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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: P00747




SWISS-2DPAGE:  P00747


P00747


General information about the entry
View entry in simple text format
Entry namePLMN_HUMAN
Primary accession numberP00747
integrated into SWISS-2DPAGE on August 1, 1993 (release 0)
2D Annotations were last modified onDecember 1, 2000 (version 1)
General Annotations were last modified on May 19, 2011 (version 11)
Name and origin of the protein
DescriptionRecName: Full=Plasminogen; EC=3.4.21.7; Contains: RecName: Full=Plasmin heavy chain A; Contains: RecName: Full=Activation peptide; Contains: RecName: Full=Angiostatin; Contains: RecName: Full=Plasmin heavy chain A, short form; Contains: RecName: Full=Plasmin light chain B; Flags: Precursor;.
Gene nameName=PLG
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
MEDLINE=78094420; PubMed=271964; [NCBI, ExPASy, EBI, Israel, Japan]
Anderson N.L., Anderson N.G.
''''''High resolution two-dimensional electrophoresis of human plasma proteins'';'';''
Proc. Natl. Acad. Sci. U.S.A. 74(1):5421-5425(1977)
[2]   MAPPING ON GEL
MEDLINE=96007934; PubMed=7498157; [NCBI, ExPASy, EBI, Israel, Japan]
Sanchez J.-C., Appel R.D., Golaz O.G., Pasquali C., Ravier F., Bairoch A., Hochstrasser D.F.
''''''Inside SWISS-2DPAGE database'';'';''
Electrophoresis 16(1):1131-1151(1995)
Comments
  • SUBUNIT: SINGLE CHAIN
2D PAGE maps for identified proteins
How to interpret a protein

CSF_HUMAN {Cerebrospinal Fluid}
Homo sapiens (Human)
Tissue: Cerebrospinal fluid
CSF_HUMAN
  map experimental info
  protein estimated location
 
CSF_HUMAN

MAP LOCATIONS:
pI=6.59; Mw=113499
pI=6.68; Mw=112945
pI=6.91; Mw=108602
pI=6.77; Mw=112392
pI=7.32; Mw=110752
pI=6.99; Mw=110752
pI=7.07; Mw=109136
pI=7.21; Mw=109672
pI=6.78; Mw=107543
pI=6.59; Mw=107543
pI=6.68; Mw=107017

MAPPING (identification):
MATCHING WITH THE PLASMA MASTER GEL [2].



PLASMA_HUMAN {Plasma}
Homo sapiens (Human)
Tissue: Plasma
PLASMA_HUMAN
  map experimental info
  protein estimated location
 
PLASMA_HUMAN

MAP LOCATIONS:
pI=6.39; Mw=116057
pI=6.32; Mw=116057
pI=6.34; Mw=114423
pI=6.43; Mw=115237
pI=6.46; Mw=114423
pI=6.48; Mw=113614
pI=6.49; Mw=112811

NORMAL LEVEL:
60-250 MG/L.

PATHOLOGICAL LEVEL:
DECREASED DURING HYPERFIBRINOLYSIS, DISSAMINATED INTRAVASCULAR COAGULATION AND RESPIRATORY DISTRESS OF THE NEWBORN.

POSITIONAL VARIANTS:
TOCHIGI VARIANT.

