World-2DPAGE Home
Home  |  Contact

Attention: World-2DPAGE is no longer maintained. Previously submitted data can still be queried at World-2DPAGE Repository.

Search by  [accession number] *
[description, ID or gene] 
[author names] 
[spot ID / serial number] 
[identification methods] 
[pI / Mw range] 
[combined fields] 

Maps  [experimental info] 
[protein list] 
[graphical interface]

     Select Remote Interfaces
[All Interfaces]
World-2DPAGE Portal
World-2DPAGE Repository

Exclude local DBs
has only effect if a remote
interface is selected

Sample Preparation and Post-separation Analysis

Searching in 'SWISS-2DPAGE' for entry matching: P07954



General information about the entry
View entry in simple text format
Entry nameFUMH_HUMAN
Primary accession numberP07954
integrated into SWISS-2DPAGE on January 15, 1999 (release 9)
2D Annotations were last modified onDecember 1, 2000 (version 1)
General Annotations were last modified on May 19, 2011 (version 9)
Name and origin of the protein
DescriptionRecName: Full=Fumarate hydratase, mitochondrial; Short=Fumarase; EC=; Flags: Precursor;.
Gene nameName=FH
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Demalte-Annessi I., Sanchez J.-C., Hoogland C., Rouge V., Binz P.-A., Appel R.D., Hochstrasser D.F.
Submitted (JAN-1999) to SWISS-2DPAGE
2D PAGE maps for identified proteins
How to interpret a protein

DLD1_HUMAN {Colorectal adenocarcinoma cell line (DL-1)}
Homo sapiens (Human)
Tissue: Colon adenocarcinoma
  map experimental info
  protein estimated location

pI=6.85; Mw=45160  [identification data]

MAPPING (identification):
Peptide mass fingerprinting [1].

This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See or send email from
UniProtKB/Swiss-ProtP07954; FUMH_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.

External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameFUMH_HUMAN
Primary accession numberP07954
Sequence was last modified on October 1, 1996 (version 3)
Annotations were last modified on October 19, 2011 (version 145)
Name and origin of the protein
DescriptionRecName: Full=Fumarate hydratase, mitochondrial; Short=Fumarase; EC=; Flags: Precursor;
Gene nameName=FH
Encoded onName=FH
Keywords3D-structure; Acetylation; Alternative initiation; Complete proteome; Cytoplasm; Direct protein sequencing; Disease mutation; Lyase; Mitochondrion; Phosphoprotein; Reference proteome; Transit peptide; Tricarboxylic acid cycle; Tumor suppressor.
Copyrighted by the UniProt Consortium, see Distributed under the Creative Commons Attribution-NoDerivs License
EMBLU59309; AAB66354.1; -; mRNA
EMBLU48857; AAD00071.1; -; mRNA
EMBLBT009839; AAP88841.1; -; mRNA
EMBLBC003108; AAH03108.1; -; mRNA
EMBLBC017444; AAH17444.1; -; mRNA
EMBLM15502; AAA52483.1; -; mRNA
IPIIPI00296053; -; .
IPIIPI00759715; -; .
PIRS06213; UFHUM; .
RefSeqNP_000134.2; NM_000143.3; .
UniGeneHs.592490; -; .
PDB3E04; X-ray; 1.95 A; A/B/C/D=44-510
PDBsum3E04; -; .
ProteinModelPortalP07954; -; .
SMRP07954; 49-510; .
IntActP07954; 4; .
STRINGP07954; -; .
PhosphoSiteP07954; -; .
SWISS-2DPAGEP07954; -; .
UCD-2DPAGEP07954; -; .
PRIDEP07954; -; .
EnsemblENST00000366560; ENSP00000355518; ENSG00000091483; .
GeneID2271; -; .
KEGGhsa:2271; -; .
UCSCuc001hyx.1; human; .
CTD2271; -; .
GeneCardsGC01M212119; -; .
H-InvDBHIX0001737; -; .
HGNCHGNC:3700; FH; .
HPACAB017785; -; .
HPAHPA025770; -; .
HPAHPA025948; -; .
HPAHPA027341; -; .
MIM136850; gene; .
MIM150800; phenotype; .
MIM606812; phenotype; .
neXtProtNX_P07954; -; .
Orphanet523; Familial leiomyomatosis; .
Orphanet24; Fumaric aciduria; .
eggNOGprNOG07459; -; .
GeneTreeENSGT00390000002779; -; .
HOGENOMHBG284369; -; .
HOVERGENHBG002183; -; .
InParanoidP07954; -; .
OrthoDBEOG4F1X31; -; .
PhylomeDBP07954; -; .
BioCycMetaCyc:ENSG00000091483-MONOMER; -; .
BRENDA4.2.1.2; 2681; .
ReactomeREACT_1046; Pyruvate metabolism and Citric Acid (TCA) cycle; .
NextBio9235; -; .
ArrayExpressP07954; -; .
BgeeP07954; -; .
CleanExHS_FH; -; .
GenevestigatorP07954; -; .
GermOnlineENSG00000091483; Homo sapiens; .
GOGO:0030054; C:cell junction; IDA:HPA; .
GOGO:0005759; C:mitochondrial matrix; TAS:Reactome; .
GOGO:0045239; C:tricarboxylic acid cycle enzyme complex; IEA:InterPro; .
GOGO:0004333; F:fumarate hydratase activity; EXP:Reactome; .
GOGO:0006106; P:fumarate metabolic process; TAS:ProtInc; .
GOGO:0006099; P:tricarboxylic acid cycle; TAS:Reactome; .
InterProIPR005677; Fum_hydII; .
InterProIPR018951; Fumarase_C_C; .
InterProIPR000362; Fumarate_lyase; .
InterProIPR020557; Fumarate_lyase_CS; .
InterProIPR008948; L-Aspartase-like; .
InterProIPR024083; L-Aspartase-like_N; .
InterProIPR022761; Lyase1_N; .
Gene3DG3DSA:; G3DSA:; 1; .
PfamPF10415; FumaraseC_C; 1; .
PfamPF00206; Lyase_1; 1; .
SUPFAMSSF48557; L-Aspartase-like; 1; .
TIGRFAMsTIGR00979; FumC_II; 1; .


SWISS-2DPAGE (search AC)

Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server