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Sample Preparation and Post-separation Analysis

Searching in 'SWISS-2DPAGE' for entry matching: RRP44_HUMAN



General information about the entry
View entry in simple text format
Entry nameRRP44_HUMAN
Primary accession numberQ9Y2L1
integrated into SWISS-2DPAGE on November 9, 2001 (release 15)
2D Annotations were last modified onMay 15, 2003 (version 1)
General Annotations were last modified on May 19, 2011 (version 7)
Name and origin of the protein
DescriptionRecName: Full=Exosome complex exonuclease RRP44; EC=3.1.13.-; EC=3.1.26.-; AltName: Full=Protein DIS3 homolog; AltName: Full=Ribosomal RNA-processing protein 44;.
Gene nameName=DIS3
Synonyms=KIAA1008, RRP44
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
PubMed=12429849; [NCBI, Expasy, EBI, Israel, Japan]
Scherl A., Coute Y., Deon C., Calle A., Kindbeiter K., Sanchez J.-C., Greco A., Hochstrasser D.F., Diaz J.-J.
''''''Functional proteomic analysis of human nucleolus'';'';''
Mol. Biol. Cell. 13(1):4100-4109(2002)
2D PAGE maps for identified proteins
How to interpret a protein

NUCLEOLI_HELA_1D_HUMAN {SDS-PAGE of nucleolar proteins from Human HeLa cells}
Homo sapiens (Human)
Tissue: Cervix carcinoma
  map experimental info
  protein estimated location

Mw=105656  [identification data]

MAPPING (identification):
Tandem mass spectrometry [1].

This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See or send email from
UniProtKB/Swiss-ProtQ9Y2L1; RRP44_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.

External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameRRP44_HUMAN
Primary accession numberQ9Y2L1
Secondary accession number(s) A6NI21 B2RBL2 Q5W0P7 Q5W0P8 Q658Z7 Q7Z481 Q8WWI2 Q9UG36
Sequence was last modified on August 16, 2005 (version 2)
Annotations were last modified on October 19, 2011 (version 117)
Name and origin of the protein
DescriptionRecName: Full=Exosome complex exonuclease RRP44; EC=3.1.13.-; EC=3.1.26.-; AltName: Full=Protein DIS3 homolog; AltName: Full=Ribosomal RNA-processing protein 44;
Gene nameName=DIS3
Synonyms=KIAA1008, RRP44
Encoded onName=DIS3; Synonyms=KIAA1008, RRP44
KeywordsAcetylation; Alternative splicing; Complete proteome; Cytoplasm; Endonuclease; Exonuclease; Exosome; Hydrolase; Magnesium; Manganese; Nuclease; Nucleus; Polymorphism; Reference proteome; RNA-binding; rRNA processing.
Copyrighted by the UniProt Consortium, see Distributed under the Creative Commons Attribution-NoDerivs License
EMBLAF330044; AAL37479.1; -; mRNA
EMBLAB023225; BAA76852.2; ALT_INIT; mRNA
EMBLAL832266; CAH56266.1; -; mRNA
EMBLAK314715; BAG37259.1; -; mRNA
EMBLAL080158; CAB45749.1; -; mRNA
EMBLAL138695; CAH72709.1; -; Genomic_DNA
EMBLAL391384; CAH72709.1; JOINED; Genomic_DNA
EMBLAL138695; CAH72708.1; -; Genomic_DNA
EMBLAL391384; CAH72708.1; JOINED; Genomic_DNA
EMBLAL391384; CAI15670.1; -; Genomic_DNA
EMBLAL138695; CAI15670.1; JOINED; Genomic_DNA
EMBLAL391384; CAI15671.1; -; Genomic_DNA
EMBLAL138695; CAI15671.1; JOINED; Genomic_DNA
EMBLCH471093; EAW80517.1; -; Genomic_DNA
EMBLBC056143; AAH56143.1; -; mRNA
IPIIPI00183462; -; .
IPIIPI00746351; -; .
PIRJE0110; JE0110; .
RefSeqNP_001121698.1; NM_001128226.1; .
RefSeqNP_055768.3; NM_014953.3; .
UniGeneHs.728935; -; .
ProteinModelPortalQ9Y2L1; -; .
SMRQ9Y2L1; 20-928; .
IntActQ9Y2L1; 8; .
STRINGQ9Y2L1; -; .
PhosphoSiteQ9Y2L1; -; .
PRIDEQ9Y2L1; -; .
EnsemblENST00000377767; ENSP00000366997; ENSG00000083520; .
GeneID22894; -; .
KEGGhsa:22894; -; .
NMPDRfig|9606.3.peg.8934; -; .
UCSCuc001vix.2; human; .
UCSCuc001viy.2; human; .
CTD22894; -; .
GeneCardsGC13M054026; -; .
H-InvDBHIX0011365; -; .
HGNCHGNC:20604; DIS3; .
HPAHPA039281; -; .
MIM607533; gene; .
neXtProtNX_Q9Y2L1; -; .
PharmGKBPA162383628; -; .
eggNOGprNOG14141; -; .
GeneTreeENSGT00530000063106; -; .
HOVERGENHBG059397; -; .
InParanoidQ9Y2L1; -; .
OrthoDBEOG45B1DT; -; .
PhylomeDBQ9Y2L1; -; .
ReactomeREACT_21257; Metabolism of RNA; .
NextBio43511; -; .
ArrayExpressQ9Y2L1; -; .
BgeeQ9Y2L1; -; .
CleanExHS_DIS3; -; .
GenevestigatorQ9Y2L1; -; .
GermOnlineENSG00000083520; Homo sapiens; .
GOGO:0005829; C:cytosol; TAS:Reactome; .
GOGO:0000176; C:nuclear exosome (RNase complex); IDA:UniProtKB; .
GOGO:0005730; C:nucleolus; IEA:UniProtKB-SubCell; .
GOGO:0005654; C:nucleoplasm; IDA:UniProtKB; .
GOGO:0000175; F:3'-5'-exoribonuclease activity; IMP:UniProtKB; .
GOGO:0004519; F:endonuclease activity; IMP:UniProtKB; .
GOGO:0005085; F:guanyl-nucleotide exchange factor activity; IDA:UniProtKB; .
GOGO:0005515; F:protein binding; IPI:IntAct; .
GOGO:0003723; F:RNA binding; IEA:UniProtKB-KW; .
GOGO:0071034; P:CUT catabolic process; IMP:UniProtKB; .
GOGO:0043928; P:exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay; TAS:Reactome; .
GOGO:0016075; P:rRNA catabolic process; IMP:UniProtKB; .
GOGO:0006364; P:rRNA processing; TAS:UniProtKB; .
InterProIPR006596; PINc_nuc-bd; .
InterProIPR001900; RNase_II/R; .
InterProIPR022966; RNase_II/R_CS; .
PfamPF00773; RNB; 1; .
SMARTSM00670; PINc; 1; .
SMARTSM00955; RNB; 1; .


SWISS-2DPAGE (search AC)

Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the Expasy web server