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World-2DPAGE Repository  Search by  [accession number]  [description, ID or gene]  [author names]  [spot ID / serial number]  [identification methods]  [pI / Mw range]  [combined fields]  Maps  [experimental info]  [protein list]  [graphical interface]      Databases 0001 0002 0003 0004 0005 0006 0007 0008 0009 0010 0011 0012 0014 0017 0018 0019 0020 0021 0022 0023 0024 0026 0027 0029 0030 0031 0032 0034 0035 0036 0037 0038 0039 0040 0042 0043 0044 0046 0047 0050 0051 0053 0054 0056 0059 0061 0062 0063 0066 0068 0069 0076 0077 0080 0084 0085 0088 use 'Ctrl' to select several databases Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal Exclude local DBs has only effect if a remote interface is selected

Searching in 'World-2DPAGE Repository [0054]' for entry matching: 1433Z_HUMAN World-2DPAGE Repository (0054):  1433Z_HUMAN 1433Z_HUMAN General information about the entry View entry in simple text format Entry name 1433Z_HUMAN Primary accession number P63104 integrated into World-2DPAGE Repository (0054) on  November 28, 2012 (release 1) 2D Annotations were last modified on November 28, 2012 (version 1) General Annotations were last modified on  October 23, 2014 (version 2) Name and origin of the protein Description RecName: Full=14-3-3 protein zeta/delta; AltName: Full=Protein kinase C inhibitor protein 1; Short=KCIP-1;. Gene name Name=YWHAZ Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION DOI=10.1074/mcp.M112.022947; Vernocchi S., Battello N., Schmitz S., Revets D., Billing A.M., Turner J.D., Muller C.P. ''Membrane glucocorticoid receptor activation induces proteomic changes aligning with classical glucocorticoid-effects'' Molecular & Cellular Proteomics 12(7):1764-1779 (2013) 2D PAGE maps for identified proteins How to interpret a protein HSAPIENS_CCRF-CEM_3-10 {CCRF-CEM cells stimulated with Cort-BSA (internal standard)} Homo sapiens (Human)   map experimental info   HSAPIENS_CCRF-CEM_3-10 MAP LOCATIONS: SPOT 1039: pI=5.57; Mw=29804   [identification data] %COV: SPOT 1039: 64 [1]. SCORE: SPOT 1039: 662 [1]. SEARCH ENGINE: SPOT 1039: Mascot [1]. MAPPING (identification): SPOT 1039: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1]. Copyright Data from Dr. Claude P. Muller, Centre de Recherche Public de la Sante / National Public Health Laboratory, Luxembourg Cross-references UniProtKB/Swiss-Prot P63104; 1433Z_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name 1433Z_HUMAN Primary accession number P63104 Secondary accession number(s) A8K1N0 B7Z465 P29213 P29312 Q32P43 Q5XJ08 Q6GPI2 Q6IN74 Q6NUR9 Q6P3U9 Q86V33 Sequence was last modified on  September 13, 2004 (version 1) Annotations were last modified on  October 1, 2014 (version 131) Name and origin of the protein Description RecName: Full=14-3-3 protein zeta/delta; AltName: Full=Protein kinase C inhibitor protein 1; Short=KCIP-1; Gene name Name=YWHAZ Encoded on Name=YWHAZ Keywords 3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Phosphoprotein; Reference proteome. Copyright Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL M86400; AAA36446.1; -; mRNA EMBL