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SWISS-2DPAGE 
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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: P05121




SWISS-2DPAGE:  P05121


P05121


General information about the entry
View entry in simple text format
Entry namePAI1_HUMAN
Primary accession numberP05121
integrated into SWISS-2DPAGE on September 1, 1997 (release 6)
2D Annotations were last modified onMarch 31, 2004 (version 1)
General Annotations were last modified on May 19, 2011 (version 12)
Name and origin of the protein
DescriptionRecName: Full=Plasminogen activator inhibitor 1; Short=PAI; Short=PAI-1; AltName: Full=Endothelial plasminogen activator inhibitor; AltName: Full=Serpin E1; Flags: Precursor;.
Gene nameName=SERPINE1
Synonyms=PAI1, PLANH1
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
MEDLINE=98163346; PubMed=9504818; [NCBI, ExPASy, EBI, Israel, Japan]
Reymond M.A., Sanchez J.-C., Hughes G.J., Riese J., Tortola S., Peinado M.A., Kirchner T., Hohenberger W., Hochstrasser D.F., Kockerling F.
''''''Standardized characterization of gene expression in human colorectal epithelium by two-dimensional electrophoresis'';'';''
Electrophoresis 18(1):2842-2848(1997)
2D PAGE maps for identified proteins
How to interpret a protein

CEC_HUMAN {Colorectal epithelia cells}
Homo sapiens (Human)
Tissue: Colon epithelium
CEC_HUMAN
  map experimental info
  protein estimated location
 
