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World-2DPAGE Repository  Search by  [accession number]  [description, ID or gene]  [author names]  [spot ID / serial number]  [identification methods]  [pI / Mw range]  [combined fields]  Maps  [experimental info]  [protein list]  [graphical interface]      Databases 0001 0002 0003 0004 0005 0006 0007 0008 0009 0010 0011 0012 0014 0017 0018 0019 0020 0021 0022 0023 0024 0026 0027 0029 0030 0031 0032 0034 0035 0036 0037 0038 0039 0040 0042 0043 0044 0046 0047 0050 0051 0053 0054 0056 0059 0061 0062 0063 0066 0068 0069 0076 0077 0080 0084 0085 0088 use 'Ctrl' to select several databases Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal Exclude local DBs has only effect if a remote interface is selected

Searching in 'World-2DPAGE Repository [0019]' for entry matching: 1433E_HUMAN World-2DPAGE Repository (0019):  1433E_HUMAN 1433E_HUMAN General information about the entry View entry in simple text format Entry name 1433E_HUMAN Primary accession number P62258 Secondary accession number(s) Q4VJB6 integrated into World-2DPAGE Repository (0019) on  December 9, 2009 (release 1) 2D Annotations were last modified on May 30, 2011 (version 2) General Annotations were last modified on  January 13, 2012 (version 2) Name and origin of the protein Description RecName: Full=14-3-3 protein epsilon; Short=14-3-3E;. Gene name Name=YWHAE Annotated species Rattus norvegicus (Rat) [TaxID: 10116] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus. References [1]   2D-PAGE GEL CHARACTERIZATION DOI=10.1111/j.1471-4159.2010.06719.x; VanGuilder H.D., Yan H., Farley J.A., Sonntag W.E., Freeman W.M. ''Aging alters the expression of neurotransmission-regulating proteins in the hippocampal synaptoproteome'' J of Neurochemistry 113(6):1577-1588 (2010) 2D PAGE maps for identified proteins How to interpret a protein HIPP_SYNAP {Rat hippocampal synaptoproteome} Rattus norvegicus (Rat) Tissue: Hippocampus   map experimental info   HIPP_SYNAP MAP LOCATIONS: SPOT 1074: pI=4.63; Mw=29326   [identification data] IDENTIFICATION: SPOT 1074: Peptides number=14. SeqCov=54.1%. MOWSE score=1.06E+9 [1]. MAPPING (identification): SPOT 1074: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1]. Copyright Data from Dr. Willard Freeman, Penn State College of Medicine, USA Cross-references UniProtKB/Swiss-Prot P62258; 1433E_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 2011_12 Entry name 1433E_HUMAN Primary accession number P62258 Secondary accession number(s) B3KY71 D3DTH5 P29360 P42655 Q4VJB6 Q53XZ5 Q63631 Q7M4R4 Sequence was last modified on  July 5, 2004 (version 1) Annotations were last modified on  December 14, 2011 (version 95) Name and origin of the protein Description RecName: Full=14-3-3 protein epsilon; Short=14-3-3E; Gene name Name=YWHAE Encoded on Name=YWHAE Keywords 3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Host-virus interaction; Phosphoprotein; Reference proteome. Copyright Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL U20972; AAC50175.1; -; mRNA EMBL U54778; AAC50710.1; -; mRNA EMBL U43399; AAC50625.1; -; mRNA EMBL U43430; AAD00026.1; -; mRNA EMBL U28936; AAA75301.1; -; mRNA EMBL AB017103; BAA32538.1; -; Genomic_DNA EMBL AY883089; AAX68683.1; -; mRNA EMBL AK128785; BAG54733.1; -; mRNA EMBL AK295260; BAG58249.1; -; mRNA EMBL AK316185; BAH14556.1; -; mRNA EMBL BT007161; AAP35825.1; -; mRNA EMBL CH471108; EAW90628.1; -; Genomic_DNA EMBL CH471108; EAW90629.1; -; Genomic_DNA