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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: P07203




SWISS-2DPAGE:  P07203


P07203


General information about the entry
View entry in simple text format
Entry nameGPX1_HUMAN
Primary accession numberP07203
integrated into SWISS-2DPAGE on August 1, 1993 (release 0)
2D Annotations were last modified onMarch 31, 2004 (version 1)
General Annotations were last modified on May 19, 2011 (version 13)
Name and origin of the protein
DescriptionRecName: Full=Glutathione peroxidase 1; Short=GPx-1; Short=GSHPx-1; EC=1.11.1.9; AltName: Full=Cellular glutathione peroxidase;.
Gene nameName=GPX1
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
MEDLINE=93120196; PubMed=1477117; [NCBI, ExPASy, EBI, Israel, Japan]
Golaz O., Walzer C., Hochstrasser D.F., Bjellqvist B., Turler H., Balant L.P.
''''''Red blood cell protein map: a comparison between carrier-ampholyte pH gradient and immobilized pH gradient, and identification of four red blood cell enzymes'';'';''
Appl. Theor. Electrophor. 3(1):77-82(1992)
Comments
  • SUBUNIT: HOMOTETRAMER
2D PAGE maps for identified proteins
How to interpret a protein

RBC_HUMAN {Red blood cells}
Homo sapiens (Human)
Tissue: Erythrocyte
RBC_HUMAN
  map experimental info
  protein estimated location
 
RBC_HUMAN

MAP LOCATIONS:
pI=5.85; Mw=19224
pI=5.36; Mw=18964

PATHOLOGICAL LEVEL:
DECREASED IN A FORM OF HEMOLYTIC ANEMIA [1].

MAPPING (identification):
COMIGRATION [1].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from license@isb-sib.ch).
Cross-references
OGP-WWWP07203.
UniProtKB/Swiss-ProtP07203; GPX1_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameGPX1_HUMAN
Primary accession numberP07203
Secondary accession number(s) Q7Z5H1 Q9BW12
Sequence was last modified on November 2, 2010 (version 4)
Annotations were last modified on October 19, 2011 (version 141)
Name and origin of the protein
DescriptionRecName: Full=Glutathione peroxidase 1; Short=GPx-1; Short=GSHPx-1; EC=1.11.1.9; AltName: Full=Cellular glutathione peroxidase;
Gene nameName=GPX1
Encoded onName=GPX1
Keywords3D-structure; Acetylation; Complete proteome; Cytoplasm; Oxidoreductase; Peroxidase; Polymorphism; Reference proteome; Selenocysteine.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLY00433; CAA68491.1; -; mRNA
EMBLY00483; CAB37833.1; -; Genomic_DNA
EMBLX13709; CAA31992.1; -; mRNA
EMBLX13710; CAA31993.1; -; mRNA
EMBLM21304; AAA75389.2; -; mRNA
EMBLM83094; AAA67540.2; -; Genomic_DNA
EMBLAY327818; AAP80181.1; -; Genomic_DNA
EMBLAC121247; -; NOT_ANNOTATED_CDS; Genomic_DNA
EMBLBC000742; AAH00742.3; -; mRNA
IPIIPI00927606; -; .
PIRA42152; OPHUE; .
RefSeqNP_000572.2; NM_000581.2; .
RefSeqNP_958799.1; NM_201397.1; .
UniGeneHs.76686; -; .
PDB2F8A; X-ray; 1.50 A; A/B=14-196
PDBsum2F8A; -; .
ProteinModelPortalP07203; -; .
SMRP07203; 14-197; .
STRINGP07203; -; .
PeroxiBase3600; HsGPx01-a; .
PhosphoSiteP07203; -; .
SWISS-2DPAGEP07203; -; .
OGPP07203; -; .
PRIDEP07203; -; .
EnsemblENST00000419783; ENSP00000407375; ENSG00000233276; .
GeneID2876; -; .
KEGGhsa:2876; -; .
CTD2876; -; .
GeneCardsGC03M049369; -; .
H-InvDBHIX0003298; -; .
HGNCHGNC:4553; GPX1; .
HPACAB011582; -; .
MIM138320; gene+phenotype; .
neXtProtNX_P07203; -; .
PharmGKBPA28949; -; .
eggNOGprNOG12554; -; .
HOGENOMHBG648990; -; .
HOVERGENHBG004333; -; .
InParanoidP07203; -; .
OMACRNDISW; -; .
OrthoDBEOG4SBF08; -; .
BioCycMetaCyc:MONOMER-9882; -; .
ReactomeREACT_1698; Metabolism of nucleotides; .
DrugBankDB00143; Glutathione; .
NextBio11353; -; .
BgeeP07203; -; .
CleanExHS_GPX1; -; .
GenevestigatorP07203; -; .
GermOnlineENSG00000211447; Homo sapiens; .
GOGO:0005829; C:cytosol; TAS:Reactome; .
GOGO:0005739; C:mitochondrion; IDA:BHF-UCL; .
GOGO:0004866; F:endopeptidase inhibitor activity; IDA:BHF-UCL; .
GOGO:0004602; F:glutathione peroxidase activity; IDA:BHF-UCL; .
GOGO:0017124; F:SH3 domain binding; IPI:BHF-UCL; .
GOGO:0006916; P:anti-apoptosis; IMP:BHF-UCL; .
GOGO:0045454; P:cell redox homeostasis; IDA:BHF-UCL; .
GOGO:0006749; P:glutathione metabolic process; IDA:BHF-UCL; .
GOGO:0060047; P:heart contraction; IMP:BHF-UCL; .
GOGO:0042744; P:hydrogen peroxide catabolic process; IDA:BHF-UCL; .
GOGO:0043154; P:negative regulation of caspase activity; IMP:BHF-UCL; .
GOGO:0006144; P:purine base metabolic process; TAS:Reactome; .
GOGO:0006195; P:purine nucleotide catabolic process; TAS:Reactome; .
GOGO:0040029; P:regulation of gene expression; epigenetic; IDA:BHF-UCL
GOGO:0033599; P:regulation of mammary gland epithelial cell proliferation; IMP:BHF-UCL; .
GOGO:0061136; P:regulation of proteasomal protein catabolic process; IDA:BHF-UCL; .
GOGO:0001836; P:release of cytochrome c from mitochondria; IMP:BHF-UCL; .
GOGO:0010269; P:response to selenium ion; IMP:BHF-UCL; .
GOGO:0009650; P:UV protection; IMP:BHF-UCL; .
InterProIPR000889; Glutathione_peroxidase; .
InterProIPR012336; Thioredoxin-like_fold; .
Gene3DG3DSA:3.40.30.10; Thioredoxin_fold; 1; .
PANTHERPTHR11592; Glut_peroxidase; 1; .
PfamPF00255; GSHPx; 1; .
PIRSFPIRSF000303; Glutathion_perox; 1; .
PRINTSPR01011; GLUTPROXDASE; .
SUPFAMSSF52833; Thiordxn-like_fd; 1; .
PROSITEPS00460; GLUTATHIONE_PEROXID_1; 1; .
PROSITEPS00763; GLUTATHIONE_PEROXID_2; 1; .
PROSITEPS51355; GLUTATHIONE_PEROXID_3; 1; .



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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server