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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: THRB_HUMAN




SWISS-2DPAGE:  THRB_HUMAN


THRB_HUMAN


General information about the entry
View entry in simple text format
Entry nameTHRB_HUMAN
Primary accession numberP00734
integrated into SWISS-2DPAGE on August 1, 1993 (release 0)
2D Annotations were last modified onDecember 1, 2000 (version 1)
General Annotations were last modified on May 19, 2011 (version 12)
Name and origin of the protein
DescriptionRecName: Full=Prothrombin; EC=3.4.21.5; AltName: Full=Coagulation factor II; Contains: RecName: Full=Activation peptide fragment 1; Contains: RecName: Full=Activation peptide fragment 2; Contains: RecName: Full=Thrombin light chain; Contains: RecName: Full=Thrombin heavy chain; Flags: Precursor;.
Gene nameName=F2
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
Anderson N.L., Nance S.L., Pearson T.W., Anderson N.G.
Electrophoresis 3(1):135-142(1982)
[2]   MAPPING ON GEL
MEDLINE=96007934; PubMed=7498157; [NCBI, ExPASy, EBI, Israel, Japan]
Sanchez J.-C., Appel R.D., Golaz O.G., Pasquali C., Ravier F., Bairoch A., Hochstrasser D.F.
''''''Inside SWISS-2DPAGE database'';'';''
Electrophoresis 16(1):1131-1151(1995)
Comments
  • SUBUNIT: SINGLE CHAIN
2D PAGE maps for identified proteins
How to interpret a protein

CSF_HUMAN {Cerebrospinal Fluid}
Homo sapiens (Human)
Tissue: Cerebrospinal fluid
CSF_HUMAN
  map experimental info
  protein estimated location
 
CSF_HUMAN

MAP LOCATIONS:
pI=4.82; Mw=87361
pI=4.88; Mw=86727
pI=4.94; Mw=86412
pI=5.03; Mw=86097
pI=5.08; Mw=85784

MAPPING (identification):
MATCHING WITH THE PLASMA MASTER GEL [2].



HEPG2SP_HUMAN {HepG2 Secreted Proteins}
Homo sapiens (Human)
Tissue: Hepatoblastoma
HEPG2SP_HUMAN
  map experimental info
  protein estimated location
 
HEPG2SP_HUMAN

MAP LOCATIONS:
pI=4.86; Mw=88155
pI=4.91; Mw=88482
pI=4.88; Mw=88155

MAPPING (identification):
MATCHING WITH THE PLASMA MASTER GEL [2].



PLASMA_HUMAN {Plasma}
Homo sapiens (Human)
Tissue: Plasma
PLASMA_HUMAN
  map experimental info
  protein estimated location
 
PLASMA_HUMAN

MAP LOCATIONS:
pI=5.05; Mw=80154
pI=4.99; Mw=80461
pI=5.01; Mw=80461
pI=5.09; Mw=80154
pI=4.95; Mw=80154

NORMAL LEVEL:
50-100 MG/L.

PATHOLOGICAL LEVEL:
DECREASED DURING DISSAMINATED INTRAVASCULAR COAGULATION AND LIVER DISEASE.

POSITIONAL VARIANTS:
THREE ALLELIC VARIANTS.

