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World-2DPAGE Repository  Search by  [accession number]  [description, ID or gene]  [author names]  [spot ID / serial number]  [identification methods]  [pI / Mw range]  [combined fields]  Maps  [experimental info]  [protein list]  [graphical interface]      Databases 0001 0002 0003 0004 0005 0006 0007 0008 0009 0010 0011 0012 0014 0017 0018 0019 0020 0021 0022 0023 0024 0026 0027 0029 0030 0031 0032 0034 0035 0036 0037 0038 0039 0040 0042 0043 0044 0046 0047 0050 0051 0053 0054 0056 0059 0061 0062 0063 0066 0068 0069 0076 0077 0080 0084 0085 0088 use 'Ctrl' to select several databases Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal Exclude local DBs has only effect if a remote interface is selected

Searching in 'World-2DPAGE Repository [0054]' for entry matching: CH60_HUMAN World-2DPAGE Repository (0054):  CH60_HUMAN CH60_HUMAN General information about the entry View entry in simple text format Entry name CH60_HUMAN Primary accession number P10809 integrated into World-2DPAGE Repository (0054) on  November 28, 2012 (release 1) 2D Annotations were last modified on November 28, 2012 (version 1) General Annotations were last modified on  October 23, 2014 (version 2) Name and origin of the protein Description RecName: Full=60 kDa heat shock protein, mitochondrial; AltName: Full=60 kDa chaperonin; AltName: Full=Chaperonin 60; Short=CPN60; AltName: Full=Heat shock protein 60; Short=HSP-60; Short=Hsp60; AltName: Full=HuCHA60; AltName: Full=Mitochondrial matrix protein P1; AltName: Full=P60 lymphocyte protein; Flags: Precursor;. Gene name Name=HSPD1 Synonyms=HSP60 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION DOI=10.1074/mcp.M112.022947; Vernocchi S., Battello N., Schmitz S., Revets D., Billing A.M., Turner J.D., Muller C.P. ''Membrane glucocorticoid receptor activation induces proteomic changes aligning with classical glucocorticoid-effects'' Molecular & Cellular Proteomics 12(7):1764-1779 (2013) 2D PAGE maps for identified proteins How to interpret a protein HSAPIENS_CCRF-CEM_3-10 {CCRF-CEM cells stimulated with Cort-BSA (internal standard)} Homo sapiens (Human)   map experimental info   HSAPIENS_CCRF-CEM_3-10 MAP LOCATIONS: SPOT 643: pI=5.24; Mw=57963   [identification data] %COV: SPOT 643: 50 [1]. SCORE: SPOT 643: 854 [1]. SEARCH ENGINE: SPOT 643: Mascot [1]. MAPPING (identification): SPOT 643: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1]. Copyright Data from Dr. Claude P. Muller, Centre de Recherche Public de la Sante / National Public Health Laboratory, Luxembourg Cross-references UniProtKB/Swiss-Prot P10809; CH60_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name CH60_HUMAN Primary accession number P10809 Secondary accession number(s) B2R5M6 B7Z712 Q38L19 Q9UCR6 Sequence was last modified on  August 1, 1990 (version 2) Annotations were last modified on  October 1, 2014 (version 181) Name and origin of the protein Description RecName: Full=60 kDa heat shock protein, mitochondrial; AltName: Full=60 kDa chaperonin; AltName: Full=Chaperonin 60; Short=CPN60; AltName: Full=Heat shock protein 60; Short=HSP-60; Short=Hsp60; AltName: Full=HuCHA60; AltName: Full=Mitochondrial matrix protein P1; AltName: Full=P60 