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World-2DPAGE Repository  Search by  [accession number]  [description, ID or gene]  [author names]  [spot ID / serial number]  [identification methods]  [pI / Mw range]  [combined fields]  Maps  [experimental info]  [protein list]  [graphical interface]      Databases 0001 0002 0003 0004 0005 0006 0007 0008 0009 0010 0011 0012 0014 0017 0018 0019 0020 0021 0022 0023 0024 0026 0027 0029 0030 0031 0032 0034 0035 0036 0037 0038 0039 0040 0042 0043 0044 0046 0047 0050 0051 0053 0054 0056 0059 0061 0062 0063 0066 0068 0069 0076 0077 0080 0084 0085 0088 use 'Ctrl' to select several databases Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal Exclude local DBs has only effect if a remote interface is selected

Searching in 'World-2DPAGE Repository [0054]' for entry matching: P11142 World-2DPAGE Repository (0054):  P11142 P11142 General information about the entry View entry in simple text format Entry name HSP7C_HUMAN Primary accession number P11142 integrated into World-2DPAGE Repository (0054) on  November 28, 2012 (release 1) 2D Annotations were last modified on November 28, 2012 (version 1) General Annotations were last modified on  October 23, 2014 (version 2) Name and origin of the protein Description RecName: Full=Heat shock cognate 71 kDa protein; AltName: Full=Heat shock 70 kDa protein 8; AltName: Full=Lipopolysaccharide-associated protein 1; Short=LAP-1; Short=LPS-associated protein 1;. Gene name Name=HSPA8 Synonyms=HSC70, HSP73, HSPA10 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION DOI=10.1074/mcp.M112.022947; Vernocchi S., Battello N., Schmitz S., Revets D., Billing A.M., Turner J.D., Muller C.P. ''Membrane glucocorticoid receptor activation induces proteomic changes aligning with classical glucocorticoid-effects'' Molecular & Cellular Proteomics 12(7):1764-1779 (2013) 2D PAGE maps for identified proteins How to interpret a protein HSAPIENS_CCRF-CEM_3-10 {CCRF-CEM cells stimulated with Cort-BSA (internal standard)} Homo sapiens (Human)   map experimental info   HSAPIENS_CCRF-CEM_3-10 MAP LOCATIONS: SPOT 535: pI=5.37; Mw=70767   [identification data] %COV: SPOT 535: 52 [1]. SCORE: SPOT 535: 901 [1]. SEARCH ENGINE: SPOT 535: Mascot [1]. MAPPING (identification): SPOT 535: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1]. Copyright Data from Dr. Claude P. Muller, Centre de Recherche Public de la Sante / National Public Health Laboratory, Luxembourg Cross-references UniProtKB/Swiss-Prot P11142; HSP7C_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name HSP7C_HUMAN Primary accession number P11142 Secondary accession number(s) Q9H3R6 Sequence was last modified on  July 1, 1989 (version 1) Annotations were last modified on  October 1, 2014 (version 182) Name and origin of the protein Description RecName: Full=Heat shock cognate 71 kDa protein; AltName: Full=Heat shock 70 kDa protein 8; AltName: Full=Lipopolysaccharide-associated protein 1; Short=LAP-1; Short=LPS-associated protein 1; Gene name Name=HSPA8 Synonyms=HSC70, HSP73, HSPA10 Encoded on Name=HSPA8; Synonyms=HSC70, HSP73, HSPA10 Keywords 3D-structure; Acetylation; Alternative splicing; ATP-binding; Cell membrane; Chaperone; Complete proteome; Cytoplasm; Direct protein