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SWISS-2DPAGE 
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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: P11021




SWISS-2DPAGE:  P11021


P11021


General information about the entry
View entry in simple text format
Entry nameGRP78_HUMAN
Primary accession numberP11021
integrated into SWISS-2DPAGE on January 15, 1999 (release 9)
2D Annotations were last modified onMay 15, 2003 (version 2)
General Annotations were last modified on May 19, 2011 (version 13)
Name and origin of the protein
DescriptionRecName: Full=78 kDa glucose-regulated protein; Short=GRP-78; AltName: Full=Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78; AltName: Full=Heat shock 70 kDa protein 5; AltName: Full=Immunoglobulin heavy chain-binding protein; Short=BiP; Flags: Precursor;.
Gene nameName=HSPA5
Synonyms=GRP78
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
Demalte-Annessi I., Sanchez J.-C., Hoogland C., Rouge V., Binz P.-A., Appel R.D., Hochstrasser D.F.
Submitted (JAN-1999) to SWISS-2DPAGE
[2]   MAPPING ON GEL
MEDLINE=20529951; PubMed=11079567; [NCBI, ExPASy, EBI, Israel, Japan]
Jung E., Hoogland C., Chiappe D., Sanchez J.-C., Hochstrasser D.F.
''''''The establishment of a human liver nuclei 2-DE reference map'';'';''
Electrophoresis 21(1):3483-3487(2000)
2D PAGE maps for identified proteins
How to interpret a protein

DLD1_HUMAN {Colorectal adenocarcinoma cell line (DL-1)}
Homo sapiens (Human)
Tissue: Colon adenocarcinoma
DLD1_HUMAN
  map experimental info
  protein estimated location
 
DLD1_HUMAN

MAP LOCATIONS:
pI=4.98; Mw=75955  [identification data]

MAPPING (identification):
Peptide mass fingerprinting [1].



NUCLEI_LIVER_HUMAN {Soluble nuclear proteins and matrix from liver tissue}
Homo sapiens (Human)
Tissue: Liver
NUCLEI_LIVER_HUMAN
  map experimental info
  protein estimated location
 
NUCLEI_LIVER_HUMAN

MAP LOCATIONS:
pI=4.97; Mw=71938  [identification data]