lymphocyte protein; Flags: Precursor; Gene name Name=HSPD1 Synonyms=HSP60 Encoded on Name=HSPD1; Synonyms=HSP60 Keywords Acetylation; Alternative splicing; ATP-binding; Chaperone; Complete proteome; Direct protein sequencing; Disease mutation; Hereditary spastic paraplegia; Host-virus interaction; Leukodystrophy; Mitochondrion; Neurodegeneration; Nucleotide-binding; Phosphoprotein; Reference proteome; Transit peptide. Copyright Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL M22382; AAA60127.1; -; mRNA EMBL M34664; AAA36022.1; -; mRNA EMBL AJ250915; CAB75426.1; -; Genomic_DNA EMBL DQ217936; ABB01006.1; -; Genomic_DNA EMBL AK301276; BAH13448.1; -; mRNA EMBL AK312240; BAG35173.1; -; mRNA EMBL AC010746; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL AC020550; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL AC114809; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL BC002676; AAH02676.1; -; mRNA EMBL BC003030; AAH03030.1; -; mRNA EMBL BC067082; AAH67082.1; -; mRNA EMBL BC073746; AAH73746.1; -; mRNA CCDS CCDS33357.1; -; . PIR A32800; A32800; . RefSeq NP_002147.2; NM_002156.4; . RefSeq NP_955472.1; NM_199440.1; . RefSeq XP_005246575.1; XM_005246518.1; . UniGene Hs.595053; -; . UniGene Hs.727543; -; . ProteinModelPortal P10809; -; . SMR P10809; 27-551; . BioGrid 109561; 127; . DIP DIP-58N; -; . IntAct P10809; 67; . MINT MINT-1162735; -; . STRING 9606.ENSP00000340019; -; . ChEMBL CHEMBL4721; -; . PhosphoSite P10809; -; . DMDM 129379; -; . DOSAC-COBS-2DPAGE P10809; -; . OGP P10809; -; . REPRODUCTION-2DPAGE IPI00784154; -; . REPRODUCTION-2DPAGE P10809; -; . SWISS-2DPAGE P10809; -; . UCD-2DPAGE P10809; -; . MaxQB P10809; -; . PaxDb P10809; -; . PRIDE P10809; -; . DNASU 3329; -; . Ensembl ENST00000345042; ENSP00000340019; ENSG00000144381; . Ensembl ENST00000388968; ENSP00000373620; ENSG00000144381; . Ensembl ENST00000544407; ENSP00000441296; ENSG00000144381; . GeneID 3329; -; . KEGG hsa:3329; -; . UCSC uc002uui.3; human; . CTD 3329; -; . GeneCards GC02M198315; -; . HGNC HGNC:5261; HSPD1; . HPA CAB002775; -; . HPA HPA001523; -; . HPA HPA050025; -; . MIM 118190; gene; . MIM 605280; phenotype; . MIM 612233; phenotype; . neXtProt NX_P10809; -; . Orphanet 100994; Autosomal dominant spastic paraplegia type 13; . Orphanet 280288; Pelizaeus-Merzbacher-like due to HSPD1 mutation; . PharmGKB PA29527; -; . eggNOG COG0459; -; . HOGENOM HOG000076290; -; . HOVERGEN HBG001982; -; . InParanoid P10809; -; . KO K04077; -; . OMA NYKAANE; -; . OrthoDB EOG7HTHGJ; -; . PhylomeDB P10809; -; . TreeFam TF300475; -; . Reactome REACT_118595; Mitochondrial protein import; . ChiTaRS HSPD1; human; . GeneWiki GroEL; -; . GenomeRNAi 3329; -; . NextBio 13188; -; . PRO PR:P10809; -; . ArrayExpress P10809; -; . Bgee P10809; -; . CleanEx HS_HSPD1; -; . Genevestigator P10809; -; . GO GO:0009986; C:cell surface; IDA:UniProtKB; . GO GO:0005905; C:coated pit; IDA:BHF-UCL; . GO GO:0030135; C:coated vesicle; IDA:BHF-UCL; . GO GO:0005737; C:cytoplasm; IDA:UniProtKB; . GO GO:0005829; C:cytosol; IDA:UniProtKB; . GO GO:0005769; C:early endosome; IDA:BHF-UCL; . GO GO:0005615; C:extracellular space; IDA:BHF-UCL; . GO GO:0070062; C:extracellular vesicular exosome; IDA:UniProtKB; . GO GO:0046696; C:lipopolysaccharide