sequencing; Host-virus interaction; Membrane; Methylation; mRNA processing; mRNA splicing; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repressor; Spliceosome; Stress response; Transcription; Transcription regulation; Ubl conjugation. Copyright Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL Y00371; CAA68445.1; -; Genomic_DNA EMBL AB034951; BAB18615.1; -; mRNA EMBL AF352832; AAK17898.1; -; mRNA EMBL BC016179; AAH16179.1; -; mRNA EMBL BC016660; AAH16660.1; -; mRNA EMBL BC019816; AAH19816.1; -; mRNA CCDS CCDS44754.1; -. [P11142-2]; . CCDS CCDS8440.1; -. [P11142-1]; . PIR A27077; A27077; . RefSeq NP_006588.1; NM_006597.5. [P11142-1]; . RefSeq NP_694881.1; NM_153201.3. [P11142-2]; . RefSeq XP_006718894.1; XM_006718831.1. [P11142-1]; . UniGene Hs.180414; -; . PDB 3AGY; X-ray; 1.85 A; C/D/F=639-646 PDB 3AGZ; X-ray; 2.51 A; C/D/E/F=639-646 PDB 3ESK; X-ray; 2.05 A; B=635-646 PDB 3FZF; X-ray; 2.20 A; A=4-381 PDB 3FZH; X-ray; 2.00 A; A=4-381 PDB 3FZK; X-ray; 2.10 A; A=4-381 PDB 3FZL; X-ray; 2.20 A; A=4-381 PDB 3FZM; X-ray; 2.30 A; A=4-381 PDB 3LDQ; X-ray; 1.90 A; A=4-381 PDB 3M3Z; X-ray; 2.10 A; A=4-381 PDB 4H5N; X-ray; 1.86 A; A/B=2-384 PDB 4H5R; X-ray; 1.64 A; A/B=2-384 PDB 4H5T; X-ray; 1.90 A; A=2-384 PDB 4H5V; X-ray; 1.75 A; A=2-384 PDB 4H5W; X-ray; 1.94 A; A/B=2-384 PDB 4HWI; X-ray; 2.27 A; A=5-381 PDBsum 3AGY; -; . PDBsum 3AGZ; -; . PDBsum 3ESK; -; . PDBsum 3FZF; -; . PDBsum 3FZH; -; . PDBsum 3FZK; -; . PDBsum 3FZL; -; . PDBsum 3FZM; -; . PDBsum 3LDQ; -; . PDBsum 3M3Z; -; . PDBsum 4H5N; -; . PDBsum 4H5R; -; . PDBsum 4H5T; -; . PDBsum 4H5V; -; . PDBsum 4H5W; -; . PDBsum 4HWI; -; . ProteinModelPortal P11142; -; . SMR P11142; 1-621; . BioGrid 109544; 254; . IntAct P11142; 91; . MINT MINT-4998609; -; . STRING 9606.ENSP00000227378; -; . BindingDB P11142; -; . ChEMBL CHEMBL1275223; -; . PhosphoSite P11142; -; . DMDM 123648; -; . DOSAC-COBS-2DPAGE P11142; -; . OGP P11142; -; . REPRODUCTION-2DPAGE IPI00003865; -; . SWISS-2DPAGE P11142; -; . UCD-2DPAGE P11142; -; . MaxQB P11142; -; . PaxDb P11142; -; . PeptideAtlas P11142; -; . PRIDE P11142; -; . DNASU 3312; -; . Ensembl ENST00000227378; ENSP00000227378; ENSG00000109971. [P11142-1]; . Ensembl ENST00000453788; ENSP00000404372; ENSG00000109971. [P11142-2]; . Ensembl ENST00000532636; ENSP00000437125; ENSG00000109971. [P11142-1]; . Ensembl ENST00000534624; ENSP00000432083; ENSG00000109971. [P11142-1]; . GeneID 3312; -; . KEGG hsa:3312; -; . UCSC uc001pyo.3; human. [P11142-1]; . UCSC uc001pyp.3; human. [P11142-2]; . CTD 3312; -; . GeneCards GC11M122969; -; . H-InvDB HIX0033867; -; . HGNC HGNC:5241; HSPA8; . HPA CAB002056; -; . MIM 600816; gene; . neXtProt NX_P11142; -; . PharmGKB PA29507; -; . eggNOG COG0443; -; . HOGENOM HOG000228135; -; . HOVERGEN HBG051845; -; . InParanoid P11142; -; . KO K03283; -; . OMA GENKIFT; -; . OrthoDB EOG7PCJGF; -; . PhylomeDB P11142; -; . TreeFam TF105042; -; . Reactome REACT_19287; Lysosome Vesicle Biogenesis; . Reactome REACT_19400; Golgi Associated Vesicle Biogenesis; . Reactome REACT_200624; Attenuation phase; . Reactome REACT_200775; HSF1-dependent transactivation; . Reactome REACT_200780; Regulation of HSF1-mediated heat shock response; . Reactome REACT_22292; CHL1 interactions; . Reactome REACT_23947; GABA synthesis; release; reuptake