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World-2DPAGE Repository  Search by  [accession number]  [description, ID or gene]  [author names]  [spot ID / serial number]  [identification methods]  [pI / Mw range]  [combined fields]  Maps  [experimental info]  [protein list]  [graphical interface]      Databases 0001 0002 0003 0004 0005 0006 0007 0008 0009 0010 0011 0012 0014 0017 0018 0019 0020 0021 0022 0023 0024 0026 0027 0029 0030 0031 0032 0034 0035 0036 0037 0038 0039 0040 0042 0043 0044 0046 0047 0050 0051 0053 0054 0056 0059 0061 0062 0063 0066 0068 0069 0076 0077 0080 0084 0085 0088 use 'Ctrl' to select several databases Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal Exclude local DBs has only effect if a remote interface is selected

Searching in 'World-2DPAGE Repository [0054]' for entry matching: P25705 World-2DPAGE Repository (0054):  P25705 P25705 General information about the entry View entry in simple text format Entry name ATPA_HUMAN Primary accession number P25705 integrated into World-2DPAGE Repository (0054) on  November 28, 2012 (release 1) 2D Annotations were last modified on November 28, 2012 (version 1) General Annotations were last modified on  October 23, 2014 (version 2) Name and origin of the protein Description RecName: Full=ATP synthase subunit alpha, mitochondrial; Flags: Precursor;. Gene name Name=ATP5A1 Synonyms=ATP5A, ATP5AL2, ATPM Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION DOI=10.1074/mcp.M112.022947; Vernocchi S., Battello N., Schmitz S., Revets D., Billing A.M., Turner J.D., Muller C.P. ''Membrane glucocorticoid receptor activation induces proteomic changes aligning with classical glucocorticoid-effects'' Molecular & Cellular Proteomics 12(7):1764-1779 (2013) 2D PAGE maps for identified proteins How to interpret a protein HSAPIENS_CCRF-CEM_3-10 {CCRF-CEM cells stimulated with Cort-BSA (internal standard)} Homo sapiens (Human)   map experimental info   HSAPIENS_CCRF-CEM_3-10 MAP LOCATIONS: SPOT 711: pI=8.28; Mw=55209   [identification data] %COV: SPOT 711: 56 [1]. SCORE: SPOT 711: 858 [1]. SEARCH ENGINE: SPOT 711: Mascot [1]. MAPPING (identification): SPOT 711: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1]. Copyright Data from Dr. Claude P. Muller, Centre de Recherche Public de la Sante / National Public Health Laboratory, Luxembourg Cross-references UniProtKB/Swiss-Prot P25705; ATPA_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name ATPA_HUMAN Primary accession number P25705 Secondary accession number(s) A8K092 B4DY56 K7ENP3 Q53XX6 Q8IXV2 Q96FB4 Q96HW2 Q96IR6 Q9BTV8 Sequence was last modified on  May 1, 1992 (version 1) Annotations were last modified on  October 1, 2014 (version 176) Name and origin of the protein Description RecName: Full=ATP synthase subunit alpha, mitochondrial; Flags: Precursor; Gene name Name=ATP5A1 Synonyms=ATP5A, ATP5AL2, ATPM Encoded on Name=ATP5A1; Synonyms=ATP5A, ATP5AL2, ATPM Keywords Acetylation; Alternative splicing; ATP synthesis; ATP-binding; Cell membrane; CF(1); Complete proteome; Direct protein sequencing; Disease mutation; Glycoprotein; Hydrogen ion transport; Ion transport; Membrane; Mitochondrion; Mitochondrion inner membrane; Nucleotide-binding; Phosphoprotein; Polymorphism; Pyrrolidone carboxylic acid; Reference proteome; Transit peptide; Transport. Copyright Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL X59066; CAA41789.1; -; mRNA EMBL X65460; CAA46452.1; -; mRNA EMBL D14710; BAA03531.1; -; mRNA EMBL D28126; BAA05672.1; -; Genomic_DNA EMBL BT007209; AAP35873.1; -; mRNA EMBL AK092735; BAG52604.1; -; mRNA EMBL AK289457; BAF82146.1; -; mRNA EMBL AK302272; BAG63618.1; -; mRNA EMBL AC012569; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL BC003119; AAH03119.1; -; mRNA EMBL BC007299; AAH07299.1; -; mRNA EMBL BC008028; AAH08028.2; -; mRNA EMBL BC011384; AAH11384.1; -; mRNA EMBL BC016046; AAH16046.1; -; mRNA EMBL BC019310; AAH19310.1; -; mRNA EMBL BC039135; AAH39135.2; -; mRNA EMBL BC064562; AAH64562.1; -; mRNA EMBL BC067385; AAH67385.1; -; mRNA CCDS CCDS11927.1; -. [P25705-1]; . CCDS CCDS58620.1; -. [P25705-2]; . CCDS CCDS59315.1; -. [P25705-3]; . PIR