MAPPING (identification):
IMMUNOBLOTTING [1].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss).
Cross-references
Siena-2DPAGEP00734; THRB_HUMAN.
UniProtKB/Swiss-ProtP00734; THRB_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameTHRB_HUMAN
Primary accession numberP00734
Secondary accession number(s) B2R7F7 B4E1A7 Q4QZ40 Q53H04 Q53H06 Q7Z7P3 Q9UCA1
Sequence was last modified on January 1, 1990 (version 2)
Annotations were last modified on October 19, 2011 (version 169)
Name and origin of the protein
DescriptionRecName: Full=Prothrombin; EC=3.4.21.5; AltName: Full=Coagulation factor II; Contains: RecName: Full=Activation peptide fragment 1; Contains: RecName: Full=Activation peptide fragment 2; Contains: RecName: Full=Thrombin light chain; Contains: RecName: Full=Thrombin heavy chain; Flags: Precursor;
Gene nameName=F2
Encoded onName=F2
Keywords3D-structure; Acute phase; Blood coagulation; Calcium; Cleavage on pair of basic residues; Complete proteome; Direct protein sequencing; Disease mutation; Disulfide bond; Gamma-carboxyglutamic acid; Glycoprotein; Hydrolase; Kringle; Pharmaceutical; Polymorphism; Protease; Reference proteome; Repeat; Secreted; Serine protease; Signal; Thrombophilia; Zymogen.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLM17262; AAC63054.1; -; Genomic_DNA
EMBLAJ972449; CAJ01369.1; -; mRNA
EMBLAK303747; BAG64719.1; -; mRNA
EMBLAK312965; BAG35804.1; -; mRNA
EMBLAK222775; BAD96495.1; -; mRNA
EMBLAK222777; BAD96497.1; -; mRNA
EMBLAF478696; AAL77436.1; -; Genomic_DNA
EMBLBC051332; AAH51332.1; -; mRNA
EMBLV00595; CAA23842.1; -; mRNA
IPIIPI00019568; -; .
PIRA29351; TBHU; .
RefSeqNP_000497.1; NM_000506.3; .
UniGeneHs.655207; -; .
PDB1A2C; X-ray; 2.10 A; H=364-622
L=328-363PDB; 1A3B; X-ray; 1.80 A
H=364-622L=328-363; PDB; 1A3E; X-ray
1.85 AH=364-622; L=328-363; PDB; 1A46
X-ray2.12 A; H=364-622; L=328-363; PDB
1A4WX-ray; 1.80 A; H=364-622; L=328-363
PDB1A5G; X-ray; 2.06 A; H=364-622
L=328-363PDB; 1A61; X-ray; 2.20 A
H=364-622L=328-363; PDB; 1ABI; X-ray
2.30 AH=364-622; L=328-363; PDB; 1ABJ
X-ray2.40 A; H=364-622; L=328-363; PDB
1AD8X-ray; 2.00 A; H=364-622; L=328-363
PDB1AE8; X-ray; 2.00 A; H=364-622
L=328-363PDB; 1AFE; X-ray; 2.00 A
H=364-622L=328-363; PDB; 1AHT; X-ray
1.60 AH=364-622; L=328-363; PDB; 1AI8
X-ray1.85 A; H=364-622; L=328-363; PDB
1AIXX-ray; 2.10 A; H=364-622; L=328-363
PDB1AWF; X-ray; 2.20 A; H=364-622
L=328-363PDB; 1AWH; X-ray; 3.00 A
A/C=328-363B/D=364-622; PDB; 1AY6; X-ray
1.80 AH=364-622; L=328-363; PDB; 1B5G
X-ray2.07 A; H=364-622; L=328-363; PDB
1B7XX-ray; 2.10 A; A=328-363; B=364-622
PDB1BA8; X-ray; 1.80 A; A=328-363
B=364-622PDB; 1BB0; X-ray; 2.10 A
A=328-363B=364-622; PDB; 1BCU; X-ray
2.00 AH=364-622; L=328-363; PDB; 1BHX
X-ray2.30 A; A=331-360; B=364-510; F=518-622
PDB1BMM; X-ray; 2.60 A; H=364-622
L=328-363PDB; 1BMN; X-ray; 2.80 A
H=364-622L=328-363; PDB; 1BTH; X-ray
2.30 AH/K=364-622; J/L=328-363; PDB; 1C1U
X-ray1.75 A; H=364-616; L=328-363; PDB
1C1VX-ray; 1.98 A; H=364-616; L=328-363
PDB1C1W; X-ray; 1.90 A; H=364-616
L=328-363PDB; 1C4U; X-ray; 2.10 A
1=328-3632=364-622; PDB; 1C4V; X-ray
2.10 A1=328-363; 2=364-622; PDB; 1C4Y
X-ray2.70 A; 1=328-363; 2=364-622; PDB
1C5LX-ray; 1.47 A; H=364-622; L=328-363
PDB1C5N; X-ray; 1.50 A; H=364-622
L=328-363PDB; 1C5O; X-ray; 1.90 A
H=364-622L=328-363; PDB; 1CA8; X-ray
2.10 AA=328-363; B=364-622; PDB; 1D3D
X-ray2.04 A; A=333-360; B=364-620; PDB
1D3PX-ray; 2.10 A; A=328-363; B=364-622
