143.1; -; Genomic_DNA EMBL CH471108; EAW90144.1; -; Genomic_DNA EMBL BC003596; AAH03596.1; -; mRNA EMBL AY429684; AAR10356.1; -; mRNA EMBL AY390341; AAQ90158.1; -; Genomic_DNA EMBL AY359814; AAR13239.1; -; Genomic_DNA EMBL U63714; AAB39322.1; -; Genomic_DNA EMBL AF209136; AAF36362.1; -; Genomic_DNA EMBL AF209128; AAF36354.1; -; Genomic_DNA EMBL AF209129; AAF36355.1; -; Genomic_DNA EMBL AF209130; AAF36356.1; -; Genomic_DNA EMBL AF209131; AAF36357.1; -; Genomic_DNA EMBL AF209132; AAF36358.1; -; Genomic_DNA EMBL AF209133; AAF36359.1; -; Genomic_DNA EMBL AF209134; AAF36360.1; -; Genomic_DNA EMBL AF209135; AAF36361.1; -; Genomic_DNA EMBL AF209148; AAF36374.1; -; Genomic_DNA EMBL AF209149; AAF36375.1; -; Genomic_DNA EMBL AF209150; AAF36376.1; -; Genomic_DNA EMBL AF209151; AAF36377.1; -; Genomic_DNA EMBL AF209152; AAF36378.1; -; Genomic_DNA EMBL AF209153; AAF36379.1; -; Genomic_DNA EMBL AF209154; AAF36380.1; -; Genomic_DNA EMBL AF209155; AAF36381.1; -; Genomic_DNA EMBL AF209156; AAF36382.1; -; Genomic_DNA EMBL AF210309; AAF63442.1; -; Genomic_DNA EMBL AF210308; AAF63442.1; JOINED; Genomic_DNA EMBL AF210310; AAF63443.1; -; Genomic_DNA EMBL AF240684; AAK76358.1; -; Genomic_DNA EMBL AF240685; AAK76359.1; -; Genomic_DNA EMBL AY270155; AAP30003.1; -; Genomic_DNA IPI IPI00025087; -; . IPI IPI00375319; -; . IPI IPI00796188; -; . IPI IPI00894418; -; . IPI IPI00895905; -; . IPI IPI00973801; -; . IPI IPI01008713; -; . IPI IPI01009016; -; . IPI IPI01009039; -; . PIR A25224; DNHU53; . RefSeq NP_000537.3; NM_000546.4; . RefSeq NP_001119584.1; NM_001126112.1; . RefSeq NP_001119585.1; NM_001126113.1; . RefSeq NP_001119586.1; NM_001126114.1; . RefSeq NP_001119587.1; NM_001126115.1; . RefSeq NP_001119588.1; NM_001126116.1; . RefSeq NP_001119589.1; NM_001126117.1; . UniGene Hs.654481; -; . PDB 1A1U; NMR; -; A/C=324-358 PDB 1AIE; X-ray; 1.50 A; A=326-356 PDB 1C26; X-ray; 1.70 A; A=325-356 PDB 1DT7; NMR; -; X/Y=367-388 PDB 1GZH; X-ray; 2.60 A; A/C=95-292 PDB 1H26; X-ray; 2.24 A; E=376-386 PDB 1HS5; NMR; -; A/B=324-357 PDB 1JSP; NMR; -; A=367-386 PDB 1KZY; X-ray; 2.50 A; A/B=95-289 PDB 1MA3; X-ray; 2.00 A; B=372-389 PDB 1OLG; NMR; -; A/B/C/D=319-360 PDB 1OLH; NMR; -; A/B/C/D=319-360 PDB 1PES; NMR; -; A/B/C/D=325-355 PDB 1PET; NMR; -; A/B/C/D=325-355 PDB 1SAE; NMR; -; A/B/C/D=319-360 PDB 1SAF; NMR; -; A/B/C/D=319-360 PDB 1SAH; NMR; -; A/B/C/D=319-360 PDB 1SAJ; NMR; -; A/B/C/D=319-360 PDB 1SAK; NMR; -; A/B/C/D=319-360 PDB 1SAL; NMR; -; A/B/C/D=319-360 PDB 1TSR; X-ray; 2.20 A; A/B/C=94-312 PDB 1TUP; X-ray; 2.20 A; A/B/C=94-312 PDB 1UOL; X-ray; 1.90 A; A/B=94-312 PDB 1XQH; X-ray; 1.75 A; B/F=369-377 PDB 1YC5; X-ray; 1.40 A; B=372-389 PDB 1YCQ; X-ray; 2.30 A; B=13-29 PDB 1YCR; X-ray; 2.60 A; B=15-29 PDB 1YCS; X-ray; 2.20 A; A=94-292 PDB 2AC0; X-ray; 1.80 A; A/B/C/D=94-293 PDB 2ADY; X-ray; 2.50 A; A/B=94-293 PDB 2AHI; X-ray; 1.85 