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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: P04179




SWISS-2DPAGE:  P04179


P04179


General information about the entry
View entry in simple text format
Entry nameSODM_HUMAN
Primary accession numberP04179
integrated into SWISS-2DPAGE on August 1, 1993 (release 0)
2D Annotations were last modified onMarch 31, 2004 (version 4)
General Annotations were last modified on May 19, 2011 (version 12)
Name and origin of the protein
DescriptionRecName: Full=Superoxide dismutase [Mn], mitochondrial; EC=1.15.1.1; Flags: Precursor;.
Gene nameName=SOD2
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
MEDLINE=93162045; PubMed=1286669; [NCBI, ExPASy, EBI, Israel, Japan]
Hochstrasser D.F., Frutiger S., Paquet N., Bairoch A., Ravier F., Pasquali C., Sanchez J.-C., Tissot J.-D., Bjellqvist B., Vargas R., Appel R.D., Hughes G.J.
''''''Human liver protein map: a reference database established by microsequencing and gel comparison'';'';''
Electrophoresis 13(1):992-1001(1992)
[2]   MAPPING ON GEL
MEDLINE=96007934; PubMed=7498157; [NCBI, ExPASy, EBI, Israel, Japan]
Sanchez J.-C., Appel R.D., Golaz O.G., Pasquali C., Ravier F., Bairoch A., Hochstrasser D.F.
''''''Inside SWISS-2DPAGE database'';'';''
Electrophoresis 16(1):1131-1151(1995)
[3]   MAPPING ON GEL
MEDLINE=97295305; PubMed=9150947; [NCBI, ExPASy, EBI, Israel, Japan]
Sarto C., Marocchi A., Sanchez J.-C., Giannone D., Frutiger S., Golaz O., Wilkins M.R., Doro G., Cappellano F., Hughes G.J., Hochstrasser D.F., Mocarelli P.
''''''Renal cell carcinoma and normal kidney protein expression'';'';''
Electrophoresis 18(1):599-604(1997)
[4]   MAPPING ON GEL
Tonella L., Hoogland C., Appel R.D., Sanchez J.-C., Hochstrasser D.F.
Submitted (JUL-1997) to SWISS-2DPAGE
[5]   MAPPING ON GEL
MEDLINE=96314065; PubMed=8740185; [NCBI, ExPASy, EBI, Israel, Japan]
Lutomski D., Caron M., Cornillot J.D., Bourin P., Dupuy C., Pontet M., Bladier D., Joubert-Caron R.
''''''Identification of different galectins by immunoblotting after two- dimensional polyacrylamide get electrophoresis with immobilized pH gradients'';'';''
Electrophoresis 17(1):600-606(1996)
[6]   MAPPING ON GEL
MEDLINE=98163346; PubMed=9504818; [NCBI, ExPASy, EBI, Israel, Japan]
Reymond M.A., Sanchez J.-C., Hughes G.J., Riese J., Tortola S., Peinado M.A., Kirchner T., Hohenberger W., Hochstrasser D.F., Kockerling F.
''''''Standardized characterization of gene expression in human colorectal epithelium by two-dimensional electrophoresis'';'';''
Electrophoresis 18(1):2842-2848(1997)
[7]   MAPPING ON GEL
Vuadens F., Crettaz D., Telenti A., Quadroni M., Duchosal M.A., Schneider P., Tissot J.-D.
''''''New insights into HIV lymphocyte infection'';'';''
(IN) Sanchez J.-C., Corthals G.L., Hochstrasser D.F. (eds.)Biomedical Application of Proteomics, pp.245-262, Wiley-VCH, Weinheim (2004)
Comments
  • SUBUNIT: HOMOTETRAMER
2D PAGE maps for identified proteins
How to interpret a protein

CEC_HUMAN {Colorectal epithelia cells}
Homo sapiens (Human)
Tissue: Colon epithelium
CEC_HUMAN
  map experimental info
  protein estimated location
 
CEC_HUMAN

MAP LOCATIONS:
pI=7.37; Mw=21201
pI=7.78; Mw=21256

MAPPING (identification):
IMMUNODETECTION [6].



HL60_HUMAN {Promyelocytic leukemia cells}
Homo sapiens (Human)
Tissue: Promyelocytic leukemia
HL60_HUMAN
  map experimental info
  protein estimated location
 
HL60_HUMAN

MAP LOCATIONS:
pI=6.94; Mw=18707
pI=7.32; Mw=18707

MAPPING (identification):
MATCHING WITH THE LIVER MASTER GEL [4][5].



KIDNEY_HUMAN {Kidney}
Homo sapiens (Human)
Tissue: Kidney
KIDNEY_HUMAN
  map experimental info
  protein estimated location
 
KIDNEY_HUMAN

MAP LOCATIONS:
pI=6.73; Mw=22324  [identification data]
pI=6.86; Mw=22283

MAPPING (identification):
MICROSEQUENCING AND AMINO ACID COMPOSITION ANALYSIS [3].



