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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: O60832




SWISS-2DPAGE:  O60832


O60832


General information about the entry
View entry in simple text format
Entry nameDKC1_HUMAN
Primary accession numberO60832
integrated into SWISS-2DPAGE on November 9, 2001 (release 15)
2D Annotations were last modified onMay 15, 2003 (version 1)
General Annotations were last modified on May 19, 2011 (version 7)
Name and origin of the protein
DescriptionRecName: Full=H/ACA ribonucleoprotein complex subunit 4; EC=5.4.99.-; AltName: Full=CBF5 homolog; AltName: Full=Dyskerin; AltName: Full=Nopp140-associated protein of 57 kDa; AltName: Full=Nucleolar protein NAP57; AltName: Full=Nucleolar protein family A member 4; AltName: Full=snoRNP protein DKC1;.
Gene nameName=DKC1
Synonyms=NOLA4
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
PubMed=12429849; [NCBI, ExPASy, EBI, Israel, Japan]
Scherl A., Coute Y., Deon C., Calle A., Kindbeiter K., Sanchez J.-C., Greco A., Hochstrasser D.F., Diaz J.-J.
''''''Functional proteomic analysis of human nucleolus'';'';''
Mol. Biol. Cell. 13(1):4100-4109(2002)
2D PAGE maps for identified proteins
How to interpret a protein

NUCLEOLI_HELA_1D_HUMAN {SDS-PAGE of nucleolar proteins from Human HeLa cells}
Homo sapiens (Human)
Tissue: Cervix carcinoma
NUCLEOLI_HELA_1D_HUMAN
  map experimental info
  protein estimated location
 
NUCLEOLI_HELA_1D_HUMAN

MAP LOCATIONS:
Mw=59243  [identification data]

