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World-2DPAGE Repository  Search by  [accession number]  [description, ID or gene]  [author names]  [spot ID / serial number]  [identification methods]  [pI / Mw range]  [combined fields]  Maps  [experimental info]  [protein list]  [graphical interface]      Databases 0001 0002 0003 0004 0005 0006 0007 0008 0009 0010 0011 0012 0014 0017 0018 0019 0020 0021 0022 0023 0024 0026 0027 0029 0030 0031 0032 0034 0035 0036 0037 0038 0039 0040 0042 0043 0044 0046 0047 0050 0051 0053 0054 0056 0059 0061 0062 0063 0066 0068 0069 0076 0077 0080 0084 0085 0088 use 'Ctrl' to select several databases Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal Exclude local DBs has only effect if a remote interface is selected

Searching in 'World-2DPAGE Repository [0054]' for entry matching: LGUL_HUMAN World-2DPAGE Repository (0054):  LGUL_HUMAN LGUL_HUMAN General information about the entry View entry in simple text format Entry name LGUL_HUMAN Primary accession number Q04760 integrated into World-2DPAGE Repository (0054) on  November 28, 2012 (release 1) 2D Annotations were last modified on November 28, 2012 (version 1) General Annotations were last modified on  October 23, 2014 (version 2) Name and origin of the protein Description RecName: Full=Lactoylglutathione lyase; EC=4.4.1.5; AltName: Full=Aldoketomutase; AltName: Full=Glyoxalase I; Short=Glx I; AltName: Full=Ketone-aldehyde mutase; AltName: Full=Methylglyoxalase; AltName: Full=S-D-lactoylglutathione methylglyoxal lyase;. Gene name Name=GLO1 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION DOI=10.1074/mcp.M112.022947; Vernocchi S., Battello N., Schmitz S., Revets D., Billing A.M., Turner J.D., Muller C.P. ''Membrane glucocorticoid receptor activation induces proteomic changes aligning with classical glucocorticoid-effects'' Molecular & Cellular Proteomics 12(7):1764-1779 (2013) 2D PAGE maps for identified proteins How to interpret a protein HSAPIENS_CCRF-CEM_3-10 {CCRF-CEM cells stimulated with Cort-BSA (internal standard)} Homo sapiens (Human)   map experimental info   HSAPIENS_CCRF-CEM_3-10 MAP LOCATIONS: SPOT 1115: pI=5.44; Mw=23225   [identification data] %COV: SPOT 1115: 63 [1]. SCORE: SPOT 1115: 410 [1]. SEARCH ENGINE: SPOT 1115: Mascot [1]. MAPPING (identification): SPOT 1115: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1]. Copyright Data from Dr. Claude P. Muller, Centre de Recherche Public de la Sante / National Public Health Laboratory, Luxembourg Cross-references UniProtKB/Swiss-Prot Q04760; LGUL_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name LGUL_HUMAN Primary accession number Q04760 Secondary accession number(s) B2R6P7 B4DDV0 P78375 Q59EL0 Q5TZW3 Q96FC0 Q96J41 Sequence was last modified on  March 6, 2007 (version 4) Annotations were last modified on  October 1, 2014 (version 155) Name and origin of the protein Description RecName: Full=Lactoylglutathione lyase; EC=4.4.1.5; AltName: Full=Aldoketomutase; AltName: Full=Glyoxalase I; Short=Glx I; AltName: Full=Ketone-aldehyde mutase; AltName: Full=Methylglyoxalase; AltName: Full=S-D-lactoylglutathione methylglyoxal lyase; Gene name Name=GLO1 Encoded on Name=GLO1 Keywords 3D-structure; Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Disulfide