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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: P02765




SWISS-2DPAGE:  P02765


P02765


General information about the entry
View entry in simple text format
Entry nameFETUA_HUMAN
Primary accession numberP02765
integrated into SWISS-2DPAGE on August 1, 1993 (release 0)
2D Annotations were last modified onMay 15, 2003 (version 1)
General Annotations were last modified on May 19, 2011 (version 15)
Name and origin of the protein
DescriptionRecName: Full=Alpha-2-HS-glycoprotein; AltName: Full=Alpha-2-Z-globulin; AltName: Full=Ba-alpha-2-glycoprotein; AltName: Full=Fetuin-A; Contains: RecName: Full=Alpha-2-HS-glycoprotein chain A; Contains: RecName: Full=Alpha-2-HS-glycoprotein chain B; Flags: Precursor;.
Gene nameName=AHSG
Synonyms=FETUA
ORFNames=PRO2743
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
MEDLINE=78094420; PubMed=271964; [NCBI, ExPASy, EBI, Israel, Japan]
Anderson N.L., Anderson N.G.
''''''High resolution two-dimensional electrophoresis of human plasma proteins'';'';''
Proc. Natl. Acad. Sci. U.S.A. 74(1):5421-5425(1977)
[2]   MAPPING ON GEL
MEDLINE=96007934; PubMed=7498157; [NCBI, ExPASy, EBI, Israel, Japan]
Sanchez J.-C., Appel R.D., Golaz O.G., Pasquali C., Ravier F., Bairoch A., Hochstrasser D.F.
''''''Inside SWISS-2DPAGE database'';'';''
Electrophoresis 16(1):1131-1151(1995)
Comments
  • SUBUNIT: A AND B CHAIN
2D PAGE maps for identified proteins
How to interpret a protein

CSF_HUMAN {Cerebrospinal Fluid}
Homo sapiens (Human)
Tissue: Cerebrospinal fluid
CSF_HUMAN
  map experimental info
  protein estimated location
 
CSF_HUMAN

MAP LOCATIONS:
pI=4.43; Mw=60957
pI=4.47; Mw=59576
pI=4.42; Mw=59576
pI=4.51; Mw=58672
pI=4.55; Mw=58077
pI=4.46; Mw=57930
pI=4.50; Mw=57051

MAPPING (identification):
MATCHING WITH THE PLASMA MASTER GEL [2].



HEPG2SP_HUMAN {HepG2 Secreted Proteins}
Homo sapiens (Human)
Tissue: Hepatoblastoma
HEPG2SP_HUMAN
  map experimental info
  protein estimated location
 
HEPG2SP_HUMAN

MAP LOCATIONS:
pI=4.16; Mw=58201
pI=4.21; Mw=57256
pI=4.26; Mw=56882
pI=4.33; Mw=55775
pI=4.39; Mw=55050
pI=4.43; Mw=54690
pI=4.28; Mw=53979
pI=4.48; Mw=52583
pI=4.33; Mw=53102
pI=4.43; Mw=52240
pI=4.39; Mw=52411

MAPPING (identification):
MATCHING WITH THE PLASMA MASTER GEL [2].



PLASMA_HUMAN {Plasma}
Homo sapiens (Human)
Tissue: Plasma
PLASMA_HUMAN
  map experimental info
  protein estimated location
 
PLASMA_HUMAN

MAP LOCATIONS:
pI=4.56; Mw=57706
pI=4.58; Mw=56773
pI=4.56; Mw=56466
pI=4.61; Mw=56313
pI=4.58; Mw=55553
pI=4.61; Mw=55403
pI=4.64; Mw=54804
pI=4.68; Mw=54359
pI=4.60; Mw=54212
pI=4.64; Mw=54065
pI=4.68; Mw=53336
pI=4.71; Mw=53191
pI=4.64; Mw=52903
pI=4.71; Mw=52474
pI=4.67; Mw=52474

NORMAL LEVEL:
400-850 MG/L.

PATHOLOGICAL LEVEL:
DECREASED DURING TUMORS AND INFLAMMATORY PROCESSES.

