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World-2DPAGE Repository  Search by  [accession number]  [description, ID or gene]  [author names]  [spot ID / serial number]  [identification methods]  [pI / Mw range]  [combined fields]  Maps  [experimental info]  [protein list]  [graphical interface]      Databases 0001 0002 0003 0004 0005 0006 0007 0008 0009 0010 0011 0012 0014 0017 0018 0019 0020 0021 0022 0023 0024 0026 0027 0029 0030 0031 0032 0034 0035 0036 0037 0038 0039 0040 0042 0043 0044 0046 0047 0050 0051 0053 0054 0056 0059 0061 0062 0063 0066 0068 0069 0076 0077 0080 0084 0085 0088 use 'Ctrl' to select several databases Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal Exclude local DBs has only effect if a remote interface is selected

Searching in 'World-2DPAGE Repository [0054]' for entry matching: P23246 World-2DPAGE Repository (0054):  P23246 P23246 General information about the entry View entry in simple text format Entry name SFPQ_HUMAN Primary accession number P23246 integrated into World-2DPAGE Repository (0054) on  November 28, 2012 (release 1) 2D Annotations were last modified on November 28, 2012 (version 1) General Annotations were last modified on  October 23, 2014 (version 2) Name and origin of the protein Description RecName: Full=Splicing factor, proline-and glutamine-rich; AltName: Full=100 kDa DNA-pairing protein; Short=hPOMp100; AltName: Full=DNA-binding p52/p100 complex, 100 kDa subunit; AltName: Full=Polypyrimidine tract-binding protein-associated-splicing factor; Short=PSF; Short=PTB-associated-splicing factor;. Gene name Name=SFPQ Synonyms=PSF Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION DOI=10.1074/mcp.M112.022947; Vernocchi S., Battello N., Schmitz S., Revets D., Billing A.M., Turner J.D., Muller C.P. ''Membrane glucocorticoid receptor activation induces proteomic changes aligning with classical glucocorticoid-effects'' Molecular & Cellular Proteomics 12(7):1764-1779 (2013) 2D PAGE maps for identified proteins How to interpret a protein HSAPIENS_CCRF-CEM_3-10 {CCRF-CEM cells stimulated with Cort-BSA (internal standard)} Homo sapiens (Human)   map experimental info   HSAPIENS_CCRF-CEM_3-10 MAP LOCATIONS: SPOT 356: pI=9.45; Mw=76149   [identification data] %COV: SPOT 356: 39 [1]. SCORE: SPOT 356: 444 [1]. SEARCH ENGINE: SPOT 356: Mascot [1]. MAPPING (identification): SPOT 356: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1]. Copyright Data from Dr. Claude P. Muller, Centre de Recherche Public de la Sante / National Public Health Laboratory, Luxembourg Cross-references UniProtKB/Swiss-Prot P23246; SFPQ_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name SFPQ_HUMAN Primary accession number P23246 Secondary accession number(s) P30808 Q5SZ71 Sequence was last modified on  October 1, 1996 (version 2) Annotations were last modified on  October 1, 2014 (version 168) Name and origin of the protein Description RecName: Full=Splicing factor, proline-and glutamine-rich; AltName: Full=100 kDa DNA-pairing protein; Short=hPOMp100; AltName: Full=DNA-binding p52/p100 complex, 100 kDa subunit; AltName: Full=Polypyrimidine tract-binding protein-associated-splicing factor; Short=PSF; Short=PTB-associated-splicing factor; Gene name Name=SFPQ Synonyms=PSF Encoded on Name=SFPQ; Synonyms=PSF Keywords Acetylation; Activator; Alternative splicing; Biological rhythms; Chromosomal rearrangement; Complete proteome; Cytoplasm; Direct protein sequencing; DNA damage; DNA