World-2DPAGE Home
Home  |  Contact

Attention: World-2DPAGE is no longer maintained. Previously submitted data can still be queried at World-2DPAGE Repository.


SWISS-2DPAGE 
Search by  [accession number] *
[description, ID or gene] 
[author names] 
[spot ID / serial number] 
[identification methods] 
[pI / Mw range] 
[combined fields] 

Maps  [experimental info] 
[protein list] 
[graphical interface]

     Select Remote Interfaces
[All Interfaces]
World-2DPAGE Portal
World-2DPAGE Repository

Exclude local DBs
has only effect if a remote
interface is selected
     

Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: P12956




SWISS-2DPAGE:  P12956


P12956


General information about the entry
View entry in simple text format
Entry nameXRCC6_HUMAN
Primary accession numberP12956
integrated into SWISS-2DPAGE on November 9, 2001 (release 15)
2D Annotations were last modified onMay 15, 2003 (version 1)
General Annotations were last modified on May 19, 2011 (version 8)
Name and origin of the protein
DescriptionRecName: Full=X-ray repair cross-complementing protein 6; EC=3.6.4.-; EC=4.2.99.-; AltName: Full=5'-deoxyribose-5-phosphate lyase Ku70; Short=5'-dRP lyase Ku70; AltName: Full=70 kDa subunit of Ku antigen; AltName: Full=ATP-dependent DNA helicase 2 subunit 1; AltName: Full=ATP-dependent DNA helicase II 70 kDa subunit; AltName: Full=CTC box-binding factor 75 kDa subunit; Short=CTC75; Short=CTCBF; AltName: Full=DNA repair protein XRCC6; AltName: Full=Lupus Ku autoantigen protein p70; Short=Ku70; AltName: Full=Thyroid-lupus autoantigen; Short=TLAA; AltName: Full=X-ray repair complementing defective repair in Chinese hamster cells 6;.
Gene nameName=XRCC6
Synonyms=G22P1
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
PubMed=12429849; [NCBI, ExPASy, EBI, Israel, Japan]
Scherl A., Coute Y., Deon C., Calle A., Kindbeiter K., Sanchez J.-C., Greco A., Hochstrasser D.F., Diaz J.-J.
''''''Functional proteomic analysis of human nucleolus'';'';''
Mol. Biol. Cell. 13(1):4100-4109(2002)
2D PAGE maps for identified proteins
How to interpret a protein

NUCLEOLI_HELA_1D_HUMAN {SDS-PAGE of nucleolar proteins from Human HeLa cells}
Homo sapiens (Human)
Tissue: Cervix carcinoma
NUCLEOLI_HELA_1D_HUMAN
  map experimental info
  protein estimated location
 
NUCLEOLI_HELA_1D_HUMAN

MAP LOCATIONS:
Mw=68364  [identification data]

