Due to maintenance work, this service will not be available Thursday August 21st between 7am and 8am CEST.
World-2DPAGE Home


SWISS-2DPAGE 
Search by  [accession number] *
[description, ID or gene] 
[author names] 
[spot ID / serial number] 
[identification methods] 
[pI / Mw range] 
[combined fields] 

Maps  [experimental info] 
[protein list] 
[graphical interface]

     Select Remote Interfaces
[All Interfaces]
World-2DPAGE Portal
World-2DPAGE Repository

Exclude local DBs
has only effect if a remote
interface is selected
     

Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: P30043




SWISS-2DPAGE:  P30043


P30043


General information about the entry
View entry in simple text format
Entry nameBLVRB_HUMAN
Primary accession numberP30043
Secondary accession number(s) P32078
integrated into SWISS-2DPAGE on August 1, 1993 (release 0)
2D Annotations were last modified onMay 15, 2003 (version 2)
General Annotations were last modified on November 9, 2011 (version 14)
Name and origin of the protein
DescriptionRecName: Full=Flavin reductase (NADPH); Short=FR; EC=1.5.1.30; AltName: Full=Biliverdin reductase B; Short=BVR-B; EC=1.3.1.24; AltName: Full=Biliverdin-IX beta-reductase; AltName: Full=Green heme-binding protein; Short=GHBP; AltName: Full=NADPH-dependent diaphorase; AltName: Full=NADPH-flavin reductase; Short=FLR;.
Gene nameName=BLVRB
Synonyms=FLR
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
MEDLINE=93162045; PubMed=1286669; [NCBI, ExPASy, EBI, Israel, Japan]
Hochstrasser D.F., Frutiger S., Paquet N., Bairoch A., Ravier F., Pasquali C., Sanchez J.-C., Tissot J.-D., Bjellqvist B., Vargas R., Appel R.D., Hughes G.J.
''''''Human liver protein map: a reference database established by microsequencing and gel comparison'';'';''
Electrophoresis 13(1):992-1001(1992)
[2]   MAPPING ON GEL
MEDLINE=94147970; PubMed=8313871; [NCBI, ExPASy, EBI, Israel, Japan]
Golaz O., Hughes G.J., Frutiger S., Paquet N., Bairoch A., Pasquali C., Sanchez J.-C., Tissot J.-D., Appel R.D., Walzer C., Balant L.P., Hochstrasser D.F.
''''''Plasma and red blood cell protein maps: update 1993'';'';''
Electrophoresis 14(1):1223-1231(1993)
[3]   MAPPING ON GEL
MEDLINE=96007934; PubMed=7498157; [NCBI, ExPASy, EBI, Israel, Japan]
Sanchez J.-C., Appel R.D., Golaz O.G., Pasquali C., Ravier F., Bairoch A., Hochstrasser D.F.
''''''Inside SWISS-2DPAGE database'';'';''
Electrophoresis 16(1):1131-1151(1995)
2D PAGE maps for identified proteins
How to interpret a protein

LIVER_HUMAN {Liver}
Homo sapiens (Human)
Tissue: Liver
LIVER_HUMAN
  map experimental info
  protein estimated location
 
LIVER_HUMAN

MAP LOCATIONS:
pI=7.42; Mw=23488

MAPPING (identification):
MICROSEQUENCING [1].



RBC_HUMAN {Red blood cells}
Homo sapiens (Human)
Tissue: Erythrocyte
RBC_HUMAN
  map experimental info
  protein estimated location
 
RBC_HUMAN

MAP LOCATIONS:
pI=7.79; Mw=22515

MAPPING (identification):
MICROSEQUENCING [2].



U937_HUMAN {Macrophage Like Cell Line}
Homo sapiens (Human)
Tissue: Histiocytic lymphoma
U937_HUMAN
  map experimental info
  protein estimated location
 
