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SWISS-2DPAGE 
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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: P01042




SWISS-2DPAGE:  P01042


P01042


General information about the entry
View entry in simple text format
Entry nameKNG1_HUMAN
Primary accession numberP01042
Secondary accession number(s) P01043
integrated into SWISS-2DPAGE on August 1, 1993 (release 0)
2D Annotations were last modified onDecember 1, 2000 (version 1)
General Annotations were last modified on May 19, 2011 (version 12)
Name and origin of the protein
DescriptionRecName: Full=Kininogen-1; AltName: Full=Alpha-2-thiol proteinase inhibitor; AltName: Full=Fitzgerald factor; AltName: Full=High molecular weight kininogen; Short=HMWK; AltName: Full=Williams-Fitzgerald-Flaujeac factor; Contains: RecName: Full=Kininogen-1 heavy chain; Contains: RecName: Full=T-kinin; AltName: Full=Ile-Ser-Bradykinin; Contains: RecName: Full=Bradykinin; AltName: Full=Kallidin I; Contains: RecName: Full=Lysyl-bradykinin; AltName: Full=Kallidin II; Contains: RecName: Full=Kininogen-1 light chain; Contains: RecName: Full=Low molecular weight growth-promoting factor; Flags: Precursor;.
Gene nameName=KNG1
Synonyms=BDK, KNG
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
MEDLINE=93092937; PubMed=1459097; [NCBI, ExPASy, EBI, Israel, Japan]
Hughes G.J., Frutiger S., Paquet N., Ravier F., Pasquali C., Sanchez J.-C., James R.W., Tissot J.-D., Bjellqvist B., Hochstrasser D.F.
''''''Plasma protein map: an update by microsequencing'';'';''
Electrophoresis 13(1):707-714(1992)
Comments
  • SUBUNIT: LIGHT AND HEAVY CHAIN
2D PAGE maps for identified proteins
How to interpret a protein

PLASMA_HUMAN {Plasma}
Homo sapiens (Human)
Tissue: Plasma
PLASMA_HUMAN
  map experimental info
  protein estimated location
 
PLASMA_HUMAN

MAP LOCATIONS:
pI=6.48; Mw=7490

NORMAL LEVEL:
90 MG/L(MEAN VALUE) [1].

PATHOLOGICAL LEVEL:
DECREASED DURING CHRONIC RENAL FAILURE, EXTRACORPORAL CIRCULATION, LIVER CIRRHOSIS AND DISSAMINATION INTRAVASCULAR COAGULATION [1].