MAPPING (identification):
Tandem mass spectrometry [1].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss).
Cross-references
UniProtKB/Swiss-ProtP12956; XRCC6_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameXRCC6_HUMAN
Primary accession numberP12956
Secondary accession number(s) Q6FG89 Q9UCQ2 Q9UCQ3
Sequence was last modified on January 23, 2007 (version 2)
Annotations were last modified on October 19, 2011 (version 150)
Name and origin of the protein
DescriptionRecName: Full=X-ray repair cross-complementing protein 6; EC=3.6.4.-; EC=4.2.99.-; AltName: Full=5'-deoxyribose-5-phosphate lyase Ku70; Short=5'-dRP lyase Ku70; AltName: Full=70 kDa subunit of Ku antigen; AltName: Full=ATP-dependent DNA helicase 2 subunit 1; AltName: Full=ATP-dependent DNA helicase II 70 kDa subunit; AltName: Full=CTC box-binding factor 75 kDa subunit; Short=CTC75; Short=CTCBF; AltName: Full=DNA repair protein XRCC6; AltName: Full=Lupus Ku autoantigen protein p70; Short=Ku70; AltName: Full=Thyroid-lupus autoantigen; Short=TLAA; AltName: Full=X-ray repair complementing defective repair in Chinese hamster cells 6;
Gene nameName=XRCC6
Synonyms=G22P1
Encoded onName=XRCC6; Synonyms=G22P1
Keywords3D-structure; Acetylation; Activator; ATP-binding; Chromosome; Complete proteome; Direct protein sequencing; DNA damage; DNA recombination; DNA repair; DNA-binding; Helicase; Hydrolase; Lyase; Multifunctional enzyme; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Systemic lupus erythematosus; Transcription; Transcription regulation.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLJ04607; AAA61177.1; -; mRNA
EMBLJ04611; AAA51733.1; -; mRNA
EMBLM32865; AAA36155.1; -; mRNA
EMBLS38729; AAB22381.1; -; mRNA
EMBLCR542219; CAG47015.1; -; mRNA
EMBLAY870329; AAW34364.1; -; Genomic_DNA
EMBLZ83840; CAB46206.1; -; Genomic_DNA
EMBLBC008343; AAH08343.1; -; mRNA
EMBLBC010034; AAH10034.1; -; mRNA
EMBLBC012154; AAH12154.1; -; mRNA
EMBLBC018259; AAH18259.1; -; mRNA
EMBLBC072449; AAH72449.1; -; mRNA
IPIIPI00644712; -; .
PIRA30299; A30894; .
RefSeqNP_001460.1; NM_001469.3; .
UniGeneHs.292493; -; .
PDB1JEQ; X-ray; 2.70 A; A=1-609
PDB1JEY; X-ray; 2.50 A; A=1-609
PDB1JJR; NMR; -; A=536-609
PDB3RZX; X-ray; 2.61 A; B=537-558
PDBsum1JEQ; -; .
PDBsum1JEY; -; .
PDBsum1JJR; -; .
PDBsum3RZX; -; .
ProteinModelPortalP12956; -; .
SMRP12956; 34-609; .
DIPDIP-24188N; -; .
IntActP12956; 60; .
MINTMINT-1416738; -; .
STRINGP12956; -; .
PhosphoSiteP12956; -; .
SWISS-2DPAGEP12956; -; .
PRIDEP12956; -; .
EnsemblENST00000359308; ENSP00000352257; ENSG00000196419; .
EnsemblENST00000360079; ENSP00000353192; ENSG00000196419; .
EnsemblENST00000405878; ENSP00000384257; ENSG00000196419; .
GeneID2547; -; .
KEGGhsa:2547; -; .
UCSCuc003bao.1; human; .
CTD2547; -; .
GeneCardsGC22P024982; -; .
H-InvDBHIX0016526; -; .
H-InvDBHIX0147981; -; .
HGNCHGNC:4055; XRCC6; .
HPACAB004254; -; .
MIM152690; gene; .
neXtProtNX_P12956; -; .
eggNOGprNOG12401; -; .
HOGENOMHBG600453; -; .
HOVERGENHBG006236; -; .
InParanoidP12956; -; .
OMAVCRYTPR; -; .
OrthoDBEOG451DQB; -; .
PhylomeDBP12956; -; .
Pathway_Interaction_DBbard1pathway; BARD1 signaling events; .
Pathway_Interaction_DBar_pathway; Coregulation of Androgen receptor activity; .
Pathway_Interaction_DBtelomerasepathway; Regulation of Telomerase; .
Pathway_Interaction_DBhdac_classiii_pathway; Signaling events mediated by HDAC Class III; .
ReactomeREACT_216; DNA Repair; .
ReactomeREACT_6185; HIV Infection; .
NextBio10043; -; .
PMAP-CutDBP12956; -; .
ArrayExpressP12956; -; .
BgeeP12956; -; .
CleanExHS_XRCC6; -; .
GenevestigatorP12956; -; .
GermOnlineENSG00000196419; Homo sapiens; .
GOGO:0005958; C:DNA-dependent protein kinase-DNA ligase 4 complex; IEA:InterPro; .
GOGO:0043564; C:Ku70:Ku80 complex; IDA:UniProtKB; .
GOGO:0005624; C:membrane fraction; TAS:ProtInc; .
GOGO:0000783; C:nuclear telomere cap complex; TAS:BHF-UCL; .
GOGO:0005667; C:transcription factor complex; IDA:UniProtKB; .
GOGO:0051575; F:5'-deoxyribose-5-phosphate lyase activity; IMP:UniProtKB; .
GOGO:0005524; F:ATP binding; IEA:UniProtKB-KW; .
GOGO:0004003; F:ATP-dependent DNA helicase activity; TAS:ProtInc; .
GOGO:0003690; F:double-stranded DNA binding; TAS:ProtInc; .
GOGO:0008022; F:protein C-terminus binding; IPI:UniProtKB; .
GOGO:0044212; F:transcription regulatory region DNA binding; IDA:BHF-UCL; .
GOGO:0006266; P:DNA ligation; TAS:ProtInc; .
GOGO:0006303; P:double-strand break repair via nonhomologous end joining; IMP:UniProtKB; .
GOGO:0019059; P:initiation of viral infection; TAS:Reactome; .
GOGO:0045892; P:negative regulation of transcription; DNA-dependent; IMP:UniProtKB
GOGO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL; .
GOGO:0019047; P:provirus integration; TAS:Reactome; .
GOGO:0000723; P:telomere maintenance; TAS:BHF-UCL; .
GOGO:0006351; P:transcription; DNA-dependent; IEA:UniProtKB-KW
InterProIPR006164; DNA_helicase_ATP-dep_Ku; .
InterProIPR006165; DNA_helicase_ATP-dep_Ku70; .
InterProIPR005160; Ku_C; .
InterProIPR005161; Ku_N; .
InterProIPR003034; SAP_DNA-bd; .
InterProIPR016194; SPOC-like; .
Gene3DG3DSA:1.10.720.30; G3DSA:1.10.720.30; 1; .
Gene3DG3DSA:2.40.290.10; G3DSA:2.40.290.10; 1; .
Gene3DG3DSA:1.10.1600.10; Ku_C; 1; .
PfamPF02735; Ku; 1; .
PfamPF03730; Ku_C; 1; .
PfamPF03731; Ku_N; 1; .
PfamPF02037; SAP; 1; .
PIRSFPIRSF003033; Ku70; 1; .
SMARTSM00559; Ku78; 1; .
SMARTSM00513; SAP; 1; .
SUPFAMSSF100939; SPOC-like; 1; .
TIGRFAMsTIGR00578; Ku70; 1; .
PROSITEPS50800; SAP; 1; .



SWISS-2DPAGE image

SWISS-2DPAGE (search AC)


Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server