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World-2DPAGE Repository  Search by  [accession number]  [description, ID or gene]  [author names]  [spot ID / serial number]  [identification methods]  [pI / Mw range]  [combined fields]  Maps  [experimental info]  [protein list]  [graphical interface]      Databases 0001 0002 0003 0004 0005 0006 0007 0008 0009 0010 0011 0012 0014 0017 0018 0019 0020 0021 0022 0023 0024 0026 0027 0029 0030 0031 0032 0034 0035 0036 0037 0038 0039 0040 0042 0043 0044 0046 0047 0050 0051 0053 0054 0056 0059 0061 0062 0063 0066 0068 0069 0076 0077 0080 0084 0085 0088 use 'Ctrl' to select several databases Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal Exclude local DBs has only effect if a remote interface is selected

Searching in 'World-2DPAGE Repository [0054]' for entry matching: P11940 World-2DPAGE Repository (0054):  P11940 P11940 General information about the entry View entry in simple text format Entry name PABP1_HUMAN Primary accession number P11940 integrated into World-2DPAGE Repository (0054) on  November 28, 2012 (release 1) 2D Annotations were last modified on November 28, 2012 (version 1) General Annotations were last modified on  October 23, 2014 (version 2) Name and origin of the protein Description RecName: Full=Polyadenylate-binding protein 1; Short=PABP-1; Short=Poly(A)-binding protein 1;. Gene name Name=PABPC1 Synonyms=PAB1, PABP1, PABPC2 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION DOI=10.1074/mcp.M112.022947; Vernocchi S., Battello N., Schmitz S., Revets D., Billing A.M., Turner J.D., Muller C.P. ''Membrane glucocorticoid receptor activation induces proteomic changes aligning with classical glucocorticoid-effects'' Molecular & Cellular Proteomics 12(7):1764-1779 (2013) 2D PAGE maps for identified proteins How to interpret a protein HSAPIENS_CCRF-CEM_3-10 {CCRF-CEM cells stimulated with Cort-BSA (internal standard)} Homo sapiens (Human)   map experimental info   HSAPIENS_CCRF-CEM_3-10 MAP LOCATIONS: SPOT 2971: pI=9.52; Mw=70671   [identification data] %COV: SPOT 2971: 22 [1]. SCORE: SPOT 2971: 210 [1]. SEARCH ENGINE: SPOT 2971: Mascot [1]. MAPPING (identification): SPOT 2971: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1]. Copyright Data from Dr. Claude P. Muller, Centre de Recherche Public de la Sante / National Public Health Laboratory, Luxembourg Cross-references UniProtKB/Swiss-Prot P11940; PABP1_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name PABP1_HUMAN Primary accession number P11940 Secondary accession number(s) Q15097 Q93004 Sequence was last modified on  July 15, 1998 (version 2) Annotations were last modified on  October 1, 2014 (version 186) Name and origin of the protein Description RecName: Full=Polyadenylate-binding protein 1; Short=PABP-1; Short=Poly(A)-binding protein 1; Gene name Name=PABPC1 Synonyms=PAB1, PABP1, PABPC2 Encoded on Name=PABPC1; Synonyms=PAB1, PABP1, PABPC2 Keywords 3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Methylation; mRNA processing; mRNA splicing; Nonsense-mediated mRNA decay; Nucleus; Phosphoprotein; Reference