MAPPING (identification):
IMMUNOBLOTTING [1].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from license@isb-sib.ch).
Cross-references
Siena-2DPAGEP00747; PLMN_HUMAN.
UniProtKB/Swiss-ProtP00747; PLMN_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry namePLMN_HUMAN
Primary accession numberP00747
Secondary accession number(s) Q15146 Q5TEH4 Q6PA00
Sequence was last modified on July 1, 1989 (version 2)
Annotations were last modified on September 21, 2011 (version 161)
Name and origin of the protein
DescriptionRecName: Full=Plasminogen; EC=3.4.21.7; Contains: RecName: Full=Plasmin heavy chain A; Contains: RecName: Full=Activation peptide; Contains: RecName: Full=Angiostatin; Contains: RecName: Full=Plasmin heavy chain A, short form; Contains: RecName: Full=Plasmin light chain B; Flags: Precursor;
Gene nameName=PLG
Encoded onName=PLG
Keywords3D-structure; Blood coagulation; Cleavage on pair of basic residues; Complete proteome; Direct protein sequencing; Disease mutation; Disulfide bond; Fibrinolysis; Glycoprotein; Hydrolase; Kringle; Phosphoprotein; Polymorphism; Protease; Reference proteome; Repeat; Secreted; Serine protease; Signal; Thrombophilia; Tissue remodeling; Zymogen.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLM34276; AAA60113.1; -; Genomic_DNA
EMBLM33272; AAA60113.1; JOINED; Genomic_DNA
EMBLM33274; AAA60113.1; JOINED; Genomic_DNA
EMBLM33275; AAA60113.1; JOINED; Genomic_DNA
EMBLM33278; AAA60113.1; JOINED; Genomic_DNA
EMBLM33279; AAA60113.1; JOINED; Genomic_DNA
EMBLM33280; AAA60113.1; JOINED; Genomic_DNA
EMBLM33282; AAA60113.1; JOINED; Genomic_DNA
EMBLM33283; AAA60113.1; JOINED; Genomic_DNA
EMBLM33284; AAA60113.1; JOINED; Genomic_DNA
EMBLM33285; AAA60113.1; JOINED; Genomic_DNA
EMBLM33286; AAA60113.1; JOINED; Genomic_DNA
EMBLM33287; AAA60113.1; JOINED; Genomic_DNA
EMBLM33288; AAA60113.1; JOINED; Genomic_DNA
EMBLM33289; AAA60113.1; JOINED; Genomic_DNA
EMBLM33290; AAA60113.1; JOINED; Genomic_DNA
EMBLM34272; AAA60113.1; JOINED; Genomic_DNA
EMBLM34273; AAA60113.1; JOINED; Genomic_DNA
EMBLM34275; AAA60113.1; JOINED; Genomic_DNA
EMBLX05199; CAA28831.1; -; mRNA
EMBLM74220; AAA36451.1; -; mRNA
EMBLAY192161; AAN85555.1; -; Genomic_DNA
EMBLAL109933; CAI22908.1; -; Genomic_DNA
EMBLBC060513; AAH60513.1; -; mRNA
EMBLK02922; AAA60124.1; -; mRNA
IPIIPI00019580; -; .
PIRA35229; PLHU; .
RefSeqNP_000292.1; NM_000301.3; .
UniGeneHs.143436; -; .
PDB1B2I; NMR; -; A=183-263
PDB1BML; X-ray; 2.90 A; A/B=561-810
PDB1BUI; X-ray; 2.65 A; A/B=561-810
PDB1CEA; X-ray; 2.06 A; A/B=100-187
PDB1CEB; X-ray; 2.07 A; A/B=100-187
PDB1DDJ; X-ray; 2.00 A; A/B/C/D=564-810
PDB1HPJ; NMR; -; A=103-181
PDB1HPK; NMR; -; A=103-181
PDB1I5K; X-ray; 2.70 A; A/B=183-262
PDB1KI0; X-ray; 1.75 A; A=100-352
PDB1KRN; X-ray; 1.67 A; A=374-461
PDB1L4D; X-ray; 2.30 A; A=562-810
PDB1L4Z; X-ray; 2.80 A; A=563-810
PDB1PK4; X-ray; 1.90 A; A=376-454
PDB1PKR; X-ray; 2.48 A; A=101-181
PDB1PMK; X-ray; 2.25 A; A/B=374-461
PDB1QRZ; X-ray; 2.00 A; A/B/C/D=565-810
PDB1RJX; X-ray; 2.30 A; B=564-810
PDB2DOH; X-ray; 2.30 A; X=100-333
PDB2DOI; X-ray; 3.10 A; A/X=100-333
PDB2KNF; NMR; -; A=480-562
PDB2L0S; NMR; -; A=272-354
PDB2PK4; X-ray; 2.25 A; A=375-454
PDB5HPG; X-ray; 1.66 A; A/B=480-563
PDBsum1B2I; -; .
PDBsum1BML; -; .
PDBsum1BUI; -; .
PDBsum1CEA; -; .
PDBsum1CEB; -; .
PDBsum1DDJ; -; .
PDBsum1HPJ; -; .
PDBsum1HPK; -; .
PDBsum1I5K; -; .
PDBsum1KI0; -; .
PDBsum1KRN; -; .
PDBsum1L4D; -; .
PDBsum1L4Z; -; .
PDBsum1PK4; -; .
PDBsum1PKR; -; .
PDBsum1PMK; -; .
PDBsum1QRZ; -; .
PDBsum1RJX; -; .
PDBsum2DOH; -; .
PDBsum2DOI; -; .
PDBsum2KNF; -; .
PDBsum2L0S; -; .
