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World-2DPAGE Repository  Search by  [accession number]  [description, ID or gene]  [author names]  [spot ID / serial number]  [identification methods]  [pI / Mw range]  [combined fields]  Maps  [experimental info]  [protein list]  [graphical interface]      Databases 0001 0002 0003 0004 0005 0006 0007 0008 0009 0010 0011 0012 0014 0017 0018 0019 0020 0021 0022 0023 0024 0026 0027 0029 0030 0031 0032 0034 0035 0036 0037 0038 0039 0040 0042 0043 0044 0046 0047 0050 0051 0053 0054 0056 0059 0061 0062 0063 0066 0068 0069 0076 0077 0080 0084 0085 0088 use 'Ctrl' to select several databases Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal Exclude local DBs has only effect if a remote interface is selected

Searching in 'World-2DPAGE Repository [0054]' for entry matching: COF1_HUMAN World-2DPAGE Repository (0054):  COF1_HUMAN COF1_HUMAN General information about the entry View entry in simple text format Entry name COF1_HUMAN Primary accession number P23528 integrated into World-2DPAGE Repository (0054) on  November 28, 2012 (release 1) 2D Annotations were last modified on November 28, 2012 (version 1) General Annotations were last modified on  October 23, 2014 (version 2) Name and origin of the protein Description RecName: Full=Cofilin-1; AltName: Full=18 kDa phosphoprotein; Short=p18; AltName: Full=Cofilin, non-muscle isoform;. Gene name Name=CFL1 Synonyms=CFL Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION DOI=10.1074/mcp.M112.022947; Vernocchi S., Battello N., Schmitz S., Revets D., Billing A.M., Turner J.D., Muller C.P. ''Membrane glucocorticoid receptor activation induces proteomic changes aligning with classical glucocorticoid-effects'' Molecular & Cellular Proteomics 12(7):1764-1779 (2013) 2D PAGE maps for identified proteins How to interpret a protein HSAPIENS_CCRF-CEM_3-10 {CCRF-CEM cells stimulated with Cort-BSA (internal standard)} Homo sapiens (Human)   map experimental info   HSAPIENS_CCRF-CEM_3-10 MAP LOCATIONS: SPOT 1219: pI=8.26; Mw=18371   [identification data] %COV: SPOT 1219: 83 [1]. SCORE: SPOT 1219: 478 [1]. SEARCH ENGINE: SPOT 1219: Mascot [1]. MAPPING (identification): SPOT 1219: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1]. Copyright Data from Dr. Claude P. Muller, Centre de Recherche Public de la Sante / National Public Health Laboratory, Luxembourg Cross-references UniProtKB/Swiss-Prot P23528; COF1_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name COF1_HUMAN Primary accession number P23528 Secondary accession number(s) B3KUQ1 Q53Y87 Q9UCA2 Sequence was last modified on  January 23, 2007 (version 3) Annotations were last modified on  October 1, 2014 (version 167) Name and origin of the protein Description RecName: Full=Cofilin-1; AltName: Full=18 kDa phosphoprotein; Short=p18; AltName: Full=Cofilin, non-muscle isoform; Gene name Name=CFL1 Synonyms=CFL Encoded on Name=CFL1; Synonyms=CFL Keywords 3D-structure; Acetylation; Actin-binding; Cell membrane; Cell projection; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Membrane; Nucleus; Phosphoprotein; Reference proteome. Copyright Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL D00682; BAA00589.1; -; mRNA EMBL U21909; AAA64501.1; -; mRNA EMBL X95404; CAA64685.1; -; mRNA EMBL BT006846; AAP35492.1; -; mRNA EMBL AK097690; BAG53513.1; -; mRNA EMBL CH471076; EAW74449.1; -; Genomic_DNA EMBL BC011005; AAH11005.1; -; mRNA EMBL BC012265; AAH12265.1; -; mRNA EMBL BC012318; AAH12318.1; -; mRNA EMBL BC018256; AAH18256.1; -; mRNA CCDS CCDS8114.1; -; . PIR S12632; S12632; . RefSeq NP_005498.1; NM_005507.2; . UniGene Hs.170622; -; . PDB 1Q8G; NMR; -; A=1-166 PDB 1Q8X; NMR; -; A=1-166 PDB 3J0S; EM; 9.00 A; M/N/O/P/Q/R/S/T/U/V/W/X=1-166 PDB 4BEX; X-ray; 2.80 A; 1=1-166 PDBsum 