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World-2DPAGE Repository  Search by  [accession number]  [description, ID or gene]  [author names]  [spot ID / serial number]  [identification methods]  [pI / Mw range]  [combined fields]  Maps  [experimental info]  [protein list]  [graphical interface]      Databases 0001 0002 0003 0004 0005 0006 0007 0008 0009 0010 0011 0012 0014 0017 0018 0019 0020 0021 0022 0023 0024 0026 0027 0029 0030 0031 0032 0034 0035 0036 0037 0038 0039 0040 0042 0043 0044 0046 0047 0050 0051 0053 0054 0056 0059 0061 0062 0063 0066 0068 0069 0076 0077 0080 0084 0085 0088 use 'Ctrl' to select several databases Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal Exclude local DBs has only effect if a remote interface is selected

Searching in 'World-2DPAGE Repository [0054]' for entry matching: P27797 World-2DPAGE Repository (0054):  P27797 P27797 General information about the entry View entry in simple text format Entry name CALR_HUMAN Primary accession number P27797 integrated into World-2DPAGE Repository (0054) on  November 28, 2012 (release 1) 2D Annotations were last modified on November 28, 2012 (version 1) General Annotations were last modified on  October 23, 2014 (version 2) Name and origin of the protein Description RecName: Full=Calreticulin; AltName: Full=CRP55; AltName: Full=Calregulin; AltName: Full=Endoplasmic reticulum resident protein 60; Short=ERp60; AltName: Full=HACBP; AltName: Full=grp60; Flags: Precursor;. Gene name Name=CALR Synonyms=CRTC Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION DOI=10.1074/mcp.M112.022947; Vernocchi S., Battello N., Schmitz S., Revets D., Billing A.M., Turner J.D., Muller C.P. ''Membrane glucocorticoid receptor activation induces proteomic changes aligning with classical glucocorticoid-effects'' Molecular & Cellular Proteomics 12(7):1764-1779 (2013) 2D PAGE maps for identified proteins How to interpret a protein HSAPIENS_CCRF-CEM_3-10 {CCRF-CEM cells stimulated with Cort-BSA (internal standard)} Homo sapiens (Human)   map experimental info   HSAPIENS_CCRF-CEM_3-10 MAP LOCATIONS: SPOT 667: pI=4.29; Mw=46466   [identification data] %COV: SPOT 667: 61 [1]. SCORE: SPOT 667: 747 [1]. SEARCH ENGINE: SPOT 667: Mascot [1]. MAPPING (identification): SPOT 667: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1]. Copyright Data from Dr. Claude P. Muller, Centre de Recherche Public de la Sante / National Public Health Laboratory, Luxembourg Cross-references UniProtKB/Swiss-Prot P27797; CALR_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name CALR_HUMAN Primary accession number P27797 Secondary accession number(s) Q6IAT4 Q9UDG2 Sequence was last modified on  August 1, 1992 (version 1) Annotations were last modified on  October 1, 2014 (version 179) Name and origin of the protein Description RecName: Full=Calreticulin; AltName: Full=CRP55; AltName: Full=Calregulin; AltName: Full=Endoplasmic reticulum resident protein 60; Short=ERp60; AltName: Full=HACBP; AltName: Full=grp60; Flags: Precursor; Gene name Name=CALR Synonyms=CRTC Encoded on Name=CALR; Synonyms=CRTC Keywords 3D-structure; Acetylation; Calcium; Chaperone; Complete proteome; Cytoplasm; Direct protein sequencing; Disulfide bond; Endoplasmic reticulum; Extracellular matrix; Glycoprotein; Lectin; Metal-binding; Reference proteome; Repeat; Sarcoplasmic reticulum; Secreted; Signal; Zinc. Copyright Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL M32294; AAA36582.1; -; mRNA EMBL M84739; AAA51916.1; -; mRNA EMBL AY047586; AAL13126.1; -; mRNA EMBL AB451408; BAG70222.1; -; mRNA EMBL BT007448; AAP36116.1; -; mRNA EMBL CR457070; CAG33351.1; -; mRNA EMBL AD000092; AAB51176.1; -; Genomic_DNA EMBL CH471106; EAW84331.1; -; Genomic_DNA EMBL BC002500; AAH02500.1; -; mRNA EMBL BC007911; AAH07911.1; -; mRNA EMBL BC020493; AAH20493.1; -; mRNA CCDS CCDS12288.1; -; . PIR A42330; A37047; . RefSeq NP_004334.1; NM_004343.3; . UniGene Hs.515162; -; . PDB 2CLR; X-ray; 2.00 A; C/F=1-10 PDB 3DOW; X-ray; 2.30 A; B=195-205 PDB 