PDB1D3Q; X-ray; 2.90 A; A=328-363
B=364-622PDB; 1D3T; X-ray; 3.00 A
A=328-363B=364-622; PDB; 1D4P; X-ray
2.07 AA=328-363; B=364-622; PDB; 1D6W
X-ray2.00 A; A=334-620; PDB; 1D9I
X-ray2.30 A; A=334-621; PDB; 1DE7
X-ray2.00 A; H/K=364-619; J/L=328-363; PDB
1DITX-ray; 2.30 A; H=364-622; L=328-363
PDB1DM4; X-ray; 2.50 A; A=328-362
B=363-622PDB; 1DOJ; X-ray; 1.70 A
A=328-622PDB; 1DWB; X-ray; 3.16 A
H=364-622L=328-363; PDB; 1DWC; X-ray
3.00 AH=364-622; L=328-363; PDB; 1DWD
X-ray3.00 A; H=364-622; L=328-363; PDB
1DWEX-ray; 3.00 A; H=364-622; L=328-363
PDB1DX5; X-ray; 2.30 A; A/B/C/D=328-363
M/N/O/P=364-622PDB; 1E0F; X-ray; 3.10 A
A/B/C=328-363D/E/F=364-620; PDB; 1EB1; X-ray
1.80 AH=364-620; L=337-360; PDB; 1EOJ
X-ray2.10 A; A=334-620; PDB; 1EOL
X-ray2.10 A; A=334-620; PDB; 1FPC
X-ray2.30 A; H=364-622; L=328-363; PDB
1FPHX-ray; 2.50 A; H=364-622; L=328-363
PDB1G30; X-ray; 2.00 A; A=328-363
B=364-622PDB; 1G32; X-ray; 1.90 A
A=328-363B=364-622; PDB; 1G37; X-ray
2.00 AA=334-620; PDB; 1GHV; X-ray
1.85 AH=364-620; L=328-363; PDB; 1GHW
X-ray1.75 A; H=364-620; L=328-363; PDB
1GHXX-ray; 1.65 A; H=364-620; L=328-363
PDB1GHY; X-ray; 1.85 A; H=364-620
L=328-363PDB; 1GJ4; X-ray; 1.81 A
H=364-621L=328-363; PDB; 1GJ5; X-ray
1.73 AH=364-621; L=328-363; PDB; 1H8D
X-ray1.40 A; H=364-621; L=333-360; PDB
1H8IX-ray; 1.75 A; H=364-622; L=334-360
PDB1HAG; X-ray; 2.00 A; E=336-622
PDB1HAH; X-ray; 2.30 A; H=364-622
L=328-363PDB; 1HAI; X-ray; 2.40 A
H=364-622L=328-363; PDB; 1HAO; X-ray
2.80 AH=364-622; L=328-363; PDB; 1HAP
X-ray2.80 A; H=364-622; L=328-363; PDB
1HBTX-ray; 2.00 A; H=364-622; L=328-363
PDB1HDT; X-ray; 2.60 A; H=364-622
L=331-363PDB; 1HGT; X-ray; 2.20 A
H=364-622L=328-363; PDB; 1HLT; X-ray
3.00 AH/K=364-622; J/L=334-360; PDB; 1HUT
X-ray2.90 A; H=364-622; L=328-363; PDB
1HXEX-ray; 2.10 A; H=364-622; L=328-363
PDB1HXF; X-ray; 2.10 A; H=364-622
L=328-363PDB; 1IHS; X-ray; 2.00 A
H=364-622L=328-363; PDB; 1IHT; X-ray
2.10 AH=364-622; L=328-363; PDB; 1JMO
X-ray2.20 A; H=363-622; L=315-362; PDB
1JOUX-ray; 1.80 A; A/C/E=315-363; B/D/F=364-622
PDB1JWT; X-ray; 2.50 A; A=328-622
PDB1K21; X-ray; 1.86 A; H=364-622
L=328-363PDB; 1K22; X-ray; 1.93 A
H=364-622L=328-363; PDB; 1KTS; X-ray
2.40 AA=328-363; B=364-622; PDB; 1KTT
X-ray2.10 A; A=328-363; B=364-622; PDB
1LHCX-ray; 1.95 A; H=364-622; L=328-363
PDB1LHD; X-ray; 2.35 A; H=364-622
L=328-363PDB; 1LHE; X-ray; 2.25 A
H=364-622L=328-363; PDB; 1LHF; X-ray
2.40 AH=364-622; L=328-363; PDB; 1LHG
X-ray2.25 A; H=364-622; L=328-363; PDB
1MH0X-ray; 2.80 A; A/B=334-620; PDB
1MU6X-ray; 1.99 A; A=328-363; B=364-622
PDB1MU8; X-ray; 2.00 A; A=328-363
B=364-622PDB; 1MUE; X-ray; 2.00 A
A=328-363B=364-622; PDB; 1NM6; X-ray
1.80 AA=335-621; PDB; 1NO9; X-ray
1.90 AH=364-622; L=328-363; PDB; 1NRN
X-ray3.10 A; H=364-622; L=328-363; PDB
1NROX-ray; 3.10 A; H=364-622; L=328-363
PDB1NRP; X-ray; 3.00 A; H=364-622
L=328-363PDB; 1NRQ; X-ray; 3.50 A
H=364-622L=328-363; PDB; 1NRR; X-ray
2.40 AH=364-622; L=328-363; PDB; 1NRS
X-ray2.40 A; H=364-622; L=328-363; PDB
1NT1X-ray; 2.00 A; A=335-621; PDB
1NU7X-ray; 2.20 A; A/E=332-359; B/F=364-622
PDB1NU9; X-ray; 2.20 A; A/D=332-622
PDB1NY2; X-ray; 2.30 A; 1=328-363
2=364-622PDB; 1NZQ; X-ray; 2.18 A
H=364-620L=328-363; PDB; 1O0D; X-ray
2.44 AH=364-622; L=328-363; PDB; 1O2G
X-ray1.58 A; H=364-622; L=328-363; PDB
1O5GX-ray; 1.75 A; H=364-622; L=328-363
PDB1OOK; X-ray; 2.30 A; A=328-363
B=364-622PDB; 1OYT; X-ray; 1.67 A
H=364-622L=328-363; PDB; 1P8V; X-ray