LIVER_HUMAN {Liver}
Homo sapiens (Human)
Tissue: Liver
LIVER_HUMAN
  map experimental info
  protein estimated location
 
LIVER_HUMAN

MAP LOCATIONS:
pI=6.76; Mw=21816
pI=6.96; Mw=21740

MAPPING (identification):
MICROSEQUENCING [1].



LYMPHOCYTE_HUMAN {Lymphocytes}
Homo sapiens (Human)
Tissue: Lymphocyte
LYMPHOCYTE_HUMAN
  map experimental info
  protein estimated location
 
LYMPHOCYTE_HUMAN

MAP LOCATIONS:
pI=7.53; Mw=22696  [identification data]

MAPPING (identification):
Peptide mass fingerprinting [7].



LYMPHOMA_HUMAN {Lymphoma}
Homo sapiens (Human)
Tissue: Lymphoma
LYMPHOMA_HUMAN
  map experimental info
  protein estimated location
 
LYMPHOMA_HUMAN

MAP LOCATIONS:
pI=7.00; Mw=21952

MAPPING (identification):
MATCHING WITH THE LIVER MASTER GEL [2].



U937_HUMAN {Macrophage Like Cell Line}
Homo sapiens (Human)
Tissue: Histiocytic lymphoma
U937_HUMAN
  map experimental info
  protein estimated location
 
