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World-2DPAGE Repository  Search by  [accession number]  [description, ID or gene]  [author names]  [spot ID / serial number]  [identification methods]  [pI / Mw range]  [combined fields]  Maps  [experimental info]  [protein list]  [graphical interface]      Databases 0001 0002 0003 0004 0005 0006 0007 0008 0009 0010 0011 0012 0014 0017 0018 0019 0020 0021 0022 0023 0024 0026 0027 0029 0030 0031 0032 0034 0035 0036 0037 0038 0039 0040 0042 0043 0044 0046 0047 0050 0051 0053 0054 0056 0059 0061 0062 0063 0066 0068 0069 0076 0077 0080 0084 0085 0088 use 'Ctrl' to select several databases Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal Exclude local DBs has only effect if a remote interface is selected

Searching in 'World-2DPAGE Repository [0054]' for entry matching: P12004 World-2DPAGE Repository (0054):  P12004 P12004 General information about the entry View entry in simple text format Entry name PCNA_HUMAN Primary accession number P12004 integrated into World-2DPAGE Repository (0054) on  November 28, 2012 (release 1) 2D Annotations were last modified on November 28, 2012 (version 1) General Annotations were last modified on  October 23, 2014 (version 2) Name and origin of the protein Description RecName: Full=Proliferating cell nuclear antigen; Short=PCNA; AltName: Full=Cyclin;. Gene name Name=PCNA Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION DOI=10.1074/mcp.M112.022947; Vernocchi S., Battello N., Schmitz S., Revets D., Billing A.M., Turner J.D., Muller C.P. ''Membrane glucocorticoid receptor activation induces proteomic changes aligning with classical glucocorticoid-effects'' Molecular & Cellular Proteomics 12(7):1764-1779 (2013) 2D PAGE maps for identified proteins How to interpret a protein HSAPIENS_CCRF-CEM_3-10 {CCRF-CEM cells stimulated with Cort-BSA (internal standard)} Homo sapiens (Human)   map experimental info   HSAPIENS_CCRF-CEM_3-10 MAP LOCATIONS: SPOT 941: pI=4.57; Mw=28769   [identification data] %COV: SPOT 941: 73 [1]. SCORE: SPOT 941: 801 [1]. SEARCH ENGINE: SPOT 941: Mascot [1]. MAPPING (identification): SPOT 941: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1]. Copyright Data from Dr. Claude P. Muller, Centre de Recherche Public de la Sante / National Public Health Laboratory, Luxembourg Cross-references UniProtKB/Swiss-Prot P12004; PCNA_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name PCNA_HUMAN Primary accession number P12004 Secondary accession number(s) B2R897 D3DW02 Sequence was last modified on  October 1, 1989 (version 1) Annotations were last modified on  October 1, 2014 (version 171) Name and origin of the protein Description RecName: Full=Proliferating cell nuclear antigen; Short=PCNA; AltName: Full=Cyclin; Gene name Name=PCNA Encoded on Name=PCNA Keywords 3D-structure; Acetylation; Complete proteome; Direct protein sequencing; DNA damage; DNA repair; DNA replication; DNA-binding; Isopeptide bond; Nucleus; Phosphoprotein; Reference proteome; Ubl conjugation. Copyright Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL M15796; AAA35736.1; -; mRNA EMBL J04718; AAA60040.1; -; Genomic_DNA EMBL AF527838; AAM78556.1; -; Genomic_DNA