2.60 AB=333-361; C=364-621; PDB; 1PPB
X-ray1.92 A; H=364-622; L=328-363; PDB
1QBVX-ray; 1.80 A; H=364-622; L=328-363
PDB1QHR; X-ray; 2.20 A; A=328-363
B=364-622PDB; 1QJ1; X-ray; 2.00 A
A=328-363B=364-622; PDB; 1QJ6; X-ray
2.20 AA=328-363; B=364-622; PDB; 1QJ7
X-ray2.20 A; A=328-363; B=364-622; PDB
1QURX-ray; 2.00 A; H=364-620; L=334-360
PDB1RD3; X-ray; 2.50 A; A/C=328-363
B/D=364-622PDB; 1RIW; X-ray; 2.04 A
A=328-363B=364-510; C=518-622; PDB; 1SB1
X-ray1.90 A; H=364-621; L=333-361; PDB
1SFQX-ray; 1.91 A; A/D=328-363; B/E=364-622
PDB1SG8; X-ray; 2.30 A; A/D=328-363
B/E=364-622PDB; 1SGI; X-ray; 2.30 A
A/D=328-363B/E=364-622; PDB; 1SHH; X-ray
1.55 AA/D=328-363; B/E=364-622; PDB; 1SL3
X-ray1.81 A; A=335-620; PDB; 1SR5
X-ray3.10 A; B=328-363; C=364-622; PDB
1T4UX-ray; 2.00 A; H=364-622; L=334-359
PDB1T4V; X-ray; 2.00 A; H=364-622
L=334-359PDB; 1TA2; X-ray; 2.30 A
A=335-621PDB; 1TA6; X-ray; 1.90 A
A=335-621PDB; 1TB6; X-ray; 2.50 A
H=364-622L=315-363; PDB; 1TBZ; X-ray
2.30 AH=364-622; L=328-363; PDB; 1THP
X-ray2.10 A; A=328-363; B=364-622; PDB
1THRX-ray; 2.30 A; H=364-622; L=328-363
PDB1THS; X-ray; 2.20 A; H=364-622
L=328-363PDB; 1TMB; X-ray; 2.30 A
H=364-622L=328-363; PDB; 1TMT; X-ray
2.20 AH=364-622; L=328-363; PDB; 1TMU
X-ray2.50 A; H=364-622; L=333-360; PDB
1TOMX-ray; 1.80 A; H=364-622; L=328-363
PDB1TQ0; X-ray; 2.80 A; A/C=333-363
B/D=364-620PDB; 1TQ7; X-ray; 2.40 A
A=320-363B=364-620; PDB; 1TWX; X-ray
2.40 AA=334-361; B=364-622; PDB; 1UMA
X-ray2.00 A; H=364-622; L=328-363; PDB
1UVSX-ray; 2.80 A; H=364-622; L=328-363
PDB1VR1; X-ray; 1.90 A; H=364-620
L=334-360PDB; 1VZQ; X-ray; 1.54 A
H=364-620L=334-360; PDB; 1W7G; X-ray
1.65 AH=364-622; L=328-363; PDB; 1WAY
X-ray2.02 A; A=328-363; B=364-622; PDB
1WBGX-ray; 2.20 A; A=328-363; B=364-622
PDB1XM1; X-ray; 2.30 A; A=328-622
PDB1XMN; X-ray; 1.85 A; A/C/E/G=328-363
B/D/F/H=364-622PDB; 1YPE; X-ray; 1.81 A
H=364-620L=334-360; PDB; 1YPG; X-ray
1.80 AH=364-620; L=334-360; PDB; 1YPJ
X-ray1.78 A; H=364-620; L=334-360; PDB
1YPKX-ray; 1.78 A; H=364-620; L=334-360
PDB1YPL; X-ray; 1.85 A; H=364-620
L=334-360PDB; 1YPM; X-ray; 1.85 A
H=364-620L=334-360; PDB; 1Z71; X-ray
1.80 AA=336-621; PDB; 1Z8I; X-ray
2.00 AA=324-361; B=364-622; PDB; 1Z8J
X-ray2.00 A; A=322-361; B=364-622; PDB
1ZGIX-ray; 2.20 A; A=335-621; PDB
1ZGVX-ray; 2.20 A; A=335-621; PDB
1ZRBX-ray; 1.90 A; A=335-621; PDB
2A0QX-ray; 1.90 A; A/C=334-363; B/D=364-620
PDB2A2X; X-ray; 2.44 A; H=364-622
L=330-363PDB; 2A45; X-ray; 3.65 A
A/D=328-363B/E=364-622; PDB; 2AFQ; X-ray
1.93 AA/C=332-360; B/D=364-622; PDB; 2ANK
X-ray2.46 A; H=364-622; L=330-363; PDB
2ANMX-ray; 2.40 A; H=364-620; L=328-363
PDB2B5T; X-ray; 2.10 A; A/C=315-363
B/D=364-622PDB; 2BDY; X-ray; 1.61 A
A=334-622PDB; 2BVR; X-ray; 1.25 A
H=364-622L=328-363; PDB; 2BVS; X-ray
1.40 AH=364-622; L=328-363; PDB; 2BVX
X-ray3.20 A; H=364-622; L=328-363; PDB
2BXTX-ray; 1.83 A; H=364-622; L=328-363
PDB2BXU; X-ray; 2.80 A; H=364-622
L=328-363PDB; 2C8W; X-ray; 1.96 A
A=328-363B=364-622; PDB; 2C8X; X-ray
2.17 AA=328-363; B=364-622; PDB; 2C8Y
X-ray2.20 A; A=328-363; B=364-622; PDB
2C8ZX-ray; 2.14 A; A=328-363; B=364-622
PDB2C90; X-ray; 2.25 A; A=328-363
B=364-622PDB; 2C93; X-ray; 2.20 A
A=328-363B=364-622; PDB; 2CF8; X-ray
1.30 AH=364-620; L=334-361; PDB; 2CF9
X-ray1.79 A; H=364-620; L=334-361; PDB
2CN0X-ray; 1.30 A; H=364-620; L=334-361
PDB2FEQ; X-ray; 2.44 A; H=364-622
L=328-363PDB; 2FES; X-ray; 2.42 A
H=364-622L=328-363; PDB; 2GDE; X-ray
2.00 AH=364-622; L=328-363; PDB; 2GP9
