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Sample Preparation and Post-separation Analysis

Searching in 'SWISS-2DPAGE' for entry matching: P06493



General information about the entry
View entry in simple text format
Entry nameCDK1_HUMAN
Primary accession numberP06493
integrated into SWISS-2DPAGE on September 1, 1997 (release 6)
2D Annotations were last modified onDecember 30, 2004 (version 1)
General Annotations were last modified on November 9, 2011 (version 14)
Name and origin of the protein
DescriptionRecName: Full=Cyclin-dependent kinase 1; Short=CDK1; EC=; EC=; AltName: Full=Cell division control protein 2 homolog; AltName: Full=Cell division protein kinase 1; AltName: Full=p34 protein kinase;.
Gene nameName=CDK1
Synonyms=CDC2, CDC28A, CDKN1, P34CDC2
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
MEDLINE=97295311; PubMed=9150953; [NCBI, ExPASy, EBI, Israel, Japan]
Sanchez J.-C., Wirth P., Jaccoud S., Appel R.D., Sarto C., Wilkins M.R., Hochstrasser D.F.
''''''Simultaneous analysis of cyclin and oncogene expression using multiple monoclonal antibody immunoblots'';'';''
Electrophoresis 18(1):638-641(1997)
2D PAGE maps for identified proteins
How to interpret a protein

Homo sapiens (Human)
Tissue: Hepatoblastoma
  map experimental info
  protein estimated location

pI=7.04; Mw=31853
pI=8.09; Mw=31853
pI=6.92; Mw=31719
pI=7.37; Mw=31322

MAPPING (identification):

This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See or send email from
UniProtKB/Swiss-ProtP06493; CDK1_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.

