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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: P04004




SWISS-2DPAGE:  P04004


P04004


General information about the entry
View entry in simple text format
Entry nameVTNC_HUMAN
Primary accession numberP04004
Secondary accession number(s) P01141
integrated into SWISS-2DPAGE on August 1, 1993 (release 0)
2D Annotations were last modified onMay 15, 2003 (version 1)
General Annotations were last modified on May 19, 2011 (version 13)
Name and origin of the protein
DescriptionRecName: Full=Vitronectin; AltName: Full=S-protein; AltName: Full=Serum-spreading factor; AltName: Full=V75; Contains: RecName: Full=Vitronectin V65 subunit; Contains: RecName: Full=Vitronectin V10 subunit; Contains: RecName: Full=Somatomedin-B; Flags: Precursor;.
Gene nameName=VTN
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
MEDLINE=94147970; PubMed=8313871; [NCBI, ExPASy, EBI, Israel, Japan]
Golaz O., Hughes G.J., Frutiger S., Paquet N., Bairoch A., Pasquali C., Sanchez J.-C., Tissot J.-D., Appel R.D., Walzer C., Balant L.P., Hochstrasser D.F.
''''''Plasma and red blood cell protein maps: update 1993'';'';''
Electrophoresis 14(1):1223-1231(1993)
Comments
  • SUBUNIT: V65 AND V10 CHAIN
2D PAGE maps for identified proteins
How to interpret a protein

PLASMA_HUMAN {Plasma}
Homo sapiens (Human)
Tissue: Plasma
PLASMA_HUMAN
  map experimental info
  protein estimated location
 
