Attention: World-2DPAGE is no longer maintained.

World-2DPAGE Repository  Search by  [accession number]  [description, ID or gene]  [author names]  [spot ID / serial number]  [identification methods]  [pI / Mw range]  [combined fields]  Maps  [experimental info]  [protein list]  [graphical interface]      Databases 0001 0002 0003 0004 0005 0006 0007 0008 0009 0010 0011 0012 0014 0017 0018 0019 0020 0021 0022 0023 0024 0026 0027 0029 0030 0031 0032 0034 0035 0036 0037 0038 0039 0040 0042 0043 0044 0046 0047 0050 0051 0053 0054 0056 0059 0061 0062 0063 0066 0068 0069 0076 0077 0080 0084 0085 0088 use 'Ctrl' to select several databases Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal Exclude local DBs has only effect if a remote interface is selected

Searching in 'World-2DPAGE Repository [0054]' for entry matching: P23381 World-2DPAGE Repository (0054):  P23381 P23381 General information about the entry View entry in simple text format Entry name SYWC_HUMAN Primary accession number P23381 integrated into World-2DPAGE Repository (0054) on  November 28, 2012 (release 1) 2D Annotations were last modified on November 28, 2012 (version 1) General Annotations were last modified on  October 23, 2014 (version 2) Name and origin of the protein Description RecName: Full=Tryptophan--tRNA ligase, cytoplasmic; EC=6.1.1.2; AltName: Full=Interferon-induced protein 53; Short=IFP53; AltName: Full=Tryptophanyl-tRNA synthetase; Short=TrpRS; Short=hWRS; Contains: RecName: Full=T1-TrpRS; Contains: RecName: Full=T2-TrpRS;. Gene name Name=WARS Synonyms=IFI53, WRS Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION DOI=10.1074/mcp.M112.022947; Vernocchi S., Battello N., Schmitz S., Revets D., Billing A.M., Turner J.D., Muller C.P. ''Membrane glucocorticoid receptor activation induces proteomic changes aligning with classical glucocorticoid-effects'' Molecular & Cellular Proteomics 12(7):1764-1779 (2013) 2D PAGE maps for identified proteins How to interpret a protein HSAPIENS_CCRF-CEM_3-10 {CCRF-CEM cells stimulated with Cort-BSA (internal standard)} Homo sapiens (Human)   map experimental info   HSAPIENS_CCRF-CEM_3-10 MAP LOCATIONS: SPOT 691: pI=5.83; Mw=53034   [identification data] %COV: SPOT 691: 53 [1]. SCORE: SPOT 691: 518 [1]. SEARCH ENGINE: SPOT 691: Mascot [1]. MAPPING (identification): SPOT 691: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1]. Copyright Data from Dr. Claude P. Muller, Centre de Recherche Public de la Sante / National Public Health Laboratory, Luxembourg Cross-references UniProtKB/Swiss-Prot P23381; SYWC_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name SYWC_HUMAN Primary accession number P23381 Secondary accession number(s) A6NGN1 A6NID3 P78535 Q502Y0 Q53XB6 Q9UDI5 Q9UDL3 Sequence was last modified on  December 1, 1992 (version 2) Annotations were last modified on  October 1, 2014 (version 151) Name and origin of the protein Description RecName: Full=Tryptophan--tRNA ligase, cytoplasmic; EC=6.1.1.2; AltName: Full=Interferon-induced protein 53; Short=IFP53; AltName: Full=Tryptophanyl-tRNA synthetase; Short=TrpRS; Short=hWRS; Contains: RecName: Full=T1-TrpRS; Contains: RecName: Full=T2-TrpRS; Gene name Name=WARS Synonyms=IFI53, WRS Encoded on Name=WARS; Synonyms=IFI53, WRS Keywords 3D-structure; Alternative splicing; Aminoacyl-tRNA synthetase; Angiogenesis; ATP-binding; Complete proteome; Cytoplasm; Direct protein sequencing; Ligase; Nucleotide-binding; Polymorphism; Protein biosynthesis; Reference proteome. Copyright Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL M77804; AAA67324.1; -; mRNA EMBL X59892; CAA42545.1; -; mRNA EMBL M61715; AAA61298.1; -; mRNA EMBL X62570; CAA44450.1; -; mRNA EMBL BX248006; CAD62335.1; -; mRNA EMBL AK056100; BAG51626.1; -; mRNA EMBL AK291141; BAF83830.1; -; mRNA EMBL AL157871; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL CH471061; EAW81700.1; -; Genomic_DNA EMBL BC017489; AAH17489.1; -; mRNA EMBL BC095453; AAH95453.1; -; mRNA EMBL S82905; AAB39381.1; -; Genomic_DNA EMBL X67920; CAB94198.1; -; Genomic_DNA EMBL X67921; CAB94198.1; JOINED; Genomic_DNA EMBL X67922; CAB94198.1; JOINED; Genomic_DNA EMBL X67923; CAB94199.1; -; Genomic_DNA