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World-2DPAGE Repository  Search by  [accession number]  [description, ID or gene]  [author names]  [spot ID / serial number]  [identification methods]  [pI / Mw range]  [combined fields]  Maps  [experimental info]  [protein list]  [graphical interface]      Databases 0001 0002 0003 0004 0005 0006 0007 0008 0009 0010 0011 0012 0014 0017 0018 0019 0020 0021 0022 0023 0024 0026 0027 0029 0030 0031 0032 0034 0035 0036 0037 0038 0039 0040 0042 0043 0044 0046 0047 0050 0051 0053 0054 0056 0059 0061 0062 0063 0066 0068 0069 0076 0077 0080 0084 0085 0088 use 'Ctrl' to select several databases Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal Exclude local DBs has only effect if a remote interface is selected

Searching in 'World-2DPAGE Repository [0054]' for entry matching: EF2_HUMAN World-2DPAGE Repository (0054):  EF2_HUMAN EF2_HUMAN General information about the entry View entry in simple text format Entry name EF2_HUMAN Primary accession number P13639 integrated into World-2DPAGE Repository (0054) on  November 28, 2012 (release 1) 2D Annotations were last modified on November 28, 2012 (version 1) General Annotations were last modified on  October 23, 2014 (version 2) Name and origin of the protein Description RecName: Full=Elongation factor 2; Short=EF-2;. Gene name Name=EEF2 Synonyms=EF2 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION DOI=10.1074/mcp.M112.022947; Vernocchi S., Battello N., Schmitz S., Revets D., Billing A.M., Turner J.D., Muller C.P. ''Membrane glucocorticoid receptor activation induces proteomic changes aligning with classical glucocorticoid-effects'' Molecular & Cellular Proteomics 12(7):1764-1779 (2013) 2D PAGE maps for identified proteins How to interpret a protein HSAPIENS_CCRF-CEM_3-10 {CCRF-CEM cells stimulated with Cort-BSA (internal standard)} Homo sapiens (Human)   map experimental info   HSAPIENS_CCRF-CEM_3-10 MAP LOCATIONS: SPOT 420: pI=6.42; Mw=95207   [identification data] %COV: SPOT 420: 51 [1]. SCORE: SPOT 420: 664 [1]. SEARCH ENGINE: SPOT 420: Mascot [1]. MAPPING (identification): SPOT 420: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1]. Copyright Data from Dr. Claude P. Muller, Centre de Recherche Public de la Sante / National Public Health Laboratory, Luxembourg Cross-references UniProtKB/Swiss-Prot P13639; EF2_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name EF2_HUMAN Primary accession number P13639 Secondary accession number(s) B2RMP5 D6W618 Q58J86 Sequence was last modified on  January 23, 2007 (version 4) Annotations were last modified on  October 1, 2014 (version 163) Name and origin of the protein Description RecName: Full=Elongation factor 2; Short=EF-2; Gene name Name=EEF2 Synonyms=EF2 Encoded on Name=EEF2; Synonyms=EF2 Keywords 3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Disease mutation; Elongation factor; GTP-binding; Neurodegeneration; Nucleotide-binding; Phosphoprotein; Protein biosynthesis; Reference proteome; Spinocerebellar ataxia; Ubl conjugation. Copyright Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL X51466; CAA35829.1; -; mRNA EMBL Z11692; CAA77750.1; -; mRNA EMBL AY942181; AAX34409.1; -; mRNA EMBL CH471139; EAW69274.1; -; Genomic_DNA EMBL CH471139; EAW69275.1; -; Genomic_DNA EMBL BC126259; AAI26260.1; -; mRNA EMBL BC136313; AAI36314.1; -; mRNA EMBL