EMBL AK313286; BAG36094.1; -; mRNA EMBL AL121924; CAC27344.1; -; Genomic_DNA EMBL CH471133; EAX10428.1; -; Genomic_DNA EMBL CH471133; EAX10429.1; -; Genomic_DNA EMBL CH471133; EAX10430.1; -; Genomic_DNA EMBL BC000491; AAH00491.1; -; mRNA EMBL BC062439; AAH62439.1; -; mRNA CCDS CCDS13087.1; -; . PIR A27445; WMHUET; . RefSeq NP_002583.1; NM_002592.2; . RefSeq NP_872590.1; NM_182649.1; . UniGene Hs.147433; -; . UniGene Hs.744934; -; . PDB 1AXC; X-ray; 2.60 A; A/C/E=1-261 PDB 1U76; X-ray; 2.60 A; A/C/E=1-261 PDB 1U7B; X-ray; 1.88 A; A=1-261 PDB 1UL1; X-ray; 2.90 A; A/B/C=1-261 PDB 1VYJ; X-ray; 2.80 A; A/C/E/G/I/K=1-261 PDB 1VYM; X-ray; 2.30 A; A/B/C=1-261 PDB 1W60; X-ray; 3.15 A; A/B=1-261 PDB 2ZVK; X-ray; 2.70 A; A/B/C=1-261 PDB 2ZVL; X-ray; 2.50 A; A/B/C/D/E/F=1-261 PDB 2ZVM; X-ray; 2.30 A; A/B/C=1-261 PDB 3P87; X-ray; 2.99 A; A/B/C/D/E/F=1-261 PDB 3TBL; X-ray; 2.90 A; A/B/C=1-261 PDB 3VKX; X-ray; 2.10 A; A=1-261 PDB 3WGW; X-ray; 2.80 A; A/B=1-261 PDBsum 1AXC; -; . PDBsum 1U76; -; . PDBsum 1U7B; -; . PDBsum 1UL1; -; . PDBsum 1VYJ; -; . PDBsum 1VYM; -; . PDBsum 1W60; -; . PDBsum 2ZVK; -; . PDBsum 2ZVL; -; . PDBsum 2ZVM; -; . PDBsum 3P87; -; . PDBsum 3TBL; -; . PDBsum 3VKX; -; . PDBsum 3WGW; -; . ProteinModelPortal P12004; -; . SMR P12004; 1-255; . BioGrid 111142; 222; . DIP DIP-1098N; -; . IntAct P12004; 52; . MINT MINT-5000943; -; . STRING 9606.ENSP00000368438; -; . ChEMBL CHEMBL2346488; -; . PhosphoSite P12004; -; . DMDM 129694; -; . SWISS-2DPAGE P12004; -; . MaxQB P12004; -; . PaxDb P12004; -; . PeptideAtlas P12004; -; . PRIDE P12004; -; . DNASU 5111; -; . Ensembl ENST00000379143; ENSP00000368438; ENSG00000132646; . Ensembl ENST00000379160; ENSP00000368458; ENSG00000132646; . GeneID 5111; -; . KEGG hsa:5111; -; . UCSC uc002wlp.3; human; . CTD 5111; -; . GeneCards GC20M005095; -; . HGNC HGNC:8729; PCNA; . HPA CAB000148; -; . HPA HPA030521; -; . HPA HPA030522; -; . HPA HPA030523; -; . MIM 176740; gene; . neXtProt NX_P12004; -; . PharmGKB PA263; -; . eggNOG COG0592; -; . HOGENOM HOG000211098; -; . HOVERGEN HBG000947; -; . InParanoid P12004; -; . KO K04802; -; . OMA MKLMNLD; -; . OrthoDB EOG7JX34W; -; . PhylomeDB P12004; -; . TreeFam TF313441; -; . Reactome REACT_111214; G0 and Early G1; . Reactome REACT_1385; Processive synthesis on the lagging strand; . Reactome REACT_1792; Polymerase switching; . Reactome REACT_1838; Leading Strand Synthesis; . Reactome REACT_1993; Repair synthesis for gap-filling by DNA polymerase in TC-NER; . Reactome REACT_2192; Removal of DNA patch containing abasic residue; . Reactome REACT_378; Repair synthesis of patch ~27-30 bases long by DNA polymerase; . Reactome REACT_471; E2F mediated regulation of DNA replication; . Reactome REACT_683; G1/S-Specific Transcription; . Reactome REACT_70; Removal of the Flap Intermediate; . Reactome REACT_7961; Telomere C-strand (Lagging Strand) Synthesis; . Reactome REACT_7987; Polymerase switching on the C-strand of the telomere; . Reactome REACT_7999; Removal of the Flap Intermediate from the C-strand; . Reactome REACT_8027; Processive synthesis on the C-strand of the telomere; . SignaLink P12004; -; . ChiTaRS PCNA; human; . EvolutionaryTrace P12004; -; . GeneWiki