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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: P26599




SWISS-2DPAGE:  P26599


P26599


General information about the entry
View entry in simple text format
Entry namePTBP1_HUMAN
Primary accession numberP26599
integrated into SWISS-2DPAGE on May 15, 2003 (release 16)
2D Annotations were last modified onMay 15, 2003 (version 1)
General Annotations were last modified on May 19, 2011 (version 6)
Name and origin of the protein
DescriptionRecName: Full=Polypyrimidine tract-binding protein 1; Short=PTB; AltName: Full=57 kDa RNA-binding protein PPTB-1; AltName: Full=Heterogeneous nuclear ribonucleoprotein I; Short=hnRNP I;.
Gene nameName=PTBP1
Synonyms=PTB
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
PubMed=12429849; [NCBI, ExPASy, EBI, Israel, Japan]
Scherl A., Coute Y., Deon C., Calle A., Kindbeiter K., Sanchez J.-C., Greco A., Hochstrasser D.F., Diaz J.-J.
''''''Functional proteomic analysis of human nucleolus'';'';''
Mol. Biol. Cell. 13(1):4100-4109(2002)
2D PAGE maps for identified proteins
How to interpret a protein

NUCLEOLI_HELA_1D_HUMAN {SDS-PAGE of nucleolar proteins from Human HeLa cells}
Homo sapiens (Human)
Tissue: Cervix carcinoma
NUCLEOLI_HELA_1D_HUMAN
  map experimental info
  protein estimated location
 
NUCLEOLI_HELA_1D_HUMAN

MAP LOCATIONS:
Mw=56716  [identification data]

MAPPING (identification):
Tandem mass spectrometry [1].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from license@isb-sib.ch).
Cross-references
UniProtKB/Swiss-ProtP26599; PTBP1_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry namePTBP1_HUMAN
Primary accession numberP26599
Sequence was last modified on August 1, 1992 (version 1)
Annotations were last modified on October 19, 2011 (version 139)
Name and origin of the protein
DescriptionRecName: Full=Polypyrimidine tract-binding protein 1; Short=PTB; AltName: Full=57 kDa RNA-binding protein PPTB-1; AltName: Full=Heterogeneous nuclear ribonucleoprotein I; Short=hnRNP I;
Gene nameName=PTBP1
Synonyms=PTB
Encoded onName=PTBP1; Synonyms=PTB
Keywords3D-structure; Acetylation; Activator; Alternative splicing; Complete proteome; Direct protein sequencing; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Repeat; Repressor; RNA-binding.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLX62006; CAA43973.1; -; mRNA
EMBLX65371; CAA46443.1; -; mRNA
EMBLX65372; CAA46444.1; -; mRNA
EMBLX60648; CAA43056.1; -; mRNA
EMBLX66975; CAA47386.1; -; mRNA
EMBLAC006273; AAC99798.1; -; Genomic_DNA
EMBLBC004383; AAH04383.1; -; mRNA
IPIIPI00179964; -; .
IPIIPI00334175; -; .
PIRS23016; S23016; .
RefSeqNP_002810.1; NM_002819.4; .
RefSeqNP_114367.1; NM_031990.3; .
RefSeqNP_114368.1; NM_031991.3; .
RefSeqNP_787041.1; NM_175847.2; .
UniGeneHs.172550; -; .
PDB1QM9; NMR; -; A=335-531
PDB1SJQ; NMR; -; A=55-147
PDB1SJR; NMR; -; A=147-301
PDB2AD9; NMR; -; A=49-146
PDB2ADB; NMR; -; A=172-298
PDB2ADC; NMR; -; A=324-531
PDB2EVZ; NMR; -; A=324-531
PDBsum1QM9; -; .
PDBsum1SJQ; -; .
PDBsum1SJR; -; .
PDBsum2AD9; -; .
PDBsum2ADB; -; .
PDBsum2ADC; -; .
PDBsum2EVZ; -; .
ProteinModelPortalP26599; -; .
SMRP26599; 49-531; .
IntActP26599; 20; .
MINTMINT-1348690; -; .
STRINGP26599; -; .
PhosphoSiteP26599; -; .
SWISS-2DPAGEP26599; -; .
Aarhus/Ghent-2DPAGE1505; NEPHGE; .
PRIDEP26599; -; .
EnsemblENST00000349038; ENSP00000014112; ENSG00000011304; .
GeneID5725; -; .
KEGGhsa:5725; -; .
UCSCuc002lpq.1; human; .
UCSCuc002lpr.1; human; .
CTD5725; -; .
GeneCardsGC19P000567; -; .
HGNCHGNC:9583; PTBP1; .
HPACAB013507; -; .
MIM600693; gene; .
neXtProtNX_P26599; -; .
eggNOGprNOG10547; -; .
HOVERGENHBG069548; -; .
PhylomeDBP26599; -; .
ReactomeREACT_1675; mRNA Processing; .
ReactomeREACT_71; Gene Expression; .
NextBio22252; -; .
PMAP-CutDBP26599; -; .
ArrayExpressP26599; -; .
BgeeP26599; -; .
CleanExHS_PTBP1; -; .
GenevestigatorP26599; -; .
GermOnlineENSG00000011304; Homo sapiens; .
GOGO:0030530; C:heterogeneous nuclear ribonucleoprotein complex; TAS:ProtInc; .
GOGO:0005730; C:nucleolus; TAS:ProtInc; .
GOGO:0005654; C:nucleoplasm; TAS:Reactome; .
GOGO:0003729; F:mRNA binding; IDA:UniProtKB; .
GOGO:0000166; F:nucleotide binding; IEA:InterPro; .
GOGO:0008187; F:poly-pyrimidine tract binding; TAS:ProtInc; .
GOGO:0005515; F:protein binding; IPI:IntAct; .
GOGO:0051148; P:negative regulation of muscle cell differentiation; IDA:UniProtKB; .
GOGO:0048025; P:negative regulation of nuclear mRNA splicing; via spliceosome; IDA:UniProtKB
GOGO:0000398; P:nuclear mRNA splicing; via spliceosome; TAS:Reactome
GOGO:0000381; P:regulation of alternative nuclear mRNA splicing; via spliceosome; IDA:UniProtKB
InterProIPR006536; HnRNP-L_PTB; .
InterProIPR012677; Nucleotide-bd_a/b_plait; .
InterProIPR000504; RRM_dom; .
Gene3DG3DSA:3.30.70.330; a_b_plait_nuc_bd; 4; .
PfamPF00076; RRM_1; 3; .
SMARTSM00360; RRM; 4; .
TIGRFAMsTIGR01649; HnRNP-L_PTB; 1; .
PROSITEPS50102; RRM; 4; .



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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server