World-2DPAGE Repository

RecName: Full=60 kDa heat shock protein, mitochondrial; AltName: Full=60 kDa chaperonin; AltName: Full=Chaperonin 60; Short=CPN60; AltName: Full=HSP-65; AltName: Full=Heat shock protein 60; Short=HSP-60; Short=Hsp60; AltName: Full=Mitochondrial matrix protein P1; Flags: Precursor;.

Gene name

Name=Hspd1
Synonyms=Hsp60

Annotated species

Rattus norvegicus (Rat) [TaxID: 10116]

Taxonomy

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.

References

[1]	MAPPING ON GEL PubMed=19343716; DOI=10.1002/pmic.200800664; [NCBI, EBI, Israel, Japan] Maurya D.K., Sundaram C.S., Bhargava P. ''Proteome profile of the mature rat olfactory bulb'' Proteomics 9(1):2593-2599 (2009)

2D PAGE maps for identified proteins

How to interpret a protein

OB21DSUB {2-DE gel for Olfactory bulb proteome}
Rattus norvegicus (Rat)
Tissue: Olfactory bulb

map experimental info

OB21DSUB

MAP LOCATIONS:

SPOT 298:

pI=5.53; Mw=56000

[identification data]

MAPPING (identification):

SPOT 298: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1].

Copyright

Data from Dr. Purnima Bhargava, Centre for Cellular and Molecular Biology, India

Cross-references

UniProtKB/Swiss-Prot

P63039; CH60_RAT.

2D PAGE maps for identified proteins
How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.

External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_12
Entry name	CH60_RAT
Primary accession number	P63039
Secondary accession number(s)	P19226 P19227 P97602
Sequence was last modified on	August 31, 2004 (version 1)
Annotations were last modified on	November 16, 2011 (version 74)
Name and origin of the protein
Description	RecName: Full=60 kDa heat shock protein, mitochondrial; AltName: Full=60 kDa chaperonin; AltName: Full=Chaperonin 60; Short=CPN60; AltName: Full=HSP-65; AltName: Full=Heat shock protein 60; Short=HSP-60; Short=Hsp60; AltName: Full=Mitochondrial matrix protein P1; Flags: Precursor;
Gene name	Name=Hspd1 Synonyms=Hsp60
Encoded on	Name=Hspd1; Synonyms=Hsp60
Keywords	Acetylation; ATP-binding; Chaperone; Complete proteome; Direct protein sequencing; Mitochondrion; Nucleotide-binding; Phosphoprotein; Reference proteome; Transit peptide.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBL	X54793; CAA38564.1; -; mRNA
EMBL	U68562; AAC53362.1; -; Genomic_DNA
EMBL	BC086507; AAH86507.1; -; mRNA
EMBL	X53585; CAA37654.1; -; mRNA
IPI	IPI00339148; -; .
PIR	S13089; HHRT60; .
RefSeq	NP_071565.2; NM_022229.2; .
UniGene	Rn.102058; -; .
ProteinModelPortal	P63039; -; .
SMR	P63039; 27-554; .
IntAct	P63039; 2; .
MINT	MINT-1860257; -; .
STRING	P63039; -; .
PhosphoSite	P63039; -; .
World-2DPAGE	0004:P63039; -; .
PRIDE	P63039; -; .
Ensembl	ENSRNOT00000019912; ENSRNOP00000019912; ENSRNOG00000014525; .
GeneID	63868; -; .
KEGG	rno:63868; -; .
UCSC	NM_022229; rat; .
CTD	3329; -; .
RGD	621314; Hspd1; .
eggNOG	roNOG14286; -; .
GeneTree	ENSGT00390000005727; -; .
HOVERGEN	HBG001982; -; .
InParanoid	P63039; -; .
OrthoDB	EOG4PK27J; -; .
PhylomeDB	P63039; -; .
NextBio	612488; -; .
Genevestigator	P63039; -; .
GermOnline	ENSRNOG00000014525; Rattus norvegicus; .
GO	GO:0009986; C:cell surface; IDA:RGD; .
GO	GO:0005829; C:cytosol; IDA:RGD; .
GO	GO:0005794; C:Golgi apparatus; IDA:RGD; .
GO	GO:0045121; C:membrane raft; IDA:RGD; .
GO	GO:0030061; C:mitochondrial crista; IDA:RGD; .
GO	GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell; .
GO	GO:0005791; C:rough endoplasmic reticulum; IDA:RGD; .
GO	GO:0042588; C:zymogen granule; IDA:RGD; .
GO	GO:0005524; F:ATP binding; IEA:UniProtKB-KW; .
GO	GO:0043559; F:insulin binding; IPI:RGD; .
GO	GO:0051787; F:misfolded protein binding; IPI:RGD; .
GO	GO:0002020; F:protease binding; IPI:RGD; .
GO	GO:0046982; F:protein heterodimerization activity; IPI:RGD; .
GO	GO:0006916; P:anti-apoptosis; IMP:RGD; .
GO	GO:0051085; P:chaperone mediated protein folding requiring cofactor; IDA:RGD; .
GO	GO:0002236; P:detection of misfolded protein; IDA:RGD; .
GO	GO:0045768; P:positive regulation of anti-apoptosis; IMP:RGD; .
GO	GO:0050729; P:positive regulation of inflammatory response; IDA:RGD; .
GO	GO:0042026; P:protein refolding; IEA:InterPro; .
GO	GO:0033198; P:response to ATP; IEP:RGD; .
GO	GO:0042220; P:response to cocaine; IEP:RGD; .
GO	GO:0042493; P:response to drug; IEP:RGD; .
GO	GO:0043627; P:response to estrogen stimulus; IEP:RGD; .
GO	GO:0009408; P:response to heat; IEP:RGD; .
GO	GO:0042542; P:response to hydrogen peroxide; IEP:RGD; .
GO	GO:0001666; P:response to hypoxia; IEP:RGD; .
GO	GO:0032496; P:response to lipopolysaccharide; IEP:RGD; .
InterPro	IPR018370; Chaperonin_Cpn60_CS; .
InterPro	IPR001844; Chaprnin_Cpn60; .
InterPro	IPR002423; Cpn60/TCP-1; .
KO	K04077; -; .
PANTHER	PTHR11353; Cpn60/TCP-1; 1; .
Pfam	PF00118; Cpn60_TCP1; 1; .
PRINTS	PR00298; CHAPERONIN60; .
SUPFAM	SSF48592; GroEL-ATPase; 1; .
TIGRFAMs	TIGR02348; GroEL; 1; .
PROSITE	PS00296; CHAPERONINS_CPN60; 1; .

World-2DPAGE Repository (search AC)

Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the Expasy web server

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