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World-2DPAGE Repository  Search by  [accession number]  [description, ID or gene]  [author names]  [spot ID / serial number]  [identification methods]  [pI / Mw range]  [combined fields]  Maps  [experimental info]  [protein list]  [graphical interface]      Databases 0001 0002 0003 0004 0005 0006 0007 0008 0009 0010 0011 0012 0014 0017 0018 0019 0020 0021 0022 0023 0024 0026 0027 0029 0030 0031 0032 0034 0035 0036 0037 0038 0039 0040 0042 0043 0044 0046 0047 0050 0051 0053 0054 0056 0059 0061 0062 0063 0066 0068 0069 0076 0077 0080 0084 0085 0088 use 'Ctrl' to select several databases Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal Exclude local DBs has only effect if a remote interface is selected

Searching in 'World-2DPAGE Repository [0054]' for entry matching: HMGB1_HUMAN World-2DPAGE Repository (0054):  HMGB1_HUMAN HMGB1_HUMAN General information about the entry View entry in simple text format Entry name HMGB1_HUMAN Primary accession number P09429 integrated into World-2DPAGE Repository (0054) on  November 28, 2012 (release 1) 2D Annotations were last modified on November 28, 2012 (version 1) General Annotations were last modified on  October 23, 2014 (version 2) Name and origin of the protein Description RecName: Full=High mobility group protein B1; AltName: Full=High mobility group protein 1; Short=HMG-1;. Gene name Name=HMGB1 Synonyms=HMG1 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION DOI=10.1074/mcp.M112.022947; Vernocchi S., Battello N., Schmitz S., Revets D., Billing A.M., Turner J.D., Muller C.P. ''Membrane glucocorticoid receptor activation induces proteomic changes aligning with classical glucocorticoid-effects'' Molecular & Cellular Proteomics 12(7):1764-1779 (2013) 2D PAGE maps for identified proteins How to interpret a protein HSAPIENS_CCRF-CEM_3-10 {CCRF-CEM cells stimulated with Cort-BSA (internal standard)} Homo sapiens (Human)   map experimental info   HSAPIENS_CCRF-CEM_3-10 MAP LOCATIONS: SPOT 664: pI=5.60; Mw=24763   [identification data] %COV: SPOT 664: 43 [1]. SCORE: SPOT 664: 135 [1]. SEARCH ENGINE: SPOT 664: Mascot [1]. MAPPING (identification): SPOT 664: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1]. Copyright Data from Dr. Claude P. Muller, Centre de Recherche Public de la Sante / National Public Health Laboratory, Luxembourg Cross-references UniProtKB/Swiss-Prot P09429; HMGB1_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name HMGB1_HUMAN Primary accession number P09429 Secondary accession number(s) A5D8W9 Q14321 Q5T7C3 Q6IBE1 Sequence was last modified on  January 23, 2007 (version 3) Annotations were last modified on  October 1, 2014 (version 161) Name and origin of the protein Description RecName: Full=High mobility group protein B1; AltName: Full=High mobility group protein 1; Short=HMG-1; Gene name Name=HMGB1 Synonyms=HMG1 Encoded on Name=HMGB1; Synonyms=HMG1 Keywords 3D-structure; Acetylation; Chromosome; Complete proteome; Direct protein sequencing; DNA-binding; Isopeptide bond; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Ubl conjugation. Copyright Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL X12597; CAA31110.1; -; mRNA EMBL U51677; AAB08987.1; -; Genomic_DNA EMBL D63874; BAA09924.1; -; mRNA EMBL EF157968; ABM47301.1; -; Genomic_DNA EMBL AY377859; AAQ91389.1; -; mRNA EMBL AK291494; BAF84183.1; -; mRNA EMBL AK122825; BAG53745.1; -; mRNA EMBL CR749614; CAH18408.1; -; mRNA EMBL CR456863; CAG33144.1; -; mRNA EMBL BT006940; AAP35586.1; -; mRNA EMBL BT020159; AAV38961.1; -; mRNA EMBL EU012027; ABS29271.1; -; Genomic_DNA EMBL AL353648; CAI15600.1; -; Genomic_DNA EMBL CH471075; EAX08457.1; -; Genomic_DNA EMBL BC003378; AAH03378.1; -; mRNA EMBL BC030981; AAH30981.1; -; mRNA EMBL BC066889; AAH66889.1; -; mRNA EMBL BC067732; AAH67732.1; -; mRNA EMBL BC141844; AAI41845.1; -; mRNA CCDS CCDS9335.1; -; . PIR S02826; S02826; . RefSeq NP_002119.1; NM_002128.4; . RefSeq XP_005266420.1; XM_005266363.1; . RefSeq XP_005266422.1; XM_005266365.1; . UniGene Hs.434102; -; . UniGene Hs.593339; -; . UniGene Hs.596078; -; . PDB 2LY4; NMR; -; A=2-84 PDB 2RTU; NMR; -; A=1-84 PDB 2YRQ; NMR; -; A=1-166 PDBsum 2LY4; -; . PDBsum 2RTU; -; . PDBsum 2YRQ; -; . ProteinModelPortal P09429; -; . SMR P09429; 5-166; . BioGrid 109389; 63; . DIP DIP-24195N; -; . IntAct P09429; 19; . MINT MINT-153055; -; . STRING 