MAPPING (identification):
Peptide mass fingerprinting and tandem mass SPECTROMETRY [1].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from license@isb-sib.ch).
Cross-references
UniProtKB/Swiss-ProtO60832; DKC1_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameDKC1_HUMAN
Primary accession numberO60832
Secondary accession number(s) O43845 Q96G67 Q9Y505
Sequence was last modified on January 23, 2007 (version 3)
Annotations were last modified on October 19, 2011 (version 134)
Name and origin of the protein
DescriptionRecName: Full=H/ACA ribonucleoprotein complex subunit 4; EC=5.4.99.-; AltName: Full=CBF5 homolog; AltName: Full=Dyskerin; AltName: Full=Nopp140-associated protein of 57 kDa; AltName: Full=Nucleolar protein NAP57; AltName: Full=Nucleolar protein family A member 4; AltName: Full=snoRNP protein DKC1;
Gene nameName=DKC1
Synonyms=NOLA4
Encoded onName=DKC1; Synonyms=NOLA4
KeywordsAcetylation; Complete proteome; Direct protein sequencing; Disease mutation; Dyskeratosis congenita; Isomerase; Nucleus; Phosphoprotein; Reference proteome; Ribonucleoprotein; Ribosome biogenesis; RNA-binding; rRNA processing.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLAJ224481; CAA11970.1; -; Genomic_DNA
EMBLAJ010395; CAB51168.1; -; Genomic_DNA
EMBLAJ010396; CAB51168.1; JOINED; Genomic_DNA
EMBLAF067008; AAD11815.1; -; mRNA
EMBLAF067023; AAD20232.1; -; Genomic_DNA
EMBLAF067009; AAD20232.1; JOINED; Genomic_DNA
EMBLAF067010; AAD20232.1; JOINED; Genomic_DNA
EMBLAF067011; AAD20232.1; JOINED; Genomic_DNA
EMBLAF067012; AAD20232.1; JOINED; Genomic_DNA
EMBLAF067013; AAD20232.1; JOINED; Genomic_DNA
EMBLAF067014; AAD20232.1; JOINED; Genomic_DNA
EMBLAF067015; AAD20232.1; JOINED; Genomic_DNA
EMBLAF067016; AAD20232.1; JOINED; Genomic_DNA
EMBLAF067017; AAD20232.1; JOINED; Genomic_DNA
EMBLAF067018; AAD20232.1; JOINED; Genomic_DNA
EMBLAF067019; AAD20232.1; JOINED; Genomic_DNA
EMBLAF067020; AAD20232.1; JOINED; Genomic_DNA
EMBLAF067021; AAD20232.1; JOINED; Genomic_DNA
EMBLAF067022; AAD20232.1; JOINED; Genomic_DNA
EMBLU59151; AAB94299.1; -; mRNA
EMBLBC009928; AAH09928.1; -; mRNA
EMBLBC010015; AAH10015.1; -; mRNA
IPIIPI00221394; -; .
RefSeqNP_001354.1; NM_001363.3; .
UniGeneHs.4747; -; .
ProteinModelPortalO60832; -; .
SMRO60832; 61-379; .
IntActO60832; 14; .
MINTMINT-1379892; -; .
STRINGO60832; -; .
PhosphoSiteO60832; -; .
SWISS-2DPAGEO60832; -; .
PeptideAtlasO60832; -; .
PRIDEO60832; -; .
EnsemblENST00000369550; ENSP00000358563; ENSG00000130826; .
GeneID1736; -; .
KEGGhsa:1736; -; .
NMPDRfig|9606.3.peg.33669; -; .
UCSCuc004fmm.1; human; .
CTD1736; -; .
GeneCardsGC0XP153984; -; .
GeneCardsGC0XP154003; -; .
H-InvDBHIX0017164; -; .
HGNCHGNC:2890; DKC1; .
HPAHPA000166; -; .
HPAHPA000447; -; .
MIM300126; gene; .
MIM300240; phenotype; .
MIM305000; phenotype; .
neXtProtNX_O60832; -; .
Orphanet1775; Dyskeratosis congenita; .
Orphanet3322; Hoyeraal-Hreidarsson syndrome; .
PharmGKBPA27344; -; .
eggNOGprNOG14784; -; .
GeneTreeENSGT00510000047092; -; .
HOVERGENHBG081442; -; .
OrthoDBEOG4NS3BP; -; .
PhylomeDBO60832; -; .
Pathway_Interaction_DBtelomerasepathway; Regulation of Telomerase; .
ReactomeREACT_22172; Chromosome Maintenance; .
NextBio7039; -; .
ArrayExpressO60832; -; .
BgeeO60832; -; .
CleanExHS_DKC1; -; .
GenevestigatorO60832; -; .
GermOnlineENSG00000130826; Homo sapiens; .
GOGO:0015030; C:Cajal body; IEA:UniProtKB-SubCell; .
GOGO:0005730; C:nucleolus; IDA:HPA; .
GOGO:0005697; C:telomerase holoenzyme complex; IDA:UniProtKB; .
GOGO:0005515; F:protein binding; IPI:UniProtKB; .
GOGO:0009982; F:pseudouridine synthase activity; IEA:InterPro; .
GOGO:0003723; F:RNA binding; TAS:ProtInc; .
GOGO:0003720; F:telomerase activity; IDA:UniProtKB; .
GOGO:0008283; P:cell proliferation; TAS:ProtInc; .
GOGO:0001522; P:pseudouridine synthesis; IEA:InterPro; .
GOGO:0006364; P:rRNA processing; TAS:ProtInc; .
GOGO:0007004; P:telomere maintenance via telomerase; TAS:Reactome; .
InterProIPR012960; Dyskerin-like; .
InterProIPR002501; PsdUridine_synth; .
InterProIPR020103; PsdUridine_synth_cat_dom; .
InterProIPR004802; Pseudouridine_synthase-related; .
InterProIPR002478; PUA; .
InterProIPR015947; PUA-like_domain; .
InterProIPR004521; Uncharacterised_CHP00451; .
PANTHERPTHR23127; PTHR23127; 1; .
PfamPF08068; DKCLD; 1; .
PfamPF01472; PUA; 1; .
PfamPF01509; TruB_N; 1; .
SMARTSM00359; PUA; 1; .
SUPFAMSSF55120; PsdUridine_synth_cat_dom; 1; .
SUPFAMSSF88697; PUA-like; 1; .
TIGRFAMsTIGR00425; CBF5; 1; .
TIGRFAMsTIGR00451; Unchar_dom_2; 1; .
PROSITEPS50890; PUA; 1; .



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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server