A; A/B/C/D=94-293 PDB 2ATA; X-ray; 2.20 A; A/B/C/D=94-293 PDB 2B3G; X-ray; 1.60 A; B=33-60 PDB 2BIM; X-ray; 1.98 A; A/B=94-312 PDB 2BIN; X-ray; 1.90 A; A=94-312 PDB 2BIO; X-ray; 1.90 A; A=94-312 PDB 2BIP; X-ray; 1.80 A; A=94-312 PDB 2BIQ; X-ray; 1.80 A; A=94-312 PDB 2F1X; X-ray; 2.30 A; A/B=359-368 PDB 2FEJ; NMR; -; A=94-297 PDB 2FOJ; X-ray; 1.60 A; B=363-367 PDB 2FOO; X-ray; 2.20 A; B=358-363 PDB 2GS0; NMR; -; B=20-73 PDB 2H1L; X-ray; 3.16 A; M/N/O/P/Q/R/S/T/U/V/W/X=92-292 PDB 2H2D; X-ray; 1.70 A; B=372-389 PDB 2H2F; X-ray; 2.20 A; B=372-389 PDB 2H4F; X-ray; 2.00 A; D=372-389 PDB 2H4H; X-ray; 1.99 A; B=372-389 PDB 2H4J; X-ray; 2.10 A; D=372-389 PDB 2H59; X-ray; 1.90 A; D/E=372-389 PDB 2J0Z; NMR; -; A/B/C/D=326-356 PDB 2J10; NMR; -; A/B/C/D=326-356 PDB 2J11; NMR; -; A/B/C/D=332-356 PDB 2J1W; X-ray; 1.80 A; A/B=94-312 PDB 2J1X; X-ray; 1.65 A; A/B=94-312 PDB 2J1Y; X-ray; 1.69 A; A/B/C/D=94-293 PDB 2J1Z; X-ray; 1.80 A; A/B=94-312 PDB 2J20; X-ray; 1.80 A; A/B=94-312 PDB 2J21; X-ray; 1.60 A; A/B=94-312 PDB 2K8F; NMR; -; B=1-39 PDB 2L14; NMR; -; B=13-61 PDB 2OCJ; X-ray; 2.05 A; A/B/C/D=94-312 PDB 2PCX; X-ray; 1.54 A; A=94-292 PDB 2QVQ; X-ray; 2.00 A; A=94-289 PDB 2QXA; X-ray; 1.50 A; A/B/C/D=95-289 PDB 2QXB; X-ray; 2.50 A; A/B/C/D=95-289 PDB 2QXC; X-ray; 1.85 A; A/B/C/D=95-289 PDB 2VUK; X-ray; 1.50 A; A/B=94-312 PDB 2WGX; X-ray; 1.75 A; A/B=94-310 PDB 2X0U; X-ray; 1.60 A; A/B=94-312 PDB 2X0V; X-ray; 1.80 A; A/B=94-312 PDB 2X0W; X-ray; 2.10 A; A/B=94-312 PDB 2XWR; X-ray; 1.68 A; A/B=89-293 PDB 2YBG; X-ray; 1.90 A; A/B/C/D=94-293 PDB 2Z5S; X-ray; 2.30 A; P/Q/R=15-29 PDB 2Z5T; X-ray; 2.30 A; P/Q/R=15-29 PDB 3D05; X-ray; 1.70 A; A=94-293 PDB 3D06; X-ray; 1.20 A; A=94-293 PDB 3D07; X-ray; 2.20 A; A/B=94-293 PDB 3D08; X-ray; 1.40 A; A=94-293 PDB 3D09; X-ray; 1.90 A; A=94-293 PDB 3D0A; X-ray; 1.80 A; A/B/C/D=94-293 PDB 3DAB; X-ray; 1.90 A; B/D/F/H=15-29 PDB 3DAC; X-ray; 1.80 A; B/P=17-37 PDB 3IGK; X-ray; 1.70 A; A=94-293 PDB 3IGL; X-ray; 1.80 A; A=94-293 PDB 3KMD; X-ray; 2.15 A; A/B/C/D=92-291 PDB 3KZ8; X-ray; 1.91 A; A/B=94-293 PDB 3LW1; X-ray; 1.28 A; P=385-393 PDB 3PDH; X-ray; 1.80 A; D=372-389 PDB 3Q01; X-ray; 2.10 A; A/B=94-356 PDB 3Q05; X-ray; 2.40 A; A/B/C/D=94-355 PDB 3Q06; X-ray; 3.20 A; A/B/C/D=96-354 PDB 3SAK; NMR; -; A/B/C/D=319-360 PDB 3TG5; X-ray; 2.30 A; B=365-375 PDBsum 1A1U; -; . PDBsum 1AIE; -; . PDBsum 1C26; -; . PDBsum 1DT7; -; . PDBsum 1GZH; -; . PDBsum 1H26; -; . PDBsum 1HS5; -; . PDBsum 1JSP; -; . PDBsum 1KZY; -; . PDBsum 1MA3; -; . PDBsum 1OLG; -; . PDBsum 1OLH; -; . PDBsum 1PES; -; . PDBsum 1PET; -; . PDBsum 1SAE; -; . PDBsum 1SAF; -; . PDBsum 1SAH; -; . PDBsum 1SAJ; -; . PDBsum 1SAK; -; . PDBsum 1SAL; -; . PDBsum 1TSR; -; . PDBsum 1TUP; -; . PDBsum 1UOL; -; . PDBsum 1XQH; -; . PDBsum 1YC5; -; . PDBsum 1YCQ; -; . PDBsum 1YCR; -; . PDBsum 1YCS; -; . PDBsum 2AC0; -; . PDBsum 2ADY; -; . PDBsum 