PDBsum2PK4; -; .
PDBsum5HPG; -; .
ProteinModelPortalP00747; -; .
SMRP00747; 17-810; .
DisProtDP00191; -; .
IntActP00747; 13; .
STRINGP00747; -; .
MEROPSS01.233; -; .
GlycoSuiteDBP00747; -; .
PhosphoSiteP00747; -; .
SWISS-2DPAGEP00747; -; .
PeptideAtlasP00747; -; .
PRIDEP00747; -; .
EnsemblENST00000308192; ENSP00000308938; ENSG00000122194; .
GeneID5340; -; .
KEGGhsa:5340; -; .
UCSCuc003qtm.2; human; .
CTD5340; -; .
GeneCardsGC06P158569; -; .
H-InvDBHIX0032909; -; .
HGNCHGNC:9071; PLG; .
HPACAB000668; -; .
HPACAB016678; -; .
HPAHPA021602; -; .
MIM173350; gene+phenotype; .
MIM188050; phenotype; .
MIM217090; phenotype; .
neXtProtNX_P00747; -; .
Orphanet722; Hypoplasminogenemia; .
Orphanet97231; Ligneous conjunctivitis; .
PharmGKBPA33405; -; .
eggNOGprNOG15519; -; .
HOGENOMHBG755338; -; .
HOVERGENHBG004381; -; .
InParanoidP00747; -; .
OMAENKVCNR; -; .
OrthoDBEOG4RR6GQ; -; .
PhylomeDBP00747; -; .
BioCycMetaCyc:MONOMER-12950; -; .
Pathway_Interaction_DBamb2_neutrophils_pathway; amb2 Integrin signaling; .
Pathway_Interaction_DBp75ntrpathway; p75(NTR)-mediated signaling; .
Pathway_Interaction_DBsyndecan_4_pathway; Syndecan-4-mediated signaling events; .
ReactomeREACT_15380; Diabetes pathways; .
ReactomeREACT_16888; Signaling by PDGF; .
ReactomeREACT_604; Hemostasis; .
DrugBankDB00513; Aminocaproic Acid; .
DrugBankDB00086; Streptokinase; .
DrugBankDB00302; Tranexamic Acid; .
DrugBankDB00013; Urokinase; .
NextBio20698; -; .
PMAP-CutDBP00747; -; .
ArrayExpressP00747; -; .
BgeeP00747; -; .
CleanExHS_PLG; -; .
GenevestigatorP00747; -; .
GermOnlineENSG00000122194; Homo sapiens; .
GOGO:0005615; C:extracellular space; IDA:HGNC; .
GOGO:0031232; C:extrinsic to external side of plasma membrane; IDA:BHF-UCL; .
GOGO:0031093; C:platelet alpha granule lumen; TAS:Reactome; .
GOGO:0034185; F:apolipoprotein binding; IPI:BHF-UCL; .
GOGO:0043498; F:cell surface binding; IDA:BHF-UCL; .
GOGO:0004252; F:serine-type endopeptidase activity; IDA:BHF-UCL; .
GOGO:0022617; P:extracellular matrix disassembly; IDA:BHF-UCL; .
GOGO:0042730; P:fibrinolysis; TAS:Reactome; .
GOGO:0008285; P:negative regulation of cell proliferation; TAS:ProtInc; .
GOGO:0010812; P:negative regulation of cell-substrate adhesion; IDA:BHF-UCL; .
GOGO:0051918; P:negative regulation of fibrinolysis; IDA:BHF-UCL; .
GOGO:0030168; P:platelet activation; TAS:Reactome; .
GOGO:0002576; P:platelet degranulation; TAS:Reactome; .
GOGO:0051919; P:positive regulation of fibrinolysis; IDA:BHF-UCL; .
GOGO:0006508; P:proteolysis; IEA:InterPro; .
GOGO:0048771; P:tissue remodeling; IEA:UniProtKB-KW; .
InterProIPR000001; Kringle; .
InterProIPR013806; Kringle-like; .
InterProIPR018056; Kringle_CS; .
InterProIPR003014; PAN-1_domain; .
InterProIPR003609; Pan_app; .
InterProIPR009003; Pept_cys/ser_Trypsin-like; .
InterProIPR023317; Pept_S1A_plasmin; .
InterProIPR018114; Peptidase_S1/S6_AS; .
InterProIPR001254; Peptidase_S1_S6; .
InterProIPR001314; Peptidase_S1A; .
Gene3DG3DSA:2.40.20.10; Kringle; 5; .
PfamPF00051; Kringle; 5; .
PfamPF00024; PAN_1; 1; .
PfamPF00089; Trypsin; 1; .
PIRSFPIRSF001150; Plasmin; 1; .
PRINTSPR00722; CHYMOTRYPSIN; .
PRINTSPR00018; KRINGLE; .
SMARTSM00130; KR; 5; .
SMARTSM00473; PAN_AP; 1; .
SMARTSM00020; Tryp_SPc; 1; .
SUPFAMSSF57440; Kringle-like; 5; .
SUPFAMSSF50494; Pept_Ser_Cys; 1; .
PROSITEPS00021; KRINGLE_1; 5; .
PROSITEPS50070; KRINGLE_2; 5; .
PROSITEPS50948; PAN; 1; .
PROSITEPS50240; TRYPSIN_DOM; 1; .
PROSITEPS00134; TRYPSIN_HIS; 1; .
PROSITEPS00135; TRYPSIN_SER; 1; .



SWISS-2DPAGE image

SWISS-2DPAGE (search AC)


Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server