X-ray1.87 A; A=328-363; B=364-622; PDB
2H9TX-ray; 2.40 A; H=364-622; L=328-363
PDB2HGT; X-ray; 2.20 A; H=364-622
L=328-363PDB; 2HNT; X-ray; 2.50 A
C=364-433E=437-517; F=518-622; L=328-363; PDB
2HPPX-ray; 3.30 A; H=364-622; L=328-363
PDB2HPQ; X-ray; 3.30 A; H=364-622
L=328-363P=213-291; PDB; 2HWL; X-ray
2.40 AA/C=328-363; B/D=364-622; PDB; 2JH0
X-ray1.70 A; C=328-363; D=364-622; PDB
2JH5X-ray; 2.50 A; C=328-363; D=364-622
PDB2JH6; X-ray; 2.21 A; C=328-363
D=364-622PDB; 2OD3; X-ray; 1.75 A
A=328-363B=364-622; PDB; 2PGB; X-ray
1.54 AA=328-363; B=364-622; PDB; 2PGQ
X-ray1.80 A; A=319-363; B=364-622; PDB
2PKSX-ray; 2.50 A; A=334-360; B=364-510
C=518-619PDB; 2PW8; X-ray; 1.84 A
H=364-621L=334-360; PDB; 2R2M; X-ray
2.10 AA=334-359; B=364-622; PDB; 2THF
X-ray2.10 A; A=328-363; B=364-622; PDB
2UUFX-ray; 1.26 A; A=328-363; B=364-622
PDB2UUJ; X-ray; 1.32 A; A=328-363
B=364-622PDB; 2UUK; X-ray; 1.39 A
A=328-363B=364-622; PDB; 2V3H; X-ray
1.79 AH=364-620; L=334-361; PDB; 2V3O
X-ray1.79 A; H=364-620; L=334-361; PDB
2ZC9X-ray; 1.58 A; H=364-622; L=328-363
PDB2ZDA; X-ray; 1.73 A; H=364-622
L=328-363PDB; 2ZDV; X-ray; 1.72 A
H=364-622L=328-363; PDB; 2ZF0; X-ray
2.20 AH=364-622; L=328-363; PDB; 2ZFF
X-ray1.47 A; H=364-622; L=328-363; PDB
2ZFPX-ray; 2.25 A; H=364-622; L=328-363
PDB2ZFQ; X-ray; 1.80 A; H=364-622
L=328-363PDB; 2ZFR; X-ray; 1.85 A
H=364-622L=328-363; PDB; 2ZG0; X-ray
1.75 AH=364-622; L=328-363; PDB; 2ZGB
X-ray1.60 A; H=364-622; L=328-363; PDB
2ZGXX-ray; 1.80 A; H=364-622; L=328-363
PDB2ZHE; X-ray; 2.10 A; H=364-622
L=328-363PDB; 2ZHF; X-ray; 1.98 A
H=364-622L=328-363; PDB; 2ZHQ; X-ray
1.96 AH=364-622; L=328-363; PDB; 2ZHW
X-ray2.02 A; H=364-622; L=328-363; PDB
2ZI2X-ray; 1.65 A; H=364-622; L=328-363
PDB2ZIQ; X-ray; 1.65 A; H=364-622
L=328-363PDB; 2ZNK; X-ray; 1.80 A
H=364-622L=328-363; PDB; 2ZO3; X-ray
1.70 AH=364-622; L=328-363; PDB; 3B9F
X-ray1.60 A; H=364-622; L=315-363; PDB
3BEFX-ray; 2.20 A; A/D=318-363; B/E=364-622
PDB3BEI; X-ray; 1.55 A; A=320-363
B=364-622PDB; 3BF6; X-ray; 2.50 A
H=364-622L=328-363; PDB; 3BIU; X-ray
2.30 AH=364-620; L=333-361; PDB; 3BIV
X-ray1.80 A; H=364-620; L=333-361; PDB
3BV9X-ray; 1.80 A; B=364-622; PDB
3C1KX-ray; 1.84 A; A=335-621; PDB
3C27X-ray; 2.18 A; A=334-359; B=364-622
PDB3D49; X-ray; 1.50 A; H=364-622
L=328-363PDB; 3DA9; X-ray; 1.80 A
A=328-363B=364-622; PDB; 3DD2; X-ray
1.90 AH=364-621; L=332-361; PDB; 3DHK
X-ray1.73 A; H=364-622; L=328-363; PDB
3DT0X-ray; 2.40 A; H=364-622; L=328-363
PDB3DUX; X-ray; 1.60 A; H=364-622
L=328-363PDB; 3E6P; X-ray; 2.10 A
H=364-622L=206-363; PDB; 3EE0; X-ray
2.75 AA=328-363; B=364-622; PDB; 3EGK
X-ray2.20 A; H=364-622; L=328-363; PDB
3EQ0X-ray; 1.53 A; H=364-622; L=328-363
PDB3F68; X-ray; 1.75 A; H=364-622
L=328-363PDB; 3GIC; X-ray; 1.55 A
A=328-363B=364-622; PDB; 3GIS; X-ray
2.40 AA/C/E=315-363; B/D/F=364-622; PDB; 3HAT
X-ray2.50 A; H=364-622; L=328-363; PDB
3HKJX-ray; 2.60 A; A/D=333-363; B/E=364-622
PDB3HTC; X-ray; 2.30 A; H=364-622
L=328-363PDB; 3JZ1; X-ray; 1.60 A
A=328-363B=364-622; PDB; 3JZ2; X-ray
2.40 AA=328-363; B=364-622; PDB; 3K65
X-ray1.85 A; A=199-314; B=315-622; PDB
3LDXX-ray; 2.25 A; H=364-622; L=328-363
PDB3LU9; X-ray; 1.80 A; A/D=318-363
B/E=364-622PDB; 3NXP; X-ray; 2.20 A
A=199-622PDB; 3P6Z; X-ray; 1.70 A
A/G=328-363B/H=364-622; PDB; 3PMH; X-ray
3.20 AA=328-363; B=364-622; PDB; 3QDZ
X-ray2.80 A; A/C=333-363; B/D=364-622; PDB
3QGNX-ray; 2.10 A; A=333-363; B=364-622
PDB3R3G; X-ray; 1.75 A; A=333-363