U28964; AAC52052.1; -; mRNA EMBL AK289945; BAF82634.1; -; mRNA EMBL AK296902; BAH12451.1; -; mRNA EMBL CH471060; EAW91823.1; -; Genomic_DNA EMBL BC003623; AAH03623.3; -; mRNA EMBL BC051814; AAH51814.1; ALT_INIT; mRNA EMBL BC063824; AAH63824.2; -; mRNA EMBL BC068456; AAH68456.2; -; mRNA EMBL BC072426; AAH72426.2; -; mRNA EMBL BC073141; AAH73141.1; ALT_INIT; mRNA EMBL BC083508; AAH83508.2; -; mRNA EMBL BC099904; AAH99904.1; -; mRNA EMBL BC101483; AAI01484.1; -; mRNA EMBL BC108281; AAI08282.1; -; mRNA EMBL BC111951; AAI11952.1; -; mRNA CCDS CCDS6290.1; -. [P63104-1]; . PIR A38246; PSHUAM; . RefSeq NP_001129171.1; NM_001135699.1. [P63104-1]; . RefSeq NP_001129172.1; NM_001135700.1. [P63104-1]; . RefSeq NP_001129173.1; NM_001135701.1. [P63104-1]; . RefSeq NP_001129174.1; NM_001135702.1. [P63104-1]; . RefSeq NP_003397.1; NM_003406.3. [P63104-1]; . RefSeq NP_663723.1; NM_145690.2. [P63104-1]; . RefSeq XP_005251118.1; XM_005251061.1. [P63104-1]; . RefSeq XP_005251119.1; XM_005251062.1. [P63104-1]; . RefSeq XP_005251120.1; XM_005251063.1. [P63104-1]; . UniGene Hs.492407; -; . PDB 1IB1; X-ray; 2.70 A; A/B/C/D=1-245 PDB 1QJA; X-ray; 2.00 A; A/B=1-245 PDB 1QJB; X-ray; 2.00 A; A/B=1-245 PDB 2C1J; X-ray; 2.60 A; A/B=1-245 PDB 2C1N; X-ray; 2.00 A; A/B=1-245 PDB 2O02; X-ray; 1.50 A; A/B=1-230 PDB 2WH0; X-ray; 2.25 A; A/B/C/D=1-245 PDB 3CU8; X-ray; 2.40 A; A/B=1-245 PDB 3NKX; X-ray; 2.40 A; A/B=1-245 PDB 3RDH; X-ray; 2.39 A; A/B/C/D=1-245 PDB 4BG6; X-ray; 2.30 A; A/B=1-245 PDB 4FJ3; X-ray; 1.95 A; A/B=1-230 PDB 4HKC; X-ray; 2.20 A; A=1-245 PDB 4IHL; X-ray; 2.20 A; A/B=1-230 PDB 4N7G; X-ray; 2.25 A; A=1-230 PDB 4N7Y; X-ray; 2.16 A; A/B=1-230 PDB 4N84; X-ray; 2.50 A; A/B=1-230 PDBsum 1IB1; -; . PDBsum 1QJA; -; . PDBsum 1QJB; -; . PDBsum 2C1J; -; . PDBsum 2C1N; -; . PDBsum 2O02; -; . PDBsum 2WH0; -; . PDBsum 3CU8; -; . PDBsum 3NKX; -; . PDBsum 3RDH; -; . PDBsum 4BG6; -; . PDBsum 4FJ3; -; . PDBsum 4HKC; -; . PDBsum 4IHL; -; . PDBsum 4N7G; -; . PDBsum 4N7Y; -; . PDBsum 4N84; -; . ProteinModelPortal P63104; -; . SMR P63104; 1-230; . BioGrid 113366; 367; . DIP DIP-563N; -; . IntAct P63104; 514; . MINT MINT-89071; -; . PhosphoSite P63104; -; . DMDM 52000887; -; . DOSAC-COBS-2DPAGE P63104; -; . OGP P63104; -; . UCD-2DPAGE P63104; -; . MaxQB P63104; -; . PaxDb P63104; -; . PRIDE P63104; -; . DNASU 7534; -; . Ensembl ENST00000353245; ENSP00000309503; ENSG00000164924. [P63104-1]; . Ensembl ENST00000395951; ENSP00000379281; ENSG00000164924. [P63104-1]; . Ensembl ENST00000395953; ENSP00000379283; ENSG00000164924. [P63104-1]; . Ensembl ENST00000395956; ENSP00000379286; ENSG00000164924. [P63104-1]; . Ensembl ENST00000395957; ENSP00000379287; ENSG00000164924. [P63104-1]; . Ensembl ENST00000395958; ENSP00000379288; ENSG00000164924. [P63104-1]; . Ensembl ENST00000419477; ENSP00000395114; ENSG00000164924. [P63104-1]; . Ensembl ENST00000457309; ENSP00000398599; ENSG00000164924. [P63104-1]; . Ensembl ENST00000522542; ENSP00000430072; ENSG00000164924. [P63104-2]; . GeneID 7534; -; . KEGG hsa:7534; -; . UCSC uc003yjv.2; human. [P63104-1]; . CTD 7534; -; . GeneCards GC08M101930; -; . HGNC HGNC:12855; YWHAZ; . HPA CAB005065; -; . MIM 