MAPPING (identification):
Peptide mass fingerprinting [2].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss).
Cross-references
DOSAC-COBS 2D-PAGEP11021; P11021.
DOSAC-COBS-2DPAGEP11021; GRP78_HUMAN.
OGP-WWWP11021.
PHCI-2DPAGEP11021.
PMMA-2DPAGEP11021.
REPRODUCTION-2DPAGEP11021; P11021.
Siena-2DPAGEP11021; GRP78_HUMAN.
UCD-2DPAGEP11021; GRP78_HUMAN.
UniProtKB/Swiss-ProtP11021; GRP78_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameGRP78_HUMAN
Primary accession numberP11021
Secondary accession number(s) B0QZ61 Q2EF78 Q9NPF1 Q9UK02
Sequence was last modified on July 11, 2001 (version 2)
Annotations were last modified on October 19, 2011 (version 139)
Name and origin of the protein
DescriptionRecName: Full=78 kDa glucose-regulated protein; Short=GRP-78; AltName: Full=Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78; AltName: Full=Heat shock 70 kDa protein 5; AltName: Full=Immunoglobulin heavy chain-binding protein; Short=BiP; Flags: Precursor;
Gene nameName=HSPA5
Synonyms=GRP78
Encoded onName=HSPA5; Synonyms=GRP78
Keywords3D-structure; Acetylation; ATP-binding; Complete proteome; Direct protein sequencing; Endoplasmic reticulum; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Signal.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLM19645; AAA52614.1; -; Genomic_DNA
EMBLX87949; CAA61201.1; -; mRNA
EMBLAJ271729; CAB71335.1; -; mRNA
EMBLAF216292; AAF42836.1; -; mRNA
EMBLDQ385847; ABD04090.1; -; Genomic_DNA
EMBLAL354710; CAQ08732.1; -; Genomic_DNA
EMBLCH471090; EAW87620.1; -; Genomic_DNA
EMBLBC020235; AAH20235.1; -; mRNA
EMBLX59969; CAA42595.1; -; Genomic_DNA
EMBLAF188611; AAF13605.1; ALT_SEQ; mRNA
IPIIPI00003362; -; .
PIRA29821; A29821; .
RefSeqNP_005338.1; NM_005347.4; .
UniGeneHs.605502; -; .
PDB3IUC; X-ray; 2.40 A; A/C=26-410
PDB3LDL; X-ray; 2.30 A; A/B=26-407
PDB3LDN; X-ray; 2.20 A; A/B=26-407
PDB3LDO; X-ray; 1.95 A; A/B=26-407
PDB3LDP; X-ray; 2.20 A; A/B=26-407
PDBsum3IUC; -; .
PDBsum3LDL; -; .
PDBsum3LDN; -; .
PDBsum3LDO; -; .
PDBsum3LDP; -; .
ProteinModelPortalP11021; -; .
SMRP11021; 26-641; .
IntActP11021; 42; .
MINTMINT-1135308; -; .
STRINGP11021; -; .
PhosphoSiteP11021; -; .
SWISS-2DPAGEP11021; -; .
DOSAC-COBS-2DPAGEP11021; -; .
OGPP11021; -; .
PHCI-2DPAGEP11021; -; .
PMMA-2DPAGEP11021; -; .
REPRODUCTION-2DPAGEP11021; -; .
Siena-2DPAGEP11021; -; .
UCD-2DPAGEP11021; -; .
PRIDEP11021; -; .
EnsemblENST00000324460; ENSP00000324173; ENSG00000044574; .
GeneID3309; -; .
KEGGhsa:3309; -; .
UCSCuc004bpn.1; human; .
CTD3309; -; .
GeneCardsGC09M097610; -; .
H-InvDBHIX0008382; -; .
HGNCHGNC:5238; HSPA5; .
HPACAB005221; -; .
HPACAB019420; -; .
HPAHPA038845; -; .
HPAHPA038846; -; .
MIM138120; gene; .
neXtProtNX_P11021; -; .
PharmGKBPA29504; -; .
eggNOGprNOG14855; -; .
HOVERGENHBG051845; -; .
InParanoidP11021; -; .
OMANQLTTNP; -; .
OrthoDBEOG444KJV; -; .
PhylomeDBP11021; -; .
ReactomeREACT_15380; Diabetes pathways; .
ReactomeREACT_604; Hemostasis; .
ReactomeREACT_6900; Immune System; .
DrugBankDB00025; Antihemophilic Factor; .
NextBio13123; -; .
ArrayExpressP11021; -; .
BgeeP11021; -; .
CleanExHS_HSPA5; -; .
GenevestigatorP11021; -; .
GermOnlineENSG00000044574; Homo sapiens; .
GOGO:0009986; C:cell surface; IDA:UniProtKB; .
GOGO:0034663; C:endoplasmic reticulum chaperone complex; IDA:UniProtKB; .
GOGO:0005788; C:endoplasmic reticulum lumen; TAS:UniProtKB; .
GOGO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IDA:UniProtKB; .
GOGO:0030176; C:integral to endoplasmic reticulum membrane; IDA:UniProtKB; .
GOGO:0042470; C:melanosome; IEA:UniProtKB-SubCell; .
GOGO:0030496; C:midbody; IDA:UniProtKB; .
GOGO:0005634; C:nucleus; IDA:UniProtKB; .
GOGO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB; .
GOGO:0005524; F:ATP binding; NAS:UniProtKB; .
GOGO:0016887; F:ATPase activity; ISS:UniProtKB; .
GOGO:0005509; F:calcium ion binding; TAS:UniProtKB; .
GOGO:0043027; F:caspase inhibitor activity; IDA:UniProtKB; .
GOGO:0051087; F:chaperone binding; TAS:BHF-UCL; .
GOGO:0051787; F:misfolded protein binding; IDA:UniProtKB; .
GOGO:0030674; F:protein binding; bridging; NAS:UniProtKB
GOGO:0019904; F:protein domain specific binding; IPI:UniProtKB; .
GOGO:0031625; F:ubiquitin protein ligase binding; IPI:UniProtKB; .
GOGO:0051082; F:unfolded protein binding; TAS:UniProtKB; .
GOGO:0006916; P:anti-apoptosis; IMP:UniProtKB; .
GOGO:0042149; P:cellular response to glucose starvation; IDA:UniProtKB; .
GOGO:0030433; P:ER-associated protein catabolic process; TAS:BHF-UCL; .
GOGO:0030168; P:platelet activation; TAS:Reactome; .
GOGO:0002576; P:platelet degranulation; TAS:Reactome; .
GOGO:0060904; P:regulation of protein folding in endoplasmic reticulum; TAS:BHF-UCL; .
InterProIPR018181; Heat_shock_70_CS; .
InterProIPR001023; Hsp70; .
InterProIPR013126; Hsp_70; .
PANTHERPTHR19375; Hsp70; 1; .
PfamPF00012; HSP70; 1; .
PRINTSPR00301; HEATSHOCK70; .
PROSITEPS00014; ER_TARGET; 1; .
PROSITEPS00297; HSP70_1; 1; .
PROSITEPS00329; HSP70_2; 1; .
PROSITEPS01036; HSP70_3; 1; .



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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server