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SWISS-2DPAGE 
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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: P11142




SWISS-2DPAGE:  P11142


P11142


General information about the entry
View entry in simple text format
Entry nameHSP7C_HUMAN
Primary accession numberP11142
integrated into SWISS-2DPAGE on January 15, 1999 (release 9)
2D Annotations were last modified onMay 15, 2003 (version 3)
General Annotations were last modified on May 19, 2011 (version 12)
Name and origin of the protein
DescriptionRecName: Full=Heat shock cognate 71 kDa protein; AltName: Full=Heat shock 70 kDa protein 8;.
Gene nameName=HSPA8
Synonyms=HSC70, HSP73, HSPA10
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
Demalte-Annessi I., Sanchez J.-C., Hoogland C., Rouge V., Binz P.-A., Appel R.D., Hochstrasser D.F.
Submitted (JAN-1999) to SWISS-2DPAGE
[2]   MAPPING ON GEL
MEDLINE=20529951; PubMed=11079567; [NCBI, ExPASy, EBI, Israel, Japan]
Jung E., Hoogland C., Chiappe D., Sanchez J.-C., Hochstrasser D.F.
''''''The establishment of a human liver nuclei 2-DE reference map'';'';''
Electrophoresis 21(1):3483-3487(2000)
[3]   MAPPING ON GEL
PubMed=12429849; [NCBI, ExPASy, EBI, Israel, Japan]
Scherl A., Coute Y., Deon C., Calle A., Kindbeiter K., Sanchez J.-C., Greco A., Hochstrasser D.F., Diaz J.-J.
''''''Functional proteomic analysis of human nucleolus'';'';''
Mol. Biol. Cell. 13(1):4100-4109(2002)
2D PAGE maps for identified proteins
How to interpret a protein

DLD1_HUMAN {Colorectal adenocarcinoma cell line (DL-1)}
Homo sapiens (Human)
Tissue: Colon adenocarcinoma
DLD1_HUMAN
  map experimental info
  protein estimated location
 
DLD1_HUMAN

MAP LOCATIONS:
pI=5.17; Mw=69894  [identification data]

MAPPING (identification):
Peptide mass fingerprinting [1].



NUCLEI_LIVER_HUMAN {Soluble nuclear proteins and matrix from liver tissue}
Homo sapiens (Human)
Tissue: Liver
NUCLEI_LIVER_HUMAN
  map experimental info
  protein estimated location
 
NUCLEI_LIVER_HUMAN

MAP LOCATIONS:
pI=5.39; Mw=67478  [identification data]
pI=5.31; Mw=67478  [identification data]

MAPPING (identification):
Peptide mass fingerprinting [2].



NUCLEOLI_HELA_2D_HUMAN {2D-PAGE of nucleolar proteins from Human HeLa cells}
Homo sapiens (Human)
Tissue: Cervix carcinoma
NUCLEOLI_HELA_2D_HUMAN
  map experimental info
  protein estimated location
 
NUCLEOLI_HELA_2D_HUMAN

MAP LOCATIONS:
pI=5.50; Mw=70432  [identification data]