3POS; X-ray; 1.65 A; A/B/C=18-204 A/B/C=302-368 PDB; 3POW; X-ray; 1.55 A A=18-204 A=302-368; PDBsum; 2CLR; - PDBsum 3DOW; -; . PDBsum 3POS; -; . PDBsum 3POW; -; . DisProt DP00333; -; . ProteinModelPortal P27797; -; . SMR P27797; 18-367; . BioGrid 107262; 83; . DIP DIP-104N; -; . IntAct P27797; 28; . MINT MINT-101756; -; . STRING 9606.ENSP00000320866; -; . DrugBank DB00009; Alteplase; . DrugBank DB00029; Anistreplase; . DrugBank DB00025; Antihemophilic Factor; . DrugBank DB00015; Reteplase; . DrugBank DB00031; Tenecteplase; . PhosphoSite P27797; -; . DMDM 117501; -; . DOSAC-COBS-2DPAGE P27797; -; . OGP P27797; -; . REPRODUCTION-2DPAGE IPI00020599; -; . SWISS-2DPAGE P27797; -; . UCD-2DPAGE P27797; -; . MaxQB P27797; -; . PaxDb P27797; -; . PRIDE P27797; -; . DNASU 811; -; . Ensembl ENST00000316448; ENSP00000320866; ENSG00000179218; . GeneID 811; -; . KEGG hsa:811; -; . UCSC uc002mvu.2; human; . CTD 811; -; . GeneCards GC19P013049; -; . HGNC HGNC:1455; CALR; . HPA CAB001513; -; . HPA CAB019952; -; . HPA HPA002242; -; . MIM 109091; gene; . neXtProt NX_P27797; -; . Orphanet 3318; Essential thrombocythemia; . Orphanet 824; Myelofibrosis with myeloid metaplasia; . PharmGKB PA26046; -; . eggNOG NOG305105; -; . HOGENOM HOG000192435; -; . HOVERGEN HBG005407; -; . InParanoid P27797; -; . KO K08057; -; . OMA VKLFPDG; -; . OrthoDB EOG77126Z; -; . PhylomeDB P27797; -; . TreeFam TF338438; -; . Reactome REACT_111178; ER-Phagosome pathway; . Reactome REACT_163699; Scavenging by Class A Receptors; . Reactome REACT_163813; Scavenging by Class F Receptors; . Reactome REACT_18423; ATF6-alpha activates chaperone genes; . Reactome REACT_23810; Calnexin/calreticulin cycle; . Reactome REACT_6277; Assembly of Viral Components at the Budding Site; . Reactome REACT_75795; Antigen Presentation: Folding; assembly and peptide loading of class I MHC; . ChiTaRS CALR; human; . EvolutionaryTrace P27797; -; . GeneWiki Calreticulin; -; . GenomeRNAi 811; -; . NextBio 3292; -; . PRO PR:P27797; -; . ArrayExpress P27797; -; . Bgee P27797; -; . CleanEx HS_CALR; -; . Genevestigator P27797; -; . GO GO:0001669; C:acrosomal vesicle; IEA:Ensembl; . GO GO:0009986; C:cell surface; TAS:BHF-UCL; . GO GO:0005737; C:cytoplasm; IDA:BHF-UCL; . GO GO:0005829; C:cytosol; IDA:UniProtKB; . GO GO:0071682; C:endocytic vesicle lumen; TAS:Reactome; . GO GO:0005783; C:endoplasmic reticulum; TAS:UniProtKB; . GO GO:0005788; C:endoplasmic reticulum lumen; IDA:UniProtKB; . GO GO:0009897; C:external side of plasma membrane; IEA:Ensembl; . GO GO:0005576; C:extracellular region; TAS:Reactome; . GO GO:0005615; C:extracellular space; IDA:BHF-UCL; . GO GO:0070062; C:extracellular vesicular exosome; IDA:UniProt; . GO GO:0005794; C:Golgi apparatus; IEA:Ensembl; . GO GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome; . GO GO:0005622; C:intracellular; TAS:UniProtKB; . GO GO:0016020; C:membrane; IDA:UniProtKB; . GO GO:0042824; C:MHC class I peptide loading complex; ISS:BHF-UCL; . GO GO:0005634; C:nucleus; IDA:BHF-UCL; . GO GO:0048471; C:perinuclear region of cytoplasm; IDA:BHF-UCL; . GO GO:0005844; C:polysome; ISS:BHF-UCL; . GO GO:0005578; C:proteinaceous extracellular matrix; IEA:UniProtKB-SubCell; . GO GO:0033018; C:sarcoplasmic reticulum lumen; IEA:UniProtKB-SubCell; . GO GO:0050681; F:androgen receptor binding; IDA:BHF-UCL; . GO GO:0005509; F:calcium ion binding; ISS:UniProtKB; . GO GO:0030246; F:carbohydrate binding; TAS:BHF-UCL; . GO GO:0051087; F:chaperone binding; TAS:BHF-UCL; . GO GO:0001849; F:complement component C1q binding; TAS:BHF-UCL; . GO GO:0003677; F:DNA binding; NAS:UniProtKB; . GO GO:0001948; F:glycoprotein binding; IPI:UniProt; . GO GO:0042562; F:hormone binding; IEA:Ensembl; . GO GO:0005178; F:integrin binding; IPI:BHF-UCL; . GO GO:0005506; F:iron ion binding; IEA:Ensembl; . GO GO:0003729; F:mRNA binding; IDA:BHF-UCL; . GO GO:0042277; F:peptide binding; IEA:Ensembl; . GO GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB; . GO GO:0005515; F:protein binding; IPI:IntAct; . GO GO:0044183; F:protein