U937_HUMAN

MAP LOCATIONS:
pI=6.95; Mw=21935

MAPPING (identification):
MATCHING WITH THE LIVER MASTER GEL [2].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from license@isb-sib.ch).
Cross-references
DOSAC-COBS 2D-PAGEP04179; P04179.
DOSAC-COBS-2DPAGEP04179; SODM_HUMAN.
HSC-2DPAGEP04179; HUMAN.
OGP-WWWP04179.
PMMA-2DPAGEP04179; SODM_HUMAN.
Siena-2DPAGEP04179; SODM_HUMAN.
UCD-2DPAGEP04179; SODM_HUMAN.
UniProtKB/Swiss-ProtP04179; SODM_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameSODM_HUMAN
Primary accession numberP04179
Secondary accession number(s) B2R7R1 E1P5A9 P78434 Q16792 Q5TCM1 Q96EE6 Q9P2Z3
Sequence was last modified on April 1, 1990 (version 2)
Annotations were last modified on October 19, 2011 (version 153)
Name and origin of the protein
DescriptionRecName: Full=Superoxide dismutase [Mn], mitochondrial; EC=1.15.1.1; Flags: Precursor;
Gene nameName=SOD2
Encoded onName=SOD2
Keywords3D-structure; Acetylation; Complete proteome; Direct protein sequencing; Manganese; Metal-binding; Mitochondrion; Nitration; Oxidoreductase; Polymorphism; Reference proteome; Transit peptide.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLX59445; CAA42066.1; -; mRNA
EMBLY00472; CAA68533.1; -; mRNA
EMBLY00985; CAA68791.1; -; mRNA
EMBLX07834; CAA30687.1; -; mRNA
EMBLM36693; AAA36622.1; -; mRNA
EMBLX15132; CAA33228.1; -; mRNA
EMBLX14322; CAA32502.1; -; mRNA
EMBLS77127; AAD14248.1; ALT_SEQ; Genomic_DNA
EMBLBT006967; AAP35613.1; -; mRNA
EMBLAY267901; AAP03428.1; -; Genomic_DNA
EMBLAK313082; BAG35908.1; -; mRNA
EMBLAL135914; CAI21845.1; -; Genomic_DNA
EMBLCH471051; EAW47630.1; -; Genomic_DNA
EMBLCH471051; EAW47631.1; -; Genomic_DNA
EMBLBC012423; AAH12423.1; -; mRNA
IPIIPI00022314; -; .
PIRS13162; DSHUN; .
RefSeqNP_000627.2; NM_000636.2; .
RefSeqNP_001019636.1; NM_001024465.1; .
UniGeneHs.487046; -; .
PDB1AP5; X-ray; 2.20 A; A/B=25-222
PDB1AP6; X-ray; 1.90 A; A/B=25-222
PDB1EM1; X-ray; 2.13 A; A/B=25-222
PDB1JA8; X-ray; 2.12 A; A/B=25-222
PDB1LUV; X-ray; 1.85 A; A/B=25-222
PDB1LUW; X-ray; 2.30 A; A/B=25-222
PDB1MSD; X-ray; 3.20 A; A/B=25-222
PDB1N0J; X-ray; 2.20 A; A/B=25-222
PDB1N0N; X-ray; 1.82 A; A/B=25-222
PDB1PL4; X-ray; 1.47 A; A/B/C/D=25-222
PDB1PM9; X-ray; 1.70 A; A/B=25-222
PDB1QNM; X-ray; 2.30 A; A/B=25-222
PDB1SZX; X-ray; 1.95 A; A/B=25-222
PDB1VAR; X-ray; 2.50 A; A/B=25-222
PDB1XDC; X-ray; 1.85 A; A/B=25-222
PDB1XIL; X-ray; 1.53 A; A/B=25-222
PDB1ZSP; X-ray; 1.90 A; A/B=25-222
PDB1ZTE; X-ray; 1.85 A; A/B/C/D=25-222
PDB1ZUQ; X-ray; 2.00 A; A/B=25-222
PDB2ADP; X-ray; 2.40 A; A=25-222
PDB2ADQ; X-ray; 2.40 A; B=25-222
PDB2GDS; X-ray; 2.30 A; A/B/C/D=25-222
PDB2P4K; X-ray; 1.48 A; A/B/C/D=25-222
PDB2QKA; X-ray; 2.20 A; A/C=25-220
PDB2QKC; X-ray; 2.30 A; A/C=25-220
PDB3C3S; X-ray; 2.50 A; A/B=25-222
PDB3C3T; X-ray; 2.20 A; A/B=25-222
PDBsum1AP5; -; .
PDBsum1AP6; -; .
PDBsum1EM1; -; .
PDBsum1JA8; -; .
PDBsum1LUV; -; .
PDBsum1LUW; -; .
PDBsum1MSD; -; .
PDBsum1N0J; -; .
PDBsum1N0N; -; .
PDBsum1PL4; -; .
PDBsum1PM9; -; .
PDBsum1QNM; -; .
PDBsum1SZX; -; .
PDBsum1VAR; -; .
PDBsum1XDC; -; .
PDBsum1XIL; -; .
PDBsum1ZSP; -; .
PDBsum1ZTE; -; .
PDBsum1ZUQ; -; .
PDBsum2ADP; -; .
PDBsum2ADQ; -; .
PDBsum2GDS; -; .
PDBsum2P4K; -; .
PDBsum2QKA; -; .
PDBsum2QKC; -; .
PDBsum3C3S; -; .
PDBsum3C3T; -; .
ProteinModelPortalP04179; -; .
SMRP04179; 25-222; .
IntActP04179; 18; .
MINTMINT-5002369; -; .
STRINGP04179; -; .
Allergome784; Hom s MnSOD; .
PhosphoSiteP04179; -; .
SWISS-2DPAGEP04179; -; .
DOSAC-COBS-2DPAGEP04179; -; .
OGPP04179; -; .
PMMA-2DPAGEP04179; -; .
Siena-2DPAGEP04179; -; .
UCD-2DPAGEP04179; -; .
PRIDEP04179; -; .
EnsemblENST00000337404; ENSP00000337127; ENSG00000112096; .
EnsemblENST00000367055; ENSP00000356022; ENSG00000112096; .
GeneID6648; -; .
KEGGhsa:6648; -; .
CTD6648; -; .
GeneCardsGC06M157570; -; .
HGNCHGNC:11180; SOD2; .
HPACAB002013; -; .
HPAHPA001814; -; .
MIM147460; gene; .
MIM612634; phenotype; .
neXtProtNX_P04179; -; .
eggNOGprNOG18046; -; .
HOGENOMHBG507761; -; .
HOVERGENHBG004451; -; .
InParanoidP04179; -; .
OrthoDBEOG4R503R; -; .
PhylomeDBP04179; -; .
Pathway_Interaction_DBfoxopathway; FoxO family signaling; .
NextBio25907; -; .
ArrayExpressP04179; -; .
BgeeP04179; -; .
CleanExHS_SOD2; -; .
GenevestigatorP04179; -; .
GermOnlineENSG00000112096; Homo sapiens; .
GOGO:0030145; F:manganese ion binding; IDA:UniProtKB; .
GOGO:0004784; F:superoxide dismutase activity; IDA:UniProtKB; .
GOGO:0001315; P:age-dependent response to reactive oxygen species; IMP:UniProtKB; .
GOGO:0043524; P:negative regulation of neuron apoptosis; IGI:BHF-UCL; .
GOGO:0032364; P:oxygen homeostasis; IMP:BHF-UCL; .
GOGO:0051289; P:protein homotetramerization; IPI:UniProtKB; .
GOGO:0006357; P:regulation of transcription from RNA polymerase II promoter; IMP:UniProtKB; .
GOGO:0001836; P:release of cytochrome c from mitochondria; ISS:BHF-UCL; .
GOGO:0019430; P:removal of superoxide radicals; IMP:BHF-UCL; .
GOGO:0003069; P:vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure; ISS:BHF-UCL; .
InterProIPR001189; Mn/Fe_SOD; .
InterProIPR019833; Mn/Fe_SOD_BS; .
InterProIPR019832; Mn/Fe_SOD_C; .
InterProIPR019831; Mn/Fe_SOD_N; .
PANTHERPTHR11404; SODismutase; 1; .
PfamPF02777; Sod_Fe_C; 1; .
PfamPF00081; Sod_Fe_N; 1; .
PIRSFPIRSF000349; SODismutase; 1; .
PRINTSPR01703; MNSODISMTASE; .
SUPFAMSSF46609; SODismutase; 1; .
SUPFAMSSF54719; SODismutase; 1; .
PROSITEPS00088; SOD_MN; 1; .



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SWISS-2DPAGE (search AC)


Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server