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SWISS-2DPAGE 
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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: P11177




SWISS-2DPAGE:  P11177


P11177


General information about the entry
View entry in simple text format
Entry nameODPB_HUMAN
Primary accession numberP11177
integrated into SWISS-2DPAGE on September 1, 1997 (release 6)
2D Annotations were last modified onDecember 1, 2000 (version 1)
General Annotations were last modified on May 19, 2011 (version 11)
Name and origin of the protein
DescriptionRecName: Full=Pyruvate dehydrogenase E1 component subunit beta, mitochondrial; Short=PDHE1-B; EC=1.2.4.1; Flags: Precursor;.
Gene nameName=PDHB
Synonyms=PHE1B
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
MEDLINE=98163346; PubMed=9504818; [NCBI, ExPASy, EBI, Israel, Japan]
Reymond M.A., Sanchez J.-C., Hughes G.J., Riese J., Tortola S., Peinado M.A., Kirchner T., Hohenberger W., Hochstrasser D.F., Kockerling F.
''''''Standardized characterization of gene expression in human colorectal epithelium by two-dimensional electrophoresis'';'';''
Electrophoresis 18(1):2842-2848(1997)
2D PAGE maps for identified proteins
How to interpret a protein

CEC_HUMAN {Colorectal epithelia cells}
Homo sapiens (Human)
Tissue: Colon epithelium
CEC_HUMAN
  map experimental info
  protein estimated location
 
CEC_HUMAN

MAP LOCATIONS:
pI=5.38; Mw=34240

MAPPING (identification):
MICROSEQUENCING [1].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss).
Cross-references
HSC-2DPAGEP11177; HUMAN.
REPRODUCTION-2DPAGEIPI00549885; IPI00549885.
Siena-2DPAGEP11177; ODPB_HUMAN.
UCD-2DPAGEP11177; ODPB_HUMAN.
UniProtKB/Swiss-ProtP11177; ODPB_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameODPB_HUMAN
Primary accession numberP11177
Secondary accession number(s) B2R7L0 Q6FH45 Q9BQ27 Q9UFK3
Sequence was last modified on March 6, 2007 (version 3)
Annotations were last modified on October 19, 2011 (version 143)
Name and origin of the protein
DescriptionRecName: Full=Pyruvate dehydrogenase E1 component subunit beta, mitochondrial; Short=PDHE1-B; EC=1.2.4.1; Flags: Precursor;
Gene nameName=PDHB
Synonyms=PHE1B
Encoded onName=PDHB; Synonyms=PHE1B
Keywords3D-structure; Alternative splicing; Complete proteome; Direct protein sequencing; Disease mutation; Glycolysis; Mitochondrion; Oxidoreductase; Phosphoprotein; Polymorphism; Pyruvate; Reference proteome; Thiamine pyrophosphate; Transit peptide.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLM34479; AAA36428.1; -; mRNA
EMBLM19123; AAA60052.1; ALT_SEQ; mRNA
EMBLM54788; AAA60053.1; -; mRNA
EMBLM34055; AAA60233.1; -; mRNA
EMBLM34056; AAA60054.1; -; mRNA
EMBLD90086; BAA14123.1; -; Genomic_DNA
EMBLJ03576; AAA88097.1; -; mRNA
EMBLAL117618; CAB56017.1; -; mRNA
EMBLCR541911; CAG46709.1; -; mRNA
EMBLAK313022; BAG35857.1; -; mRNA
EMBLCH471055; EAW65371.1; -; Genomic_DNA
EMBLBC000439; AAH00439.1; -; mRNA
EMBLBC001924; AAH01924.1; -; mRNA
EMBLX57778; CAA40924.1; -; mRNA
IPIIPI00003925; -; .
IPIIPI00549885; -; .
PIRJU0145; DEHUPB; .
RefSeqNP_000916.2; NM_000925.3; .
UniGeneHs.161357; -; .
PDB1NI4; X-ray; 1.95 A; B/D=31-359
PDB2OZL; X-ray; 1.90 A; B/D=32-359
PDB3EXE; X-ray; 1.98 A; B/D/F/H=31-359
PDB3EXF; X-ray; 3.00 A; B/D/F/H=31-359
PDB3EXG; X-ray; 3.01 A; 2/4/6/B/D/F/H/J/L/N/P/R/T/V/X/Z=31-359
PDB3EXH; X-ray; 2.44 A; B/D/F/H=31-359
PDB3EXI; X-ray; 2.20 A; B=31-359
PDBsum1NI4; -; .
PDBsum2OZL; -; .
PDBsum3EXE; -; .
PDBsum3EXF; -; .
PDBsum3EXG; -; .
PDBsum3EXH; -; .
PDBsum3EXI; -; .
ProteinModelPortalP11177; -; .
SMRP11177; 30-359; .
DIPDIP-37651N; -; .
IntActP11177; 3; .
MINTMINT-3007546; -; .
STRINGP11177; -; .
PhosphoSiteP11177; -; .
SWISS-2DPAGEP11177; -; .
REPRODUCTION-2DPAGEIPI00549885; -; .
UCD-2DPAGEP11177; -; .
PRIDEP11177; -; .
EnsemblENST00000302746; ENSP00000307241; ENSG00000168291; .
GeneID5162; -; .
KEGGhsa:5162; -; .
UCSCuc003dkf.2; human; .
UCSCuc003dkg.2; human; .
CTD5162; -; .
GeneCardsGC03M058388; -; .
H-InvDBHIX0003404; -; .
HGNCHGNC:8808; PDHB; .
HPAHPA036744; -; .
MIM179060; gene; .
MIM614111; phenotype; .
neXtProtNX_P11177; -; .
Orphanet255138; Pyruvate dehydrogenase complex E1 component subunit beta deficiency; .
eggNOGprNOG06752; -; .
GeneTreeENSGT00530000063423; -; .
HOGENOMHBG753264; -; .
HOVERGENHBG000917; -; .
InParanoidP11177; -; .
OMAMEHAFDY; -; .
OrthoDBEOG4CJVHD; -; .
PhylomeDBP11177; -; .
ReactomeREACT_1046; Pyruvate metabolism and Citric Acid (TCA) cycle; .
DrugBankDB00157; NADH; .
DrugBankDB00119; Pyruvic acid; .
NextBio19970; -; .
ArrayExpressP11177; -; .
BgeeP11177; -; .
CleanExHS_PDHB; -; .
GenevestigatorP11177; -; .
GermOnlineENSG00000168291; Homo sapiens; .
GOGO:0005759; C:mitochondrial matrix; TAS:Reactome; .
GOGO:0004739; F:pyruvate dehydrogenase (acetyl-transferring) activity; TAS:ProtInc; .
GOGO:0006096; P:glycolysis; IEA:UniProtKB-KW; .
GOGO:0010510; P:regulation of acetyl-CoA biosynthetic process from pyruvate; TAS:Reactome; .
GOGO:0006099; P:tricarboxylic acid cycle; TAS:ProtInc; .
InterProIPR009014; Transketo_C/Pyr-ferredox_oxred; .
InterProIPR015941; Transketolase-like_C; .
InterProIPR005475; Transketolase-like_Pyr-bd; .
InterProIPR005476; Transketolase_C; .
Gene3DG3DSA:3.40.50.920; Transketo_C_like; 1; .
PfamPF02779; Transket_pyr; 1; .
PfamPF02780; Transketolase_C; 1; .
SMARTSM00861; Transket_pyr; 1; .
SUPFAMSSF52922; Transketo_C_like; 1; .



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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server