Proliferating_cell_nuclear_antigen; -; . GenomeRNAi 5111; -; . NextBio 19722; -; . PRO PR:P12004; -; . Bgee P12004; -; . CleanEx HS_PCNA; -; . Genevestigator P12004; -; . GO GO:0005813; C:centrosome; IDA:MGI; . GO GO:0005737; C:cytoplasm; IDA:HPA; . GO GO:0005663; C:DNA replication factor C complex; TAS:UniProtKB; . GO GO:0070062; C:extracellular vesicular exosome; IDA:UniProt; . GO GO:0043596; C:nuclear replication fork; IDA:BHF-UCL; . GO GO:0005654; C:nucleoplasm; TAS:Reactome; . GO GO:0005634; C:nucleus; IDA:HPA; . GO GO:0043626; C:PCNA complex; IBA:RefGenome; . GO GO:0070557; C:PCNA-p21 complex; IDA:UniProtKB; . GO GO:0032139; F:dinucleotide insertion or deletion binding; IDA:BHF-UCL; . GO GO:0070182; F:DNA polymerase binding; IPI:UniProt; . GO GO:0030337; F:DNA polymerase processivity factor activity; IEA:InterPro; . GO GO:0042802; F:identical protein binding; IPI:IntAct; . GO GO:0032405; F:MutLalpha complex binding; IDA:HGNC; . GO GO:0005515; F:protein binding; IPI:UniProtKB; . GO GO:0000701; F:purine-specific mismatch base pair DNA N-glycosylase activity; IDA:BHF-UCL; . GO GO:0030971; F:receptor tyrosine kinase binding; IPI:UniProtKB; . GO GO:0006284; P:base-excision repair; TAS:Reactome; . GO GO:0008283; P:cell proliferation; TAS:ProtInc; . GO GO:0006281; P:DNA repair; NAS:UniProtKB; . GO GO:0006260; P:DNA replication; NAS:UniProtKB; . GO GO:0006271; P:DNA strand elongation involved in DNA replication; TAS:Reactome; . GO GO:0030855; P:epithelial cell differentiation; IEP:UniProt; . GO GO:0000082; P:G1/S transition of mitotic cell cycle; TAS:Reactome; . GO GO:0007507; P:heart development; IEA:Ensembl; . GO GO:0006272; P:leading strand elongation; IBA:RefGenome; . GO GO:0006298; P:mismatch repair; IDA:BHF-UCL; . GO GO:0000278; P:mitotic cell cycle; TAS:Reactome; . GO GO:0006289; P:nucleotide-excision repair; TAS:Reactome; . GO GO:0006297; P:nucleotide-excision repair; DNA gap filling; TAS:Reactome GO GO:0048015; P:phosphatidylinositol-mediated signaling; NAS:UniProtKB; . GO GO:0032077; P:positive regulation of deoxyribonuclease activity; IDA:UniProtKB; . GO GO:0006275; P:regulation of DNA replication; IEA:InterPro; . GO GO:0000083; P:regulation of transcription involved in G1/S transition of mitotic cell cycle; TAS:Reactome; . GO GO:0046686; P:response to cadmium ion; IEA:Ensembl; . GO GO:0033993; P:response to lipid; IEA:Ensembl; . GO GO:0000723; P:telomere maintenance; TAS:Reactome; . GO GO:0000722; P:telomere maintenance via recombination; TAS:Reactome; . GO GO:0032201; P:telomere maintenance via semi-conservative replication; TAS:Reactome; . GO GO:0006283; P:transcription-coupled nucleotide-excision repair; TAS:Reactome; . GO GO:0019985; P:translesion synthesis; IDA:UniProtKB; . HAMAP MF_00317; DNApol_clamp_arch; 1; . InterPro IPR000730; Pr_cel_nuc_antig; . InterPro IPR022649; Pr_cel_nuc_antig_C; . InterPro IPR022659; Pr_cel_nuc_antig_CS; . InterPro IPR022648; Pr_cel_nuc_antig_N; . PANTHER PTHR11352; PTHR11352; 1; . Pfam PF02747; PCNA_C; 1; . Pfam PF00705; PCNA_N; 1; . PRINTS PR00339; PCNACYCLIN; . TIGRFAMs TIGR00590; pcna; 1; . PROSITE PS01251; PCNA_1; 1; . PROSITE PS00293; PCNA_2; 1; . 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