2AHI; -; . PDBsum 2ATA; -; . PDBsum 2B3G; -; . PDBsum 2BIM; -; . PDBsum 2BIN; -; . PDBsum 2BIO; -; . PDBsum 2BIP; -; . PDBsum 2BIQ; -; . PDBsum 2F1X; -; . PDBsum 2FEJ; -; . PDBsum 2FOJ; -; . PDBsum 2FOO; -; . PDBsum 2GS0; -; . PDBsum 2H1L; -; . PDBsum 2H2D; -; . PDBsum 2H2F; -; . PDBsum 2H4F; -; . PDBsum 2H4H; -; . PDBsum 2H4J; -; . PDBsum 2H59; -; . PDBsum 2J0Z; -; . PDBsum 2J10; -; . PDBsum 2J11; -; . PDBsum 2J1W; -; . PDBsum 2J1X; -; . PDBsum 2J1Y; -; . PDBsum 2J1Z; -; . PDBsum 2J20; -; . PDBsum 2J21; -; . PDBsum 2K8F; -; . PDBsum 2L14; -; . PDBsum 2OCJ; -; . PDBsum 2PCX; -; . PDBsum 2QVQ; -; . PDBsum 2QXA; -; . PDBsum 2QXB; -; . PDBsum 2QXC; -; . PDBsum 2VUK; -; . PDBsum 2WGX; -; . PDBsum 2X0U; -; . PDBsum 2X0V; -; . PDBsum 2X0W; -; . PDBsum 2XWR; -; . PDBsum 2YBG; -; . PDBsum 2Z5S; -; . PDBsum 2Z5T; -; . PDBsum 3D05; -; . PDBsum 3D06; -; . PDBsum 3D07; -; . PDBsum 3D08; -; . PDBsum 3D09; -; . PDBsum 3D0A; -; . PDBsum 3DAB; -; . PDBsum 3DAC; -; . PDBsum 3IGK; -; . PDBsum 3IGL; -; . PDBsum 3KMD; -; . PDBsum 3KZ8; -; . PDBsum 3LW1; -; . PDBsum 3PDH; -; . PDBsum 3Q01; -; . PDBsum 3Q05; -; . PDBsum 3Q06; -; . PDBsum 3SAK; -; . PDBsum 3TG5; -; . ProteinModelPortal P04637; -; . SMR P04637; 13-61; 91-360; . DisProt DP00086; -; . DIP DIP-368N; -; . IntAct P04637; 159; . MINT MINT-91013; -; . STRING P04637; -; . PhosphoSite P04637; -; . SWISS-2DPAGE P04637; -; . PRIDE P04637; -; . Ensembl ENST00000269305; ENSP00000269305; ENSG00000141510; . Ensembl ENST00000359597; ENSP00000352610; ENSG00000141510; . Ensembl ENST00000396473; ENSP00000379735; ENSG00000141510; . Ensembl ENST00000419024; ENSP00000402130; ENSG00000141510; . Ensembl ENST00000420246; ENSP00000391127; ENSG00000141510; . Ensembl ENST00000445888; ENSP00000391478; ENSG00000141510; . Ensembl ENST00000455263; ENSP00000398846; ENSG00000141510; . GeneID 7157; -; . KEGG hsa:7157; -; . UCSC uc002gij.2; human; . CTD 7157; -; . GeneCards GC17M007465; -; . HGNC HGNC:11998; TP53; . HPA CAB002973; -; . HPA CAB039238; -; . HPA CAB039239; -; . MIM 133239; phenotype; . MIM 151623; phenotype; . MIM 191170; gene+phenotype; . MIM 202300; phenotype; . MIM 211980; phenotype; . MIM 260500; phenotype; . MIM 275355; phenotype; . neXtProt NX_P04637; -; . Orphanet 67038; Chronic B-cell lymphocytic leukemia; . Orphanet 1333; Familial pancreatic carcinoma; . Orphanet 360; Glioblastoma; . Orphanet 524; Li-Fraumeni syndrome; . Orphanet 2807; Papilloma of choroid plexus; . PharmGKB PA36679; -; . HOVERGEN HBG005201; -; . InParanoid P04637; -; . OMA IHYNFMC; -; . OrthoDB EOG45757H; -; . Pathway_Interaction_DB aurora_a_pathway; Aurora A signaling; . Pathway_Interaction_DB bard1pathway; BARD1 signaling events; . Pathway_Interaction_DB pi3kciaktpathway; Class I PI3K signaling events mediated by Akt; . Pathway_Interaction_DB hif1apathway; Hypoxic and oxygen homeostasis regulation of