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SWISS-2DPAGE 
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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: P22352




SWISS-2DPAGE:  P22352


P22352


General information about the entry
View entry in simple text format
Entry nameGPX3_HUMAN
Primary accession numberP22352
integrated into SWISS-2DPAGE on April 1, 2000 (release 12)
2D Annotations were last modified onMay 15, 2003 (version 1)
General Annotations were last modified on May 19, 2011 (version 9)
Name and origin of the protein
DescriptionRecName: Full=Glutathione peroxidase 3; Short=GPx-3; Short=GSHPx-3; EC=1.11.1.9; AltName: Full=Extracellular glutathione peroxidase; AltName: Full=Plasma glutathione peroxidase; Short=GPx-P; Short=GSHPx-P; Flags: Precursor;.
Gene nameName=GPX3
Synonyms=GPXP
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
MEDLINE=20074427; PubMed=10608715; [NCBI, ExPASy, EBI, Israel, Japan]
Sarto C., Frutiger S., Cappellano F., Sanchez J.-C., Doro G., Catanzaro F., Hughes G.J., Hochstrasser D.F., Mocarelli P.
''''''Modified expression of plasma glutathione peroidase and manganese superoxide dismutase in human renal cell carcinoma'';'';''
Electrophoresis 20(1):3458-3466(1999)
2D PAGE maps for identified proteins
How to interpret a protein

KIDNEY_HUMAN {Kidney}
Homo sapiens (Human)
Tissue: Kidney
KIDNEY_HUMAN
  map experimental info
  protein estimated location
 
KIDNEY_HUMAN

MAP LOCATIONS:
pI=5.38; Mw=22786
pI=5.36; Mw=22786  [identification data]

EXPRESSION:
NOT DETECTED IN RENAL CARCINOMA CELLS [1].

MAPPING (identification):
Peptide mass fingerprinting and microsequencing (DCHGXISGTIYE) [1].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss).
Cross-references
REPRODUCTION-2DPAGEIPI00026199; IPI00026199.
UniProtKB/Swiss-ProtP22352; GPX3_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameGPX3_HUMAN
Primary accession numberP22352
Secondary accession number(s) O43787 Q86W78 Q9NZ74 Q9UEL1
Sequence was last modified on February 26, 2008 (version 2)
Annotations were last modified on September 21, 2011 (version 125)
Name and origin of the protein
DescriptionRecName: Full=Glutathione peroxidase 3; Short=GPx-3; Short=GSHPx-3; EC=1.11.1.9; AltName: Full=Extracellular glutathione peroxidase; AltName: Full=Plasma glutathione peroxidase; Short=GPx-P; Short=GSHPx-P; Flags: Precursor;
Gene nameName=GPX3
Synonyms=GPXP
Encoded onName=GPX3; Synonyms=GPXP
Keywords3D-structure; Complete proteome; Direct protein sequencing; Oxidoreductase; Peroxidase; Polymorphism; Reference proteome; Secreted; Selenocysteine; Signal.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLD00632; BAA00525.1; -; mRNA
EMBLX58295; CAA41228.2; -; mRNA
EMBLD16360; BAA03862.1; -; Genomic_DNA
EMBLD16361; BAA03863.2; -; Genomic_DNA
EMBLD16362; BAA03864.1; -; Genomic_DNA
EMBLAF217787; AAF43005.1; -; mRNA
EMBLAY310878; AAP50261.1; -; Genomic_DNA
EMBLAC008641; -; NOT_ANNOTATED_CDS; Genomic_DNA
EMBLBC013601; AAH13601.1; -; mRNA
EMBLBC035841; AAH35841.1; -; mRNA
EMBLBC050378; AAH50378.2; -; mRNA
IPIIPI00026199; -; .
PIRI53822; JQ0476; .
RefSeqNP_002075.2; NM_002084.3; .
UniGeneHs.386793; -; .
PDB2R37; X-ray; 1.85 A; A/B=25-223
PDBsum2R37; -; .
ProteinModelPortalP22352; -; .
SMRP22352; 36-223; .
IntActP22352; 6; .
STRINGP22352; -; .
PeroxiBase3602; HsGPx03; .
SWISS-2DPAGEP22352; -; .
REPRODUCTION-2DPAGEIPI00026199; -; .
PRIDEP22352; -; .
EnsemblENST00000388825; ENSP00000373477; ENSG00000211445; .
GeneID2878; -; .
KEGGhsa:2878; -; .
CTD2878; -; .
GeneCardsGC05P145545; -; .
H-InvDBHIX0024803; -; .
HGNCHGNC:4555; GPX3; .
MIM138321; gene; .
neXtProtNX_P22352; -; .
PharmGKBPA28951; -; .
eggNOGprNOG17922; -; .
HOGENOMHBG648990; -; .
HOVERGENHBG004333; -; .
InParanoidP22352; -; .
OMASNVKMDI; -; .
OrthoDBEOG4CRM10; -; .
PhylomeDBP22352; -; .
BioCycMetaCyc:MONOMER-9873; -; .
DrugBankDB00143; Glutathione; .
NextBio11363; -; .
ArrayExpressP22352; -; .
BgeeP22352; -; .
CleanExHS_GPX3; -; .
GenevestigatorP22352; -; .
GermOnlineENSG00000211445; Homo sapiens; .
GOGO:0005615; C:extracellular space; IDA:UniProtKB; .
GOGO:0004602; F:glutathione peroxidase activity; IDA:UniProtKB; .
GOGO:0008430; F:selenium binding; IDA:UniProtKB; .
GOGO:0008134; F:transcription factor binding; TAS:UniProtKB; .
GOGO:0042744; P:hydrogen peroxide catabolic process; TAS:UniProtKB; .
GOGO:0051289; P:protein homotetramerization; IDA:UniProtKB; .
GOGO:0006982; P:response to lipid hydroperoxide; TAS:UniProtKB; .
InterProIPR000889; Glutathione_peroxidase; .
InterProIPR012336; Thioredoxin-like_fold; .
Gene3DG3DSA:3.40.30.10; Thioredoxin_fold; 1; .
PANTHERPTHR11592; Glut_peroxidase; 1; .
PfamPF00255; GSHPx; 1; .
PIRSFPIRSF000303; Glutathion_perox; 1; .
PRINTSPR01011; GLUTPROXDASE; .
SUPFAMSSF52833; Thiordxn-like_fd; 1; .
PROSITEPS00460; GLUTATHIONE_PEROXID_1; 1; .
PROSITEPS00763; GLUTATHIONE_PEROXID_2; 1; .
PROSITEPS51355; GLUTATHIONE_PEROXID_3; 1; .



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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server