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SWISS-2DPAGE 
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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: Q01780




SWISS-2DPAGE:  Q01780


Q01780


General information about the entry
View entry in simple text format
Entry nameEXOSX_HUMAN
Primary accession numberQ01780
integrated into SWISS-2DPAGE on May 15, 2003 (release 16)
2D Annotations were last modified onDecember 30, 2004 (version 1)
General Annotations were last modified on May 19, 2011 (version 7)
Name and origin of the protein
DescriptionRecName: Full=Exosome component 10; EC=3.1.13.-; AltName: Full=Autoantigen PM/Scl 2; AltName: Full=P100 polymyositis-scleroderma overlap syndrome-associated autoantigen; AltName: Full=Polymyositis/scleroderma autoantigen 100 kDa; Short=PM/Scl-100; AltName: Full=Polymyositis/scleroderma autoantigen 2;.
Gene nameName=EXOSC10
Synonyms=PMSCL, PMSCL2, RRP6
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
PubMed=12429849; [NCBI, ExPASy, EBI, Israel, Japan]
Scherl A., Coute Y., Deon C., Calle A., Kindbeiter K., Sanchez J.-C., Greco A., Hochstrasser D.F., Diaz J.-J.
''''''Functional proteomic analysis of human nucleolus'';'';''
Mol. Biol. Cell. 13(1):4100-4109(2002)
Comments
  • SUBUNIT: COMPONENT OF THE EXOSOME MULTIENZYME RIBONUCLEASE COMPLEX COMPOSED OF AT LEAST 11 PROTEINS: RRP4, RRP40, RRP41/SKI6, RRP42, RRP44/DIS3, PM/SCL-75, RRP46, CSL4 AND PM/SCL-100 (ONLY IN THE NUCLEAR COMPLEX). ALSO ASSOCIATED WITH THE GTPASE RAN (BY SIMILARITY)
2D PAGE maps for identified proteins
How to interpret a protein

NUCLEOLI_HELA_1D_HUMAN {SDS-PAGE of nucleolar proteins from Human HeLa cells}
Homo sapiens (Human)
Tissue: Cervix carcinoma
NUCLEOLI_HELA_1D_HUMAN
  map experimental info
  protein estimated location
 
NUCLEOLI_HELA_1D_HUMAN

MAP LOCATIONS:
Mw=96301  [identification data]

