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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: P06727




SWISS-2DPAGE:  P06727


P06727


General information about the entry
View entry in simple text format
Entry nameAPOA4_HUMAN
Primary accession numberP06727
integrated into SWISS-2DPAGE on August 1, 1993 (release 0)
2D Annotations were last modified onDecember 1, 2000 (version 1)
General Annotations were last modified on May 19, 2011 (version 11)
Name and origin of the protein
DescriptionRecName: Full=Apolipoprotein A-IV; Short=Apo-AIV; Short=ApoA-IV; AltName: Full=Apolipoprotein A4; Flags: Precursor;.
Gene nameName=APOA4
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
MEDLINE=93092937; PubMed=1459097; [NCBI, ExPASy, EBI, Israel, Japan]
Hughes G.J., Frutiger S., Paquet N., Ravier F., Pasquali C., Sanchez J.-C., James R.W., Tissot J.-D., Bjellqvist B., Hochstrasser D.F.
''''''Plasma protein map: an update by microsequencing'';'';''
Electrophoresis 13(1):707-714(1992)
[2]   MAPPING ON GEL
MEDLINE=96007934; PubMed=7498157; [NCBI, ExPASy, EBI, Israel, Japan]
Sanchez J.-C., Appel R.D., Golaz O.G., Pasquali C., Ravier F., Bairoch A., Hochstrasser D.F.
''''''Inside SWISS-2DPAGE database'';'';''
Electrophoresis 16(1):1131-1151(1995)
Comments
  • SUBUNIT: SINGLE CHAIN
2D PAGE maps for identified proteins
How to interpret a protein

CSF_HUMAN {Cerebrospinal Fluid}
Homo sapiens (Human)
Tissue: Cerebrospinal fluid
CSF_HUMAN
  map experimental info
  protein estimated location
 
CSF_HUMAN

MAP LOCATIONS:
pI=5.05; Mw=45212
pI=5.09; Mw=45212
pI=5.15; Mw=45075

MAPPING (identification):
MATCHING WITH THE PLASMA MASTER GEL [2].



PLASMA_HUMAN {Plasma}
Homo sapiens (Human)
Tissue: Plasma
PLASMA_HUMAN
  map experimental info
  protein estimated location
 
PLASMA_HUMAN

MAP LOCATIONS:
pI=5.10; Mw=43391
pI=5.16; Mw=43627
pI=5.05; Mw=43391
pI=5.11; Mw=21945
pI=4.93; Mw=11115
pI=4.97; Mw=10530
pI=4.87; Mw=9922
pI=4.96; Mw=9149

NORMAL LEVEL:
140 MG/L.

PATHOLOGICAL LEVEL:
DECREASED DURING TANGIER DISEASE AND ARTERIOSCLEROSIS; INCREASED DURING LIVER DISEASE.

POSITIONAL VARIANTS:
APO-AIV-0, 1, 2 AND 3.