U937_HUMAN

MAP LOCATIONS:
pI=6.33; Mw=29717
pI=7.34; Mw=22307

MAPPING (identification):
MATCHING WITH THE LIVER MASTER GEL [3].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from license@isb-sib.ch).
Cross-references
DOSAC-COBS 2D-PAGEP30043; P30043.
DOSAC-COBS-2DPAGEP30043; BLVRB_HUMAN.
REPRODUCTION-2DPAGEIPI00783862; IPI00783862.
UCD-2DPAGEP30043; BLVRB_HUMAN.
UniProtKB/Swiss-ProtP30043; BLVRB_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameBLVRB_HUMAN
Primary accession numberP30043
Secondary accession number(s) A6NKD8 B2R5C6 P32078 P53005 Q32LZ2
Sequence was last modified on January 23, 2007 (version 3)
Annotations were last modified on October 19, 2011 (version 117)
Name and origin of the protein
DescriptionRecName: Full=Flavin reductase (NADPH); Short=FR; EC=1.5.1.30; AltName: Full=Biliverdin reductase B; Short=BVR-B; EC=1.3.1.24; AltName: Full=Biliverdin-IX beta-reductase; AltName: Full=Green heme-binding protein; Short=GHBP; AltName: Full=NADPH-dependent diaphorase; AltName: Full=NADPH-flavin reductase; Short=FLR;
Gene nameName=BLVRB
Synonyms=FLR
Encoded onName=BLVRB; Synonyms=FLR
Keywords3D-structure; Complete proteome; Cytoplasm; Direct protein sequencing; NADP; Oxidoreductase; Polymorphism; Reference proteome.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLD26308; BAA05370.1; -; mRNA
EMBLD32143; BAA06874.1; -; mRNA
EMBLAK312137; BAG35073.1; -; mRNA
EMBLAY340485; AAP88933.1; -; Genomic_DNA
EMBLAC010271; -; NOT_ANNOTATED_CDS; Genomic_DNA
EMBLCH471126; EAW56969.1; -; Genomic_DNA
EMBLBC109371; AAI09372.1; -; mRNA
IPIIPI00783862; -; .
PIRJC2070; JC2070; .
RefSeqNP_000704.1; NM_000713.2; .
UniGeneHs.515785; -; .
PDB1HDO; X-ray; 1.15 A; A=1-206
PDB1HE2; X-ray; 1.20 A; A=1-206
PDB1HE3; X-ray; 1.40 A; A=1-206
PDB1HE4; X-ray; 1.40 A; A=1-206
PDB1HE5; X-ray; 1.50 A; A=1-206
PDBsum1HDO; -; .
PDBsum1HE2; -; .
PDBsum1HE3; -; .
PDBsum1HE4; -; .
PDBsum1HE5; -; .
ProteinModelPortalP30043; -; .
SMRP30043; 1-205; .
IntActP30043; 2; .
STRINGP30043; -; .
PhosphoSiteP30043; -; .
SWISS-2DPAGEP30043; -; .
DOSAC-COBS-2DPAGEP30043; -; .
REPRODUCTION-2DPAGEIPI00783862; -; .
UCD-2DPAGEP30043; -; .
PRIDEP30043; -; .
EnsemblENST00000263368; ENSP00000263368; ENSG00000090013; .
GeneID645; -; .
KEGGhsa:645; -; .
UCSCuc002onw.2; human; .
CTD645; -; .
GeneCardsGC19M037389; -; .
H-InvDBHIX0040129; -; .
HGNCHGNC:1063; BLVRB; .
HPAHPA041698; -; .
HPAHPA041937; -; .
MIM600941; gene; .
neXtProtNX_P30043; -; .
PharmGKBPA25374; -; .
eggNOGprNOG16594; -; .
GeneTreeENSGT00390000014810; -; .
HOGENOMHBG315541; -; .
HOVERGENHBG050695; -; .
InParanoidP30043; -; .
OMAPHIADEP; -; .
OrthoDBEOG4M0F2R; -; .
ReactomeREACT_9431; Metabolism of porphyrins; .
DrugBankDB00157; NADH; .
DrugBankDB00140; Riboflavin; .
NextBio2618; -; .
ArrayExpressP30043; -; .
BgeeP30043; -; .
CleanExHS_BLVRB; -; .
GenevestigatorP30043; -; .
GermOnlineENSG00000090013; Homo sapiens; .
GOGO:0005829; C:cytosol; IDA:UniProtKB; .
GOGO:0004074; F:biliverdin reductase activity; IDA:UniProtKB; .
GOGO:0005488; F:binding; IEA:InterPro; .
GOGO:0042602; F:flavin reductase activity; IDA:UniProtKB; .
GOGO:0042167; P:heme catabolic process; IDA:UniProtKB; .
InterProIPR016040; NAD(P)-bd_dom; .
InterProIPR008030; NmrA; .
Gene3DG3DSA:3.40.50.720; NAD(P)-bd; 1; .
PfamPF05368; NmrA; 1; .



SWISS-2DPAGE image

SWISS-2DPAGE (search AC)


Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server