MAPPING (identification):
Tandem mass spectrometry [1].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss).
Cross-references
UniProtKB/Swiss-ProtQ01780; EXOSX_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameEXOSX_HUMAN
Primary accession numberQ01780
Secondary accession number(s) B1AKQ0 B1AKQ1 Q15158
Sequence was last modified on December 1, 2000 (version 2)
Annotations were last modified on October 19, 2011 (version 128)
Name and origin of the protein
DescriptionRecName: Full=Exosome component 10; EC=3.1.13.-; AltName: Full=Autoantigen PM/Scl 2; AltName: Full=P100 polymyositis-scleroderma overlap syndrome-associated autoantigen; AltName: Full=Polymyositis/scleroderma autoantigen 100 kDa; Short=PM/Scl-100; AltName: Full=Polymyositis/scleroderma autoantigen 2;
Gene nameName=EXOSC10
Synonyms=PMSCL, PMSCL2, RRP6
Encoded onName=EXOSC10; Synonyms=PMSCL, PMSCL2, RRP6
Keywords3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Exonuclease; Exosome; Hydrolase; Nonsense-mediated mRNA decay; Nuclease; Nucleus; Reference proteome; RNA-binding; rRNA processing.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLX66113; CAA46904.1; -; mRNA
EMBLL01457; AAB59352.1; -; mRNA
EMBLAJ300188; CAC15569.1; -; Genomic_DNA
EMBLAL109811; CAI22106.1; -; Genomic_DNA
EMBLAL109811; CAI22107.1; -; Genomic_DNA
EMBLCH471130; EAW71679.1; -; Genomic_DNA
EMBLBC039901; AAH39901.1; -; mRNA
EMBLBC073788; AAH73788.1; -; mRNA
IPIIPI00009464; -; .
IPIIPI00220336; -; .
PIRA43920; A43920; .
PIRJH0796; JH0796; .
RefSeqNP_001001998.1; NM_001001998.1; .
RefSeqNP_002676.1; NM_002685.2; .
UniGeneHs.632368; -; .
PDB2CPR; NMR; -; A=483-593
PDB3SAF; X-ray; 2.50 A; A/B=180-606
PDB3SAG; X-ray; 2.70 A; A/B=180-606
PDB3SAH; X-ray; 2.65 A; A/B=180-606
PDBsum2CPR; -; .
PDBsum3SAF; -; .
PDBsum3SAG; -; .
PDBsum3SAH; -; .
ProteinModelPortalQ01780; -; .
SMRQ01780; 179-595; .
IntActQ01780; 45; .
MINTMINT-1143843; -; .
STRINGQ01780; -; .
PhosphoSiteQ01780; -; .
SWISS-2DPAGEQ01780; -; .
PRIDEQ01780; -; .
EnsemblENST00000376936; ENSP00000366135; ENSG00000171824; .
GeneID5394; -; .
KEGGhsa:5394; -; .
UCSCuc001asa.1; human; .
UCSCuc001asb.1; human; .
CTD5394; -; .
GeneCardsGC01M010278; -; .
H-InvDBHIX0000121; -; .
HGNCHGNC:9138; EXOSC10; .
HPAHPA028470; -; .
HPAHPA028484; -; .
MIM605960; gene; .
neXtProtNX_Q01780; -; .
PharmGKBPA33464; -; .
eggNOGprNOG16036; -; .
HOGENOMHBG445478; -; .
HOVERGENHBG051524; -; .
InParanoidQ01780; -; .
OMAFENPFRM; -; .
OrthoDBEOG4X6C7P; -; .
PhylomeDBQ01780; -; .
NextBio20912; -; .
ArrayExpressQ01780; -; .
BgeeQ01780; -; .
CleanExHS_EXOSC10; -; .
GenevestigatorQ01780; -; .
GermOnlineENSG00000171824; Homo sapiens; .
GOGO:0005737; C:cytoplasm; IDA:UniProtKB; .
GOGO:0000176; C:nuclear exosome (RNase complex); IEA:InterPro; .
GOGO:0005730; C:nucleolus; IDA:UniProtKB; .
GOGO:0035327; C:transcriptionally active chromatin; IMP:UniProtKB; .
GOGO:0008408; F:3'-5' exonuclease activity; IEA:InterPro; .
GOGO:0004532; F:exoribonuclease activity; IDA:UniProtKB; .
GOGO:0000166; F:nucleotide binding; IEA:InterPro; .
GOGO:0005515; F:protein binding; IPI:IntAct; .
GOGO:0004674; F:protein serine/threonine kinase activity; TAS:ProtInc; .
GOGO:0003723; F:RNA binding; IEA:UniProtKB-KW; .
GOGO:0071034; P:CUT catabolic process; IMP:UniProtKB; .
GOGO:0071044; P:histone mRNA catabolic process; IMP:UniProtKB; .
GOGO:0000460; P:maturation of 5.8S rRNA; IMP:UniProtKB; .
GOGO:0071035; P:nuclear polyadenylation-dependent rRNA catabolic process; IMP:UniProtKB; .
GOGO:0071048; P:nuclear retention of unspliced pre-mRNA at the site of transcription; IMP:UniProtKB; .
GOGO:0000184; P:nuclear-transcribed mRNA catabolic process; nonsense-mediated decay; IMP:UniProtKB
InterProIPR002562; 3'-5'_exonuclease; .
InterProIPR012588; Exosome-assoc_fac_Rrp6_N; .
InterProIPR002121; Helicase/RNaseD_C; .
InterProIPR010997; HRDC-like; .
InterProIPR012337; RNaseH-like; .
PfamPF01612; DNA_pol_A_exo1; 1; .
PfamPF00570; HRDC; 1; .
PfamPF08066; PMC2NT; 1; .
SMARTSM00474; 35EXOc; 1; .
SMARTSM00341; HRDC; 1; .
SUPFAMSSF47819; HRDC_like; 1; .
SUPFAMSSF53098; RNaseH_fold; 1; .
PROSITEPS50967; HRDC; 1; .



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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server