EMBL BC000179; AAH00179.1; -; mRNA EMBL BC001440; AAH01440.1; -; mRNA IPI IPI00000816; -; . IPI IPI00974544; -; . PIR A61235; A61235; . PIR I38947; I38947; . RefSeq NP_006752.1; NM_006761.4; . UniGene Hs.513851; -; . PDB 2BR9; X-ray; 1.75 A; A=1-233 PDBsum 2BR9; -; . ProteinModelPortal P62258; -; . SMR P62258; 3-232; . IntAct P62258; 84; . MINT MINT-4998623; -; . STRING P62258; -; . PhosphoSite P62258; -; . DMDM 51702210; -; . OGP P42655; -; . UCD-2DPAGE P62258; -; . PeptideAtlas P62258; -; . PRIDE P62258; -; . Ensembl ENST00000264335; ENSP00000264335; ENSG00000108953; . GeneID 7531; -; . KEGG hsa:7531; -; . UCSC uc002fsj.1; human; . CTD 7531; -; . GeneCards GC17M001148; -; . H-InvDB HIX0013397; -; . H-InvDB HIX0013751; -; . H-InvDB HIX0030006; -; . HGNC HGNC:12851; YWHAE; . HPA CAB016200; -; . HPA CAB021109; -; . HPA HPA008445; -; . MIM 605066; gene; . neXtProt NX_P62258; -; . Orphanet 217385; 17p13.3 microduplication syndrome; . PharmGKB PA37440; -; . eggNOG prNOG19467; -; . HOVERGEN HBG050423; -; . InParanoid P62258; -; . OMA KESALIM; -; . OrthoDB EOG4HHP34; -; . PhylomeDB P62258; -; . Pathway_Interaction_DB a6b1_a6b4_integrin_pathway; a6b1 and a6b4 Integrin signaling; . Pathway_Interaction_DB pi3kciaktpathway; Class I PI3K signaling events mediated by Akt; . Pathway_Interaction_DB foxopathway; FoxO family signaling; . Pathway_Interaction_DB igf1_pathway; IGF1 pathway; . Pathway_Interaction_DB insulin_glucose_pathway; Insulin-mediated glucose transport; . Pathway_Interaction_DB lis1pathway; Lissencephaly gene (LIS1) in neuronal migration and development; . Pathway_Interaction_DB p38_mk2pathway; p38 signaling mediated by MAPKAP kinases; . Pathway_Interaction_DB p75ntrpathway; p75(NTR)-mediated signaling; . Pathway_Interaction_DB telomerasepathway; Regulation of Telomerase; . Pathway_Interaction_DB nfat_3pathway; Role of Calcineurin-dependent NFAT signaling in lymphocytes; . Pathway_Interaction_DB hdac_classii_pathway; Signaling events mediated by HDAC Class II; . Pathway_Interaction_DB tgfbrpathway; TGF-beta receptor signaling; . Pathway_Interaction_DB pi3kplctrkpathway; Trk receptor signaling mediated by PI3K and PLC-gamma; . Reactome REACT_111102; Signal Transduction; . Reactome REACT_152; Cell Cycle; Mitotic; . NextBio 29461; -; . PMAP-CutDB P62258; -; . ArrayExpress P62258; -; . Bgee P62258; -; . CleanEx HS_YWHAE; -; . Genevestigator P62258; -; . GermOnline ENSG00000108953; Homo sapiens; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0042470; C:melanosome; IEA:UniProtKB-SubCell; . GO GO:0042826; F:histone deacetylase binding; IPI:BHF-UCL; . GO GO:0050815; F:phosphoserine binding; IPI:BHF-UCL; . GO GO:0006915; P:apoptotic process; TAS:Reactome; . GO GO:0000086; P:G2/M transition of mitotic cell cycle; TAS:Reactome; . GO GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome; . GO GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW; . GO GO:0035556; P:intracellular signal transduction; TAS:ProtInc; . GO GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome; . InterPro IPR000308; 14-3-3; . InterPro IPR023409; 14-3-3_CS; . InterPro IPR023410; 14-3-3_domain; . Gene3D G3DSA:1.20.190.20; 14-3-3; 1; . KO K06630; -; . PANTHER PTHR18860; 14-3-3; 1; . Pfam PF00244; 14-3-3; 1; . PIRSF PIRSF000868; 14-3-3; 1; . PRINTS PR00305; 1433ZETA; . SMART SM00101; 14_3_3; 1; . SUPFAM SSF48445; 14-3-3; 1; . PROSITE PS00796; 1433_1; 1; . PROSITE PS00797; 1433_2; 1; . World-2DPAGE Repository (search AC)