B=364-622PDB; 3S7H; X-ray; 1.90 A
A=329-363B=364-622; PDB; 3S7K; X-ray
1.90 AA/C=329-363; B/D=364-622; PDB; 4HTC
X-ray2.30 A; H=364-622; L=328-363; PDB
4THNX-ray; 2.50 A; H=364-622; L=328-363
PDB5GDS; X-ray; 2.10 A; H=364-622
L=328-363PDB; 7KME; X-ray; 2.10 A
H=364-622L=328-363; PDB; 8KME; X-ray
2.10 A1=328-363; 2=364-620; PDBsum; 1A2C
PDBsum1A3B; -; .
PDBsum1A3E; -; .
PDBsum1A46; -; .
PDBsum1A4W; -; .
PDBsum1A5G; -; .
PDBsum1A61; -; .
PDBsum1ABI; -; .
PDBsum1ABJ; -; .
PDBsum1AD8; -; .
PDBsum1AE8; -; .
PDBsum1AFE; -; .
PDBsum1AHT; -; .
PDBsum1AI8; -; .
PDBsum1AIX; -; .
PDBsum1AWF; -; .
PDBsum1AWH; -; .
PDBsum1AY6; -; .
PDBsum1B5G; -; .
PDBsum1B7X; -; .
PDBsum1BA8; -; .
PDBsum1BB0; -; .
PDBsum1BCU; -; .
PDBsum1BHX; -; .
PDBsum1BMM; -; .
PDBsum1BMN; -; .
PDBsum1BTH; -; .
PDBsum1C1U; -; .
PDBsum1C1V; -; .
PDBsum1C1W; -; .
PDBsum1C4U; -; .
PDBsum1C4V; -; .
PDBsum1C4Y; -; .
PDBsum1C5L; -; .
PDBsum1C5N; -; .
PDBsum1C5O; -; .
PDBsum1CA8; -; .
PDBsum1D3D; -; .
PDBsum1D3P; -; .
PDBsum1D3Q; -; .
PDBsum1D3T; -; .
PDBsum1D4P; -; .
PDBsum1D6W; -; .
PDBsum1D9I; -; .
PDBsum1DE7; -; .
PDBsum1DIT; -; .
PDBsum1DM4; -; .
PDBsum1DOJ; -; .
PDBsum1DWB; -; .
PDBsum1DWC; -; .
PDBsum1DWD; -; .
PDBsum1DWE; -; .
PDBsum1DX5; -; .
PDBsum1E0F; -; .
PDBsum1EB1; -; .
PDBsum1EOJ; -; .
PDBsum1EOL; -; .
PDBsum1FPC; -; .
PDBsum1FPH; -; .
PDBsum1G30; -; .
PDBsum1G32; -; .
PDBsum1G37; -; .
PDBsum1GHV; -; .
PDBsum1GHW; -; .
PDBsum1GHX; -; .
PDBsum1GHY; -; .
PDBsum1GJ4; -; .
PDBsum1GJ5; -; .
PDBsum1H8D; -; .
PDBsum1H8I; -; .
PDBsum1HAG; -; .
PDBsum1HAH; -; .
PDBsum1HAI; -; .
PDBsum1HAO; -; .
PDBsum1HAP; -; .
PDBsum1HBT; -; .
PDBsum1HDT; -; .
PDBsum1HGT; -; .
PDBsum1HLT; -; .
PDBsum1HUT; -; .
PDBsum1HXE; -; .
PDBsum1HXF; -; .
PDBsum1IHS; -; .
PDBsum1IHT; -; .
PDBsum1JMO; -; .
PDBsum1JOU; -; .
PDBsum1JWT; -; .
PDBsum1K21; -; .
PDBsum1K22; -; .
PDBsum1KTS; -; .
PDBsum1KTT; -; .
PDBsum1LHC; -; .
PDBsum1LHD; -; .
PDBsum1LHE; -; .
PDBsum1LHF; -; .
PDBsum1LHG; -; .
PDBsum1MH0; -; .
PDBsum1MU6; -; .
PDBsum1MU8; -; .
PDBsum1MUE; -; .
PDBsum1NM6; -; .
PDBsum1NO9; -; .
PDBsum1NRN; -; .
PDBsum1NRO; -; .
PDBsum1NRP; -; .
PDBsum1NRQ; -; .
PDBsum1NRR; -; .
PDBsum1NRS; -; .
PDBsum1NT1; -; .
PDBsum1NU7; -; .
PDBsum1NU9; -; .
PDBsum1NY2; -; .
PDBsum1NZQ; -; .
PDBsum1O0D; -; .
PDBsum1O2G; -; .
PDBsum1O5G; -; .
PDBsum1OOK; -; .
PDBsum1OYT; -; .
PDBsum1P8V; -; .
PDBsum1PPB; -; .
PDBsum1QBV; -; .
PDBsum1QHR; -; .
PDBsum1QJ1; -; .
PDBsum1QJ6; -; .
PDBsum1QJ7; -; .
PDBsum1QUR; -; .
PDBsum1RD3; -; .
PDBsum1RIW; -; .
PDBsum1SB1; -; .
PDBsum1SFQ; -; .
PDBsum1SG8; -; .
PDBsum1SGI; -; .
PDBsum1SHH; -; .
PDBsum1SL3; -; .
PDBsum1SR5; -; .
PDBsum1T4U; -; .
PDBsum1T4V; -; .
PDBsum1TA2; -; .
PDBsum1TA6; -; .
PDBsum1TB6; -; .
PDBsum1TBZ; -; .
PDBsum1THP; -; .
PDBsum1THR; -; .
PDBsum1THS; -; .
PDBsum1TMB; -; .
PDBsum1TMT; -; .
PDBsum1TMU; -; .
PDBsum1TOM; -; .
PDBsum1TQ0; -; .
PDBsum1TQ7; -; .
PDBsum1TWX; -; .
PDBsum1UMA; -; .
PDBsum1UVS; -; .
PDBsum1VR1; -; .
PDBsum1VZQ; -; .
PDBsum1W7G; -; .
PDBsum1WAY; -; .
PDBsum1WBG; -; .
PDBsum1XM1; -; .
PDBsum1XMN; -; .
PDBsum1YPE; -; .
PDBsum1YPG; -; .
PDBsum1YPJ; -; .
PDBsum1YPK; -; .
PDBsum1YPL; -; .
PDBsum1YPM; -; .
PDBsum1Z71; -; .
PDBsum1Z8I; -; .
PDBsum1Z8J; -; .
PDBsum1ZGI; -; .
PDBsum1ZGV; -; .
PDBsum1ZRB; -; .
PDBsum2A0Q; -; .
PDBsum2A2X; -; .
PDBsum2A45; -; .
PDBsum2AFQ; -; .
PDBsum2ANK; -; .
PDBsum2ANM; -; .
PDBsum2B5T; -; .
PDBsum2BDY; -; .
PDBsum2BVR; -; .
PDBsum2BVS; -; .
PDBsum2BVX; -; .
PDBsum2BXT; -; .