receptor complex; IDA:BHF-UCL; . GO GO:0016020; C:membrane; IDA:UniProtKB; . GO GO:0005743; C:mitochondrial inner membrane; ISS:BHF-UCL; . GO GO:0005759; C:mitochondrial matrix; TAS:BHF-UCL; . GO GO:0005739; C:mitochondrion; IDA:UniProtKB; . GO GO:0005886; C:plasma membrane; IEA:Ensembl; . GO GO:0043234; C:protein complex; IDA:UniProtKB; . GO GO:0030141; C:secretory granule; ISS:BHF-UCL; . GO GO:0005524; F:ATP binding; IEA:UniProtKB-KW; . GO GO:0016887; F:ATPase activity; ISS:BHF-UCL; . GO GO:0051087; F:chaperone binding; IPI:UniProtKB; . GO GO:0003688; F:DNA replication origin binding; ISS:BHF-UCL; . GO GO:0003725; F:double-stranded RNA binding; IDA:MGI; . GO GO:0001530; F:lipopolysaccharide binding; IDA:BHF-UCL; . GO GO:0002039; F:p53 binding; IPI:UniProtKB; . GO GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB; . GO GO:0005515; F:protein binding; IPI:UniProtKB; . GO GO:0003697; F:single-stranded DNA binding; ISS:BHF-UCL; . GO GO:0051082; F:unfolded protein binding; IC:UniProtKB; . GO GO:0006458; P:'de novo' protein folding; ISS:BHF-UCL; . GO GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:BHF-UCL; . GO GO:0006200; P:ATP catabolic process; ISS:GOC; . GO GO:0042113; P:B cell activation; IDA:BHF-UCL; . GO GO:0002368; P:B cell cytokine production; IDA:BHF-UCL; . GO GO:0042100; P:B cell proliferation; IDA:BHF-UCL; . GO GO:0051131; P:chaperone-mediated protein complex assembly; ISS:BHF-UCL; . GO GO:0048291; P:isotype switching to IgG isotypes; IDA:BHF-UCL; . GO GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IDA:BHF-UCL; . GO GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB; . GO GO:0043065; P:positive regulation of apoptotic process; IMP:BHF-UCL; . GO GO:0032727; P:positive regulation of interferon-alpha production; IDA:BHF-UCL; . GO GO:0032729; P:positive regulation of interferon-gamma production; IDA:BHF-UCL; . GO GO:0032733; P:positive regulation of interleukin-10 production; IDA:BHF-UCL; . GO GO:0032735; P:positive regulation of interleukin-12 production; IDA:BHF-UCL; . GO GO:0032755; P:positive regulation of interleukin-6 production; IDA:BHF-UCL; . GO GO:0043032; P:positive regulation of macrophage activation; IDA:BHF-UCL; . GO GO:0050870; P:positive regulation of T cell activation; IDA:BHF-UCL; . GO GO:0002842; P:positive regulation of T cell mediated immune response to tumor cell; IDA:BHF-UCL; . GO GO:0051604; P:protein maturation; ISS:BHF-UCL; . GO GO:0042026; P:protein refolding; IDA:UniProtKB; . GO GO:0050821; P:protein stabilization; IMP:UniProtKB; . GO GO:0006986; P:response to unfolded protein; IDA:BHF-UCL; . GO GO:0042110; P:T cell activation; IDA:MGI; . GO GO:0016032; P:viral process; IEA:UniProtKB-KW; . Gene3D 1.10.560.10; -; 2; . Gene3D 3.50.7.10; -; 1; . HAMAP MF_00600; CH60; 1; . InterPro IPR018370; Chaperonin_Cpn60_CS; . InterPro IPR001844; Chaprnin_Cpn60; . InterPro IPR002423; Cpn60/TCP-1; . InterPro IPR027409; GroEL-like_apical_dom; . InterPro IPR027413; GROEL-like_equatorial; . PANTHER PTHR11353; PTHR11353; 1; . Pfam PF00118; Cpn60_TCP1; 1; . PRINTS PR00298; CHAPERONIN60; . SUPFAM SSF48592; SSF48592; 2; . SUPFAM SSF52029; SSF52029; 1; . TIGRFAMs TIGR02348; GroEL; 1; . PROSITE PS00296; CHAPERONINS_CPN60; 1; . World-2DPAGE Repository (search AC)