binding involved in protein folding; TAS:BHF-UCL; . GO GO:0031625; F:ubiquitin protein ligase binding; IPI:UniProtKB; . GO GO:0051082; F:unfolded protein binding; TAS:BHF-UCL; . GO GO:0008270; F:zinc ion binding; TAS:BHF-UCL; . GO GO:0006987; P:activation of signaling protein activity involved in unfolded protein response; TAS:Reactome; . GO GO:0042590; P:antigen processing and presentation of exogenous peptide antigen via MHC class I; TAS:Reactome; . GO GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I; TAP-dependent; TAS:Reactome GO GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome; . GO GO:0055007; P:cardiac muscle cell differentiation; IEA:Ensembl; . GO GO:0007050; P:cell cycle arrest; IGI:BHF-UCL; . GO GO:0006874; P:cellular calcium ion homeostasis; TAS:UniProtKB; . GO GO:0044267; P:cellular protein metabolic process; TAS:Reactome; . GO GO:0071285; P:cellular response to lithium ion; IEA:Ensembl; . GO GO:0090398; P:cellular senescence; IGI:BHF-UCL; . GO GO:0061077; P:chaperone-mediated protein folding; IEA:Ensembl; . GO GO:0030866; P:cortical actin cytoskeleton organization; IEA:Ensembl; . GO GO:0030968; P:endoplasmic reticulum unfolded protein response; TAS:Reactome; . GO GO:0042921; P:glucocorticoid receptor signaling pathway; TAS:BHF-UCL; . GO GO:0033144; P:negative regulation of intracellular steroid hormone receptor signaling pathway; IDA:BHF-UCL; . GO GO:0045665; P:negative regulation of neuron differentiation; IDA:BHF-UCL; . GO GO:0048387; P:negative regulation of retinoic acid receptor signaling pathway; IDA:BHF-UCL; . GO GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL; . GO GO:0045892; P:negative regulation of transcription; DNA-templated; IDA:BHF-UCL GO GO:0017148; P:negative regulation of translation; ISS:BHF-UCL; . GO GO:0002502; P:peptide antigen assembly with MHC class I protein complex; ISS:BHF-UCL; . GO GO:0045787; P:positive regulation of cell cycle; IGI:BHF-UCL; . GO GO:0008284; P:positive regulation of cell proliferation; IGI:BHF-UCL; . GO GO:2000510; P:positive regulation of dendritic cell chemotaxis; IMP:UniProtKB; . GO GO:0045740; P:positive regulation of DNA replication; IGI:BHF-UCL; . GO GO:0010628; P:positive regulation of gene expression; IEA:Ensembl; . GO GO:0050766; P:positive regulation of phagocytosis; ISS:BHF-UCL; . GO GO:1900026; P:positive regulation of substrate adhesion-dependent cell spreading; IMP:UniProtKB; . GO GO:0043687; P:post-translational protein modification; TAS:Reactome; . GO GO:0006611; P:protein export from nucleus; IDA:UniProtKB; . GO GO:0006457; P:protein folding; TAS:BHF-UCL; . GO GO:0034504; P:protein localization to nucleus; IDA:UniProtKB; . GO GO:0022417; P:protein maturation by protein folding; TAS:BHF-UCL; . GO GO:0018279; P:protein N-linked glycosylation via asparagine; TAS:Reactome; . GO GO:0050821; P:protein stabilization; ISS:UniProtKB; . GO GO:0042981; P:regulation of apoptotic process; TAS:UniProtKB; . GO GO:0040020; P:regulation of meiosis; IEA:Ensembl; . GO GO:0006355; P:regulation of transcription; DNA-templated; TAS:ProtInc GO GO:0042493; P:response to drug; IEA:Ensembl; . GO GO:0032355; P:response to estradiol; IEA:Ensembl; . GO GO:0033574; P:response to testosterone; IEA:Ensembl; . GO GO:0051208; P:sequestering of calcium ion; TAS:BHF-UCL; . GO GO:0007283; P:spermatogenesis; IEA:Ensembl; . Gene3D 2.60.120.200; -; 2; . InterPro IPR001580; Calret/calnex; . InterPro IPR018124; Calret/calnex_CS; . InterPro IPR009169; Calreticulin; . InterPro IPR009033; Calreticulin/calnexin_P_dom; . InterPro IPR008985; ConA-like_lec_gl_sf; . InterPro IPR013320; ConA-like_subgrp; . PANTHER PTHR11073; PTHR11073; 1; . Pfam PF00262; Calreticulin; 1; . PIRSF PIRSF002356; Calreticulin; 1; . PRINTS PR00626; CALRETICULIN; . SUPFAM SSF49899; SSF49899; 1; . SUPFAM SSF63887; SSF63887; 1; . PROSITE PS00803; CALRETICULIN_1; 1; . PROSITE PS00804; CALRETICULIN_2; 1; . PROSITE PS00805; CALRETICULIN_REPEAT; 3; . PROSITE PS00014; ER_TARGET; 1; . World-2DPAGE Repository (search AC)