Attention: World-2DPAGE is no longer maintained.

RecName: Full=Polypyrimidine tract-binding protein 1; Short=PTB; AltName: Full=57 kDa RNA-binding protein PPTB-1; AltName: Full=Heterogeneous nuclear ribonucleoprotein I; Short=hnRNP I;.

Gene name

Name=PTBP1
Synonyms=PTB

Annotated species

Homo sapiens (Human) [TaxID: 9606]

Taxonomy

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

References

[1]	MAPPING ON GEL PubMed=12429849; [NCBI, Expasy, EBI, Israel, Japan] Scherl A., Coute Y., Deon C., Calle A., Kindbeiter K., Sanchez J.-C., Greco A., Hochstrasser D.F., Diaz J.-J. ''''''Functional proteomic analysis of human nucleolus'';'';'' Mol. Biol. Cell. 13(1):4100-4109(2002)

2D PAGE maps for identified proteins

How to interpret a protein

NUCLEOLI_HELA_1D_HUMAN {SDS-PAGE of nucleolar proteins from Human HeLa cells}
Homo sapiens (Human)
Tissue: Cervix carcinoma

map experimental info
protein estimated location

NUCLEOLI_HELA_1D_HUMAN

MAP LOCATIONS:

BAND 1D-001V8H:

Mw=56716

[identification data]

MAPPING (identification):
Tandem mass spectrometry [1].

Copyright

This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss).

Cross-references

UniProtKB/Swiss-Prot

P26599; PTBP1_HUMAN.

2D PAGE maps for identified proteins

How to interpret a protein map
You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.

External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry name	PTBP1_HUMAN
Primary accession number	P26599
Sequence was last modified on	August 1, 1992 (version 1)
Annotations were last modified on	October 19, 2011 (version 139)
Name and origin of the protein
Description	RecName: Full=Polypyrimidine tract-binding protein 1; Short=PTB; AltName: Full=57 kDa RNA-binding protein PPTB-1; AltName: Full=Heterogeneous nuclear ribonucleoprotein I; Short=hnRNP I;
Gene name	Name=PTBP1 Synonyms=PTB
Encoded on	Name=PTBP1; Synonyms=PTB
Keywords	3D-structure; Acetylation; Activator; Alternative splicing; Complete proteome; Direct protein sequencing; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Repeat; Repressor; RNA-binding.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBL	X62006; CAA43973.1; -; mRNA
EMBL	X65371; CAA46443.1; -; mRNA
EMBL	X65372; CAA46444.1; -; mRNA
EMBL	X60648; CAA43056.1; -; mRNA
EMBL	X66975; CAA47386.1; -; mRNA
EMBL	AC006273; AAC99798.1; -; Genomic_DNA
EMBL	BC004383; AAH04383.1; -; mRNA
IPI	IPI00179964; -; .
IPI	IPI00334175; -; .
PIR	S23016; S23016; .
RefSeq	NP_002810.1; NM_002819.4; .
RefSeq	NP_114367.1; NM_031990.3; .
RefSeq	NP_114368.1; NM_031991.3; .
RefSeq	NP_787041.1; NM_175847.2; .
UniGene	Hs.172550; -; .
PDB	1QM9; NMR; -; A=335-531
PDB	1SJQ; NMR; -; A=55-147
PDB	1SJR; NMR; -; A=147-301
PDB	2AD9; NMR; -; A=49-146
PDB	2ADB; NMR; -; A=172-298
PDB	2ADC; NMR; -; A=324-531
PDB	2EVZ; NMR; -; A=324-531
PDBsum	1QM9; -; .
PDBsum	1SJQ; -; .
PDBsum	1SJR; -; .
PDBsum	2AD9; -; .
PDBsum	2ADB; -; .
PDBsum	2ADC; -; .
PDBsum	2EVZ; -; .
ProteinModelPortal	P26599; -; .
SMR	P26599; 49-531; .
IntAct	P26599; 20; .
MINT	MINT-1348690; -; .
STRING	P26599; -; .
PhosphoSite	P26599; -; .
SWISS-2DPAGE	P26599; -; .
Aarhus/Ghent-2DPAGE	1505; NEPHGE; .
PRIDE	P26599; -; .
Ensembl	ENST00000349038; ENSP00000014112; ENSG00000011304; .
GeneID	5725; -; .
KEGG	hsa:5725; -; .
UCSC	uc002lpq.1; human; .
UCSC	uc002lpr.1; human; .
CTD	5725; -; .
GeneCards	GC19P000567; -; .
HGNC	HGNC:9583; PTBP1; .
HPA	CAB013507; -; .
MIM	600693; gene; .
neXtProt	NX_P26599; -; .
eggNOG	prNOG10547; -; .
HOVERGEN	HBG069548; -; .
PhylomeDB	P26599; -; .
Reactome	REACT_1675; mRNA Processing; .
Reactome	REACT_71; Gene Expression; .
NextBio	22252; -; .
PMAP-CutDB	P26599; -; .
ArrayExpress	P26599; -; .
Bgee	P26599; -; .
CleanEx	HS_PTBP1; -; .
Genevestigator	P26599; -; .
GermOnline	ENSG00000011304; Homo sapiens; .
GO	GO:0030530; C:heterogeneous nuclear ribonucleoprotein complex; TAS:ProtInc; .
GO	GO:0005730; C:nucleolus; TAS:ProtInc; .
GO	GO:0005654; C:nucleoplasm; TAS:Reactome; .
GO	GO:0003729; F:mRNA binding; IDA:UniProtKB; .
GO	GO:0000166; F:nucleotide binding; IEA:InterPro; .
GO	GO:0008187; F:poly-pyrimidine tract binding; TAS:ProtInc; .
GO	GO:0005515; F:protein binding; IPI:IntAct; .
GO	GO:0051148; P:negative regulation of muscle cell differentiation; IDA:UniProtKB; .
GO	GO:0048025; P:negative regulation of nuclear mRNA splicing; via spliceosome; IDA:UniProtKB
GO	GO:0000398; P:nuclear mRNA splicing; via spliceosome; TAS:Reactome
GO	GO:0000381; P:regulation of alternative nuclear mRNA splicing; via spliceosome; IDA:UniProtKB
InterPro	IPR006536; HnRNP-L_PTB; .
InterPro	IPR012677; Nucleotide-bd_a/b_plait; .
InterPro	IPR000504; RRM_dom; .
Gene3D	G3DSA:3.30.70.330; a_b_plait_nuc_bd; 4; .
Pfam	PF00076; RRM_1; 3; .
SMART	SM00360; RRM; 4; .
TIGRFAMs	TIGR01649; HnRNP-L_PTB; 1; .
PROSITE	PS50102; RRM; 4; .

SWISS-2DPAGE (search AC)

Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the Expasy web server