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World-2DPAGE Repository  Search by  [accession number]  [description, ID or gene]  [author names]  [spot ID / serial number]  [identification methods]  [pI / Mw range]  [combined fields]  Maps  [experimental info]  [protein list]  [graphical interface]      Databases 0001 0002 0003 0004 0005 0006 0007 0008 0009 0010 0011 0012 0014 0017 0018 0019 0020 0021 0022 0023 0024 0026 0027 0029 0030 0031 0032 0034 0035 0036 0037 0038 0039 0040 0042 0043 0044 0046 0047 0050 0051 0053 0054 0056 0059 0061 0062 0063 0066 0068 0069 0076 0077 0080 0084 0085 0088 use 'Ctrl' to select several databases Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal Exclude local DBs has only effect if a remote interface is selected

Searching in 'World-2DPAGE Repository [0054]' for entry matching: P31040 World-2DPAGE Repository (0054):  P31040 P31040 General information about the entry View entry in simple text format Entry name SDHA_HUMAN Primary accession number P31040 integrated into World-2DPAGE Repository (0054) on  November 28, 2012 (release 1) 2D Annotations were last modified on November 28, 2012 (version 1) General Annotations were last modified on  October 23, 2014 (version 2) Name and origin of the protein Description RecName: Full=Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; EC=1.3.5.1; AltName: Full=Flavoprotein subunit of complex II; Short=Fp; Flags: Precursor;. Gene name Name=SDHA Synonyms=SDH2, SDHF Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION DOI=10.1074/mcp.M112.022947; Vernocchi S., Battello N., Schmitz S., Revets D., Billing A.M., Turner J.D., Muller C.P. ''Membrane glucocorticoid receptor activation induces proteomic changes aligning with classical glucocorticoid-effects'' Molecular & Cellular Proteomics 12(7):1764-1779 (2013) 2D PAGE maps for identified proteins How to interpret a protein HSAPIENS_CCRF-CEM_3-10 {CCRF-CEM cells stimulated with Cort-BSA (internal standard)} Homo sapiens (Human)   map experimental info   HSAPIENS_CCRF-CEM_3-10 MAP LOCATIONS: SPOT 587: pI=6.25; Mw=68012   [identification data] %COV: SPOT 587: 50 [1]. SCORE: SPOT 587: 951 [1]. SEARCH ENGINE: SPOT 587: Mascot [1]. MAPPING (identification): SPOT 587: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1]. Copyright Data from Dr. Claude P. Muller, Centre de Recherche Public de la Sante / National Public Health Laboratory, Luxembourg Cross-references UniProtKB/Swiss-Prot P31040; SDHA_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name SDHA_HUMAN Primary accession number P31040 Secondary accession number(s) A8K5J6 B4DJ60 E9PBJ5 Q16395 Q59GW8 Q8IW48 Q9UMY5 Sequence was last modified on  November 1, 1995 (version 2) Annotations were last modified on  October 1, 2014 (version 170) Name and origin of the protein Description RecName: Full=Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; EC=1.3.5.1; AltName: Full=Flavoprotein subunit of complex II; Short=Fp; Flags: Precursor; Gene name Name=SDHA Synonyms=SDH2, SDHF Encoded on Name=SDHA; Synonyms=SDH2, SDHF Keywords Acetylation; Alternative splicing; Cardiomyopathy; Complete proteome; Direct protein sequencing; Disease mutation; Electron transport; FAD; Flavoprotein; Leigh syndrome; Membrane; Mitochondrion; Mitochondrion inner membrane; Oxidoreductase; Phosphoprotein; Polymorphism; Reference proteome; Transit peptide; Transport; Tricarboxylic acid cycle; Tumor suppressor. Copyright Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL D30648; BAA06332.1; -; mRNA EMBL L21936; AAA20683.1; -; mRNA EMBL AF171030; AAD51006.1; -; Genomic_DNA EMBL AF171017; AAD51006.1; JOINED; Genomic_DNA EMBL AF171018; AAD51006.1; JOINED; Genomic_DNA EMBL AF171019; AAD51006.1; JOINED; Genomic_DNA EMBL AF171020; AAD51006.1; JOINED; Genomic_DNA EMBL AF171021; AAD51006.1; JOINED; Genomic_DNA EMBL AF171022; AAD51006.1; JOINED; Genomic_DNA EMBL AF171023; AAD51006.1; JOINED; Genomic_DNA EMBL AF171024; AAD51006.1; JOINED; Genomic_DNA