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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: P01019




SWISS-2DPAGE:  P01019


P01019


General information about the entry
View entry in simple text format
Entry nameANGT_HUMAN
Primary accession numberP01019
integrated into SWISS-2DPAGE on August 1, 1993 (release 0)
2D Annotations were last modified onMay 15, 2003 (version 1)
General Annotations were last modified on May 19, 2011 (version 15)
Name and origin of the protein
DescriptionRecName: Full=Angiotensinogen; AltName: Full=Serpin A8; Contains: RecName: Full=Angiotensin-1; AltName: Full=Angiotensin I; Short=Ang I; Contains: RecName: Full=Angiotensin-2; AltName: Full=Angiotensin II; Short=Ang II; Contains: RecName: Full=Angiotensin-3; AltName: Full=Angiotensin III; Short=Ang III; AltName: Full=Des-Asp[1]-angiotensin II; Flags: Precursor;.
Gene nameName=AGT
Synonyms=SERPINA8
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
MEDLINE=93092937; PubMed=1459097; [NCBI, ExPASy, EBI, Israel, Japan]
Hughes G.J., Frutiger S., Paquet N., Ravier F., Pasquali C., Sanchez J.-C., James R.W., Tissot J.-D., Bjellqvist B., Hochstrasser D.F.
''''''Plasma protein map: an update by microsequencing'';'';''
Electrophoresis 13(1):707-714(1992)
Comments
  • SUBUNIT: SINGLE CHAIN
2D PAGE maps for identified proteins
How to interpret a protein

PLASMA_HUMAN {Plasma}
Homo sapiens (Human)
Tissue: Plasma
PLASMA_HUMAN
  map experimental info
  protein estimated location
 
PLASMA_HUMAN

MAP LOCATIONS:
pI=5.07; Mw=58973

NORMAL LEVEL:
30-60 MG/L [1].

PATHOLOGICAL LEVEL:
INCREASED DURING HYPERTENSION [1].