S17193; PWHUA; . RefSeq NP_001001935.1; NM_001001935.2. [P25705-2]; . RefSeq NP_001001937.1; NM_001001937.1. [P25705-1]; . RefSeq NP_001244263.1; NM_001257334.1. [P25705-3]; . RefSeq NP_001244264.1; NM_001257335.1. [P25705-2]; . RefSeq NP_004037.1; NM_004046.5. [P25705-1]; . UniGene Hs.298280; -; . ProteinModelPortal P25705; -; . SMR P25705; 56-553; . BioGrid 106987; 76; . DIP DIP-32871N; -; . IntAct P25705; 34; . MINT MINT-1163289; -; . STRING 9606.ENSP00000282050; -; . ChEMBL CHEMBL2062351; -; . PhosphoSite P25705; -; . DMDM 114517; -; . OGP P25705; -; . REPRODUCTION-2DPAGE P25705; -; . UCD-2DPAGE P25705; -; . MaxQB P25705; -; . PaxDb P25705; -; . PRIDE P25705; -; . DNASU 498; -; . Ensembl ENST00000282050; ENSP00000282050; ENSG00000152234. [P25705-1]; . Ensembl ENST00000398752; ENSP00000381736; ENSG00000152234. [P25705-1]; . Ensembl ENST00000590665; ENSP00000467037; ENSG00000152234. [P25705-3]; . Ensembl ENST00000593152; ENSP00000465477; ENSG00000152234. [P25705-2]; . GeneID 498; -; . KEGG hsa:498; -; . UCSC uc002lbr.2; human. [P25705-1]; . CTD 498; -; . GeneCards GC18M043664; -; . HGNC HGNC:823; ATP5A1; . HPA CAB013067; -; . MIM 164360; gene; . MIM 615228; phenotype; . neXtProt NX_P25705; -; . Orphanet 254913; Isolated ATP synthase deficiency; . PharmGKB PA25115; -; . eggNOG COG0056; -; . HOVERGEN HBG001536; -; . InParanoid P25705; -; . KO K02132; -; . OMA KEPMLTG; -; . OrthoDB EOG773XFP; -; . PhylomeDB P25705; -; . TreeFam TF300321; -; . Reactome REACT_118595; Mitochondrial protein import; . Reactome REACT_6759; Formation of ATP by chemiosmotic coupling; . ChiTaRS ATP5A1; human; . GenomeRNAi 498; -; . NextBio 2089; -; . PMAP-CutDB P25705; -; . PRO PR:P25705; -; . ArrayExpress P25705; -; . Bgee P25705; -; . CleanEx HS_ATP5A1; -; . Genevestigator P25705; -; . GO GO:0070062; C:extracellular vesicular exosome; IDA:UniProt; . GO GO:0016020; C:membrane; IDA:UniProtKB; . GO GO:0005743; C:mitochondrial inner membrane; IDA:UniProtKB; . GO GO:0005759; C:mitochondrial matrix; TAS:Reactome; . GO GO:0005753; C:mitochondrial proton-transporting ATP synthase complex; IDA:UniProtKB; . GO GO:0005739; C:mitochondrion; NAS:UniProtKB; . GO GO:0005886; C:plasma membrane; IDA:UniProtKB; . GO GO:0045261; C:proton-transporting ATP synthase complex; catalytic core F(1); IEA:UniProtKB-KW GO GO:0005524; F:ATP binding; ISS:UniProtKB; . GO GO:0042288; F:MHC class I protein binding; IDA:UniProtKB; . GO GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB; . GO GO:0005515; F:protein binding; IPI:UniProtKB; . GO GO:0046933; F:proton-transporting ATP synthase activity; rotational mechanism; ISS:UniProtKB GO GO:0046961; F:proton-transporting ATPase activity; rotational mechanism; IEA:InterPro GO GO:0022857; F:transmembrane transporter activity; IC:UniProtKB; . GO GO:0006754; P:ATP biosynthetic process; NAS:UniProtKB; . GO GO:0006200; P:ATP catabolic process; IDA:GOC; . GO GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro; . GO GO:0044237; P:cellular metabolic process; TAS:Reactome; . GO GO:0009790; P:embryo development; ISS:UniProtKB; . GO GO:0006629; P:lipid metabolic process; ISS:UniProtKB; . GO GO:0042776; P:mitochondrial ATP synthesis coupled proton transport; IC:UniProtKB; . GO GO:0001937; P:negative regulation of endothelial cell proliferation; IMP:UniProtKB; . GO GO:0022904; P:respiratory electron transport chain; TAS:Reactome; . GO GO:0044281; P:small molecule metabolic process; TAS:Reactome; . Gene3D 2.40.30.20; -; 1; . Gene3D 3.40.50.300; -; 1; . HAMAP MF_01346; ATP_synth_alpha_bact; 1; . InterPro IPR020003; ATPase_a/bsu_AS; . InterPro IPR023366; ATPase_asu-like; . InterPro IPR005294; ATPase_F1-cplx_asu; . InterPro IPR000793; ATPase_F1/V1/A1-cplx_a/bsu_C; . InterPro IPR000194; ATPase_F1/V1/A1_a/bsu_nucl-bd; . InterPro IPR004100; ATPase_F1_a/bsu_N; . InterPro IPR027417; P-loop_NTPase; . Pfam PF00006; ATP-synt_ab; 1; . Pfam PF00306; ATP-synt_ab_C; 1; . Pfam PF02874; ATP-synt_ab_N; 1; . SUPFAM SSF47917; SSF47917; 1; . SUPFAM SSF50615; SSF50615; 1; . SUPFAM SSF52540; SSF52540; 1; . TIGRFAMs TIGR00962; atpA; 1; . PROSITE PS00152; ATPASE_ALPHA_BETA; 1; . World-2DPAGE Repository (search AC)