EMBL AF171025; AAD51006.1; JOINED; Genomic_DNA EMBL AF171026; AAD51006.1; JOINED; Genomic_DNA EMBL AF171027; AAD51006.1; JOINED; Genomic_DNA EMBL AF171028; AAD51006.1; JOINED; Genomic_DNA EMBL AF171029; AAD51006.1; JOINED; Genomic_DNA EMBL AK291311; BAF84000.1; -; mRNA EMBL AK295937; BAG58722.1; -; mRNA EMBL AB208991; BAD92228.1; ALT_INIT; mRNA EMBL AC021087; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL CH471235; EAW50983.1; -; Genomic_DNA EMBL BC001380; AAH01380.1; -; mRNA EMBL BC041016; AAH41016.1; -; mRNA EMBL X53943; CAA37886.1; ALT_SEQ; mRNA EMBL S79641; AAB35332.1; -; Genomic_DNA CCDS CCDS3853.1; -. [P31040-1]; . PIR JX0336; JX0336; . PIR S21302; S21302; . RefSeq NP_004159.2; NM_004168.2; . UniGene Hs.440475; -; . ProteinModelPortal P31040; -; . SMR P31040; 52-664; . BioGrid 112290; 65; . IntAct P31040; 16; . MINT MINT-3012212; -; . STRING 9606.ENSP00000264932; -; . ChEMBL CHEMBL5758; -; . DrugBank DB00139; Succinic acid; . PhosphoSite P31040; -; . DMDM 1169337; -; . REPRODUCTION-2DPAGE IPI00305166; -; . MaxQB P31040; -; . PaxDb P31040; -; . PeptideAtlas P31040; -; . PRIDE P31040; -; . DNASU 6389; -; . Ensembl ENST00000264932; ENSP00000264932; ENSG00000073578. [P31040-1]; . Ensembl ENST00000510361; ENSP00000427703; ENSG00000073578. [P31040-2]; . GeneID 6389; -; . KEGG hsa:6389; -; . UCSC uc003jao.4; human. [P31040-1]; . CTD 6389; -; . GeneCards GC05P000208; -; . GeneReviews SDHA; -; . H-InvDB HIX0120996; -; . HGNC HGNC:10680; SDHA; . HPA CAB034929; -; . HPA HPA041981; -; . MIM 252011; phenotype; . MIM 256000; phenotype; . MIM 600857; gene; . MIM 613642; phenotype; . MIM 614165; phenotype; . neXtProt NX_P31040; -; . Orphanet 154; Familial isolated dilated cardiomyopathy; . Orphanet 44890; Gastrointestinal stromal tumor; . Orphanet 29072; Hereditary pheochromocytoma-paraganglioma; . Orphanet 3208; Isolated succinate-CoQ reductase deficiency; . Orphanet 255241; Leigh syndrome with leukodystrophy; . PharmGKB PA35605; -; . eggNOG COG1053; -; . HOVERGEN HBG001461; -; . InParanoid P31040; -; . KO K00234; -; . OMA RDGPILQ; -; . OrthoDB EOG7MH0XJ; -; . PhylomeDB P31040; -; . TreeFam TF300763; -; . BioCyc MetaCyc:ENSG00000073578-MONOMER; -; . Reactome REACT_1785; Citric acid cycle (TCA cycle); . Reactome REACT_22393; Respiratory electron transport; . UniPathway UPA00223; UER01006; . GeneWiki SDHA; -; . GenomeRNAi 6389; -; . NextBio 24820; -; . PRO PR:P31040; -; . ArrayExpress P31040; -; . Bgee P31040; -; . CleanEx HS_SDHA; -; . Genevestigator P31040; -; . GO GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB; . GO GO:0005749; C:mitochondrial respiratory chain complex II; ISS:UniProtKB; . GO GO:0005739; C:mitochondrion; IDA:UniProtKB; . GO GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro; . GO GO:0005515; F:protein binding; IPI:UniProtKB; . GO GO:0008177; F:succinate dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC; . GO GO:0044237; P:cellular metabolic process; TAS:Reactome; . GO GO:0007399; P:nervous system development; IMP:UniProtKB; . GO GO:0055114; P:oxidation-reduction process; IDA:UniProtKB; . GO GO:0022904; P:respiratory electron transport chain; IDA:UniProtKB; . GO GO:0044281; P:small molecule metabolic process; TAS:Reactome; . GO GO:0006105; P:succinate metabolic process; IDA:UniProtKB; . GO GO:0006099; P:tricarboxylic acid cycle; TAS:UniProtKB; . Gene3D 1.20.58.100; -; 1; . Gene3D 3.90.700.10; -; 1; . InterPro IPR003953; FAD_bind_dom; . InterPro IPR003952; FRD_SDH_FAD_BS; . InterPro IPR015939; Fum_Rdtase/Succ_DH_flav-like_C; . InterPro IPR027477; Succ_DH/fumarate_Rdtase_cat; . InterPro IPR011281; Succ_DH_flav_su_fwd; . InterPro IPR014006; Succ_Dhase_FrdA_Gneg; . Pfam PF00890; FAD_binding_2; 1; . Pfam PF02910; Succ_DH_flav_C; 1; . SUPFAM SSF46977; SSF46977; 1; . SUPFAM SSF56425; SSF56425; 1; . TIGRFAMs TIGR01816; sdhA_forward; 1; . TIGRFAMs TIGR01812; sdhA_frdA_Gneg; 1; . PROSITE PS00504; FRD_SDH_FAD_BINDING; 1; . World-2DPAGE Repository (search AC)