and degradation Reactome REACT_25325; AUF1 (hnRNP D0) destabilizes mRNA; . ChiTaRS HSPA8; human; . EvolutionaryTrace P11142; -; . GeneWiki HSPA8; -; . GenomeRNAi 3312; -; . NextBio 13136; -; . PMAP-CutDB P11142; -; . PRO PR:P11142; -; . ArrayExpress P11142; -; . Bgee P11142; -; . CleanEx HS_HSPA8; -; . Genevestigator P11142; -; . GO GO:0072562; C:blood microparticle; IDA:UniProt; . GO GO:0061202; C:clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane; TAS:Reactome; . GO GO:0005829; C:cytosol; IDA:UniProt; . GO GO:0005615; C:extracellular space; IDA:UniProt; . GO GO:0070062; C:extracellular vesicular exosome; IDA:UniProtKB; . GO GO:0005622; C:intracellular; NAS:UniProtKB; . GO GO:0042470; C:melanosome; IEA:UniProtKB-SubCell; . GO GO:0016020; C:membrane; IDA:UniProtKB; . GO GO:0005730; C:nucleolus; IDA:UniProtKB; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:0005886; C:plasma membrane; TAS:Reactome; . GO GO:0000974; C:Prp19 complex; IDA:UniProtKB; . GO GO:0030529; C:ribonucleoprotein complex; IDA:UniProtKB; . GO GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW; . GO GO:0005524; F:ATP binding; IDA:BHF-UCL; . GO GO:0016887; F:ATPase activity; IDA:BHF-UCL; . GO GO:0042623; F:ATPase activity; coupled; NAS:UniProtKB GO GO:0019899; F:enzyme binding; IPI:BHF-UCL; . GO GO:0031072; F:heat shock protein binding; IPI:BHF-UCL; . GO GO:0023026; F:MHC class II protein complex binding; IDA:UniProt; . GO GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB; . GO GO:0005515; F:protein binding; IPI:UniProtKB; . GO GO:0051082; F:unfolded protein binding; IDA:UniProt; . GO GO:0006200; P:ATP catabolic process; IDA:BHF-UCL; . GO GO:0007411; P:axon guidance; TAS:Reactome; . GO GO:0051085; P:chaperone mediated protein folding requiring cofactor; IEA:Ensembl; . GO GO:0010467; P:gene expression; TAS:Reactome; . GO GO:0061024; P:membrane organization; TAS:Reactome; . GO GO:0016071; P:mRNA metabolic process; TAS:Reactome; . GO GO:0006397; P:mRNA processing; IEA:UniProtKB-KW; . GO GO:1902904; P:negative regulation of fibril organization; IDA:BHF-UCL; . GO GO:0045892; P:negative regulation of transcription; DNA-templated; IDA:UniProtKB GO GO:0007269; P:neurotransmitter secretion; TAS:Reactome; . GO GO:0006892; P:post-Golgi vesicle-mediated transport; TAS:Reactome; . GO GO:0006457; P:protein folding; NAS:UniProtKB; . GO GO:0042026; P:protein refolding; IDA:UniProt; . GO GO:0051726; P:regulation of cell cycle; IEA:Ensembl; . GO GO:0006986; P:response to unfolded protein; NAS:UniProtKB; . GO GO:0016070; P:RNA metabolic process; TAS:Reactome; . GO GO:0008380; P:RNA splicing; IEA:UniProtKB-KW; . GO GO:0007268; P:synaptic transmission; TAS:Reactome; . GO GO:0006351; P:transcription; DNA-templated; IEA:UniProtKB-KW GO GO:0016032; P:viral process; IEA:UniProtKB-KW; . Gene3D 1.20.1270.10; -; 1; . Gene3D 2.60.34.10; -; 1; . InterPro IPR018181; Heat_shock_70_CS; . InterPro IPR029048; HSP70_C; . InterPro IPR029047; HSP70_peptide-bd; . InterPro IPR013126; Hsp_70_fam; . Pfam PF00012; HSP70; 1; . PRINTS PR00301; HEATSHOCK70; . SUPFAM SSF100920; SSF100920; 1; . SUPFAM SSF100934; SSF100934; 1; . PROSITE PS00297; HSP70_1; 1; . PROSITE PS00329; HSP70_2; 1; . PROSITE PS01036; HSP70_3; 1; . World-2DPAGE Repository (search AC)