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Sample Preparation and Post-separation Analysis

Searching in 'SWISS-2DPAGE' for entry matching: P10518



General information about the entry
View entry in simple text format
Entry nameHEM2_MOUSE
Primary accession numberP10518
integrated into SWISS-2DPAGE on October 31, 1999 (release 11)
2D Annotations were last modified onOctober 1, 2001 (version 1)
General Annotations were last modified on May 19, 2011 (version 7)
Name and origin of the protein
DescriptionRecName: Full=Delta-aminolevulinic acid dehydratase; Short=ALADH; EC=; AltName: Full=Porphobilinogen synthase;.
Gene nameName=Alad
Annotated speciesMus musculus (Mouse) [TaxID: 10090]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus.
PubMed=11680894; [NCBI, ExPASy, EBI, Israel, Japan]
Sanchez J.-C., Chiappe D., Converset V., Hoogland C., Binz P.-A., Paesano S., Appel R.D., Wang S., Sennitt M., Nolan A., Cawthorne M.A., Hochstrasser D.F.
''''''The mouse SWISS-2DPAGE database: a tool for proteomics study of diabetes and obesity'';'';''
Proteomics 1(1):136-163(2001)
2D PAGE maps for identified proteins
How to interpret a protein

Mus musculus (Mouse)
Tissue: Liver
  map experimental info
  protein estimated location

pI=6.37; Mw=36671  [identification data]

MAPPING (identification):
Peptide mass fingerprinting [1].

This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See or send email from
UniProtKB/Swiss-ProtP10518; HEM2_MOUSE.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.

External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameHEM2_MOUSE
Primary accession numberP10518
Secondary accession number(s) Q3THV6
Sequence was last modified on July 1, 1989 (version 1)
Annotations were last modified on September 21, 2011 (version 103)
Name and origin of the protein
DescriptionRecName: Full=Delta-aminolevulinic acid dehydratase; Short=ALADH; EC=; AltName: Full=Porphobilinogen synthase;
Gene nameName=Alad
Encoded onName=Alad; Synonyms=Lv
Keywords3D-structure; Allosteric enzyme; Complete proteome; Heme biosynthesis; Lyase; Metal-binding; Porphyrin biosynthesis; Reference proteome; Zinc.
Copyrighted by the UniProt Consortium, see Distributed under the Creative Commons Attribution-NoDerivs License
EMBLX13752; CAA32015.1; -; mRNA
EMBLAK032908; BAC28080.1; -; mRNA
EMBLAK167673; BAE39722.1; -; mRNA
EMBLAK168119; BAE40090.1; -; mRNA
EMBLAK168132; BAE40101.1; -; mRNA
EMBLBC055930; AAH55930.1; -; mRNA
IPIIPI00112719; -; .
PIRS03187; S03187; .
RefSeqNP_032551.3; NM_008525.3; .
UniGeneMm.6988; -; .
PDB2Z0I; X-ray; 3.20 A; A/B=1-330
PDB2Z1B; X-ray; 3.30 A; A/B/C/D=1-330
PDBsum2Z0I; -; .
PDBsum2Z1B; -; .
ProteinModelPortalP10518; -; .
SMRP10518; 5-328; .
IntActP10518; 1; .
STRINGP10518; -; .
PhosphoSiteP10518; -; .
SWISS-2DPAGEP10518; -; .
PRIDEP10518; -; .
EnsemblENSMUST00000030090; ENSMUSP00000030090; ENSMUSG00000028393; .
EnsemblENSMUST00000107444; ENSMUSP00000103068; ENSMUSG00000028393; .
GeneID17025; -; .
KEGGmmu:17025; -; .
NMPDRfig|10090.3.peg.9704; -; .
UCSCuc008tez.1; mouse; .
CTD210; -; .
MGIMGI:96853; Alad; .
HOGENOMHBG285270; -; .
HOVERGENHBG001222; -; .
InParanoidP10518; -; .
OrthoDBEOG4BRWM1; -; .
PhylomeDBP10518; -; .
NextBio291138; -; .
ArrayExpressP10518; -; .
BgeeP10518; -; .
CleanExMM_ALAD; -; .
GenevestigatorP10518; -; .
GermOnlineENSMUSG00000028393; Mus musculus; .
GOGO:0042802; F:identical protein binding; IPI:MGI; .
GOGO:0032791; F:lead ion binding; ISS:UniProtKB; .
GOGO:0004655; F:porphobilinogen synthase activity; ISS:UniProtKB; .
GOGO:0008270; F:zinc ion binding; ISS:UniProtKB; .
GOGO:0006783; P:heme biosynthetic process; ISS:UniProtKB; .
InterProIPR001731; 4pyrrol_synth_porphobiln_synth; .
InterProIPR013785; Aldolase_TIM; .
Gene3DG3DSA:; Aldolase_TIM; 1; .
PANTHERPTHR11458; AlaD_dehydratase; 1; .
PfamPF00490; ALAD; 1; .
PIRSFPIRSF001415; Porphbilin_synth; 1; .


SWISS-2DPAGE (search AC)

Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server