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Searching in 'World-2DPAGE Repository [0043]' for entry matching: P20029

World-2DPAGE Repository (0043):  P20029


General information about the entry
View entry in simple text format
Entry nameGRP78_MOUSE
Primary accession numberP20029
integrated into World-2DPAGE Repository (0043) on January 4, 2012 (release 1)
2D Annotations were last modified onJanuary 6, 2012 (version 1)
General Annotations were last modified on April 18, 2012 (version 2)
Name and origin of the protein
DescriptionRecName: Full=78 kDa glucose-regulated protein; Short=GRP-78; AltName: Full=Heat shock 70 kDa protein 5; AltName: Full=Immunoglobulin heavy chain-binding protein; Short=BiP; Flags: Precursor;.
Gene nameName=Hspa5
Annotated speciesMus musculus (Mouse) [TaxID: 10090]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus.
DOI=10.1016/j.jprot.2012.04.001 ;
Sun Z., Biela L.M., Hamilton K.L., Reardon K.F.
''Concentration-dependent effects of the soy phytoestrogen genistein on the proteome of cultured cardiomyocytes''
Journal of Proteomics 0(0):0-0 (2012)
2D PAGE maps for identified proteins
How to interpret a protein

MMUSCULUS_HL-1PHO_4-7 {mouse HL-1 cultured cardiomyocytes hydrophobic extraction}
Mus musculus (Mouse)
Tissue: Cardiac myocyte
  map experimental info

Mw=72492  [identification data]

%COV: BAND pho28: 8.65 [1].
GENEID: BAND pho28: GRP78_MOUSE [1].
SCORE: BAND pho28: 318 [1].
SEARCH ENGINE: BAND pho28: Mascot [1].
MAPPING (identification):
BAND pho28: Tandem mass spectrometry [1].

Data from Dr. Zeyu Sun, Department of Chemical and Biological Engineering, Colorado State University, Fort Collins, USA
UniProtKB/Swiss-ProtP20029; GRP78_MOUSE.

2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.

External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2012_03
Entry nameGRP78_MOUSE
Primary accession numberP20029
Secondary accession number(s) O35642 Q3UFF2 Q61630
Sequence was last modified on November 1, 1997 (version 3)
Annotations were last modified on February 22, 2012 (version 126)
Name and origin of the protein
DescriptionRecName: Full=78 kDa glucose-regulated protein; Short=GRP-78; AltName: Full=Heat shock 70 kDa protein 5; AltName: Full=Immunoglobulin heavy chain-binding protein; Short=BiP; Flags: Precursor;
Gene nameName=Hspa5
Encoded onName=Hspa5; Synonyms=Grp78
KeywordsAcetylation; ATP-binding; Complete proteome; Direct protein sequencing; Endoplasmic reticulum; Nitration; Nucleotide-binding; Phosphoprotein; Reference proteome; Signal.
Copyrighted by the UniProt Consortium, see Distributed under the Creative Commons Attribution-NoDerivs License
EMBLAJ002387; CAA05361.1; -; mRNA
EMBLM19351; AAA37315.1; -; mRNA
EMBLD78645; BAA11462.1; -; mRNA
EMBLAK076079; BAC36166.1; -; mRNA
EMBLAK146647; BAE27328.1; -; mRNA
EMBLAK148539; BAE28609.1; -; mRNA
EMBLAK151647; BAE30576.1; -; mRNA
EMBLAK152020; BAE30882.1; -; mRNA
EMBLAK166739; BAE38982.1; -; mRNA
EMBLAK169034; BAE40825.1; -; mRNA
EMBLBC050927; AAH50927.1; -; mRNA
EMBLU16277; AAA76734.1; -; Genomic_DNA
EMBLM30779; AAA37742.1; -; mRNA
IPIIPI00319992; -; .
PIRA37048; A37048; .
RefSeqNP_001156906.1; NM_001163434.1; .
RefSeqNP_071705.3; NM_022310.3; .
UniGeneMm.330160; -; .
UniGeneMm.470180; -; .
ProteinModelPortalP20029; -; .
SMRP20029; 27-636; .
DIPDIP-32341N; -; .
IntActP20029; 11; .
MINTMINT-1177274; -; .
STRINGP20029; -; .
PhosphoSiteP20029; -; .
SWISS-2DPAGEP20029; -; .
UCD-2DPAGEP20029; -; .
PRIDEP20029; -; .
EnsemblENSMUST00000028222; ENSMUSP00000028222; ENSMUSG00000026864; .
EnsemblENSMUST00000100171; ENSMUSP00000097747; ENSMUSG00000026864; .
GeneID14828; -; .
KEGGmmu:14828; -; .
CTD3309; -; .
MGIMGI:95835; Hspa5; .
eggNOGCOG0443; -; .
GeneTreeENSGT00550000074467; -; .
HOGENOMHBG334976; -; .
HOVERGENHBG051845; -; .
InParanoidP20029; -; .
KOK09490; -; .
OrthoDBEOG444KJV; -; .
PhylomeDBP20029; -; .
ReactomeREACT_89750; Hemostasis; .
ArrayExpressP20029; -; .
BgeeP20029; -; .
CleanExMM_HSPA5; -; .
GenevestigatorP20029; -; .
GermOnlineENSMUSG00000026864; Mus musculus; .
GOGO:0009986; C:cell surface; IDA:MGI; .
GOGO:0005788; C:endoplasmic reticulum lumen; IDA:BHF-UCL; .
GOGO:0005576; C:extracellular region; TAS:Reactome; .
GOGO:0042470; C:melanosome; IEA:UniProtKB-SubCell; .
GOGO:0005524; F:ATP binding; IEA:UniProtKB-KW; .
GOGO:0051787; F:misfolded protein binding; IDA:BHF-UCL; .
GOGO:0043022; F:ribosome binding; IDA:MGI; .
GOGO:0006987; P:activation of signaling protein activity involved in unfolded protein response; IMP:BHF-UCL; .
GOGO:0021680; P:cerebellar Purkinje cell layer development; IMP:BHF-UCL; .
GOGO:0021589; P:cerebellum structural organization; IMP:BHF-UCL; .
GOGO:0006983; P:ER overload response; IDA:MGI; .
GOGO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; IGI:MGI; .
GOGO:0040019; P:positive regulation of embryonic development; TAS:BHF-UCL; .
GOGO:0031398; P:positive regulation of protein ubiquitination; IMP:BHF-UCL; .
GOGO:0051603; P:proteolysis involved in cellular protein catabolic process; IDA:BHF-UCL; .
InterProIPR018181; Heat_shock_70_CS; .
InterProIPR001023; Hsp70; .
InterProIPR013126; Hsp_70; .
PANTHERPTHR19375; Hsp70; 1; .
PfamPF00012; HSP70; 1; .
PROSITEPS00297; HSP70_1; 1; .
PROSITEPS00329; HSP70_2; 1; .
PROSITEPS01036; HSP70_3; 1; .

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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the Expasy web server