EMBL X67924; CAB94199.1; JOINED; Genomic_DNA EMBL X67925; CAB94199.1; JOINED; Genomic_DNA EMBL X67926; CAB94199.1; JOINED; Genomic_DNA EMBL X67927; CAB94199.1; JOINED; Genomic_DNA EMBL X67928; CAB94199.1; JOINED; Genomic_DNA CCDS CCDS9960.1; -. [P23381-1]; . CCDS CCDS9961.1; -. [P23381-2]; . PIR A41633; A41706; . RefSeq NP_004175.2; NM_004184.3. [P23381-1]; . RefSeq NP_776049.1; NM_173701.1. [P23381-1]; . RefSeq NP_998810.1; NM_213645.1; . RefSeq NP_998811.1; NM_213646.1; . RefSeq XP_005268101.1; XM_005268044.1. [P23381-1]; . RefSeq XP_006720311.1; XM_006720248.1. [P23381-1]; . RefSeq XP_006720312.1; XM_006720249.1. [P23381-1]; . UniGene Hs.497599; -; . PDB 1O5T; X-ray; 2.50 A; A=94-471 PDB 1R6T; X-ray; 2.10 A; A/B=1-466 PDB 1R6U; X-ray; 2.00 A; A/B=48-471 PDB 1ULH; X-ray; 2.31 A; A/B=82-471 PDB 2AKE; X-ray; 3.10 A; A=94-471 PDB 2AZX; X-ray; 2.80 A; A/B=1-471 PDB 2DR2; X-ray; 3.00 A; A=94-471 PDB 2QUH; X-ray; 2.40 A; A/B=1-471 PDB 2QUI; X-ray; 2.40 A; A/B=1-471 PDB 2QUJ; X-ray; 2.42 A; A/B=1-471 PDB 2QUK; X-ray; 2.80 A; A=1-471 PDBsum 1O5T; -; . PDBsum 1R6T; -; . PDBsum 1R6U; -; . PDBsum 1ULH; -; . PDBsum 2AKE; -; . PDBsum 2AZX; -; . PDBsum 2DR2; -; . PDBsum 2QUH; -; . PDBsum 2QUI; -; . PDBsum 2QUJ; -; . PDBsum 2QUK; -; . ProteinModelPortal P23381; -; . SMR P23381; 82-471; . BioGrid 113292; 34; . DIP DIP-29493N; -; . IntAct P23381; 5; . MINT MINT-1408962; -; . STRING 9606.ENSP00000347495; -; . DrugBank DB00150; L-Tryptophan; . PhosphoSite P23381; -; . DMDM 135191; -; . OGP P23381; -; . MaxQB P23381; -; . PaxDb P23381; -; . PeptideAtlas P23381; -; . PRIDE P23381; -; . Ensembl ENST00000344102; ENSP00000339485; ENSG00000140105. [P23381-2]; . Ensembl ENST00000355338; ENSP00000347495; ENSG00000140105. [P23381-1]; . Ensembl ENST00000358655; ENSP00000351481; ENSG00000140105. [P23381-2]; . Ensembl ENST00000392882; ENSP00000376620; ENSG00000140105. [P23381-1]; . Ensembl ENST00000556645; ENSP00000451887; ENSG00000140105. [P23381-2]; . Ensembl ENST00000557135; ENSP00000451460; ENSG00000140105. [P23381-1]; . GeneID 7453; -; . KEGG hsa:7453; -; . UCSC uc001yhg.2; human. [P23381-1]; . CTD 7453; -; . GeneCards GC14M100800; -; . HGNC HGNC:12729; WARS; . HPA HPA018944; -; . MIM 191050; gene; . neXtProt NX_P23381; -; . PharmGKB PA37340; -; . eggNOG COG0180; -; . HOVERGEN HBG002325; -; . InParanoid P23381; -; . KO K01867; -; . OMA KTFIFNN; -; . OrthoDB EOG7T4MK3; -; . PhylomeDB P23381; -; . TreeFam TF105669; -; . Reactome REACT_15306; Cytosolic tRNA aminoacylation; . ChiTaRS WARS; human; . EvolutionaryTrace P23381; -; . GeneWiki WARS_(gene); -; . GenomeRNAi 7453; -; . NextBio 29178; -; . PRO PR:P23381; -; . ArrayExpress P23381; -; . Bgee P23381; -; . CleanEx HS_WARS; -; . Genevestigator P23381; -; . GO GO:0005737; C:cytoplasm; TAS:UniProtKB; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0070062; C:extracellular vesicular exosome; IDA:UniProt; . GO GO:0005634; C:nucleus; IDA:UniProt; . GO GO:0005524; F:ATP binding; IEA:UniProtKB-KW; . GO GO:0005515; F:protein binding; IPI:UniProtKB; . GO GO:0004830; F:tryptophan-tRNA ligase activity; NAS:UniProtKB; . GO GO:0001525; P:angiogenesis; IEA:UniProtKB-KW; . GO GO:0010467; P:gene expression; TAS:Reactome; . GO GO:0008285; P:negative regulation of cell proliferation; TAS:ProtInc; . GO GO:0045765; P:regulation of angiogenesis; IDA:UniProtKB; . GO GO:0006412; P:translation; TAS:ProtInc; . GO GO:0006418; P:tRNA aminoacylation for protein translation; TAS:Reactome; . GO GO:0006436; P:tryptophanyl-tRNA aminoacylation; NAS:UniProtKB; . Gene3D 1.10.287.10; -; 1; . Gene3D 3.40.50.620; -; 1; . InterPro IPR001412; aa-tRNA-synth_I_CS; . InterPro IPR002305; aa-tRNA-synth_Ic; . InterPro IPR014729; Rossmann-like_a/b/a_fold; . InterPro IPR009068; S15_NS1_RNA-bd; . InterPro IPR002306; Trp-tRNA-ligase; . InterPro IPR000738; WHEP-TRS; . PANTHER PTHR10055; PTHR10055; 1; . Pfam PF00579; tRNA-synt_1b; 1; . Pfam PF00458; WHEP-TRS; 1; . PRINTS PR01039; TRNASYNTHTRP; . SMART SM00991; WHEP-TRS; 1; . SUPFAM SSF47060; SSF47060; 1; . TIGRFAMs TIGR00233; trpS; 1; . PROSITE PS00178; AA_TRNA_LIGASE_I; 1; . PROSITE PS00762; WHEP_TRS_1; 1; . PROSITE PS51185; WHEP_TRS_2; 1; . World-2DPAGE Repository (search AC)