HIF-1-alpha; . Pathway_Interaction_DB p75ntrpathway; p75(NTR)-mediated signaling; . Pathway_Interaction_DB hdac_classiii_pathway; Signaling events mediated by HDAC Class III; . Pathway_Interaction_DB p38alphabetadownstreampathway; Signaling mediated by p38-alpha and p38-beta; . Reactome REACT_1538; Cell Cycle Checkpoints; . Reactome REACT_604; Hemostasis; . PMAP-CutDB P04637; -; . ArrayExpress P04637; -; . Bgee P04637; -; . Genevestigator P04637; -; . GermOnline ENSG00000141510; Homo sapiens; . GO GO:0005737; C:cytoplasm; IDA:UniProtKB; . GO GO:0005829; C:cytosol; IBA:RefGenome; . GO GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell; . GO GO:0005626; C:insoluble fraction; IDA:UniProtKB; . GO GO:0005739; C:mitochondrion; IDA:UniProtKB; . GO GO:0000790; C:nuclear chromatin; IDA:BHF-UCL; . GO GO:0016363; C:nuclear matrix; IDA:UniProtKB; . GO GO:0005730; C:nucleolus; IDA:UniProtKB; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:0016605; C:PML body; IDA:BHF-UCL; . GO GO:0043234; C:protein complex; IDA:BHF-UCL; . GO GO:0005657; C:replication fork; IBA:RefGenome; . GO GO:0005524; F:ATP binding; IDA:UniProtKB; . GO GO:0051087; F:chaperone binding; IPI:UniProtKB; . GO GO:0003682; F:chromatin binding; IDA:MGI; . GO GO:0005507; F:copper ion binding; IDA:UniProtKB; . GO GO:0003684; F:damaged DNA binding; IBA:RefGenome; . GO GO:0000739; F:DNA strand annealing activity; IDA:UniProtKB; . GO GO:0035035; F:histone acetyltransferase binding; IPI:UniProtKB; . GO GO:0002039; F:p53 binding; IBA:RefGenome; . GO GO:0002020; F:protease binding; IPI:UniProtKB; . GO GO:0005515; F:protein binding; IPI:IntAct; . GO GO:0046982; F:protein heterodimerization activity; IPI:UniProtKB; . GO GO:0019901; F:protein kinase binding; IPI:UniProtKB; . GO GO:0047485; F:protein N-terminus binding; IPI:UniProtKB; . GO GO:0051721; F:protein phosphatase 2A binding; IPI:UniProtKB; . GO GO:0001085; F:RNA polymerase II transcription factor binding; IPI:BHF-UCL; . GO GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:UniProtKB; . GO GO:0044212; F:transcription regulatory region DNA binding; IDA:BHF-UCL; . GO GO:0016564; ?:transcription repressor activity; IBA:RefGenome; . GO GO:0031625; F:ubiquitin protein ligase binding; IPI:UniProtKB; . GO GO:0008270; F:zinc ion binding; TAS:UniProtKB; . GO GO:0008635; P:activation of caspase activity by cytochrome c; IDA:UniProtKB; . GO GO:0006284; P:base-excision repair; TAS:UniProtKB; . GO GO:0007596; P:blood coagulation; TAS:Reactome; . GO GO:0007050; P:cell cycle arrest; IDA:BHF-UCL; . GO GO:0030154; P:cell differentiation; TAS:UniProtKB; . GO GO:0008283; P:cell proliferation; TAS:UniProtKB; . GO GO:0034613; P:cellular protein localization; IDA:UniProtKB; . GO GO:0035690; P:cellular response to drug; IEP:UniProtKB; . GO GO:0042149; P:cellular response to glucose starvation; IDA:MGI; . GO