MAPPING (identification):
MICROSEQUENCING [1].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss).
Cross-references
UniProtKB/Swiss-ProtP01042; KNG1_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameKNG1_HUMAN
Primary accession numberP01042
Secondary accession number(s) A8K474 B2RCR2 P01043 Q53EQ0 Q6PAU9 Q7M4P1
Sequence was last modified on January 23, 2007 (version 2)
Annotations were last modified on September 21, 2011 (version 140)
Name and origin of the protein
DescriptionRecName: Full=Kininogen-1; AltName: Full=Alpha-2-thiol proteinase inhibitor; AltName: Full=Fitzgerald factor; AltName: Full=High molecular weight kininogen; Short=HMWK; AltName: Full=Williams-Fitzgerald-Flaujeac factor; Contains: RecName: Full=Kininogen-1 heavy chain; Contains: RecName: Full=T-kinin; AltName: Full=Ile-Ser-Bradykinin; Contains: RecName: Full=Bradykinin; AltName: Full=Kallidin I; Contains: RecName: Full=Lysyl-bradykinin; AltName: Full=Kallidin II; Contains: RecName: Full=Kininogen-1 light chain; Contains: RecName: Full=Low molecular weight growth-promoting factor; Flags: Precursor;
Gene nameName=KNG1
Synonyms=BDK, KNG
Encoded onName=KNG1; Synonyms=BDK, KNG
Keywords3D-structure; Alternative splicing; Blood coagulation; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Hydroxylation; Inflammatory response; Phosphoprotein; Polymorphism; Protease inhibitor; Pyrrolidone carboxylic acid; Reference proteome; Repeat; Secreted; Signal; Thiol protease inhibitor; Vasoactive; Vasodilator.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLK02566; AAA35497.1; -; mRNA
EMBLM11437; AAB59550.1; -; Genomic_DNA
EMBLM11438; AAB59550.1; JOINED; Genomic_DNA
EMBLM11521; AAB59550.1; JOINED; Genomic_DNA
EMBLM11522; AAB59550.1; JOINED; Genomic_DNA
EMBLM11523; AAB59550.1; JOINED; Genomic_DNA
EMBLM11524; AAB59550.1; JOINED; Genomic_DNA
EMBLM11525; AAB59550.1; JOINED; Genomic_DNA
EMBLM11526; AAB59550.1; JOINED; Genomic_DNA
EMBLM11527; AAB59550.1; JOINED; Genomic_DNA
EMBLM11528; AAB59550.1; JOINED; Genomic_DNA
EMBLM11437; AAB59551.1; -; Genomic_DNA
EMBLM11438; AAB59551.1; JOINED; Genomic_DNA
EMBLM11521; AAB59551.1; JOINED; Genomic_DNA
EMBLM11522; AAB59551.1; JOINED; Genomic_DNA
EMBLM11523; AAB59551.1; JOINED; Genomic_DNA
EMBLM11524; AAB59551.1; JOINED; Genomic_DNA
EMBLM11525; AAB59551.1; JOINED; Genomic_DNA
EMBLM11526; AAB59551.1; JOINED; Genomic_DNA
EMBLM11527; AAB59551.1; JOINED; Genomic_DNA
EMBLM11528; AAB59551.1; JOINED; Genomic_DNA
EMBLAK315230; BAG37659.1; -; mRNA
EMBLAY248697; AAO61092.1; -; Genomic_DNA
EMBLAK290839; BAF83528.1; -; mRNA
EMBLAK223589; BAD97309.1; -; mRNA
EMBLCH471052; EAW78179.1; -; Genomic_DNA
EMBLBC060039; AAH60039.1; -; mRNA
IPIIPI00032328; -; .
IPIIPI00215894; -; .
PIRA01279; KGHUH1; .
PIRA01280; KGHUL1; .
PIRS13279; S13279; .
RefSeqNP_000884.1; NM_000893.3; .
RefSeqNP_001095886.1; NM_001102416.2; .
UniGeneHs.77741; -; .
PDB2WOK; X-ray; 1.70 A; B=381-389
PDBsum2WOK; -; .
ProteinModelPortalP01042; -; .
SMRP01042; 21-127; 139-251; 258-372
STRINGP01042; -; .
MEROPSI25.016; -; .
MEROPSI25.017; -; .
MEROPSI25.950; -; .
PhosphoSiteP01042; -; .
SWISS-2DPAGEP01042; -; .
PeptideAtlasP01042; -; .
PRIDEP01042; -; .
EnsemblENST00000265023; ENSP00000265023; ENSG00000113889; .
GeneID3827; -; .
KEGGhsa:3827; -; .
UCSCuc003fqr.1; human; .
UCSCuc010hyt.1; human; .
CTD3827; -; .
GeneCardsGC03P183844; -; .
HGNCHGNC:6383; KNG1; .
HPACAB009809; -; .
HPAHPA001616; -; .
HPAHPA001645; -; .
MIM228960; phenotype; .
MIM612358; gene; .
neXtProtNX_P01042; -; .
Orphanet483; Congenital high-molecular-weight kininogen deficiency; .
eggNOGprNOG15782; -; .
GeneTreeENSGT00440000039713; -; .
HOVERGENHBG006224; -; .
InParanoidP01042; -; .
OMAGRPWKPV; -; .
OrthoDBEOG4QNMVT; -; .
PhylomeDBP01042; -; .
Pathway_Interaction_DBamb2_neutrophils_pathway; amb2 Integrin signaling; .
Pathway_Interaction_DBsyndecan_2_pathway; Syndecan-2-mediated signaling events; .
ReactomeREACT_14797; Signaling by GPCR; .
ReactomeREACT_604; Hemostasis; .
DrugBankDB01092; Ouabain; .
NextBio15047; -; .
PMAP-CutDBP01042; -; .
ArrayExpressP01042; -; .
BgeeP01042; -; .
CleanExHS_KNG1; -; .
GenevestigatorP01042; -; .
GermOnlineENSG00000113889; Homo sapiens; .
GOGO:0005615; C:extracellular space; IEA:UniProtKB-SubCell; .
GOGO:0005886; C:plasma membrane; TAS:Reactome; .
GOGO:0031093; C:platelet alpha granule lumen; TAS:Reactome; .
GOGO:0004869; F:cysteine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW; .
GOGO:0008201; F:heparin binding; NAS:UniProtKB; .
GOGO:0005102; F:receptor binding; IPI:UniProtKB; .
GOGO:0008270; F:zinc ion binding; NAS:UniProtKB; .
GOGO:0007597; P:blood coagulation; intrinsic pathway; TAS:Reactome
GOGO:0007204; P:elevation of cytosolic calcium ion concentration; IDA:UniProtKB; .
GOGO:0006954; P:inflammatory response; TAS:UniProtKB; .
GOGO:0030195; P:negative regulation of blood coagulation; IDA:UniProtKB; .
GOGO:0007162; P:negative regulation of cell adhesion; IDA:UniProtKB; .
GOGO:0030168; P:platelet activation; TAS:Reactome; .
GOGO:0002576; P:platelet degranulation; TAS:Reactome; .
GOGO:0043065; P:positive regulation of apoptosis; NAS:UniProtKB; .
GOGO:0035815; P:positive regulation of renal sodium excretion; TAS:UniProtKB; .
GOGO:0035810; P:positive regulation of urine volume; TAS:UniProtKB; .
GOGO:0006939; P:smooth muscle contraction; TAS:UniProtKB; .
GOGO:0042311; P:vasodilation; IEA:UniProtKB-KW; .
InterProIPR002395; Kininogen; .
InterProIPR000010; Prot_inh_cystat; .
InterProIPR018073; Prot_inh_cystat_CS; .
PfamPF00031; Cystatin; 3; .
PRINTSPR00334; KININOGEN; .
SMARTSM00043; CY; 3; .
PROSITEPS00287; CYSTATIN; 2; .



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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server