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Searching in 'World-2DPAGE Repository [0030]' for entry matching: O89049

World-2DPAGE Repository (0030):  O89049


General information about the entry
View entry in simple text format
Entry nameTRXR1_RAT
Primary accession numberO89049
integrated into World-2DPAGE Repository (0030) on November 9, 2010 (release 1)
2D Annotations were last modified onJune 21, 2011 (version 2)
General Annotations were last modified on November 23, 2011 (version 2)
Name and origin of the protein
DescriptionRecName: Full=Thioredoxin reductase 1, cytoplasmic; Short=TR; EC=; AltName: Full=NADPH-dependent thioredoxin reductase; AltName: Full=Thioredoxin reductase TR1;.
Gene nameName=Txnrd1
Annotated speciesRattus norvegicus (Rat) [TaxID: 10116]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
D'Hertog W., Maris M., Thorrez L., Waelkens E., Overbergh L., Mathieu C.
''Two-dimensional gel proteome reference map of INS-1E cells''
Proteomics 11(7):1365-1369 (2011)
2D PAGE maps for identified proteins
How to interpret a protein

RAT_INS1E_4-7 {INS-1E cell line, a model rat cell line for pancreatic beta cells, PH4-7}
Rattus norvegicus (Rat)
  map experimental info

pI=6.20; Mw=67646  [identification data]

IDENTIFICATION: SPOT 850: Mascot protein score=44. Number of peptides=2 [1].
MAPPING (identification):
SPOT 850: Tandem mass spectrometry [1].

Data from Dr. Wannes D'Hertog, Catholic University Leuven, Belgium
UniProtKB/Swiss-ProtO89049; TRXR1_RAT.
World-2DPAGE RepositoryO89049; TRXR1_RAT.

2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.

External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_11
Entry nameTRXR1_RAT
Primary accession numberO89049
Secondary accession number(s) Q5U344 Q9JKZ3 Q9JKZ4 Q9R1I3
Sequence was last modified on November 16, 2011 (version 5)
Annotations were last modified on November 16, 2011 (version 103)
Name and origin of the protein
DescriptionRecName: Full=Thioredoxin reductase 1, cytoplasmic; Short=TR; EC=; AltName: Full=NADPH-dependent thioredoxin reductase; AltName: Full=Thioredoxin reductase TR1;
Gene nameName=Txnrd1
Encoded onName=Txnrd1; Synonyms=Trxr1
Keywords3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Disulfide bond; FAD; Flavoprotein; NADP; Oxidoreductase; Phosphoprotein; Redox-active center; Reference proteome; Selenocysteine.
Copyrighted by the UniProt Consortium, see Distributed under the Creative Commons Attribution-NoDerivs License
EMBLU63923; AAC35244.2; -; mRNA
EMBLAF108213; AAD43039.1; ALT_SEQ; mRNA
EMBLAF220760; AAF32362.1; -; mRNA
EMBLAF220761; AAF32363.1; -; mRNA
EMBLBC085726; AAH85726.1; ALT_INIT; mRNA
IPIIPI00454559; -; .
UniGeneRn.67581; -; .
PDB1H6V; X-ray; 3.00 A; A/B/C/D/E/F=1-498
PDB3EAN; X-ray; 2.75 A; A/B/C/D/E/F=1-498
PDB3EAO; X-ray; 3.10 A; A/B/C/D/E/F=1-498
PDBsum1H6V; -; .
PDBsum3EAN; -; .
PDBsum3EAO; -; .
ProteinModelPortalO89049; -; .
STRINGO89049; -; .
PhosphoSiteO89049; -; .
PRIDEO89049; -; .
UCSCU63923; rat; .
RGD61959; Txnrd1; .
eggNOGroNOG05959; -; .
GeneTreeENSGT00390000007578; -; .
HOVERGENHBG004959; -; .
InParanoidO89049; -; .
OrthoDBEOG4H463K; -; .
BioCycMetaCyc:MONOMER-15194; -; .
ArrayExpressO89049; -; .
GenevestigatorO89049; -; .
GOGO:0005829; C:cytosol; IDA:RGD; .
GOGO:0043025; C:neuronal cell body; IDA:RGD; .
GOGO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro; .
GOGO:0045340; F:mercury ion binding; IDA:RGD; .
GOGO:0016174; F:NAD(P)H oxidase activity; IDA:RGD; .
GOGO:0050661; F:NADP binding; IEA:InterPro; .
GOGO:0042803; F:protein homodimerization activity; IDA:RGD; .
GOGO:0033797; F:selenate reductase activity; IDA:RGD; .
GOGO:0004791; F:thioredoxin-disulfide reductase activity; IDA:RGD; .
GOGO:0042537; P:benzene-containing compound metabolic process; IDA:RGD; .
GOGO:0045454; P:cell redox homeostasis; IEA:InterPro; .
GOGO:0071455; P:cellular response to hyperoxia; IEP:RGD; .
GOGO:0006749; P:glutathione metabolic process; IEP:RGD; .
GOGO:0070276; P:halogen metabolic process; IEP:RGD; .
GOGO:0042744; P:hydrogen peroxide catabolic process; IMP:RGD; .
GOGO:0042191; P:methylmercury metabolic process; IEP:RGD; .
GOGO:0070995; P:NADPH oxidation; IDA:RGD; .
GOGO:0001890; P:placenta development; IEP:RGD; .
GOGO:0010942; P:positive regulation of cell death; IMP:RGD; .
GOGO:0051262; P:protein tetramerization; IDA:RGD; .
GOGO:0048678; P:response to axon injury; IEP:RGD; .
GOGO:0042493; P:response to drug; IEP:RGD; .
GOGO:0010269; P:response to selenium ion; IEP:RGD; .
GOGO:0016259; P:selenocysteine metabolic process; IMP:RGD; .
InterProIPR016156; FAD/NAD-linked_Rdtase_dimer; .
InterProIPR013027; FAD_pyr_nucl-diS_OxRdtase; .
InterProIPR004099; Pyr_nucl-diS_OxRdtase_dimer; .
InterProIPR023753; Pyr_nucl-diS_OxRdtase_FAD/NAD; .
InterProIPR012999; Pyr_OxRdtase_I_AS; .
InterProIPR001327; Pyr_OxRdtase_NAD-bd_dom; .
InterProIPR006338; Thioredoxin/glutathione_Rdtase; .
Gene3DG3DSA:3.30.390.30; Pyr_redox_dim; 1; .
PANTHERPTHR22912:SF23; Reduct_Se; 1; .
PfamPF00070; Pyr_redox; 1; .
PfamPF07992; Pyr_redox_2; 1; .
PfamPF02852; Pyr_redox_dim; 1; .
SUPFAMSSF55424; FAD/NAD-linked_reductase_dimer; 1; .
TIGRFAMsTIGR01438; TGR; 1; .

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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the Expasy web server