MAPPING (identification):
MICROSEQUENCING [1].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from license@isb-sib.ch).
Cross-references
UniProtKB/Swiss-ProtP01019; ANGT_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameANGT_HUMAN
Primary accession numberP01019
Secondary accession number(s) Q16358 Q16359 Q96F91
Sequence was last modified on July 21, 1986 (version 1)
Annotations were last modified on October 19, 2011 (version 146)
Name and origin of the protein
DescriptionRecName: Full=Angiotensinogen; AltName: Full=Serpin A8; Contains: RecName: Full=Angiotensin-1; AltName: Full=Angiotensin I; Short=Ang I; Contains: RecName: Full=Angiotensin-2; AltName: Full=Angiotensin II; Short=Ang II; Contains: RecName: Full=Angiotensin-3; AltName: Full=Angiotensin III; Short=Ang III; AltName: Full=Des-Asp[1]-angiotensin II; Flags: Precursor;
Gene nameName=AGT
Synonyms=SERPINA8
Encoded onName=AGT; Synonyms=SERPINA8
Keywords3D-structure; Complete proteome; Direct protein sequencing; Disease mutation; Disulfide bond; Glycoprotein; Polymorphism; Reference proteome; Secreted; Signal; Vasoactive; Vasoconstrictor.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLK02215; AAA51731.1; -; mRNA
EMBLM24689; AAA51679.1; -; Genomic_DNA
EMBLM24686; AAA51679.1; JOINED; Genomic_DNA
EMBLM24687; AAA51679.1; JOINED; Genomic_DNA
EMBLM24688; AAA51679.1; JOINED; Genomic_DNA
EMBLX15324; CAA33385.1; -; Genomic_DNA
EMBLX15325; CAA33385.1; JOINED; Genomic_DNA
EMBLX15326; CAA33385.1; JOINED; Genomic_DNA
EMBLX15327; CAA33385.1; JOINED; Genomic_DNA
EMBLBC011519; AAH11519.1; -; mRNA
EMBLM69110; AAA52282.1; -; mRNA
EMBLS78529; AAD14287.1; -; Genomic_DNA
EMBLS78530; AAD14288.1; -; Genomic_DNA
IPIIPI00032220; -; .
PIRA35203; ANHU; .
RefSeqNP_000020.1; NM_000029.3; .
UniGeneHs.19383; -; .
PDB1N9U; NMR; -; A=34-43
PDB1N9V; NMR; -; A=34-41
PDB2JP8; NMR; -; P=34-40
PDB2WXW; X-ray; 3.30 A; A=34-485
PDB2X0B; X-ray; 4.33 A; B/D/F/H=34-485
PDBsum1N9U; -; .
PDBsum1N9V; -; .
PDBsum2JP8; -; .
PDBsum2WXW; -; .
PDBsum2X0B; -; .
ProteinModelPortalP01019; -; .
SMRP01019; 34-482; .
DIPDIP-309N; -; .
IntActP01019; 3; .
MINTMINT-1472115; -; .
STRINGP01019; -; .
MEROPSI04.953; -; .
PhosphoSiteP01019; -; .
SWISS-2DPAGEP01019; -; .
PeptideAtlasP01019; -; .
PRIDEP01019; -; .
EnsemblENST00000366667; ENSP00000355627; ENSG00000135744; .
GeneID183; -; .
KEGGhsa:183; -; .
UCSCuc001hty.2; human; .
CTD183; -; .
GeneCardsGC01M201323; -; .
H-InvDBHIX0001686; -; .
HGNCHGNC:333; AGT; .
HPAHPA001557; -; .
MIM106150; gene; .
MIM145500; phenotype; .
MIM267430; phenotype; .
neXtProtNX_P01019; -; .
Orphanet243761; Essential hypertension; .
Orphanet97369; Renal tubular dysgenesis of genetic origin; .
eggNOGprNOG11287; -; .
HOVERGENHBG004233; -; .
InParanoidP01019; -; .
OMATYVHFQG; -; .
OrthoDBEOG44TP89; -; .
PhylomeDBP01019; -; .
Pathway_Interaction_DBprlsignalingeventspathway; Signaling events mediated by PRL; .
ReactomeREACT_14797; Signaling by GPCR; .
ReactomeREACT_22258; Metabolism of lipids and lipoproteins; .
DrugBankDB01258; Aliskiren; .
DrugBankDB01076; Atorvastatin; .
DrugBankDB01340; Cilazapril; .
DrugBankDB01029; Irbesartan; .
DrugBankDB00722; Lisinopril; .
DrugBankDB01092; Ouabain; .
DrugBankDB00641; Simvastatin; .
NextBio748; -; .
PMAP-CutDBP01019; -; .
ArrayExpressP01019; -; .
BgeeP01019; -; .
CleanExHS_AGT; -; .
GenevestigatorP01019; -; .
GermOnlineENSG00000135744; Homo sapiens; .
GOGO:0005615; C:extracellular space; IDA:BHF-UCL; .
GOGO:0005625; C:soluble fraction; TAS:ProtInc; .
GOGO:0010698; F:acetyltransferase activator activity; IDA:BHF-UCL; .
GOGO:0008083; F:growth factor activity; TAS:BHF-UCL; .
GOGO:0005179; F:hormone activity; ISS:BHF-UCL; .
GOGO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:RefGenome; .
GOGO:0031702; F:type 1 angiotensin receptor binding; IPI:BHF-UCL; .
GOGO:0031703; F:type 2 angiotensin receptor binding; IPI:BHF-UCL; .
GOGO:0007200; P:activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger; NAS:BHF-UCL; .
GOGO:0001974; P:blood vessel remodeling; TAS:BHF-UCL; .
GOGO:0007267; P:cell-cell signaling; TAS:ProtInc; .
GOGO:0044255; P:cellular lipid metabolic process; TAS:Reactome; .
GOGO:0007199; P:G-protein signaling; coupled to cGMP nucleotide second messenger; TAS:BHF-UCL
GOGO:0001822; P:kidney development; IMP:BHF-UCL; .
GOGO:0034374; P:low-density lipoprotein particle remodeling; NAS:BHF-UCL; .
GOGO:0051387; P:negative regulation of nerve growth factor receptor signaling pathway; IDA:BHF-UCL; .
GOGO:0007263; P:nitric oxide mediated signal transduction; TAS:BHF-UCL; .
GOGO:0010535; P:positive regulation of activation of JAK2 kinase activity; IMP:UniProtKB; .
GOGO:0090190; P:positive regulation of branching involved in ureteric bud morphogenesis; IDA:UniProtKB; .
GOGO:0010613; P:positive regulation of cardiac muscle hypertrophy; ISS:BHF-UCL; .
GOGO:0010873; P:positive regulation of cholesterol esterification; IDA:BHF-UCL; .
GOGO:0001819; P:positive regulation of cytokine production; TAS:BHF-UCL; .
GOGO:0010595; P:positive regulation of endothelial cell migration; IDA:BHF-UCL; .
GOGO:0045742; P:positive regulation of epidermal growth factor receptor signaling pathway; IDA:BHF-UCL; .
GOGO:0048146; P:positive regulation of fibroblast proliferation; ISS:BHF-UCL; .
GOGO:0050729; P:positive regulation of inflammatory response; TAS:BHF-UCL; .
GOGO:0010744; P:positive regulation of macrophage derived foam cell differentiation; IC:BHF-UCL; .
GOGO:0033864; P:positive regulation of NAD(P)H oxidase activity; TAS:BHF-UCL; .
GOGO:0051092; P:positive regulation of NF-kappaB transcription factor activity; TAS:BHF-UCL; .
GOGO:0014068; P:positive regulation of phosphatidylinositol 3-kinase cascade; IDA:BHF-UCL; .
GOGO:0061098; P:positive regulation of protein tyrosine kinase activity; IMP:UniProtKB; .
GOGO:0045893; P:positive regulation of transcription; DNA-dependent; IDA:UniProtKB
GOGO:0030162; P:regulation of proteolysis; IBA:RefGenome; .
GOGO:0002019; P:regulation of renal output by angiotensin; NAS:BHF-UCL; .
GOGO:0019229; P:regulation of vasoconstriction; NAS:BHF-UCL; .
GOGO:0002018; P:renin-angiotensin regulation of aldosterone production; NAS:BHF-UCL; .
GOGO:0014873; P:response to muscle activity involved in regulation of muscle adaptation; ISS:BHF-UCL; .
InterProIPR000227; Angiotensngn; .
InterProIPR000215; Protease_inhib_I4_serpin; .
InterProIPR023795; Protease_inhib_I4_serpin_CS; .
InterProIPR023796; Sepin_dom; .
PANTHERPTHR11461; Prot_inh_serpin; 1; .
PfamPF00079; Serpin; 1; .
PRINTSPR00654; ANGIOTENSNGN; .
SMARTSM00093; SERPIN; 1; .
SUPFAMSSF56574; Prot_inh_serpin; 1; .
PROSITEPS00284; SERPIN; 1; .



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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server