1Q8G; -; . PDBsum 1Q8X; -; . PDBsum 3J0S; -; . PDBsum 4BEX; -; . ProteinModelPortal P23528; -; . SMR P23528; 1-166; . BioGrid 107499; 56; . DIP DIP-33000N; -; . IntAct P23528; 44; . MINT MINT-4999473; -; . STRING 9606.ENSP00000309629; -; . ChEMBL CHEMBL1075129; -; . PhosphoSite P23528; -; . DMDM 116848; -; . DOSAC-COBS-2DPAGE P23528; -; . OGP P23528; -; . REPRODUCTION-2DPAGE IPI00012011; -; . SWISS-2DPAGE P23528; -; . UCD-2DPAGE P23528; -; . MaxQB P23528; -; . PaxDb P23528; -; . PRIDE P23528; -; . DNASU 1072; -; . Ensembl ENST00000308162; ENSP00000309629; ENSG00000172757; . Ensembl ENST00000525451; ENSP00000432660; ENSG00000172757; . GeneID 1072; -; . KEGG hsa:1072; -; . UCSC uc001ofs.3; human; . CTD 1072; -; . GeneCards GC11M065622; -; . H-InvDB HIX0009009; -; . HGNC HGNC:1874; CFL1; . HPA CAB037077; -; . MIM 601442; gene; . neXtProt NX_P23528; -; . PharmGKB PA26423; -; . eggNOG NOG286948; -; . HOGENOM HOG000039697; -; . HOVERGEN HBG000381; -; . InParanoid P23528; -; . KO K05765; -; . OrthoDB EOG7353Z9; -; . PhylomeDB P23528; -; . TreeFam TF328601; -; . Reactome REACT_160086; Regulation of actin dynamics for phagocytic cup formation; . Reactome REACT_19236; Sema3A PAK dependent Axon repulsion; . SignaLink P23528; -; . ChiTaRS CFL1; human; . EvolutionaryTrace P23528; -; . GeneWiki Cofilin_1; -; . GenomeRNAi 1072; -; . NextBio 4476; -; . PMAP-CutDB P23528; -; . PRO PR:P23528; -; . ArrayExpress P23528; -; . Bgee P23528; -; . Genevestigator P23528; -; . GO GO:0030864; C:cortical actin cytoskeleton; IEA:Ensembl; . GO GO:0005737; C:cytoplasm; TAS:UniProtKB; . GO GO:0005615; C:extracellular space; IDA:UniProt; . GO GO:0070062; C:extracellular vesicular exosome; IDA:UniProt; . GO GO:0031258; C:lamellipodium membrane; IEA:UniProtKB-SubCell; . GO GO:0016020; C:membrane; IDA:UniProtKB; . GO GO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell; . GO GO:0005634; C:nucleus; TAS:UniProtKB; . GO GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell; . GO GO:0031982; C:vesicle; IDA:UniProtKB; . GO GO:0005515; F:protein binding; IPI:IntAct; . GO GO:0030036; P:actin cytoskeleton organization; TAS:ProtInc; . GO GO:0030042; P:actin filament depolymerization; IEA:InterPro; . GO GO:0007411; P:axon guidance; TAS:Reactome; . GO GO:0007596; P:blood coagulation; TAS:Reactome; . GO GO:0007010; P:cytoskeleton organization; IMP:UniProtKB; . GO GO:0030010; P:establishment of cell polarity; IEA:Ensembl; . GO GO:0038096; P:Fc-gamma receptor signaling pathway involved in phagocytosis; TAS:Reactome; . GO GO:0045087; P:innate immune response; TAS:Reactome; . GO GO:0043066; P:negative regulation of apoptotic process; TAS:UniProtKB; . GO GO:0045792; P:negative regulation of cell size; IEA:Ensembl; . GO GO:0001755; P:neural crest cell migration; IEA:Ensembl; . GO GO:0001842; P:neural fold formation; IEA:Ensembl; . GO GO:0030168; P:platelet activation; TAS:Reactome; . GO GO:0002576; P:platelet degranulation; TAS:Reactome; . GO GO:0030836; P:positive regulation of actin filament depolymerization; IEA:Ensembl; . GO GO:0006606; P:protein import into nucleus; IEA:Ensembl; . GO GO:0006468; P:protein phosphorylation; IEA:Ensembl; . GO GO:0022604; P:regulation of cell morphogenesis; IMP:UniProtKB; . GO GO:0043200; P:response to amino acid; IEA:Ensembl; . GO GO:0009615; P:response to virus; IEP:UniProtKB; . GO GO:0007266; P:Rho protein signal transduction; TAS:ProtInc; . Gene3D 3.40.20.10; -; 1; . InterPro IPR002108; ADF-H; . InterPro IPR029006; ADF-H/Gelsolin-like_dom; . InterPro IPR017904; ADF/Cofilin/Destrin; . InterPro IPR027234; Cofilin_1; . PANTHER PTHR11913; PTHR11913; 1; . PANTHER PTHR11913:SF17; PTHR11913:SF17; 1; . Pfam PF00241; Cofilin_ADF; 1; . PRINTS PR00006; COFILIN; . SMART SM00102; ADF; 1; . PROSITE PS51263; ADF_H; 1; . World-2DPAGE Repository (search AC)