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It will be discontinued on 31-May-2024.

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Sample Preparation and Post-separation Analysis

Searching in 'SWISS-2DPAGE' for entry matching: Q9H0D6



General information about the entry
View entry in simple text format
Entry nameXRN2_HUMAN
Primary accession numberQ9H0D6
Secondary accession number(s) Q9UL53
integrated into SWISS-2DPAGE on November 9, 2001 (release 15)
2D Annotations were last modified onMay 15, 2003 (version 1)
General Annotations were last modified on May 19, 2011 (version 8)
Name and origin of the protein
DescriptionRecName: Full=5'-3' exoribonuclease 2; EC=3.1.13.-; AltName: Full=DHM1-like protein; Short=DHP protein;.
Gene nameName=XRN2
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
PubMed=12429849; [NCBI, Expasy, EBI, Israel, Japan]
Scherl A., Coute Y., Deon C., Calle A., Kindbeiter K., Sanchez J.-C., Greco A., Hochstrasser D.F., Diaz J.-J.
''''''Functional proteomic analysis of human nucleolus'';'';''
Mol. Biol. Cell. 13(1):4100-4109(2002)
2D PAGE maps for identified proteins
How to interpret a protein

NUCLEOLI_HELA_1D_HUMAN {SDS-PAGE of nucleolar proteins from Human HeLa cells}
Homo sapiens (Human)
Tissue: Cervix carcinoma
  map experimental info
  protein estimated location

Mw=105656  [identification data]

MAPPING (identification):
Tandem mass spectrometry [1].

This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See or send email from
UniProtKB/Swiss-ProtQ9H0D6; XRN2_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.

External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameXRN2_HUMAN
Primary accession numberQ9H0D6
Secondary accession number(s) Q3L8N4 Q6KGZ9 Q9BQL1 Q9NTW0 Q9NXS6 Q9UL53
Sequence was last modified on March 1, 2001 (version 1)
Annotations were last modified on October 19, 2011 (version 98)
Name and origin of the protein
DescriptionRecName: Full=5'-3' exoribonuclease 2; EC=3.1.13.-; AltName: Full=DHM1-like protein; Short=DHP protein;
Gene nameName=XRN2
Encoded onName=XRN2
KeywordsAcetylation; Alternative splicing; Complete proteome; Exonuclease; Hydrolase; Metal-binding; mRNA processing; Nuclease; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transcription; Transcription regulation; Transcription termination; Zinc; Zinc-finger.
Copyrighted by the UniProt Consortium, see Distributed under the Creative Commons Attribution-NoDerivs License
EMBLAF064257; AAD55138.1; -; mRNA
EMBLAF152169; AAQ13577.1; -; mRNA
EMBLAY382900; AAR24369.1; ALT_FRAME; mRNA
EMBLAL136841; CAB66775.1; -; mRNA
EMBLAL117332; CAI19756.1; -; Genomic_DNA
EMBLAL158013; CAI19756.1; JOINED; Genomic_DNA
EMBLAL158013; CAH71495.1; -; Genomic_DNA
EMBLAL117332; CAH71495.1; JOINED; Genomic_DNA
EMBLAK000084; BAA90934.1; ALT_INIT; mRNA
EMBLBC006417; AAH06417.2; -; mRNA
IPIIPI00100151; -; .
IPIIPI00788157; -; .
RefSeqNP_036387.2; NM_012255.3; .
UniGeneHs.255932; -; .
ProteinModelPortalQ9H0D6; -; .
SMRQ9H0D6; 1-793; .
IntActQ9H0D6; 20; .
MINTMINT-3065664; -; .
STRINGQ9H0D6; -; .
PhosphoSiteQ9H0D6; -; .
PeptideAtlasQ9H0D6; -; .
PRIDEQ9H0D6; -; .
EnsemblENST00000377191; ENSP00000366396; ENSG00000088930; .
GeneID22803; -; .
KEGGhsa:22803; -; .
UCSCuc002wsf.1; human; .
UCSCuc002wsg.1; human; .
CTD22803; -; .
GeneCardsGC20P021283; -; .
H-InvDBHIX0015683; -; .
HGNCHGNC:12836; XRN2; .
MIM608851; gene; .
neXtProtNX_Q9H0D6; -; .
PharmGKBPA37427; -; .
eggNOGprNOG09774; -; .
GeneTreeENSGT00600000084422; -; .
HOVERGENHBG036677; -; .
InParanoidQ9H0D6; -; .
OrthoDBEOG4M0F0Z; -; .
PhylomeDBQ9H0D6; -; .
ReactomeREACT_17015; Metabolism of proteins; .
NextBio43160; -; .
PMAP-CutDBQ9H0D6; -; .
ArrayExpressQ9H0D6; -; .
BgeeQ9H0D6; -; .
CleanExHS_XRN2; -; .
GenevestigatorQ9H0D6; -; .
GermOnlineENSG00000088930; Homo sapiens; .
GOGO:0005730; C:nucleolus; IDA:UniProtKB; .
GOGO:0004534; F:5'-3' exoribonuclease activity; TAS:UniProtKB; .
GOGO:0003676; F:nucleic acid binding; IEA:InterPro; .
GOGO:0008270; F:zinc ion binding; IEA:InterPro; .
GOGO:0016049; P:cell growth; ISS:UniProtKB; .
GOGO:0000738; P:DNA catabolic process; exonucleolytic; IDA:UniProtKB
GOGO:0006397; P:mRNA processing; IEA:UniProtKB-KW; .
GOGO:0006355; P:regulation of transcription; DNA-dependent; IEA:UniProtKB-KW
GOGO:0006401; P:RNA catabolic process; TAS:ProtInc; .
GOGO:0007283; P:spermatogenesis; IEP:UniProtKB; .
GOGO:0006353; P:transcription termination; DNA-dependent; IEA:UniProtKB-KW
InterProIPR017151; 5_3_exoribonuclease_2; .
InterProIPR004859; Put_53exo; .
InterProIPR001878; Znf_CCHC; .
PfamPF03159; XRN_N; 1; .
PIRSFPIRSF037239; Exonuclease_Xrn2; 1; .
SMARTSM00343; ZnF_C2HC; 1; .


SWISS-2DPAGE (search AC)

Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the Expasy web server