Attention: World-2DPAGE is no longer maintained.

RecName: Full=Glutathione peroxidase 3; Short=GPx-3; Short=GSHPx-3; EC=1.11.1.9; AltName: Full=Extracellular glutathione peroxidase; AltName: Full=Plasma glutathione peroxidase; Short=GPx-P; Short=GSHPx-P; Flags: Precursor;.

Gene name

Name=GPX3
Synonyms=GPXP

Annotated species

Homo sapiens (Human) [TaxID: 9606]

Taxonomy

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

References

[1]

MAPPING ON GEL
MEDLINE=20074427; PubMed=10608715; [NCBI, Expasy, EBI, Israel, Japan]
Sarto C., Frutiger S., Cappellano F., Sanchez J.-C., Doro G., Catanzaro F., Hughes G.J., Hochstrasser D.F., Mocarelli P.
''''''Modified expression of plasma glutathione peroidase and manganese superoxide dismutase in human renal cell carcinoma'';'';''
Electrophoresis 20(1):3458-3466(1999)

2D PAGE maps for identified proteins

How to interpret a protein

KIDNEY_HUMAN {Kidney}
Homo sapiens (Human)
Tissue: Kidney

map experimental info
protein estimated location

KIDNEY_HUMAN

MAP LOCATIONS:

SPOT 2D-000NT4:

pI=5.38; Mw=22786

SPOT 2D-000NT7:

pI=5.36; Mw=22786

[identification data]

EXPRESSION:
NOT DETECTED IN RENAL CARCINOMA CELLS [1].

MAPPING (identification):
Peptide mass fingerprinting and microsequencing (DCHGXISGTIYE) [1].

Copyright

This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss).

Cross-references

REPRODUCTION-2DPAGE

IPI00026199; IPI00026199.

UniProtKB/Swiss-Prot

P22352; GPX3_HUMAN.

2D PAGE maps for identified proteins

How to interpret a protein map
You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.

External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry name	GPX3_HUMAN
Primary accession number	P22352
Secondary accession number(s)	O43787 Q86W78 Q9NZ74 Q9UEL1
Sequence was last modified on	February 26, 2008 (version 2)
Annotations were last modified on	September 21, 2011 (version 125)
Name and origin of the protein
Description	RecName: Full=Glutathione peroxidase 3; Short=GPx-3; Short=GSHPx-3; EC=1.11.1.9; AltName: Full=Extracellular glutathione peroxidase; AltName: Full=Plasma glutathione peroxidase; Short=GPx-P; Short=GSHPx-P; Flags: Precursor;
Gene name	Name=GPX3 Synonyms=GPXP
Encoded on	Name=GPX3; Synonyms=GPXP
Keywords	3D-structure; Complete proteome; Direct protein sequencing; Oxidoreductase; Peroxidase; Polymorphism; Reference proteome; Secreted; Selenocysteine; Signal.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBL	D00632; BAA00525.1; -; mRNA
EMBL	X58295; CAA41228.2; -; mRNA
EMBL	D16360; BAA03862.1; -; Genomic_DNA
EMBL	D16361; BAA03863.2; -; Genomic_DNA
EMBL	D16362; BAA03864.1; -; Genomic_DNA
EMBL	AF217787; AAF43005.1; -; mRNA
EMBL	AY310878; AAP50261.1; -; Genomic_DNA
EMBL	AC008641; -; NOT_ANNOTATED_CDS; Genomic_DNA
EMBL	BC013601; AAH13601.1; -; mRNA
EMBL	BC035841; AAH35841.1; -; mRNA
EMBL	BC050378; AAH50378.2; -; mRNA
IPI	IPI00026199; -; .
PIR	I53822; JQ0476; .
RefSeq	NP_002075.2; NM_002084.3; .
UniGene	Hs.386793; -; .
PDB	2R37; X-ray; 1.85 A; A/B=25-223
PDBsum	2R37; -; .
ProteinModelPortal	P22352; -; .
SMR	P22352; 36-223; .
IntAct	P22352; 6; .
STRING	P22352; -; .
PeroxiBase	3602; HsGPx03; .
SWISS-2DPAGE	P22352; -; .
REPRODUCTION-2DPAGE	IPI00026199; -; .
PRIDE	P22352; -; .
Ensembl	ENST00000388825; ENSP00000373477; ENSG00000211445; .
GeneID	2878; -; .
KEGG	hsa:2878; -; .
CTD	2878; -; .
GeneCards	GC05P145545; -; .
H-InvDB	HIX0024803; -; .
HGNC	HGNC:4555; GPX3; .
MIM	138321; gene; .
neXtProt	NX_P22352; -; .
PharmGKB	PA28951; -; .
eggNOG	prNOG17922; -; .
HOGENOM	HBG648990; -; .
HOVERGEN	HBG004333; -; .
InParanoid	P22352; -; .
OMA	SNVKMDI; -; .
OrthoDB	EOG4CRM10; -; .
PhylomeDB	P22352; -; .
BioCyc	MetaCyc:MONOMER-9873; -; .
DrugBank	DB00143; Glutathione; .
NextBio	11363; -; .
ArrayExpress	P22352; -; .
Bgee	P22352; -; .
CleanEx	HS_GPX3; -; .
Genevestigator	P22352; -; .
GermOnline	ENSG00000211445; Homo sapiens; .
GO	GO:0005615; C:extracellular space; IDA:UniProtKB; .
GO	GO:0004602; F:glutathione peroxidase activity; IDA:UniProtKB; .
GO	GO:0008430; F:selenium binding; IDA:UniProtKB; .
GO	GO:0008134; F:transcription factor binding; TAS:UniProtKB; .
GO	GO:0042744; P:hydrogen peroxide catabolic process; TAS:UniProtKB; .
GO	GO:0051289; P:protein homotetramerization; IDA:UniProtKB; .
GO	GO:0006982; P:response to lipid hydroperoxide; TAS:UniProtKB; .
InterPro	IPR000889; Glutathione_peroxidase; .
InterPro	IPR012336; Thioredoxin-like_fold; .
Gene3D	G3DSA:3.40.30.10; Thioredoxin_fold; 1; .
PANTHER	PTHR11592; Glut_peroxidase; 1; .
Pfam	PF00255; GSHPx; 1; .
PIRSF	PIRSF000303; Glutathion_perox; 1; .
PRINTS	PR01011; GLUTPROXDASE; .
SUPFAM	SSF52833; Thiordxn-like_fd; 1; .
PROSITE	PS00460; GLUTATHIONE_PEROXID_1; 1; .
PROSITE	PS00763; GLUTATHIONE_PEROXID_2; 1; .
PROSITE	PS51355; GLUTATHIONE_PEROXID_3; 1; .

SWISS-2DPAGE (search AC)

Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the Expasy web server