MAPPING (identification):
IMMUNOBLOTTING [1].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from license@isb-sib.ch).
Cross-references
DOSAC-COBS 2D-PAGEP02765; P02765.
DOSAC-COBS-2DPAGEP02765; FETUA_HUMAN.
Siena-2DPAGEP02765; FETUA_HUMAN.
UniProtKB/Swiss-ProtP02765; FETUA_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameFETUA_HUMAN
Primary accession numberP02765
Secondary accession number(s) A8K9N6 B2R7G1 O14961 O14962 Q9P152
Sequence was last modified on April 1, 1988 (version 1)
Annotations were last modified on October 19, 2011 (version 139)
Name and origin of the protein
DescriptionRecName: Full=Alpha-2-HS-glycoprotein; AltName: Full=Alpha-2-Z-globulin; AltName: Full=Ba-alpha-2-glycoprotein; AltName: Full=Fetuin-A; Contains: RecName: Full=Alpha-2-HS-glycoprotein chain A; Contains: RecName: Full=Alpha-2-HS-glycoprotein chain B; Flags: Precursor;
Gene nameName=AHSG
Synonyms=FETUA
ORFNames=PRO2743
Encoded onName=AHSG; Synonyms=FETUA; ORFNames=PRO2743
KeywordsComplete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Mineral balance; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Secreted; Signal.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLM16961; AAA51683.1; -; mRNA
EMBLD67013; BAA22652.1; -; Genomic_DNA
EMBLAB038689; BAA92189.1; -; Genomic_DNA
EMBLAK292751; BAF85440.1; -; mRNA
EMBLAK312969; BAG35808.1; -; mRNA
EMBLAC068631; -; NOT_ANNOTATED_CDS; Genomic_DNA
EMBLCH471052; EAW78189.1; -; Genomic_DNA
EMBLBC048198; AAH48198.1; -; mRNA
EMBLBC052590; AAH52590.1; -; mRNA
EMBLD67012; BAA22651.1; -; mRNA
EMBLAF119895; AAF69649.1; -; mRNA
IPIIPI00953689; -; .
PIRA29081; WOHU; .
RefSeqNP_001613.2; NM_001622.2; .
UniGeneHs.324746; -; .
ProteinModelPortalP02765; -; .
IntActP02765; 8; .
MINTMINT-5004009; -; .
STRINGP02765; -; .
MEROPSI25.020; -; .
MEROPSI25.021; -; .
GlycoSuiteDBP02765; -; .
PhosphoSiteP02765; -; .
SWISS-2DPAGEP02765; -; .
DOSAC-COBS-2DPAGEP02765; -; .
Siena-2DPAGEP02765; -; .
PRIDEP02765; -; .
EnsemblENST00000411641; ENSP00000393887; ENSG00000145192; .
GeneID197; -; .
KEGGhsa:197; -; .
CTD197; -; .
GeneCardsGC03P183739; -; .
H-InvDBHIX0024338; -; .
HGNCHGNC:349; AHSG; .
HPACAB026209; -; .
HPAHPA001524; -; .
HPAHPA001525; -; .
MIM138680; gene; .
neXtProtNX_P02765; -; .
PharmGKBPA24642; -; .
eggNOGprNOG18563; -; .
GeneTreeENSGT00530000063413; -; .
HOVERGENHBG051607; -; .
InParanoidP02765; -; .
OrthoDBEOG4QC164; -; .
Pathway_Interaction_DBbmppathway; BMP receptor signaling; .
NextBio790; -; .
PMAP-CutDBP02765; -; .
ArrayExpressP02765; -; .
BgeeP02765; -; .
CleanExHS_AHSG; -; .
GenevestigatorP02765; -; .
GermOnlineENSG00000145192; Homo sapiens; .
GOGO:0005615; C:extracellular space; NAS:UniProtKB; .
GOGO:0004869; F:cysteine-type endopeptidase inhibitor activity; IEA:InterPro; .
GOGO:0006953; P:acute-phase response; IDA:UniProtKB; .
GOGO:0030502; P:negative regulation of bone mineralization; ISS:UniProtKB; .
GOGO:0046627; P:negative regulation of insulin receptor signaling pathway; NAS:UniProtKB; .
GOGO:0006907; P:pinocytosis; NAS:UniProtKB; .
GOGO:0050766; P:positive regulation of phagocytosis; IDA:UniProtKB; .
GOGO:0050727; P:regulation of inflammatory response; IMP:UniProtKB; .
GOGO:0001501; P:skeletal system development; NAS:UniProtKB; .
InterProIPR000010; Prot_inh_cystat; .
InterProIPR001363; Prot_inh_fetuin_CS; .
PfamPF00031; Cystatin; 1; .
SMARTSM00043; CY; 2; .
PROSITEPS51529; CYSTATIN_FETUIN_A; 2; .
PROSITEPS01254; FETUIN_1; 1; .
PROSITEPS01255; FETUIN_2; 1; .



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