GO:0071456; P:cellular response to hypoxia; IEP:UniProtKB; . GO GO:0071479; P:cellular response to ionizing radiation; IMP:BHF-UCL; . GO GO:0034644; P:cellular response to UV; IBA:RefGenome; . GO GO:0008340; P:determination of adult lifespan; ISS:BHF-UCL; . GO GO:0006977; P:DNA damage response; signal transduction by p53 class mediator resulting in cell cycle arrest; TAS:Reactome GO GO:0042771; P:DNA damage response; signal transduction by p53 class mediator resulting in induction of apoptosis; IDA:UniProtKB GO GO:0006978; P:DNA damage response; signal transduction by p53 class mediator resulting in transcription of p21 class mediator; IMP:BHF-UCL GO GO:0006983; P:ER overload response; IDA:MGI; . GO GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW; . GO GO:0043066; P:negative regulation of apoptosis; IDA:UniProtKB; . GO GO:0030308; P:negative regulation of cell growth; IMP:UniProtKB; . GO GO:0008285; P:negative regulation of cell proliferation; ISS:BHF-UCL; . GO GO:0051097; P:negative regulation of helicase activity; TAS:UniProtKB; . GO GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:BHF-UCL; . GO GO:0006289; P:nucleotide-excision repair; IMP:UniProtKB; . GO GO:0090403; P:oxidative stress-induced premature senescence; IMP:BHF-UCL; . GO GO:0031065; P:positive regulation of histone deacetylation; IBA:RefGenome; . GO GO:0043525; P:positive regulation of neuron apoptosis; IBA:RefGenome; . GO GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; ISS:BHF-UCL; . GO GO:2000379; P:positive regulation of reactive oxygen species metabolic process; IMP:BHF-UCL; . GO GO:0070245; P:positive regulation of thymocyte apoptosis; ISS:BHF-UCL; . GO GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL; . GO GO:0008104; P:protein localization; IDA:UniProtKB; . GO GO:0051262; P:protein tetramerization; TAS:UniProtKB; . GO GO:0007265; P:Ras protein signal transduction; IEP:BHF-UCL; . GO GO:0046902; P:regulation of mitochondrial membrane permeability; TAS:UniProtKB; . GO GO:0090399; P:replicative senescence; IMP:BHF-UCL; . GO GO:0046677; P:response to antibiotic; IEP:UniProtKB; . GO GO:0010332; P:response to gamma radiation; IMP:BHF-UCL; . GO GO:0010165; P:response to X-ray; IBA:RefGenome; . InterPro IPR008967; p53-like_TF_DNA-bd; . InterPro IPR012346; p53/RUNT-type_TF_DNA-bd; . InterPro IPR011615; p53_DNA-bd; . InterPro IPR010991; p53_tetrameristn; . InterPro IPR013872; p53_transactivation_domain; . InterPro IPR002117; p53_tumour_suppressor; . Gene3D G3DSA:2.60.40.720; p53_RUNT_DNA_bd; 1; . Gene3D G3DSA:4.10.170.10; p53_tetrameristn; 1; . PANTHER PTHR11447; Trp53; 1; . Pfam PF00870; P53; 1; . Pfam PF08563; P53_TAD; 1; . Pfam PF07710; P53_tetramer; 1; . PRINTS PR00386; P53SUPPRESSR; . SUPFAM SSF49417; P53_like_DNA_bnd; 1; . SUPFAM SSF47719; p53_tetrameristn; 1; . PROSITE PS00348; P53; 1; . SWISS-2DPAGE (search AC)