bond; Glutathionylation; Lyase; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Zinc. Copyright Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL D13315; BAA02572.1; -; mRNA EMBL L07837; AAA52565.1; -; mRNA EMBL S83285; AAB49495.1; -; mRNA EMBL AF146651; AAD38008.1; -; Genomic_DNA EMBL AB209801; BAD93038.1; ALT_INIT; mRNA EMBL AK293345; BAG56861.1; -; mRNA EMBL AK312662; BAG35544.1; -; mRNA EMBL BT019987; AAV38790.1; -; mRNA EMBL BT019988; AAV38791.1; -; mRNA EMBL AL391415; CAI21586.1; -; Genomic_DNA EMBL BC001741; AAH01741.1; -; mRNA EMBL BC011365; AAH11365.1; -; mRNA EMBL BC015934; AAH15934.1; -; mRNA CCDS CCDS4837.1; -. [Q04760-1]; . PIR A46714; A46714; . PIR S63603; S63603; . RefSeq NP_006699.2; NM_006708.2. [Q04760-1]; . UniGene Hs.268849; -; . PDB 1BH5; X-ray; 2.20 A; A/B/C/D=2-184 PDB 1FRO; X-ray; 2.20 A; A/B/C/D=2-184 PDB 1QIN; X-ray; 2.00 A; A/B=2-184 PDB 1QIP; X-ray; 1.72 A; A/B/C/D=2-184 PDB 3VW9; X-ray; 1.47 A; A/B=1-184 PDB 3W0T; X-ray; 1.35 A; A/B/C/D=1-184 PDB 3W0U; X-ray; 1.70 A; A/B=1-184 PDBsum 1BH5; -; . PDBsum 1FRO; -; . PDBsum 1QIN; -; . PDBsum 1QIP; -; . PDBsum 3VW9; -; . PDBsum 3W0T; -; . PDBsum 3W0U; -; . ProteinModelPortal Q04760; -; . SMR Q04760; 3-184; . BioGrid 109001; 9; . IntAct Q04760; 3; . STRING 9606.ENSP00000362463; -; . BindingDB Q04760; -; . ChEMBL CHEMBL2424; -; . DrugBank DB00143; Glutathione; . PhosphoSite Q04760; -; . DMDM 134039205; -; . OGP Q04760; -; . REPRODUCTION-2DPAGE IPI00220766; -; . REPRODUCTION-2DPAGE Q04760; -; . MaxQB Q04760; -; . PaxDb Q04760; -; . PRIDE Q04760; -; . DNASU 2739; -; . Ensembl ENST00000373365; ENSP00000362463; ENSG00000124767. [Q04760-1]; . GeneID 2739; -; . KEGG hsa:2739; -; . UCSC uc003ooc.3; human. [Q04760-1]; . CTD 2739; -; . GeneCards GC06M038643; -; . HGNC HGNC:4323; GLO1; . HPA CAB040541; -; . HPA CAB040542; -; . MIM 138750; gene; . neXtProt NX_Q04760; -; . PharmGKB PA28724; -; . eggNOG COG0346; -; . HOVERGEN HBG025852; -; . InParanoid Q04760; -; . KO K01759; -; . OMA WALSRKA; -; . OrthoDB EOG7XPZ6W; -; . PhylomeDB Q04760; -; . TreeFam TF105011; -; . BRENDA 4.4.1.5; 2681; . SABIO-RK Q04760; -; . UniPathway UPA00619; UER00675; . EvolutionaryTrace Q04760; -; . GeneWiki GLO1; -; . GeneWiki Lactoylglutathione_lyase; -; . GenomeRNAi 2739; -; . NextBio 10796; -; . PRO PR:Q04760; -; . Bgee Q04760; -; . CleanEx HS_GLO1; -; . Genevestigator Q04760; -; . GO GO:0005737; C:cytoplasm; TAS:UniProtKB; . GO GO:0070062; C:extracellular vesicular exosome; IDA:UniProt; . GO GO:0004462; F:lactoylglutathione lyase activity; IDA:UniProtKB; . GO GO:0008270; F:zinc ion binding; IDA:UniProtKB; . GO GO:0005975; P:carbohydrate metabolic process; NAS:ProtInc; . GO GO:0006749; P:glutathione metabolic process; IEA:Ensembl; . GO GO:0009438; P:methylglyoxal metabolic process; IEA:Ensembl; . GO GO:0043066; P:negative regulation of apoptotic process; IDA:UniProtKB; . GO GO:0030316; P:osteoclast differentiation; ISS:UniProtKB; . GO GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IEA:Ensembl; . Gene3D 3.10.180.10; -; 1; . InterPro IPR029068; Glyas_Bleomycin-R_OHBP_Dase; . InterPro IPR004360; Glyas_Fos-R_dOase_dom; . InterPro IPR004361; Glyoxalase_1; . InterPro IPR018146; Glyoxalase_1_CS; . Pfam PF00903; Glyoxalase; 1; . SUPFAM SSF54593; SSF54593; 1; . TIGRFAMs TIGR00068; glyox_I; 1; . PROSITE PS00934; GLYOXALASE_I_1; 1; . PROSITE PS00935; GLYOXALASE_I_2; 1; . World-2DPAGE Repository (search AC)