PDBsum2BXU; -; .
PDBsum2C8W; -; .
PDBsum2C8X; -; .
PDBsum2C8Y; -; .
PDBsum2C8Z; -; .
PDBsum2C90; -; .
PDBsum2C93; -; .
PDBsum2CF8; -; .
PDBsum2CF9; -; .
PDBsum2CN0; -; .
PDBsum2FEQ; -; .
PDBsum2FES; -; .
PDBsum2GDE; -; .
PDBsum2GP9; -; .
PDBsum2H9T; -; .
PDBsum2HGT; -; .
PDBsum2HNT; -; .
PDBsum2HPP; -; .
PDBsum2HPQ; -; .
PDBsum2HWL; -; .
PDBsum2JH0; -; .
PDBsum2JH5; -; .
PDBsum2JH6; -; .
PDBsum2OD3; -; .
PDBsum2PGB; -; .
PDBsum2PGQ; -; .
PDBsum2PKS; -; .
PDBsum2PW8; -; .
PDBsum2R2M; -; .
PDBsum2THF; -; .
PDBsum2UUF; -; .
PDBsum2UUJ; -; .
PDBsum2UUK; -; .
PDBsum2V3H; -; .
PDBsum2V3O; -; .
PDBsum2ZC9; -; .
PDBsum2ZDA; -; .
PDBsum2ZDV; -; .
PDBsum2ZF0; -; .
PDBsum2ZFF; -; .
PDBsum2ZFP; -; .
PDBsum2ZFQ; -; .
PDBsum2ZFR; -; .
PDBsum2ZG0; -; .
PDBsum2ZGB; -; .
PDBsum2ZGX; -; .
PDBsum2ZHE; -; .
PDBsum2ZHF; -; .
PDBsum2ZHQ; -; .
PDBsum2ZHW; -; .
PDBsum2ZI2; -; .
PDBsum2ZIQ; -; .
PDBsum2ZNK; -; .
PDBsum2ZO3; -; .
PDBsum3B9F; -; .
PDBsum3BEF; -; .
PDBsum3BEI; -; .
PDBsum3BF6; -; .
PDBsum3BIU; -; .
PDBsum3BIV; -; .
PDBsum3BV9; -; .
PDBsum3C1K; -; .
PDBsum3C27; -; .
PDBsum3D49; -; .
PDBsum3DA9; -; .
PDBsum3DD2; -; .
PDBsum3DHK; -; .
PDBsum3DT0; -; .
PDBsum3DUX; -; .
PDBsum3E6P; -; .
PDBsum3EE0; -; .
PDBsum3EGK; -; .
PDBsum3EQ0; -; .
PDBsum3F68; -; .
PDBsum3GIC; -; .
PDBsum3GIS; -; .
PDBsum3HAT; -; .
PDBsum3HKJ; -; .
PDBsum3HTC; -; .
PDBsum3JZ1; -; .
PDBsum3JZ2; -; .
PDBsum3K65; -; .
PDBsum3LDX; -; .
PDBsum3LU9; -; .
PDBsum3NXP; -; .
PDBsum3P6Z; -; .
PDBsum3PMH; -; .
PDBsum3QDZ; -; .
PDBsum3QGN; -; .
PDBsum3R3G; -; .
PDBsum3S7H; -; .
PDBsum3S7K; -; .
PDBsum4HTC; -; .
PDBsum4THN; -; .
PDBsum5GDS; -; .
PDBsum7KME; -; .
PDBsum8KME; -; .
ProteinModelPortalP00734; -; .
SMRP00734; 51-198; 212-622; .
DIPDIP-6115N; -; .
IntActP00734; 5; .
STRINGP00734; -; .
MEROPSS01.217; -; .
GlycoSuiteDBP00734; -; .
PhosphoSiteP00734; -; .
SWISS-2DPAGEP00734; -; .
PeptideAtlasP00734; -; .
PRIDEP00734; -; .
EnsemblENST00000311907; ENSP00000308541; ENSG00000180210; .
GeneID2147; -; .
KEGGhsa:2147; -; .
UCSCuc001ndf.2; human; .
CTD2147; -; .
GeneCardsGC11P046446; -; .
H-InvDBHIX0026188; -; .
HGNCHGNC:3535; F2; .
HPACAB016780; -; .
HPACAB018650; -; .
MIM176930; gene; .
MIM188050; phenotype; .
MIM601367; phenotype; .
MIM613679; phenotype; .
neXtProtNX_P00734; -; .
Orphanet325; Congenital factor II deficiency; .
Orphanet64738; Non rare thrombophilia; .
PharmGKBPA157; -; .
eggNOGprNOG08832; -; .
HOVERGENHBG108381; -; .
InParanoidP00734; -; .
OMAHSQHVFL; -; .
OrthoDBEOG4MPHPV; -; .
Pathway_Interaction_DBangiopoietinreceptor_pathway; Angiopoietin receptor Tie2-mediated signaling; .
Pathway_Interaction_DBhnf3bpathway; FOXA2 and FOXA3 transcription factor networks; .
Pathway_Interaction_DBsyndecan_4_pathway; Syndecan-4-mediated signaling events; .
ReactomeREACT_14797; Signaling by GPCR; .
ReactomeREACT_15380; Diabetes pathways; .
ReactomeREACT_17015; Metabolism of proteins; .
ReactomeREACT_604; Hemostasis; .
BindingDBP00734; -; .
DrugBankDB00025; Antihemophilic Factor; .
DrugBankDB00278; Argatroban; .
DrugBankDB00006; Bivalirudin; .
DrugBankDB00100; Coagulation Factor IX; .
DrugBankDB00055; Drotrecogin alfa; .
DrugBankDB01225; Enoxaparin; .
DrugBankDB01109; Heparin; .
DrugBankDB00001; Lepirudin; .
DrugBankDB00170; Menadione; .
DrugBankDB01123; Proflavine; .
DrugBankDB00641; Simvastatin; .
DrugBankDB04786; Suramin; .
DrugBankDB00682; Warfarin; .
DrugBankDB04898; Ximelagatran; .
NextBio8681; -; .
PMAP-CutDBP00734; -; .