proteome; Repeat; RNA-binding; Spliceosome. Copyright Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL Y00345; CAA68428.1; -; mRNA EMBL U68104; AAD08718.1; -; Genomic_DNA EMBL U68093; AAD08718.1; JOINED; Genomic_DNA EMBL U68094; AAD08718.1; JOINED; Genomic_DNA EMBL U68095; AAD08718.1; JOINED; Genomic_DNA EMBL U68097; AAD08718.1; JOINED; Genomic_DNA EMBL U68098; AAD08718.1; JOINED; Genomic_DNA EMBL U68099; AAD08718.1; JOINED; Genomic_DNA EMBL U68100; AAD08718.1; JOINED; Genomic_DNA EMBL U68101; AAD08718.1; JOINED; Genomic_DNA EMBL U68102; AAD08718.1; JOINED; Genomic_DNA EMBL U68103; AAD08718.1; JOINED; Genomic_DNA EMBL AP001205; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL BC015958; AAH15958.1; -; mRNA EMBL BC023520; AAH23520.1; -; mRNA EMBL Z48501; CAA88401.1; -; mRNA CCDS CCDS6289.1; -. [P11940-1]; . PIR A93668; DNHUPA; . PIR S52491; S52491; . RefSeq NP_002559.2; NM_002568.3. [P11940-1]; . RefSeq XP_005250918.1; XM_005250861.1. [P11940-1]; . UniGene Hs.387804; -; . PDB 1CVJ; X-ray; 2.60 A; A/B/C/D/E/F/G/H=1-190 PDB 1G9L; NMR; -; A=498-636 PDB 1JGN; NMR; -; A=544-636 PDB 1JH4; NMR; -; A=544-636 PDB 2K8G; NMR; -; A=90-182 PDB 2RQG; NMR; -; B=541-623 PDB 2RQH; NMR; -; B=541-623 PDB 2X04; X-ray; 1.49 A; A/B=545-619 PDB 3KTP; X-ray; 1.50 A; A=544-626 PDB 3KTR; X-ray; 1.70 A; A=544-626 PDB 3KUI; X-ray; 2.30 A; A=544-626 PDB 3KUJ; X-ray; 1.40 A; A=544-626 PDB 3KUR; X-ray; 2.50 A; A/B/C/D/E/F/G/H=544-617 PDB 3KUS; X-ray; 1.40 A; A/B=544-626 PDB 3KUT; X-ray; 1.50 A; A/B=544-626 PDB 3PKN; X-ray; 1.80 A; A=544-626 PDB 3PTH; X-ray; 1.70 A; A=543-621 PDB 4F02; X-ray; 2.00 A; A/D=1-190 PDB 4F25; X-ray; 1.90 A; A=99-199 PDB 4F26; X-ray; 2.00 A; A=99-199 PDBsum 1CVJ; -; . PDBsum 1G9L; -; . PDBsum 1JGN; -; . PDBsum 1JH4; -; . PDBsum 2K8G; -; . PDBsum 2RQG; -; . PDBsum 2RQH; -; . PDBsum 2X04; -; . PDBsum 3KTP; -; . PDBsum 3KTR; -; . PDBsum 3KUI; -; . PDBsum 3KUJ; -; . PDBsum 3KUR; -; . PDBsum 3KUS; -; . PDBsum 3KUT; -; . PDBsum 3PKN; -; . PDBsum 3PTH; -; . PDBsum 4F02; -; . PDBsum 4F25; -; . PDBsum 4F26; -; . ProteinModelPortal P11940; -; . SMR P11940; 10-376; 494-636; . BioGrid 117939; 157; . DIP DIP-31613N; -; . IntAct P11940; 86; . MINT MINT-96210; -; . STRING 9606.ENSP00000313007; -; . BindingDB P11940; -; . ChEMBL CHEMBL1293286; -; . PhosphoSite P11940; -; . DMDM 3183544; -; . MaxQB P11940; -; . PaxDb P11940; -; . PRIDE P11940; -; . DNASU 26986; -; . Ensembl ENST00000318607; ENSP00000313007; ENSG00000070756. [P11940-1]; . GeneID 26986; -; . KEGG hsa:26986; -; . UCSC uc003yjs.1; human. [P11940-1]; . CTD 26986; -; . GeneCards GC08M101715; -; . HGNC HGNC:8554; PABPC1; . HPA CAB011536; -; . HPA HPA045423; -; . MIM 604679; gene; . neXtProt NX_P11940; -; . PharmGKB PA32880; -; . eggNOG COG0724; -; . HOGENOM HOG000217922; -; . HOVERGEN HBG002295; -; . InParanoid P11940; -; . KO K13126; -; . OMA XAVDEMN; -; . OrthoDB EOG7RV9FP; -; . PhylomeDB P11940; -; . TreeFam TF300458; -; . Reactome REACT_1979; Translation initiation complex formation; . Reactome REACT_20514; Deadenylation of mRNA; . Reactome REACT_25325; AUF1 (hnRNP D0) destabilizes mRNA; . Reactome REACT_75768; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); . Reactome REACT_75822; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); . Reactome REACT_79; L13a-mediated translational silencing of Ceruloplasmin expression; . ChiTaRS PABPC1; human; . EvolutionaryTrace P11940; -; . GeneWiki PABPC1; -; . GenomeRNAi 26986; -; . NextBio 49454; -; . PMAP-CutDB P11940; -; . PRO PR:P11940; -; . ArrayExpress P11940; -; . Bgee P11940; -; . CleanEx HS_PABPC1; -; . Genevestigator P11940; -; . GO GO:0071013; C:catalytic step 2 spliceosome; IDA:UniProtKB; . GO GO:0005737; C:cytoplasm; TAS:UniProtKB; . GO GO:0036464; C:cytoplasmic ribonucleoprotein granule; IDA:ParkinsonsUK-UCL; . GO GO:0010494; C:cytoplasmic stress granule; IDA:UniProtKB; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0016020; C:membrane; IDA:UniProtKB; . GO GO:0005634; C:nucleus; IDA:MGI; . GO GO:0030529; C:ribonucleoprotein complex; IDA:UniProtKB; . GO GO:0000166; F:nucleotide binding; IEA:InterPro; . GO GO:0008143; F:poly(A) binding; TAS:UniProtKB; . GO GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB; . GO GO:0008266; F:poly(U) RNA binding; IDA:MGI; . GO GO:0005515; F:protein binding; IPI:UniProtKB; . GO GO:0008022; F:protein C-terminus binding; IPI:UniProtKB; . GO GO:0008494; F:translation activator activity; TAS:UniProtKB; . GO GO:0044267; P:cellular protein metabolic process; TAS:Reactome; . GO GO:0010467; P:gene expression; TAS:Reactome; . GO GO:0031047; P:gene silencing by RNA; ISS:UniProtKB; . GO GO:0016071; P:mRNA metabolic process; TAS:Reactome; . GO GO:0006378; P:mRNA polyadenylation; TAS:UniProtKB; . GO GO:0000398; P:mRNA splicing; via spliceosome; IC:UniProtKB GO GO:0048255; P:mRNA stabilization; TAS:UniProtKB; . GO GO:2000623; P:negative regulation of nuclear-transcribed mRNA catabolic process; nonsense-mediated decay; IDA:UniProtKB GO GO:0000288; P:nuclear-transcribed mRNA catabolic process; deadenylation-dependent decay; TAS:Reactome GO GO:0000184; P:nuclear-transcribed mRNA catabolic process; nonsense-mediated decay; TAS:Reactome GO GO:0000289; P:nuclear-transcribed mRNA poly(A) tail shortening; TAS:Reactome; . GO GO:1900153; P:positive regulation of nuclear-transcribed mRNA catabolic process; deadenylation-dependent decay; ISS:UniProtKB GO GO:0060213; P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; ISS:UniProtKB; . GO GO:0045727; P:positive regulation of translation; TAS:GOC; . GO GO:0016070; P:RNA metabolic process; TAS:Reactome; . GO GO:0006412; P:translation; TAS:Reactome; . GO GO:0006413; P:translational initiation; TAS:Reactome; . Gene3D 1.10.1900.10; -; 1; . Gene3D 3.30.70.330; -; 4; . InterPro IPR012677; Nucleotide-bd_a/b_plait; . InterPro IPR006515; PABP_1234; . InterPro IPR002004; PABP_HYD; . InterPro IPR000504; RRM_dom; . Pfam PF00658; PABP; 1; . Pfam PF00076; RRM_1; 4; . SMART SM00517; PolyA; 1; . SMART SM00360; RRM; 4; . SUPFAM SSF63570; SSF63570; 1; . TIGRFAMs TIGR01628; PABP-1234; 1; . PROSITE PS51309; PABC; 1; . PROSITE PS50102; RRM; 4; . World-2DPAGE Repository (search AC)