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Sample Preparation and Post-separation Analysis

Searching in 'SWISS-2DPAGE' for entry matching: P54278



General information about the entry
View entry in simple text format
Entry namePMS2_HUMAN
Primary accession numberP54278
integrated into SWISS-2DPAGE on September 1, 1997 (release 6)
2D Annotations were last modified onDecember 1, 2000 (version 1)
General Annotations were last modified on May 19, 2011 (version 11)
Name and origin of the protein
DescriptionRecName: Full=Mismatch repair endonuclease PMS2; EC=3.1.-.-; AltName: Full=DNA mismatch repair protein PMS2; AltName: Full=PMS1 protein homolog 2;.
Gene nameName=PMS2
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
MEDLINE=98163346; PubMed=9504818; [NCBI, ExPASy, EBI, Israel, Japan]
Reymond M.A., Sanchez J.-C., Hughes G.J., Riese J., Tortola S., Peinado M.A., Kirchner T., Hohenberger W., Hochstrasser D.F., Kockerling F.
''''''Standardized characterization of gene expression in human colorectal epithelium by two-dimensional electrophoresis'';'';''
Electrophoresis 18(1):2842-2848(1997)
2D PAGE maps for identified proteins
How to interpret a protein

CEC_HUMAN {Colorectal epithelia cells}
Homo sapiens (Human)
Tissue: Colon epithelium
  map experimental info
  protein estimated location

pI=6.39; Mw=52377

MAPPING (identification):

This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See or send email from
UniProtKB/Swiss-ProtP54278; PMS2_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.

External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry namePMS2_HUMAN
Primary accession numberP54278
Secondary accession number(s) B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2
Sequence was last modified on January 11, 2011 (version 2)
Annotations were last modified on September 21, 2011 (version 122)
Name and origin of the protein
DescriptionRecName: Full=Mismatch repair endonuclease PMS2; EC=3.1.-.-; AltName: Full=DNA mismatch repair protein PMS2; AltName: Full=PMS1 protein homolog 2;
Gene nameName=PMS2
Encoded onName=PMS2; Synonyms=PMSL2
Keywords3D-structure; Alternative splicing; Complete proteome; Disease mutation; DNA damage; DNA repair; Endonuclease; Hereditary nonpolyposis colorectal cancer; Hydrolase; Nuclease; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Tumor suppressor.
Copyrighted by the UniProt Consortium, see Distributed under the Creative Commons Attribution-NoDerivs License
EMBLU13696; AAA63923.1; -; Genomic_DNA
EMBLAB103082; BAD89425.1; -; mRNA
EMBLAB103083; BAD89426.1; -; mRNA
EMBLAB103085; BAD89428.1; -; mRNA
EMBLU14658; AAA50390.1; -; mRNA
EMBLAK312390; BAG35307.1; -; mRNA
EMBLAC005995; AAS00390.1; -; Genomic_DNA
EMBLBC093921; AAH93921.1; -; mRNA
IPIIPI00418329; -; .
IPIIPI00746337; -; .
IPIIPI00873034; -; .
IPIIPI00874088; -; .
PIRS47598; S47598; .
RefSeqNP_000526.1; NM_000535.5; .
UniGeneHs.632637; -; .
PDB1EA6; X-ray; 2.70 A; A/B=1-364
PDB1H7S; X-ray; 1.95 A; A/B=1-365
PDB1H7U; X-ray; 2.70 A; A/B=1-365
PDBsum1EA6; -; .
PDBsum1H7S; -; .
PDBsum1H7U; -; .
ProteinModelPortalP54278; -; .
SMRP54278; 29-365; 677-853; .
DIPDIP-27602N; -; .
DIPDIP-46295N; -; .
IntActP54278; 2; .
MINTMINT-2804140; -; .
STRINGP54278; -; .
PhosphoSiteP54278; -; .
SWISS-2DPAGEP54278; -; .
PRIDEP54278; -; .
EnsemblENST00000265849; ENSP00000265849; ENSG00000122512; .
GeneID5395; -; .
KEGGhsa:5395; -; .
UCSCuc003spl.1; human; .
UCSCuc010kte.1; human; .
UCSCuc010ktf.1; human; .
UCSCuc010ktg.1; human; .
CTD5395; -; .
GeneCardsGC07M005979; -; .
H-InvDBHIX0025316; -; .
HGNCHGNC:9122; PMS2; .
HPACAB010235; -; .
MIM276300; phenotype; .
MIM600259; gene+phenotype; .
neXtProtNX_P54278; -; .
Orphanet144; Hereditary nonpolyposis colon cancer; .
PharmGKBPA33448; -; .
eggNOGprNOG12421; -; .
HOVERGENHBG008219; -; .
InParanoidP54278; -; .
PhylomeDBP54278; -; .
NextBio20918; -; .
BgeeP54278; -; .
CleanExHS_PMS2; -; .
GenevestigatorP54278; -; .
GermOnlineENSG00000122512; Homo sapiens; .
GOGO:0032389; C:MutLalpha complex; IBA:RefGenome; .
GOGO:0005524; F:ATP binding; IEA:InterPro; .
GOGO:0016887; F:ATPase activity; IBA:RefGenome; .
GOGO:0004519; F:endonuclease activity; IEA:UniProtKB-KW; .
GOGO:0005515; F:protein binding; IPI:UniProtKB; .
GOGO:0032138; F:single base insertion or deletion binding; IDA:HGNC; .
GOGO:0006298; P:mismatch repair; IDA:HGNC; .
GOGO:0007131; P:reciprocal meiotic recombination; IBA:RefGenome; .
GOGO:0016446; P:somatic hypermutation of immunoglobulin genes; IBA:RefGenome; .
InterProIPR003594; ATPase-like_ATP-bd; .
InterProIPR002099; DNA_mismatch_repair; .
InterProIPR013507; DNA_mismatch_repair_C; .
InterProIPR014762; DNA_mismatch_repair_CS; .
InterProIPR014763; DNA_mismatch_repair_N; .
InterProIPR014790; MutL_C; .
InterProIPR020568; Ribosomal_S5_D2-typ_fold; .
InterProIPR014721; Ribosomal_S5_D2-typ_fold_subgr; .
Gene3DG3DSA:3.30.565.10; ATP_bd_ATPase; 1; .
Gene3DG3DSA:; Ribosomal_S5_D2-type_fold; 1; .
PANTHERPTHR10073; DNA_mis_repair; 1; .
PfamPF01119; DNA_mis_repair; 1; .
PfamPF02518; HATPase_c; 1; .
PfamPF08676; MutL_C; 1; .
SMARTSM00387; HATPase_c; 1; .
SMARTSM00853; MutL_C; 1; .
SUPFAMSSF55874; ATP_bd_ATPase; 1; .
SUPFAMSSF54211; Ribosomal_S5_D2-typ_fold; 1; .
TIGRFAMsTIGR00585; Mutl; 1; .


SWISS-2DPAGE (search AC)

Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server