ArrayExpressP00734; -; .
BgeeP00734; -; .
CleanExHS_F2; -; .
GenevestigatorP00734; -; .
GermOnlineENSG00000180210; Homo sapiens; .
GOGO:0005829; C:cytosol; IDA:GOC; .
GOGO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome; .
GOGO:0005615; C:extracellular space; IDA:BHF-UCL; .
GOGO:0005796; C:Golgi lumen; TAS:Reactome; .
GOGO:0005886; C:plasma membrane; TAS:Reactome; .
GOGO:0005625; C:soluble fraction; TAS:ProtInc; .
GOGO:0005509; F:calcium ion binding; IEA:InterPro; .
GOGO:0008083; F:growth factor activity; TAS:BHF-UCL; .
GOGO:0004252; F:serine-type endopeptidase activity; IDA:UniProtKB; .
GOGO:0070053; F:thrombospondin receptor activity; IDA:BHF-UCL; .
GOGO:0006919; P:activation of caspase activity; TAS:ProtInc; .
GOGO:0006953; P:acute-phase response; IEA:UniProtKB-KW; .
GOGO:0007597; P:blood coagulation; intrinsic pathway; TAS:Reactome
GOGO:0007166; P:cell surface receptor linked signaling pathway; IDA:BHF-UCL; .
GOGO:0051480; P:cytosolic calcium ion homeostasis; IDA:BHF-UCL; .
GOGO:0042730; P:fibrinolysis; IDA:UniProtKB; .
GOGO:0050900; P:leukocyte migration; TAS:Reactome; .
GOGO:0048712; P:negative regulation of astrocyte differentiation; IDA:BHF-UCL; .
GOGO:0051918; P:negative regulation of fibrinolysis; TAS:BHF-UCL; .
GOGO:0010544; P:negative regulation of platelet activation; TAS:BHF-UCL; .
GOGO:0045861; P:negative regulation of proteolysis; IDA:BHF-UCL; .
GOGO:0017187; P:peptidyl-glutamic acid carboxylation; TAS:Reactome; .
GOGO:0030168; P:platelet activation; IDA:BHF-UCL; .
GOGO:0032967; P:positive regulation of collagen biosynthetic process; IDA:BHF-UCL; .
GOGO:0001934; P:positive regulation of protein phosphorylation; IDA:BHF-UCL; .
GOGO:2000379; P:positive regulation of reactive oxygen species metabolic process; IDA:UniProtKB; .
GOGO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; IDA:BHF-UCL; .
GOGO:0043687; P:post-translational protein modification; TAS:Reactome; .
GOGO:0006508; P:proteolysis; TAS:Reactome; .
GOGO:0007262; P:STAT protein import into nucleus; TAS:ProtInc; .
GOGO:0007260; P:tyrosine phosphorylation of STAT protein; TAS:ProtInc; .
InterProIPR017857; Coagulation_fac_subgr_Gla_dom; .
InterProIPR000294; GLA_domain; .
InterProIPR000001; Kringle; .
InterProIPR013806; Kringle-like; .
InterProIPR018056; Kringle_CS; .
InterProIPR009003; Pept_cys/ser_Trypsin-like; .
InterProIPR018114; Peptidase_S1/S6_AS; .
InterProIPR001254; Peptidase_S1_S6; .
InterProIPR001314; Peptidase_S1A; .
InterProIPR003966; Peptidase_S1A_prothrombin; .
InterProIPR018992; Thrombin_light_chain; .
Gene3DG3DSA:4.10.740.10; Coagulation_factor_Gla; 1; .
Gene3DG3DSA:2.40.20.10; Kringle; 2; .
Gene3DG3DSA:4.10.140.10; Thrombin_light_chain; 1; .
PfamPF00594; Gla; 1; .
PfamPF00051; Kringle; 2; .
PfamPF09396; Thrombin_light; 1; .
PfamPF00089; Trypsin; 1; .
PIRSFPIRSF001149; Thrombin; 1; .
PRINTSPR00722; CHYMOTRYPSIN; .
PRINTSPR00001; GLABLOOD; .
PRINTSPR00018; KRINGLE; .
PRINTSPR01505; PROTHROMBIN; .
SMARTSM00069; GLA; 1; .
SMARTSM00130; KR; 2; .
SMARTSM00020; Tryp_SPc; 1; .
SUPFAMSSF57440; Kringle-like; 2; .
SUPFAMSSF50494; Pept_Ser_Cys; 1; .
SUPFAMSSF57630; VitK_dep_GLA; 1; .
PROSITEPS00011; GLA_1; 1; .
PROSITEPS50998; GLA_2; 1; .
PROSITEPS00021; KRINGLE_1; 2; .
PROSITEPS50070; KRINGLE_2; 2; .
PROSITEPS50240; TRYPSIN_DOM; 1; .
PROSITEPS00134; TRYPSIN_HIS; 1; .
PROSITEPS00135; TRYPSIN_SER; 1; .



SWISS-2DPAGE image

SWISS-2DPAGE (search AC)


Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server