PLASMA_HUMAN

MAP LOCATIONS:
pI=4.58; Mw=9248

MAPPING (identification):
MICROSEQUENCING [1].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss).
Cross-references
DOSAC-COBS 2D-PAGEP04004; P04004.
DOSAC-COBS-2DPAGEP04004; VTNC_HUMAN.
UniProtKB/Swiss-ProtP04004; VTNC_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameVTNC_HUMAN
Primary accession numberP04004
Secondary accession number(s) B2R7G0 P01141 Q9BSH7
Sequence was last modified on October 23, 1986 (version 1)
Annotations were last modified on October 19, 2011 (version 152)
Name and origin of the protein
DescriptionRecName: Full=Vitronectin; AltName: Full=S-protein; AltName: Full=Serum-spreading factor; AltName: Full=V75; Contains: RecName: Full=Vitronectin V65 subunit; Contains: RecName: Full=Vitronectin V10 subunit; Contains: RecName: Full=Somatomedin-B; Flags: Precursor;
Gene nameName=VTN
Encoded onName=VTN
Keywords3D-structure; Cell adhesion; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Heparin-binding; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Secreted; Signal; Sulfation.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLX03168; CAA26933.1; ALT_SEQ; mRNA
EMBLX05006; CAA28659.1; ALT_SEQ; Genomic_DNA
EMBLAK312968; BAG35807.1; -; mRNA
EMBLAF382388; AAK60270.1; -; Genomic_DNA
EMBLBC005046; AAH05046.1; -; mRNA
IPIIPI00298971; -; .
PIRA29744; SGHU1V; .
RefSeqNP_000629.3; NM_000638.3; .
UniGeneHs.2257; -; .
PDB1OC0; X-ray; 2.28 A; B=20-70
PDB1S4G; NMR; -; A=20-70
PDB1SSU; NMR; -; A=20-70
PDB2JQ8; NMR; -; A=20-66
PDB3BT1; X-ray; 2.80 A; B=21-60
PDB3BT2; X-ray; 2.50 A; B=21-60
PDBsum1OC0; -; .
PDBsum1S4G; -; .
PDBsum1SSU; -; .
PDBsum2JQ8; -; .
PDBsum3BT1; -; .
PDBsum3BT2; -; .
ProteinModelPortalP04004; -; .
SMRP04004; 20-344; 432-474; .
DIPDIP-36566N; -; .
IntActP04004; 7; .
MINTMINT-4999753; -; .
STRINGP04004; -; .
GlycoSuiteDBP04004; -; .
PhosphoSiteP04004; -; .
SWISS-2DPAGEP04004; -; .
DOSAC-COBS-2DPAGEP04004; -; .
PeptideAtlasP04004; -; .
PRIDEP04004; -; .
EnsemblENST00000226218; ENSP00000226218; ENSG00000109072; .
GeneID7448; -; .
KEGGhsa:7448; -; .
UCSCuc002hbc.1; human; .
CTD7448; -; .
GeneCardsGC17M026692; -; .
H-InvDBHIX0013644; -; .
HGNCHGNC:12724; VTN; .
MIM193190; gene; .
neXtProtNX_P04004; -; .
PharmGKBPA37335; -; .
eggNOGprNOG13909; -; .
GeneTreeENSGT00530000063751; -; .
HOGENOMHBG715902; -; .
HOVERGENHBG002902; -; .
InParanoidP04004; -; .
OMAWRFEDGV; -; .
OrthoDBEOG4JT065; -; .
PhylomeDBP04004; -; .
Pathway_Interaction_DBamb2_neutrophils_pathway; amb2 Integrin signaling; .
Pathway_Interaction_DBhnf3apathway; FOXA1 transcription factor network; .
Pathway_Interaction_DBavb3_integrin_pathway; Integrins in angiogenesis; .
ReactomeREACT_13552; Integrin cell surface interactions; .
DrugBankDB00013; Urokinase; .
NextBio29166; -; .
PMAP-CutDBP04004; -; .
ArrayExpressP04004; -; .
CleanExHS_VTN; -; .
GenevestigatorP04004; -; .
GermOnlineENSG00000109072; Homo sapiens; .
GOGO:0071062; C:alphav-beta3 integrin-vitronectin complex; TAS:BHF-UCL; .
GOGO:0005615; C:extracellular space; IDA:BHF-UCL; .
GOGO:0008201; F:heparin binding; IEA:UniProtKB-KW; .
GOGO:0005178; F:integrin binding; IPI:BHF-UCL; .
GOGO:0005044; F:scavenger receptor activity; IEA:InterPro; .
GOGO:0033627; P:cell adhesion mediated by integrin; IDA:BHF-UCL; .
GOGO:0006955; P:immune response; TAS:ProtInc; .
GOGO:0030195; P:negative regulation of blood coagulation; IC:BHF-UCL; .
GOGO:0010951; P:negative regulation of endopeptidase activity; IDA:BHF-UCL; .
GOGO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IDA:BHF-UCL; .
GOGO:0032092; P:positive regulation of protein binding; IDA:BHF-UCL; .
GOGO:0048260; P:positive regulation of receptor-mediated endocytosis; IDA:BHF-UCL; .
GOGO:0014911; P:positive regulation of smooth muscle cell migration; IDA:BHF-UCL; .
GOGO:0030949; P:positive regulation of vascular endothelial growth factor receptor signaling pathway; TAS:BHF-UCL; .
GOGO:0090303; P:positive regulation of wound healing; IC:BHF-UCL; .
GOGO:0061302; P:smooth muscle cell-matrix adhesion; IDA:BHF-UCL; .
InterProIPR000585; Hemopexin/matrixin; .
InterProIPR018486; Hemopexin/matrixin_CS; .
InterProIPR018487; Hemopexin/matrixin_repeat; .
InterProIPR020436; Somatomedin_B_chordata; .
InterProIPR001212; Somatomedin_B_dom; .
Gene3DG3DSA:2.110.10.10; Hemopexin; 3; .
PfamPF00045; Hemopexin; 4; .
PfamPF01033; Somatomedin_B; 1; .
PRINTSPR00022; SOMATOMEDINB; .
SMARTSM00120; HX; 4; .
SMARTSM00201; SO; 1; .
SUPFAMSSF50923; Hemopexin; 1; .
PROSITEPS00024; HEMOPEXIN; 2; .
PROSITEPS00524; SMB_1; 1; .
PROSITEPS50958; SMB_2; 1; .



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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server