MAPPING (identification):
Peptide mass fingerprinting and tandem mass spectrometry [3].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss).
Cross-references
DOSAC-COBS 2D-PAGEP11142; P11142.
DOSAC-COBS-2DPAGEP11142; HSP7C_HUMAN.
HSC-2DPAGEP11142; HUMAN.
OGP-WWWP11142.
PHCI-2DPAGEP11142; HS7C_HUMAN.
REPRODUCTION-2DPAGEIPI00003865; IPI00003865.
Siena-2DPAGEP11142; HSP7C_HUMAN.
UCD-2DPAGEP11142; HSP7C_HUMAN.
UniProtKB/Swiss-ProtP11142; HSP7C_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameHSP7C_HUMAN
Primary accession numberP11142
Secondary accession number(s) Q9H3R6
Sequence was last modified on July 1, 1989 (version 1)
Annotations were last modified on October 19, 2011 (version 150)
Name and origin of the protein
DescriptionRecName: Full=Heat shock cognate 71 kDa protein; AltName: Full=Heat shock 70 kDa protein 8;
Gene nameName=HSPA8
Synonyms=HSC70, HSP73, HSPA10
Encoded onName=HSPA8; Synonyms=HSC70, HSP73, HSPA10
Keywords3D-structure; Acetylation; Alternative splicing; ATP-binding; Chaperone; Complete proteome; Cytoplasm; Direct protein sequencing; Host-virus interaction; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Repressor; Stress response; Transcription; Transcription regulation; Ubl conjugation.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLY00371; CAA68445.1; -; Genomic_DNA
EMBLAB034951; BAB18615.1; -; mRNA
EMBLAF352832; AAK17898.1; -; mRNA
EMBLBC016179; AAH16179.1; -; mRNA
EMBLBC016660; AAH16660.1; -; mRNA
EMBLBC019816; AAH19816.1; -; mRNA
IPIIPI00003865; -; .
IPIIPI00037070; -; .
PIRA27077; A27077; .
RefSeqNP_006588.1; NM_006597.4; .
RefSeqNP_694881.1; NM_153201.2; .
UniGeneHs.180414; -; .
PDB3AGY; X-ray; 1.85 A; C/D/F=639-646
PDB3AGZ; X-ray; 2.51 A; C/D/E/F=639-646
PDB3ESK; X-ray; 2.05 A; B=635-646
PDB3FZF; X-ray; 2.20 A; A=4-381
PDB3FZH; X-ray; 2.00 A; A=4-381
PDB3FZK; X-ray; 2.10 A; A=4-381
PDB3FZL; X-ray; 2.20 A; A=4-381
PDB3FZM; X-ray; 2.30 A; A=4-381
PDB3LDQ; X-ray; 1.90 A; A=4-381
PDB3M3Z; X-ray; 2.10 A; A=4-381
PDBsum3AGY; -; .
PDBsum3AGZ; -; .
PDBsum3ESK; -; .
PDBsum3FZF; -; .
PDBsum3FZH; -; .
PDBsum3FZK; -; .
PDBsum3FZL; -; .
PDBsum3FZM; -; .
PDBsum3LDQ; -; .
PDBsum3M3Z; -; .
ProteinModelPortalP11142; -; .
SMRP11142; 1-621; .
IntActP11142; 45; .
MINTMINT-4998609; -; .
STRINGP11142; -; .
PhosphoSiteP11142; -; .
SWISS-2DPAGEP11142; -; .
Aarhus/Ghent-2DPAGE6504; IEF; .
Cornea-2DPAGEP11142; -; .
DOSAC-COBS-2DPAGEP11142; -; .
OGPP11142; -; .
PHCI-2DPAGEP11142; -; .
REPRODUCTION-2DPAGEIPI00003865; -; .
UCD-2DPAGEP11142; -; .
PeptideAtlasP11142; -; .
PRIDEP11142; -; .
EnsemblENST00000227378; ENSP00000227378; ENSG00000109971; .
GeneID3312; -; .
KEGGhsa:3312; -; .
UCSCuc001pyo.1; human; .
UCSCuc001pyp.1; human; .
CTD3312; -; .
GeneCardsGC11M118870; -; .
H-InvDBHIX0010213; -; .
HGNCHGNC:5241; HSPA8; .
HPACAB002056; -; .
MIM600816; gene; .
neXtProtNX_P11142; -; .
PharmGKBPA29507; -; .
eggNOGprNOG17884; -; .
HOGENOMHBG334976; -; .
HOVERGENHBG051845; -; .
InParanoidP11142; -; .
OMAHQQKDLE; -; .
OrthoDBEOG4W6NVK; -; .
PhylomeDBP11142; -; .
Pathway_Interaction_DBsmad2_3nuclearpathway; Regulation of nuclear SMAD2/3 signaling; .
ReactomeREACT_11123; Membrane Trafficking; .
ReactomeREACT_13685; Synaptic Transmission; .
ReactomeREACT_21257; Metabolism of RNA; .
NextBio13136; -; .
PMAP-CutDBP11142; -; .
CleanExHS_HSPA8; -; .
GenevestigatorP11142; -; .
GermOnlineENSG00000109971; Homo sapiens; .
GOGO:0009986; C:cell surface; IDA:UniProtKB; .
GOGO:0061202; C:clathrin sculpted gamma-aminobutyric acid transport vesicle membrane; TAS:Reactome; .
GOGO:0005829; C:cytosol; TAS:Reactome; .
GOGO:0042470; C:melanosome; IEA:UniProtKB-SubCell; .
GOGO:0005886; C:plasma membrane; TAS:Reactome; .
GOGO:0030529; C:ribonucleoprotein complex; IDA:UniProtKB; .
GOGO:0005524; F:ATP binding; IEA:UniProtKB-KW; .
GOGO:0042623; F:ATPase activity; coupled; NAS:UniProtKB
GOGO:0005515; F:protein binding; IPI:UniProtKB; .
GOGO:0016044; P:cellular membrane organization; TAS:Reactome; .
GOGO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW; .
GOGO:0016071; P:mRNA metabolic process; TAS:Reactome; .
GOGO:0045892; P:negative regulation of transcription; DNA-dependent; IDA:UniProtKB
GOGO:0007269; P:neurotransmitter secretion; TAS:Reactome; .
GOGO:0006892; P:post-Golgi vesicle-mediated transport; TAS:Reactome; .
GOGO:0006457; P:protein folding; NAS:UniProtKB; .
GOGO:0006986; P:response to unfolded protein; NAS:UniProtKB; .
GOGO:0006351; P:transcription; DNA-dependent; IEA:UniProtKB-KW
InterProIPR018181; Heat_shock_70_CS; .
InterProIPR001023; Hsp70; .
InterProIPR013126; Hsp_70; .
PANTHERPTHR19375; Hsp70; 1; .
PfamPF00012; HSP70; 1; .
PRINTSPR00301; HEATSHOCK70; .
PROSITEPS00297; HSP70_1; 1; .
PROSITEPS00329; HSP70_2; 1; .
PROSITEPS01036; HSP70_3; 1; .



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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server