recombination; DNA repair; DNA-binding; Methylation; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Repeat; Repressor; RNA-binding; Transcription; Transcription regulation. Copyright Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL X70944; CAA50283.1; -; mRNA EMBL AL590434; CAI12467.1; -; Genomic_DNA EMBL CH471059; EAX07426.1; -; Genomic_DNA EMBL X16850; CAA34747.1; -; mRNA CCDS CCDS388.1; -. [P23246-1]; . PIR A46302; A46302; . PIR S29770; S29770; . RefSeq NP_005057.1; NM_005066.2. [P23246-1]; . RefSeq XP_005271168.1; XM_005271111.2. [P23246-1]; . RefSeq XP_005271169.1; XM_005271112.2. [P23246-1]; . RefSeq XP_005271170.1; XM_005271113.2. [P23246-1]; . RefSeq XP_005271172.1; XM_005271115.2. [P23246-2]; . RefSeq XP_005271173.1; XM_005271116.2. [P23246-2]; . UniGene Hs.355934; -; . UniGene Hs.611911; -; . ProteinModelPortal P23246; -; . SMR P23246; 287-535; . BioGrid 112319; 132; . IntAct P23246; 48; . MINT MINT-1141893; -; . STRING 9606.ENSP00000349748; -; . PhosphoSite P23246; -; . DMDM 1709851; -; . SWISS-2DPAGE P23246; -; . MaxQB P23246; -; . PaxDb P23246; -; . PeptideAtlas P23246; -; . PRIDE P23246; -; . Ensembl ENST00000357214; ENSP00000349748; ENSG00000116560. [P23246-1]; . GeneID 6421; -; . KEGG hsa:6421; -; . UCSC uc001bys.3; human. [P23246-1]; . CTD 6421; -; . GeneCards GC01M035641; -; . HGNC HGNC:10774; SFPQ; . HPA CAB009886; -; . HPA HPA047513; -; . MIM 605199; gene; . neXtProt NX_P23246; -; . Orphanet 319308; Translocation renal cell carcinoma; . PharmGKB PA35690; -; . eggNOG NOG298586; -; . HOGENOM HOG000231095; -; . HOVERGEN HBG009801; -; . InParanoid P23246; -; . KO K13219; -; . OMA APGGHPK; -; . OrthoDB EOG7327P0; -; . PhylomeDB P23246; -; . TreeFam TF315795; -; . ChiTaRS SFPQ; human; . GeneWiki SFPQ; -; . GenomeRNAi 6421; -; . NextBio 24935; -; . PRO PR:P23246; -; . ArrayExpress P23246; -; . Bgee P23246; -; . CleanEx HS_SFPQ; -; . Genevestigator P23246; -; . GO GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell; . GO GO:0016363; C:nuclear matrix; IDA:BHF-UCL; . GO GO:0005654; C:nucleoplasm; IDA:BHF-UCL; . GO GO:0005634; C:nucleus; IDA:HPA; . GO GO:0042382; C:paraspeckles; IDA:BHF-UCL; . GO GO:0001047; F:core promoter binding; ISS:UniProtKB; . GO GO:0000166; F:nucleotide binding; IEA:InterPro; . GO GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB; . GO GO:0005515; F:protein binding; IPI:IntAct; . GO GO:0000976; F:transcription regulatory region sequence-specific DNA binding; ISS:UniProtKB; . GO GO:0000380; P:alternative mRNA splicing; via spliceosome; IMP:BHF-UCL GO GO:0006310; P:DNA recombination; IEA:UniProtKB-KW; . GO GO:0006281; P:DNA repair; IEA:UniProtKB-KW; . GO GO:0070932; P:histone H3 deacetylation; ISS:UniProtKB; . GO GO:0006397; P:mRNA processing; TAS:ProtInc; . GO GO:0042754; P:negative regulation of circadian rhythm; ISS:UniProtKB; . GO GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL; . GO GO:0045892; P:negative regulation of transcription; DNA-templated; ISS:UniProtKB GO GO:0042752; P:regulation of circadian rhythm; ISS:UniProtKB; . GO GO:0048511; P:rhythmic process; IEA:UniProtKB-KW; . GO GO:0008380; P:RNA splicing; TAS:ProtInc; . GO GO:0006351; P:transcription; DNA-templated; IEA:UniProtKB-KW Gene3D 3.30.70.330; -; 2; . InterPro IPR012975; NOPS; . InterPro IPR012677; Nucleotide-bd_a/b_plait; . InterPro IPR000504; RRM_dom; . Pfam PF08075; NOPS; 1; . Pfam PF00076; RRM_1; 2; . SMART SM00360; RRM; 2; . PROSITE PS50102; RRM; 2; . World-2DPAGE Repository (search AC)