9606.ENSP00000343040; -; . ChEMBL CHEMBL2311236; -; . PhosphoSite P09429; -; . DMDM 123369; -; . DOSAC-COBS-2DPAGE P09429; -; . MaxQB P09429; -; . PaxDb P09429; -; . PeptideAtlas P09429; -; . PRIDE P09429; -; . DNASU 3146; -; . Ensembl ENST00000339872; ENSP00000343040; ENSG00000189403; . Ensembl ENST00000341423; ENSP00000345347; ENSG00000189403; . Ensembl ENST00000399494; ENSP00000382417; ENSG00000189403; . Ensembl ENST00000405805; ENSP00000384678; ENSG00000189403; . GeneID 3146; -; . KEGG hsa:3146; -; . UCSC uc001usx.3; human; . CTD 3146; -; . GeneCards GC13M031032; -; . H-InvDB HIX0030745; -; . HGNC HGNC:4983; HMGB1; . HPA CAB005873; -; . HPA HPA003506; -; . MIM 163905; gene; . neXtProt NX_P09429; -; . PharmGKB PA188; -; . eggNOG COG5648; -; . HOGENOM HOG000197861; -; . HOVERGEN HBG009000; -; . InParanoid P09429; -; . KO K10802; -; . OMA DMGKPPV; -; . OrthoDB EOG7WHHBQ; -; . PhylomeDB P09429; -; . TreeFam TF105371; -; . Reactome REACT_118563; RIP-mediated NFkB activation via ZBP1; . Reactome REACT_13462; Activation of DNA fragmentation factor; . Reactome REACT_21281; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; . Reactome REACT_24969; TRAF6 mediated NF-kB activation; . Reactome REACT_25195; Advanced glycosylation endproduct receptor signaling; . ChiTaRS HMGB1; human; . EvolutionaryTrace P09429; -; . GeneWiki HMGB1; -; . GenomeRNAi 3146; -; . NextBio 12470; -; . PRO PR:P09429; -; . ArrayExpress P09429; -; . Bgee P09429; -; . CleanEx HS_HMGB1; -; . Genevestigator P09429; -; . GO GO:0009986; C:cell surface; IDA:UniProtKB; . GO GO:0000793; C:condensed chromosome; IDA:UniProtKB; . GO GO:0005576; C:extracellular region; TAS:Reactome; . GO GO:0005615; C:extracellular space; IDA:UniProtKB; . GO GO:0005654; C:nucleoplasm; TAS:Reactome; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:0042056; F:chemoattractant activity; ISS:UniProtKB; . GO GO:0005125; F:cytokine activity; ISS:UniProtKB; . GO GO:0003684; F:damaged DNA binding; ISS:UniProtKB; . GO GO:0008301; F:DNA binding; bending; IMP:UniProtKB GO GO:0003690; F:double-stranded DNA binding; ISS:UniProtKB; . GO GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB; . GO GO:0005515; F:protein binding; IPI:UniProtKB; . GO GO:0050786; F:RAGE receptor binding; ISS:UniProtKB; . GO GO:0070491; F:repressing transcription factor binding; IPI:UniProtKB; . GO GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:UniProtKB; . GO GO:0003697; F:single-stranded DNA binding; ISS:UniProtKB; . GO GO:0008134; F:transcription factor binding; IPI:UniProtKB; . GO GO:0006309; P:apoptotic DNA fragmentation; TAS:Reactome; . GO GO:0006915; P:apoptotic process; TAS:Reactome; . GO GO:0006288; P:base-excision repair; DNA ligation; IDA:UniProtKB GO GO:0006921; P:cellular component disassembly involved in execution phase of apoptosis; TAS:Reactome; . GO GO:0002407; P:dendritic cell chemotaxis; ISS:UniProtKB; . GO GO:0051103; P:DNA ligation involved in DNA repair; ISS:UniProtKB; . GO GO:0006310; P:DNA recombination; ISS:UniProtKB; . GO GO:0006265; P:DNA topological change; ISS:UniProtKB; . GO GO:0002437; P:inflammatory response to antigenic stimulus; IEP:UniProtKB; . GO GO:0045087; P:innate immune response; TAS:Reactome; . GO GO:0001773; P:myeloid dendritic cell activation; ISS:UniProtKB; . GO GO:2000426; P:negative regulation of apoptotic cell clearance; IEA:Ensembl; . GO GO:0017055; P:negative regulation of RNA polymerase II transcriptional preinitiation complex assembly; IDA:UniProtKB; . GO GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:UniProtKB; . GO GO:0031175; P:neuron projection development; ISS:UniProtKB; . GO GO:0050918; P:positive chemotaxis; ISS:GOC; . GO GO:0043065; P:positive regulation of apoptotic process; IDA:UniProtKB; . GO GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:UniProtKB; . GO GO:0043388; P:positive regulation of DNA binding; IDA:UniProtKB; . GO GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB; . GO GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB; . GO GO:0033151; P:V(D)J recombination; IDA:UniProtKB; . Gene3D 1.10.30.10; -; 2; . InterPro IPR009071; HMG_box_dom; . InterPro IPR017967; HMG_boxA_CS; . Pfam PF00505; HMG_box; 1; . Pfam PF09011; HMG_box_2; 1; . SMART SM00398; HMG; 2; . SUPFAM SSF47095; SSF47095; 2; . PROSITE PS00353; HMG_BOX_1; 1; . PROSITE PS50118; HMG_BOX_2; 2; . World-2DPAGE Repository (search AC)