MAPPING (identification):
MICROSEQUENCING [1].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from license@isb-sib.ch).
Cross-references
DOSAC-COBS 2D-PAGEP06727; P06727.
DOSAC-COBS-2DPAGEP06727; APOA4_HUMAN.
REPRODUCTION-2DPAGEIPI00304273; IPI00304273.
Siena-2DPAGEP06727; APOA4_HUMAN.
UniProtKB/Swiss-ProtP06727; APOA4_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameAPOA4_HUMAN
Primary accession numberP06727
Secondary accession number(s) A8MSL6 Q14CW8 Q6Q787
Sequence was last modified on March 7, 2006 (version 3)
Annotations were last modified on October 19, 2011 (version 138)
Name and origin of the protein
DescriptionRecName: Full=Apolipoprotein A-IV; Short=Apo-AIV; Short=ApoA-IV; AltName: Full=Apolipoprotein A4; Flags: Precursor;
Gene nameName=APOA4
Encoded onName=APOA4
KeywordsChylomicron; Complete proteome; HDL; Lipid transport; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Secreted; Signal; Transport.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLM13654; AAA51744.1; -; mRNA
EMBLM14642; AAA51745.1; -; Genomic_DNA
EMBLJ02758; AAA96731.1; -; Genomic_DNA
EMBLX13629; CAA31955.1; -; mRNA
EMBLAY422950; AAQ91809.1; -; Genomic_DNA
EMBLAY555191; AAS68228.1; -; Genomic_DNA
EMBLAP006216; -; NOT_ANNOTATED_CDS; Genomic_DNA
EMBLBC074764; AAH74764.1; -; mRNA
EMBLBC113594; AAI13595.1; -; mRNA
EMBLBC113596; AAI13597.1; -; mRNA
EMBLM14566; AAA51748.1; -; mRNA
IPIIPI00304273; -; .
PIRA94137; LPHUA4; .
UniGeneHs.1247; -; .
ProteinModelPortalP06727; -; .
SMRP06727; 19-297; .
IntActP06727; 1; .
STRINGP06727; -; .
PhosphoSiteP06727; -; .
SWISS-2DPAGEP06727; -; .
DOSAC-COBS-2DPAGEP06727; -; .
REPRODUCTION-2DPAGEIPI00304273; -; .
PeptideAtlasP06727; -; .
PRIDEP06727; -; .
EnsemblENST00000357780; ENSP00000350425; ENSG00000110244; .
UCSCuc003bnx.1; human; .
GeneCardsGC11M112623; -; .
HGNCHGNC:602; APOA4; .
HPAHPA001352; -; .
HPAHPA002549; -; .
MIM107690; gene; .
neXtProtNX_P06727; -; .
eggNOGprNOG18920; -; .
HOGENOMHBG268609; -; .
HOVERGENHBG105707; -; .
InParanoidP06727; -; .
OrthoDBEOG4G1MHJ; -; .
PhylomeDBP06727; -; .
ReactomeREACT_22258; Metabolism of lipids and lipoproteins; .
ReactomeREACT_75925; Amyloids; .
ArrayExpressP06727; -; .
BgeeP06727; -; .
CleanExHS_APOA4; -; .
GenevestigatorP06727; -; .
GermOnlineENSG00000110244; Homo sapiens; .
GOGO:0042627; C:chylomicron; IDA:BHF-UCL; .
GOGO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome; .
GOGO:0034364; C:high-density lipoprotein particle; IDA:BHF-UCL; .
GOGO:0034361; C:very-low-density lipoprotein particle; IDA:BHF-UCL; .
GOGO:0016209; F:antioxidant activity; IDA:HGNC; .
GOGO:0017127; F:cholesterol transporter activity; IDA:BHF-UCL; .
GOGO:0005507; F:copper ion binding; IDA:HGNC; .
GOGO:0031210; F:phosphatidylcholine binding; IDA:BHF-UCL; .
GOGO:0060228; F:phosphatidylcholine-sterol O-acyltransferase activator activity; IDA:BHF-UCL; .
GOGO:0042803; F:protein homodimerization activity; IDA:BHF-UCL; .
GOGO:0033344; P:cholesterol efflux; IDA:BHF-UCL; .
GOGO:0042632; P:cholesterol homeostasis; IDA:BHF-UCL; .
GOGO:0008203; P:cholesterol metabolic process; IDA:BHF-UCL; .
GOGO:0034378; P:chylomicron assembly; TAS:BHF-UCL; .
GOGO:0034371; P:chylomicron remodeling; IC:BHF-UCL; .
GOGO:0034375; P:high-density lipoprotein particle remodeling; IC:BHF-UCL; .
GOGO:0042744; P:hydrogen peroxide catabolic process; IDA:HGNC; .
GOGO:0002227; P:innate immune response in mucosa; IDA:BHF-UCL; .
GOGO:0007159; P:leukocyte cell-cell adhesion; IDA:BHF-UCL; .
GOGO:0042157; P:lipoprotein metabolic process; TAS:Reactome; .
GOGO:0044240; P:multicellular organismal lipid catabolic process; IDA:BHF-UCL; .
GOGO:0034445; P:negative regulation of plasma lipoprotein particle oxidation; IDA:BHF-UCL; .
GOGO:0046470; P:phosphatidylcholine metabolic process; IDA:BHF-UCL; .
GOGO:0033700; P:phospholipid efflux; IDA:BHF-UCL; .
GOGO:0010873; P:positive regulation of cholesterol esterification; IDA:BHF-UCL; .
GOGO:0045723; P:positive regulation of fatty acid biosynthetic process; IDA:BHF-UCL; .
GOGO:0051006; P:positive regulation of lipoprotein lipase activity; IDA:BHF-UCL; .
GOGO:0010898; P:positive regulation of triglyceride catabolic process; IDA:BHF-UCL; .
GOGO:0019430; P:removal of superoxide radicals; IDA:HGNC; .
GOGO:0006982; P:response to lipid hydroperoxide; IDA:HGNC; .
GOGO:0043691; P:reverse cholesterol transport; IDA:BHF-UCL; .
GOGO:0034372; P:very-low-density lipoprotein particle remodeling; IDA:BHF-UCL; .
InterProIPR013326; ApoA/E_ApoLp; .
InterProIPR000074; ApoA1_A4_E; .
Gene3DG3DSA:1.20.120.20; ApoA/E_ApoLp; 3; .
PfamPF01442; Apolipoprotein; 2; .



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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server