CEC_HUMAN

MAP LOCATIONS:
pI=6.97; Mw=48577

MAPPING (identification):
IMMUNODETECTION [1].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss).
Cross-references
OGP-WWWP05121.
Siena-2DPAGEP05121; PAI1_HUMAN.
UniProtKB/Swiss-ProtP05121; PAI1_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry namePAI1_HUMAN
Primary accession numberP05121
Sequence was last modified on August 13, 1987 (version 1)
Annotations were last modified on October 19, 2011 (version 147)
Name and origin of the protein
DescriptionRecName: Full=Plasminogen activator inhibitor 1; Short=PAI; Short=PAI-1; AltName: Full=Endothelial plasminogen activator inhibitor; AltName: Full=Serpin E1; Flags: Precursor;
Gene nameName=SERPINE1
Synonyms=PAI1, PLANH1
Encoded onName=SERPINE1; Synonyms=PAI1, PLANH1
Keywords3D-structure; Complete proteome; Direct protein sequencing; Glycoprotein; Polymorphism; Protease inhibitor; Reference proteome; Secreted; Serine protease inhibitor; Signal.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLX04429; CAA28025.1; -; mRNA
EMBLM14083; AAA60008.1; -; mRNA
EMBLX04729; CAA28438.1; -; mRNA
EMBLX04731; CAA28442.1; -; mRNA
EMBLM16006; AAA60003.1; -; mRNA
EMBLM22321; AAA60009.1; -; Genomic_DNA
EMBLM22314; AAA60009.1; JOINED; Genomic_DNA
EMBLM22315; AAA60009.1; JOINED; Genomic_DNA
EMBLM22316; AAA60009.1; JOINED; Genomic_DNA
EMBLM22317; AAA60009.1; JOINED; Genomic_DNA
EMBLM22318; AAA60009.1; JOINED; Genomic_DNA
EMBLM22319; AAA60009.1; JOINED; Genomic_DNA
EMBLM22320; AAA60009.1; JOINED; Genomic_DNA
EMBLX13323; -; NOT_ANNOTATED_CDS; Genomic_DNA
EMBLX13338; CAA31722.1; -; Genomic_DNA
EMBLX13339; CAB51639.1; -; Genomic_DNA
EMBLX13340; CAB51737.1; -; Genomic_DNA
EMBLX13341; CAB51606.1; -; Genomic_DNA
EMBLX13342; CAB51607.1; -; Genomic_DNA
EMBLX13343; CAB51738.1; -; Genomic_DNA
EMBLX13344; CAB51739.1; -; Genomic_DNA
EMBLX13345; CAA31729.1; -; Genomic_DNA
EMBLJ03764; AAA60007.1; -; Genomic_DNA
EMBLX12701; CAA31208.1; -; mRNA
EMBLAF386492; AAK60338.1; -; Genomic_DNA
EMBLAC004876; AAD45828.1; -; Genomic_DNA
EMBLBC010860; AAH10860.1; -; mRNA
EMBLX04744; CAA28444.1; -; mRNA
IPIIPI00007118; -; .
PIRA28107; ITHUP1; .
RefSeqNP_000593.1; NM_000602.3; .
RefSeqNP_001158885.1; NM_001165413.1; .
UniGeneHs.414795; -; .
UniGeneHs.713079; -; .
PDB1A7C; X-ray; 1.95 A; A=24-402
PDB1B3K; X-ray; 2.99 A; A/B/C/D=24-402
PDB1C5G; X-ray; 2.60 A; A=1-402
PDB1DB2; X-ray; 2.70 A; A/B=26-402
PDB1DVM; X-ray; 2.40 A; A/B/C/D=24-402
PDB1DVN; X-ray; 2.10 A; A=24-402
PDB1LJ5; X-ray; 1.80 A; A=24-402
PDB1OC0; X-ray; 2.28 A; A=24-402
PDB3CVM; X-ray; 2.02 A; A/B=21-402
PDB3EOX; X-ray; 2.61 A; A=24-402
PDB3PB1; X-ray; 2.30 A; I=24-402
PDB3Q02; X-ray; 2.30 A; A/B=24-402
PDB3Q03; X-ray; 2.64 A; A/B=24-402
PDB9PAI; X-ray; 2.70 A; A=24-369
B=370-402PDBsum; 1A7C; -; .
PDBsum1B3K; -; .
PDBsum1C5G; -; .
PDBsum1DB2; -; .
PDBsum1DVM; -; .
PDBsum1DVN; -; .
PDBsum1LJ5; -; .
PDBsum1OC0; -; .
PDBsum3CVM; -; .
PDBsum3EOX; -; .
PDBsum3PB1; -; .
PDBsum3Q02; -; .
PDBsum3Q03; -; .
PDBsum9PAI; -; .
ProteinModelPortalP05121; -; .
SMRP05121; 24-402; .
DisProtDP00320; -; .
IntActP05121; 3; .
MINTMINT-202409; -; .
STRINGP05121; -; .
MEROPSI04.020; -; .
SWISS-2DPAGEP05121; -; .
OGPP05121; -; .
PRIDEP05121; -; .
EnsemblENST00000223095; ENSP00000223095; ENSG00000106366; .
GeneID5054; -; .
KEGGhsa:5054; -; .
NMPDRfig|9606.3.peg.29170; -; .
UCSCuc003uxt.2; human; .
CTD5054; -; .
GeneCardsGC07P095363; -; .
H-InvDBHIX0006944; -; .
HGNCHGNC:8583; SERPINE1; .
HPACAB002516; -; .
MIM173360; gene; .
MIM613329; phenotype; .
neXtProtNX_P05121; -; .
Orphanet465; Congenital plasminogen activator inhibitor type 1 deficiency; .
eggNOGprNOG06883; -; .
GeneTreeENSGT00560000076706; -; .
HOGENOMHBG714743; -; .
HOVERGENHBG106493; -; .
InParanoidP05121; -; .
OMAGPWNKDE; -; .
OrthoDBEOG4X3H1K; -; .
PhylomeDBP05121; -; .
Pathway_Interaction_DBhif1_tfpathway; HIF-1-alpha transcription factor network; .
Pathway_Interaction_DBsmad2_3nuclearpathway; Regulation of nuclear SMAD2/3 signaling; .
ReactomeREACT_24941; Circadian Clock; .
ReactomeREACT_604; Hemostasis; .
DrugBankDB01076; Atorvastatin; .
DrugBankDB01093; Dimethyl sulfoxide; .
DrugBankDB00055; Drotrecogin alfa; .
DrugBankDB00641; Simvastatin; .
DrugBankDB00031; Tenecteplase; .
DrugBankDB00197; Troglitazone; .
DrugBankDB00013; Urokinase; .
NextBio19480; -; .
PMAP-CutDBP05121; -; .
ArrayExpressP05121; -; .
BgeeP05121; -; .
CleanExHS_SERPINE1; -; .
GenevestigatorP05121; -; .
GermOnlineENSG00000106366; Homo sapiens; .
GOGO:0031012; C:extracellular matrix; IDA:BHF-UCL; .
GOGO:0005615; C:extracellular space; IDA:BHF-UCL; .
GOGO:0005886; C:plasma membrane; TAS:Reactome; .
GOGO:0031093; C:platelet alpha granule lumen; TAS:Reactome; .
GOGO:0002020; F:protease binding; IPI:UniProtKB; .
GOGO:0004867; F:serine-type endopeptidase inhibitor activity; IDA:BHF-UCL; .
GOGO:0001525; P:angiogenesis; IEP:UniProtKB; .
GOGO:0070887; P:cellular response to chemical stimulus; IMP:BHF-UCL; .
GOGO:0071222; P:cellular response to lipopolysaccharide; IMP:BHF-UCL; .
GOGO:0001300; P:chronological cell aging; IEP:BHF-UCL; .
GOGO:0050829; P:defense response to Gram-negative bacterium; IGI:BHF-UCL; .
GOGO:0042730; P:fibrinolysis; TAS:Reactome; .
GOGO:0043066; P:negative regulation of apoptosis; IMP:BHF-UCL; .
GOGO:0033629; P:negative regulation of cell adhesion mediated by integrin; IDA:BHF-UCL; .
GOGO:0051918; P:negative regulation of fibrinolysis; IDA:BHF-UCL; .
GOGO:0010757; P:negative regulation of plasminogen activation; IDA:BHF-UCL; .
GOGO:0014912; P:negative regulation of smooth muscle cell migration; IDA:BHF-UCL; .
GOGO:2000098; P:negative regulation of smooth muscle cell-matrix adhesion; IDA:BHF-UCL; .
GOGO:0061044; P:negative regulation of vascular wound healing; IGI:BHF-UCL; .
GOGO:0030168; P:platelet activation; TAS:Reactome; .
GOGO:0002576; P:platelet degranulation; TAS:Reactome; .
GOGO:0045766; P:positive regulation of angiogenesis; IMP:BHF-UCL; .
GOGO:0032757; P:positive regulation of interleukin-8 production; IMP:BHF-UCL; .
GOGO:0035491; P:positive regulation of leukotriene production involved in inflammatory response; IMP:BHF-UCL; .
GOGO:0090026; P:positive regulation of monocyte chemotaxis; IMP:BHF-UCL; .
GOGO:0048260; P:positive regulation of receptor-mediated endocytosis; IDA:BHF-UCL; .
GOGO:0010469; P:regulation of receptor activity; IDA:BHF-UCL; .
InterProIPR000215; Protease_inhib_I4_serpin; .
InterProIPR023795; Protease_inhib_I4_serpin_CS; .
InterProIPR023796; Sepin_dom; .
PANTHERPTHR11461; Prot_inh_serpin; 1; .
PfamPF00079; Serpin; 1; .
SMARTSM00093; SERPIN; 1; .
SUPFAMSSF56574; Prot_inh_serpin; 1; .
PROSITEPS00284; SERPIN; 1; .



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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server