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Sample Preparation and Post-separation Analysis

Searching in 'SWISS-2DPAGE' for entry matching: RRP8_HUMAN



General information about the entry
View entry in simple text format
Entry nameRRP8_HUMAN
Primary accession numberO43159
integrated into SWISS-2DPAGE on May 15, 2003 (release 16)
2D Annotations were last modified onDecember 30, 2004 (version 1)
General Annotations were last modified on May 19, 2011 (version 7)
Name and origin of the protein
DescriptionRecName: Full=Ribosomal RNA-processing protein 8; EC=2.1.1.-; AltName: Full=Cerebral protein 1; AltName: Full=Nucleomethylin;.
Gene nameName=RRP8
Synonyms=KIAA0409, NML
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
PubMed=12429849; [NCBI, Expasy, EBI, Israel, Japan]
Scherl A., Coute Y., Deon C., Calle A., Kindbeiter K., Sanchez J.-C., Greco A., Hochstrasser D.F., Diaz J.-J.
''''''Functional proteomic analysis of human nucleolus'';'';''
Mol. Biol. Cell. 13(1):4100-4109(2002)
2D PAGE maps for identified proteins
How to interpret a protein

NUCLEOLI_HELA_1D_HUMAN {SDS-PAGE of nucleolar proteins from Human HeLa cells}
Homo sapiens (Human)
Tissue: Cervix carcinoma
  map experimental info
  protein estimated location

Mw=60781  [identification data]

MAPPING (identification):
Tandem mass spectrometry [1].

This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See or send email from
UniProtKB/Swiss-ProtO43159; RRP8_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.

External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameRRP8_HUMAN
Primary accession numberO43159
Secondary accession number(s) Q7KZ78 Q9BVM6
Sequence was last modified on April 26, 2005 (version 2)
Annotations were last modified on October 19, 2011 (version 90)
Name and origin of the protein
DescriptionRecName: Full=Ribosomal RNA-processing protein 8; EC=2.1.1.-; AltName: Full=Cerebral protein 1; AltName: Full=Nucleomethylin;
Gene nameName=RRP8
Synonyms=KIAA0409, NML
Encoded onName=RRP8; Synonyms=KIAA0409, NML; ORFNames=hucep-1
Keywords3D-structure; Chromatin regulator; Complete proteome; Methyltransferase; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repressor; rRNA processing; S-adenosyl-L-methionine; Transcription; Transcription regulation; Transferase.
Copyrighted by the UniProt Consortium, see Distributed under the Creative Commons Attribution-NoDerivs License
EMBLD87060; BAB46916.1; -; mRNA
EMBLAB007869; BAA23705.1; ALT_INIT; mRNA
EMBLBC001071; AAH01071.1; -; mRNA
IPIIPI00304932; -; .
RefSeqNP_056139.1; NM_015324.3; .
UniGeneHs.652255; -; .
PDB2ZFU; X-ray; 2.00 A; A/B=242-456
PDBsum2ZFU; -; .
ProteinModelPortalO43159; -; .
SMRO43159; 243-454; .
IntActO43159; 3; .
STRINGO43159; -; .
PhosphoSiteO43159; -; .
SWISS-2DPAGEO43159; -; .
PeptideAtlasO43159; -; .
PRIDEO43159; -; .
EnsemblENST00000254605; ENSP00000254605; ENSG00000132275; .
GeneID23378; -; .
KEGGhsa:23378; -; .
UCSCuc001med.1; human; .
CTD23378; -; .
GeneCardsGC11M006280; -; .
H-InvDBHIX0009407; -; .
HGNCHGNC:29030; RRP8; .
HPAHPA038487; -; .
neXtProtNX_O43159; -; .
PharmGKBPA164725550; -; .
eggNOGprNOG19436; -; .
GeneTreeENSGT00390000006189; -; .
InParanoidO43159; -; .
OrthoDBEOG40GCQW; -; .
PhylomeDBO43159; -; .
NextBio45466; -; .
ArrayExpressO43159; -; .
BgeeO43159; -; .
CleanExHS_KIAA0409; -; .
GenevestigatorO43159; -; .
GermOnlineENSG00000132275; Homo sapiens; .
GOGO:0005677; C:chromatin silencing complex; IDA:UniProtKB; .
GOGO:0005730; C:nucleolus; IDA:UniProtKB; .
GOGO:0033553; C:rDNA heterochromatin; IDA:UniProtKB; .
GOGO:0035064; F:methylated histone residue binding; IDA:UniProtKB; .
GOGO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; TAS:UniProtKB; .
GOGO:0016568; P:chromatin modification; IEA:UniProtKB-KW; .
GOGO:0000183; P:chromatin silencing at rDNA; IDA:UniProtKB; .
GOGO:0006364; P:rRNA processing; IEA:UniProtKB-KW; .
GOGO:0006351; P:transcription; DNA-dependent; IEA:UniProtKB-KW
InterProIPR007823; Methyltransferase-rel; .
InterProIPR023576; UbiE/COQ5_MeTrFase_CS; .
PANTHERPTHR12787; mtransfer; 1; .
PfamPF05148; Methyltransf_8; 1; .


SWISS-2DPAGE (search AC)

Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the Expasy web server