601288; gene; . neXtProt NX_P63104; -; . PharmGKB PA37444; -; . eggNOG COG5040; -; . HOVERGEN HBG050423; -; . InParanoid P63104; -; . KO K16197; -; . OrthoDB EOG7HHWT3; -; . PhylomeDB P63104; -; . TreeFam TF102003; -; . Reactome REACT_147867; Translocation of GLUT4 to the plasma membrane; . Reactome REACT_200731; deactivation of the beta-catenin transactivating complex; . Reactome REACT_23837; Interleukin-3; 5 and GM-CSF signaling; . Reactome REACT_23847; GP1b-IX-V activation signalling; . Reactome REACT_23898; Rap1 signalling; . Reactome REACT_25042; KSRP destabilizes mRNA; . SignaLink P63104; -; . ChiTaRS YWHAZ; human; . EvolutionaryTrace P63104; -; . GeneWiki YWHAZ; -; . GenomeRNAi 7534; -; . NextBio 29475; -; . PRO PR:P63104; -; . ArrayExpress P63104; -; . Bgee P63104; -; . Genevestigator P63104; -; . GO GO:0072562; C:blood microparticle; IDA:UniProt; . GO GO:0031252; C:cell leading edge; IEA:Ensembl; . GO GO:0005737; C:cytoplasm; TAS:ProtInc; . GO GO:0030659; C:cytoplasmic vesicle membrane; TAS:Reactome; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0005615; C:extracellular space; IDA:UniProt; . GO GO:0070062; C:extracellular vesicular exosome; IDA:UniProtKB; . GO GO:0042629; C:mast cell granule; IEA:GOC; . GO GO:0042470; C:melanosome; IEA:UniProtKB-SubCell; . GO GO:0005739; C:mitochondrion; IEA:Ensembl; . GO GO:0005654; C:nucleoplasm; TAS:Reactome; . GO GO:0005634; C:nucleus; IDA:UniProt; . GO GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl; . GO GO:0014069; C:postsynaptic density; IEA:Ensembl; . GO GO:0043234; C:protein complex; IEA:Ensembl; . GO GO:0042802; F:identical protein binding; IPI:IntAct; . GO GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB; . GO GO:0005515; F:protein binding; IPI:UniProtKB; . GO GO:0019901; F:protein kinase binding; IPI:UniProtKB; . GO GO:0008134; F:transcription factor binding; IPI:UniProtKB; . GO GO:0006915; P:apoptotic process; TAS:Reactome; . GO GO:0007596; P:blood coagulation; TAS:Reactome; . GO GO:0010467; P:gene expression; TAS:Reactome; . GO GO:0002553; P:histamine secretion by mast cell; IEA:Ensembl; . GO GO:0097193; P:intrinsic apoptotic signaling pathway; TAS:Reactome; . GO GO:0061024; P:membrane organization; TAS:Reactome; . GO GO:0016071; P:mRNA metabolic process; TAS:Reactome; . GO GO:0043066; P:negative regulation of apoptotic process; TAS:ProtInc; . GO GO:0030168; P:platelet activation; TAS:Reactome; . GO GO:1900740; P:positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; TAS:Reactome; . GO GO:0006626; P:protein targeting to mitochondrion; IEA:Ensembl; . GO GO:0042493; P:response to drug; IEA:Ensembl; . GO GO:0016070; P:RNA metabolic process; TAS:Reactome; . GO GO:0007165; P:signal transduction; TAS:ProtInc; . Gene3D 1.20.190.20; -; 1; . InterPro IPR000308; 14-3-3; . InterPro IPR023409; 14-3-3_CS; . InterPro IPR023410; 14-3-3_domain; . PANTHER PTHR18860; PTHR18860; 1; . Pfam PF00244; 14-3-3; 1; . PIRSF PIRSF000868; 14-3-3; 1; . PRINTS PR00305; 1433ZETA; . SMART SM00101; 14_3_3; 1; . SUPFAM SSF48445; SSF48445; 1; . PROSITE PS00796; 1433_1; 1; . PROSITE PS00797; 1433_2; 1; . World-2DPAGE Repository (search AC)