M19997; AAA50388.1; -; mRNA CCDS CCDS12117.1; -; . PIR S18294; EFHU2; . RefSeq NP_001952.1; NM_001961.3; . UniGene Hs.515070; -; . PDB 3J3A; EM; 5.00 A; z=1-858 PDBsum 3J3A; -; . ProteinModelPortal P13639; -; . SMR P13639; 3-858; . BioGrid 108258; 122; . IntAct P13639; 47; . MINT MINT-4999025; -; . STRING 9606.ENSP00000307940; -; . ChEMBL CHEMBL1795108; -; . PhosphoSite P13639; -; . DMDM 119172; -; . REPRODUCTION-2DPAGE IPI00186290; -; . MaxQB P13639; -; . PaxDb P13639; -; . PeptideAtlas P13639; -; . PRIDE P13639; -; . DNASU 1938; -; . Ensembl ENST00000309311; ENSP00000307940; ENSG00000167658; . GeneID 1938; -; . KEGG hsa:1938; -; . UCSC uc002lze.3; human; . CTD 1938; -; . GeneCards GC19M003976; -; . HGNC HGNC:3214; EEF2; . HPA CAB007795; -; . MIM 130610; gene; . MIM 609306; phenotype; . neXtProt NX_P13639; -; . Orphanet 101112; Spinocerebellar ataxia type 26; . PharmGKB PA27650; -; . eggNOG COG0480; -; . HOGENOM HOG000231589; -; . HOVERGEN HBG001838; -; . InParanoid P13639; -; . KO K03234; -; . OMA RWAPVPE; -; . OrthoDB EOG7WDN1S; -; . PhylomeDB P13639; -; . TreeFam TF300575; -; . Reactome REACT_1404; Peptide chain elongation; . ChiTaRS EEF2; human; . GeneWiki EEF2; -; . GenomeRNAi 1938; -; . NextBio 7853; -; . PRO PR:P13639; -; . ArrayExpress P13639; -; . Bgee P13639; -; . CleanEx HS_EEF2; -; . Genevestigator P13639; -; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0070062; C:extracellular vesicular exosome; IDA:UniProt; . GO GO:0016020; C:membrane; IDA:UniProtKB; . GO GO:0005634; C:nucleus; IDA:UniProt; . GO GO:0005844; C:polysome; IEA:Ensembl; . GO GO:0030529; C:ribonucleoprotein complex; IDA:MGI; . GO GO:0005525; F:GTP binding; IEA:UniProtKB-KW; . GO GO:0003924; F:GTPase activity; IEA:Ensembl; . GO GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB; . GO GO:0019901; F:protein kinase binding; IPI:UniProt; . GO GO:0008494; F:translation activator activity; IGI:UniProt; . GO GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW; . GO GO:0008219; P:cell death; IEA:UniProtKB-KW; . GO GO:0044267; P:cellular protein metabolic process; TAS:Reactome; . GO GO:0010467; P:gene expression; TAS:Reactome; . GO GO:0010628; P:positive regulation of gene expression; IGI:UniProt; . GO GO:0045727; P:positive regulation of translation; IGI:UniProt; . GO GO:0006412; P:translation; TAS:Reactome; . GO GO:0006414; P:translational elongation; TAS:Reactome; . Gene3D 3.30.230.10; -; 1; . Gene3D 3.30.70.240; -; 1; . Gene3D 3.40.50.300; -; 1; . InterPro IPR000795; EF_GTP-bd_dom; . InterPro IPR009022; EFG_III-V; . InterPro IPR000640; EFG_V; . InterPro IPR027417; P-loop_NTPase; . InterPro IPR020568; Ribosomal_S5_D2-typ_fold; . InterPro IPR014721; Ribosomal_S5_D2-typ_fold_subgr; . InterPro IPR005225; Small_GTP-bd_dom; . InterPro IPR009000; Transl_B-barrel; . InterPro IPR005517; Transl_elong_EFG/EF2_IV; . InterPro IPR004161; Transl_elong_EFTu/EF1A_2; . Pfam PF00679; EFG_C; 1; . Pfam PF14492; EFG_II; 1; . Pfam PF03764; EFG_IV; 1; . Pfam PF00009; GTP_EFTU; 1; . Pfam PF03144; GTP_EFTU_D2; 1; . PRINTS PR00315; ELONGATNFCT; . SMART SM00838; EFG_C; 1; . SMART SM00889; EFG_IV; 1; . SUPFAM SSF50447; SSF50447; 1; . SUPFAM SSF52540; SSF52540; 1; . SUPFAM SSF54211; SSF54211; 1; . SUPFAM SSF54980; SSF54980; 2; . TIGRFAMs TIGR00231; small_GTP; 1; . PROSITE PS00301; G_TR_1; 1; . PROSITE PS51722; G_TR_2; 1; . World-2DPAGE Repository (search AC)