External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameCDK1_HUMAN
Primary accession numberP06493
Secondary accession number(s) A8K7C4 C9J497 O60764
Sequence was last modified on May 31, 2011 (version 3)
Annotations were last modified on October 19, 2011 (version 159)
Name and origin of the protein
DescriptionRecName: Full=Cyclin-dependent kinase 1; Short=CDK1; EC=; EC=; AltName: Full=Cell division control protein 2 homolog; AltName: Full=Cell division protein kinase 1; AltName: Full=p34 protein kinase;
Gene nameName=CDK1
Synonyms=CDC2, CDC28A, CDKN1, P34CDC2
Encoded onName=CDK1; Synonyms=CDC2, CDC28A, CDKN1, P34CDC2
Keywords3D-structure; Acetylation; Alternative splicing; Apoptosis; ATP-binding; Cell cycle; Cell division; Complete proteome; Cytoplasm; Isopeptide bond; Kinase; Mitochondrion; Mitosis; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase; Ubl conjugation.
Copyrighted by the UniProt Consortium, see Distributed under the Creative Commons Attribution-NoDerivs License
EMBLX05360; CAA28963.1; -; mRNA
EMBLY00272; CAA68376.1; -; mRNA
EMBLD88357; BAA26001.1; -; mRNA
EMBLAK291939; BAF84628.1; -; mRNA
EMBLBT007004; AAP35650.1; -; mRNA
EMBLAF512554; AAM34793.1; -; Genomic_DNA
EMBLCH471083; EAW54204.1; ALT_SEQ; Genomic_DNA
EMBLBC014563; AAH14563.1; -; mRNA
IPIIPI00026689; -; .
IPIIPI00073536; -; .
PIRA29539; A29539; .
RefSeqNP_001777.1; NM_001786.4; .
RefSeqNP_203698.1; NM_033379.4; .
UniGeneHs.334562; -; .
PDB1LC9; Model; -; A=1-297
PDBsum1LC9; -; .
ProteinModelPortalP06493; -; .
SMRP06493; 1-289; .
DIPDIP-35N; -; .
IntActP06493; 31; .
MINTMINT-5000894; -; .
STRINGP06493; -; .
PhosphoSiteP06493; -; .
SWISS-2DPAGEP06493; -; .
PRIDEP06493; -; .
EnsemblENST00000395284; ENSP00000378699; ENSG00000170312; .
GeneID983; -; .
KEGGhsa:983; -; .
UCSCuc001jld.1; human; .
UCSCuc001jlg.1; human; .
CTD983; -; .
GeneCardsGC10P056527; -; .
H-InvDBHIX0008851; -; .
HGNCHGNC:1722; CDK1; .
HPACAB003799; -; .
HPAHPA003387; -; .
MIM116940; gene; .
neXtProtNX_P06493; -; .
PharmGKBPA99; -; .
eggNOGprNOG11741; -; .
HOVERGENHBG014652; -; .
OrthoDBEOG41NTMH; -; .
PhylomeDBP06493; -; .
BRENDA2.7.11.22; 2681; .
Pathway_Interaction_DBfoxm1pathway; FOXM1 transcription factor network; .
Pathway_Interaction_DBretinoic_acid_pathway; Retinoic acid receptors-mediated signaling; .
ReactomeREACT_11061; Signalling by NGF; .
ReactomeREACT_152; Cell Cycle; Mitotic; .
ReactomeREACT_1538; Cell Cycle Checkpoints; .
ReactomeREACT_16888; Signaling by PDGF; .
ReactomeREACT_18266; Axon guidance; .
ReactomeREACT_498; Signaling by Insulin receptor; .
ReactomeREACT_6850; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; .
ReactomeREACT_6900; Immune System; .
ReactomeREACT_9417; Signaling by EGFR; .
BindingDBP06493; -; .
NextBio4122; -; .
ArrayExpressP06493; -; .
BgeeP06493; -; .
CleanExHS_CDC2; -; .
GenevestigatorP06493; -; .
GermOnlineENSG00000170312; Homo sapiens; .
GOGO:0005829; C:cytosol; TAS:Reactome; .
GOGO:0030496; C:midbody; IDA:UniProtKB; .
GOGO:0005654; C:nucleoplasm; TAS:Reactome; .
GOGO:0005876; C:spindle microtubule; IDA:UniProtKB; .
GOGO:0005524; F:ATP binding; IEA:UniProtKB-KW; .
GOGO:0004693; F:cyclin-dependent protein kinase activity; IDA:UniProtKB; .
GOGO:0008353; F:RNA polymerase II carboxy-terminal domain kinase activity; IDA:UniProtKB; .
GOGO:0000187; P:activation of MAPK activity; TAS:Reactome; .
GOGO:0000186; P:activation of MAPKK activity; TAS:Reactome; .
GOGO:0031145; P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; TAS:Reactome; .
GOGO:0006916; P:anti-apoptosis; IDA:UniProtKB; .
GOGO:0007411; P:axon guidance; TAS:Reactome; .
GOGO:0051301; P:cell division; IEA:UniProtKB-KW; .
GOGO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome; .
GOGO:0045087; P:innate immune response; TAS:Reactome; .
GOGO:0008286; P:insulin receptor signaling pathway; TAS:Reactome; .
GOGO:0007067; P:mitosis; IEA:UniProtKB-KW; .
GOGO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; TAS:Reactome; .
GOGO:0002756; P:MyD88-independent toll-like receptor signaling pathway; TAS:Reactome; .
GOGO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome; .
GOGO:0051437; P:positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome; .
GOGO:0034501; P:protein localization to kinetochore; IDA:BHF-UCL; .
GOGO:0007265; P:Ras protein signal transduction; TAS:Reactome; .
GOGO:0000083; P:regulation of transcription involved in G1/S phase of mitotic cell cycle; TAS:Reactome; .
GOGO:0051403; P:stress-activated MAPK cascade; TAS:Reactome; .
GOGO:0008063; P:Toll signaling pathway; TAS:Reactome; .
GOGO:0034130; P:toll-like receptor 1 signaling pathway; TAS:Reactome; .
GOGO:0034134; P:toll-like receptor 2 signaling pathway; TAS:Reactome; .
GOGO:0034138; P:toll-like receptor 3 signaling pathway; TAS:Reactome; .
GOGO:0034142; P:toll-like receptor 4 signaling pathway; TAS:Reactome; .
InterProIPR011009; Kinase-like_dom; .
InterProIPR000719; Prot_kinase_cat_dom; .
InterProIPR017441; Protein_kinase_ATP_BS; .
InterProIPR017442; Se/Thr_kinase-like_dom; .
InterProIPR008271; Ser/Thr_kinase_AS; .
InterProIPR002290; Ser/Thr_kinase_dom; .
PfamPF00069; Pkinase; 1; .
SMARTSM00220; S_TKc; 1; .
SUPFAMSSF56112; Kinase_like; 1; .


SWISS-2DPAGE (search AC)

Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server